Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP)

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 6, 1998, Pages 721-734

  Watson, Corrine Y ^a   Whish, William J D ^a   Threadgill, Michael D ^a  

^a University of Bath   (United Kingdom)

Author keywords

Asymmetric reduction; Benzamide; Heck coupling; Isoquinolinone; Poly(ADP ribose)polymerase

Indexed keywords

BENZAMIDE DERIVATIVE; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN;

ANIMALS; BENZAMIDES; CELL LINE; ENZYME INHIBITORS; ISOQUINOLINES; MICE; POLY(ADP-RIBOSE) POLYMERASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031860249     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00029-7     Document Type: Article

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