Clinical Update on Nursing Home Medicine: 2016

Journal of the American Medical Directors Association

Volumn 17, Issue 11, 2016, Pages 978-993

  Messinger Rapport, Barbara J ^a   Little, Milta O ^b   Morley, John E ^b   Gammack, Julie K ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

behavioral and psychological symptoms; chronic kidney disease; dementia; Deprescription; hypotension; polypharmacy; rapid geriatric assessment; syncope; transfers; transitional care

Indexed keywords

AGING; ARTICLE; BEHAVIOR DISORDER; CHRONIC KIDNEY DISEASE; DEMENTIA; DEPRESCRIPTION; DRUG WITHDRAWAL; FAINTNESS; FRAIL ELDERLY; GERIATRIC ASSESSMENT; HEALTH CARE UTILIZATION; HIGH RISK PATIENT; HOSPITAL READMISSION; HUMAN; HYPOTENSION; KIDNEY FUNCTION; LONG TERM CARE; MENTAL DISEASE; NURSING HOME; NURSING HOME PATIENT; ORTHOSTATIC HYPOTENSION; POLYPHARMACY; PRESCRIPTION; QUALITY OF LIFE; TRANSITIONAL CARE; AGED; CHRONIC KIDNEY FAILURE; FEMALE; HEALTH CARE DELIVERY; MALE; PATHOPHYSIOLOGY;

AGED; DELIVERY OF HEALTH CARE; DEMENTIA; FEMALE; GERIATRIC ASSESSMENT; HUMANS; HYPOTENSION; MALE; NURSING HOMES; POLYPHARMACY; RENAL INSUFFICIENCY, CHRONIC; TRANSITIONAL CARE;

EID: 84992563863     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2016.09.004     Document Type: Article

References (218)

1. 1 Boyd, D.M., Darer, J., Boult, C., et al. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: Implications for pay for performance. JAMA 294 (2005), 716–724.
2. 2 McClellan, W.M., Resnick, B., Lei, L., et al. Prevalence and severity of chronic kidney disease and anemia in the nursing home population. J Am Med Dir Assoc 11 (2010), 33–41.
3. 3 American Geriatrics Society. 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc 63 (2015), 2227–2246.
4. 4 Olsson, I.N., Runnamo, R., Engfeldt, P., Medication quality and quality of life in the elderly, a cohort study. Health Qual Life Outcomes, 9, 2011, 95.
5. 5 Ballard, C., Hanney, M.L., Theodoulou, M., et al. The demetia antipsychotic withdrawal trial (DART-AD): Long-term follow-up of a randomized placebo-controlled trial. Lancet Neurol 8 (2009), 151–157.
6. 6 Garfinkel, D., Zur-Gil, S., Ben-Israel, J., The war against polypharmacy: A new cost-effective geriatric-palliative approach for improving drug therapy in disabled elderly people. Isr Med Assoc J 9 (2007), 430–434.
7. 7 Wauters, M., Elseviers, M., Vaes, B., et al. Too many, too few, or too unsafe? Impact of inappropriate prescribing on mortality and hospitalization in a cohort of community-dwelling oldest old. Br J Clin Pharmacol 82 (2016), 1382–1392.
8. 8 Moonen, J.E., Foster-Dingley, J.C., de Ruijter, W., et al. Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning–the DANTE Study Leiden: A randomized clinical trial. JAMA Intern Med 175 (2015), 1622–1630.
9. 9 Reeve, E., Andrews, J.M., Wiese, M.D., et al. Feasibility of a patient-centered deprescribing process to reduce inappropriate use of proton pump inhibitors. Ann Pharmacother 49 (2015), 29–38.
10. 10 Kutner, J.S., Blatchford, P.J., Taylor, D.H., et al. Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness. A randomized clinical trial. JAMA Intern Med 175 (2015), 691–700.
11. 11 Bain, K.T., Holmes, H.M., Beers, M.H., Discontinuing medications: A novel approach for revising the prescribing stage of the medication-use process. J Am Geriatr Soc 56 (2008), 1946–1952.
12. 12 Australian Deprescribing Network (ADeN). Available at: w11.zetaboards.com/ADeN/index. Accessed August 16, 2016.
13. 13 Canadian Institute for Health Information. Deprescribing guidelines. Available at: www.deprescribing.org. Accessed August 16, 2016.
14. 14 Loi, S.M., Westphal, A., Ames, D., Lautenschlager, N.T., Minimising psychotropic use for behavioural disturbance in residential aged care. Aust Fam Physician 44 (2015), 180–184.
15. 15 Declercq, T., Petrovic, M., Azermai, M., et al. Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev(3), 2013, CD007726.
16. 16 Proitsi, P., Lupton, M.K., Reeves, S.J., et al. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiol Aging 33 (2012), 791–803.
17. 17 Harding, R., Peel, E., ‘He was like a zombie’: Off-label prescription of antipsychotic drugs in dementia. Med Law Rev 21 (2013), 243–277.
18. 18 Restifo, S., Lemon, V., Waters, F., Pharmacological treatment of behavioural and psychological symptoms of dementia in psychogeriatric inpatient units. Australas Psychiatry 19 (2011), 59–63.
19. 19 Buhr, G.T., White, H.K., Difficult behaviors in long-term care patients with dementia. J Am Med Dir Assoc 8 (2007), e101–e113.
20. 20 Nobili, A., Pasina, L., Trevisan, S., et al. Use and misuse of antipsychotic drugs in patients with dementia in Alzheimer special care units. Int Clin Psychopharmacol 24 (2009), 97–104.
21. 21 McKean, A., Monasterio, E., Indications of atypical antipsychotics in the elderly. Expert Rev Clin Pharmacol 8 (2015), 5–7.
22. 22 Jones, T., Hungerford, C., Cleary, M., Pharmacological versus non-pharmacological approaches to managing challenging behaviours for people with dementia. Br J Community Nurs 19 (2014), 72–77.
23. 23 Kamble, P., Chen, H., Sherer, J.T., Aparasu, R.R., Use of antipsychotics among elderly nursing home residents with dementia in the US: An analysis of National Survey Data. Drugs Aging 26 (2009), 483–492.
24. 24 Wood-Mitchell, A., James, I.A., Waterworth, A., et al. Factors influencing the prescribing of medications by old age psychiatrists for behavioural and psychological symptoms of dementia: A qualitative study. Age Ageing 37 (2008), 547–552.
25. 25 Gauthier, S., Cummings, J., Ballard, C., et al. Management of behavioral problems in Alzheimer's disease. Int Psychogeriatr 22 (2010), 346–372.
26. 26 Schneider, L.S., Tariot, P.N., Dagerman, K.S., et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med 355 (2006), 1525–1538.
27. 27 Maher, A.R., Maglione, M., Bagley, S., et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: A systematic review and meta-analysis. JAMA 306 (2011), 1359–1369.
28. 28 Ravona-Springer, R., Davidson, M., Considerations in psychotropic treatments in dementia–can polypharmacy be avoided?. Int J Neuropsychopharmacol 17 (2014), 1107–1117.
29. 29 Trifiro, G., Spina, E., Gambassi, G., Use of antipsychotics in elderly patients with dementia: Do atypical and conventional agents have a similar safety profile?. Pharmacol Res 59 (2009), 1–12.
30. 30 Dorsey, E.R., Rabbani, A., Gallagher, S.A., et al. Impact of FDA black box advisory on antipsychotic medication use. Arch Intern Med 170 (2010), 96–103.
31. 31 Tampi, R.R., Tampi, D.J., Efficacy and tolerability of benzodiazepines for the treatment of behavioral and psychological symptoms of dementia: A systematic review of randomized controlled trials. Am J Alzheimers Dis Other Demen 29 (2014), 565–574.
32. 32 Sawa, M., Chan, P., Donnelly, M., et al. A case-control study regarding relative factors for behavioural and psychological symptoms of dementia at a Canadian regional long-term extended care facility: A preliminary report. Psychogeriatrics 14 (2014), 25–30.
33. 33 Rosler, M., The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia. Int J Clin Pract Suppl 127 (2002), 20–36.
34. 34 Bullock, R., Touchon, J., Bergman, H., et al. Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period. Curr Med Res Opin 21 (2005), 1317–1327.
35. 35 Tariot, P.N., Cummings, J.L., Katz, I.R., et al. A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting. J Am Geriatr Soc 49 (2001), 1590–1599.
36. 36 Birks, J.S., Grimley Evans, J., Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev(4), 2015, CD001191.
37. 37 Clerici, F., Vanacore, N., Elia, A., et al. Memantine effects on behaviour in moderately severe to severe Alzheimer's disease: A post-marketing surveillance study. Neurol Sci 33 (2012), 23–31.
38. 38 Wilcock, G.K., Ballard, C.G., Cooper, J.A., Loft, H., Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: A pooled analysis of 3 studies. J Clin Psychiatry 69 (2008), 341–348.
39. 39 Gallagher, D., Herrmann, N., Antiepileptic drugs for the treatment of agitation and aggression in dementia: Do they have a place in therapy?. Drugs 74 (2014), 1747–1755.
40. 40 Herrmann, N., Gauthier, S., Boneva, N., Lemming, O.M., Investigators. A randomized, double-blind, placebo-controlled trial of memantine in a behaviorally enriched sample of patients with moderate-to-severe Alzheimer's disease. Int Psychogeriatr 25 (2013), 919–927.
41. 41 Fox, C., Crugel, M., Maidment, I., et al. Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial. PLoS One, 7, 2012, e35185.
42. 42 Meinhold, J.M., Blake, L.M., Mini, L.J., et al. Effect of divalproex sodium on behavioural and cognitive problems in elderly dementia. Drugs Aging 22 (2005), 615–626.
43. 43 Konovalov, S., Muralee, S., Tampi, R.R., Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: A literature review. Int Psychogeriatr 20 (2008), 293–308.
44. 44 Lonergan, E., Luxenberg, J., Valproate preparations for agitation in dementia. Cochrane Database Syst Rev(3), 2009, CD003945.
45. 45 Devarajan, S., Dursun, S.M., Aggression in dementia with lamotrigine treatment. Am J Psychiatry, 157, 2000, 1178.
46. 46 De Leon, O.A., Treatment of psychotic symptoms with lamotrigine in Alzheimer disease. J Clin Psychopharmacol 24 (2004), 232–233.
47. 47 Suzuki, H., Gen, K., Clinical efficacy of lamotrigine and changes in the dosages of concomitantly used psychotropic drugs in Alzheimer's disease with behavioural and psychological symptoms of dementia: A preliminary open-label trial. Psychogeriatrics 15 (2015), 32–37.
48. 48 Yeh, Y.C., Ouyang, W.C., Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia: An update review. Kaohsiung J Med Sci 28 (2012), 185–193.
49. 49 Kim, Y., Wilkins, K.M., Tampi, R.R., Use of gabapentin in the treatment of behavioural and psychological symptoms of dementia: A review of the evidence. Drugs Aging 25 (2008), 187–196.
50. 50 Lanctot, K.L., Herrmann, N., Mazzotta, P., et al. GABAergic function in Alzheimer's disease: Evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia. Can J Psychiatry 49 (2004), 439–453.
51. 51 Cummings, J.L., Lyketsos, C.G., Peskind, E.R., et al. Effect of dextromethorphan-quinidine on agitation in patients with Alzheimer disease dementia: A randomized clinical trial. JAMA 314 (2015), 1242–1254.
52. 52 Corbett, A., Husebo, B., Malcangio, M., et al. Assessment and treatment of pain in people with dementia. Nat Rev Neurol 8 (2012), 264–274.
53. 53 Rivas Velasquez, K.M., Hames, E., Masri, H., Evaluation and management of the older adult with chronic kidney disease. Prim Care 41 (2014), 857–874.
54. 54 Wang, X., Bonventre, J.V., Parrish, A.R., The aging kidney: Increased susceptibility to nephrotoxicity. Int J Mol Sci 15 (2014), 15358–15376.
55. 55 Nitta, K., Okada, K., Yanai, M., Takahashi, S., Aging and chronic kidney disease. Kidney Blood Press Res 38 (2013), 109–120.
56. 56 Fassett, R.G., Current and emerging treatment options for the elderly patient with chronic kidney disease. Clin Interv Aging 9 (2014), 191–199.
57. 57 Maw, T.T., Fried, L., Chronic kidney disease in the elderly. Clin Geriatr Med 29 (2013), 611–624.
58. 58 Schaeffner, E.S., Ebert, N., Delanaye, P., et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med 157 (2012), 471–481.
59. 59 Ponticelli, C., Sala, G., Glassock, R.J., Drug management in the elderly adult with chronic kidney disease: A review for the primary care physician. Mayo Clin Proc 90 (2015), 633–645.
60. 60 Stevens, P.E., Lamb, E.J., Levin, A., Integrating guidelines, CKD, multimorbidity, and older adults. Am J Kidney Dis 65 (2015), 494–501.
61. 61 Hall, R.K., O'Hare, A.M., Anderson, R.A., Colon-Emeric, C.S., End-stage renal disease in nursing homes: A systematic review. J Am Med Dir Assoc 14 (2013), 242–247.
62. 62 Cohen, J.T., Jasimuddin, S.K., Tommasulo, B.C., et al. Underdiagnosis of chronic kidney disease in the nursing home population. J Am Geriatr Soc 57 (2009), 1123–1124.
63. 63 Zarowitz, B.J., Clinical approaches to assessing and managing nursing home residents with chronic kidney disease. Geriatr Nurs 30 (2009), 118–123.
64. 64 Aguilar, E.A., Ashraf, H., Frontini, M., et al. An analysis of chronic kidney disease risk factors in a Louisiana nursing home population: A cross-sectional study. J La State Med Soc 165 (2013), 260–263 265–267.
65. 65 Dharmarajan, T.S., Yoo, J., Russell, R.O., Norkus, E.P., Chronic kidney disease staging in nursing home and community older adults: Does the choice of Cockcroft-Gault, modification of diet in renal disease study, or the chronic kidney disease epidemiology collaboration initiative equations matter?. J Am Med Dir Assoc 13 (2012), 151–155.
66. 66 Palmer, S., Vecchio, M., Craig, J.C., et al. Prevalence of depression in chronic kidney disease: Systematic review and meta-analysis of observational studies. Kidney Int 84 (2013), 179–191.
67. 67 Greco, A., Paroni, G., Seripa, D., et al. Frailty, disability and physical exercise in the aging process and in chronic kidney disease. Kidney Blood Press Res 39 (2014), 164–168.
68. 68 Walker, S.R., Gill, K., Macdonald, K., et al. Association of frailty and physical function in patients with non-dialysis CKD: A systematic review. BMC Nephrol, 14, 2013, 228.
69. 69 Schnelle, J., Osterweil, D., Globe, D., et al. Chronic kidney disease, anemia, and the association between chronic kidney disease-related anemia and activities of daily living in older nursing home residents. J Am Med Dir Assoc 10 (2009), 120–126.
70. 70 Artz, A.S., Fergusson, D., Drinka, P.J., et al. Mechanisms of unexplained anemia in the nursing home. J Am Geriatr Soc 52 (2004), 423–427.
71. 71 Heras, M., Garcia-Cosmes, P., Fernandez-Reyes, M.J., Sanchez, R., Natural progression of renal function in the elderly: Analysis of poor prognosis factors associated with chronic kidney disease. Nefrologia 33 (2013), 462–469.
72. 72 Kovesdy, C.P., Bleyer, A.J., Molnar, M.Z., et al. Blood pressure and mortality in U.S. veterans with chronic kidney disease: A cohort study. Ann Intern Med 159 (2013), 233–242.
73. 73 Qian, Q., Nasr, S.H., Diagnosis and treatment of glomerular diseases in elderly patients. Adv Chronic Kidney Dis 21 (2014), 228–246.
74. 74 Lewis, R., An overview of chronic kidney disease in older people. Nurs Older People 25 (2013), 31–38.
75. 75 Pedone, C., Semeraro, R., Chiurco, D., et al. Reliability of equations to estimate glomerular filtration rate in the very old. Aging Clin Exp Res 20 (2008), 496–502.
76. 76 Schold, J.D., Navaneethan, S.D., Jolly, S.E., et al. Implications of the CKD-EPI GFR estimation equation in clinical practice. Clin J Am Soc Nephrol 6 (2011), 497–504.
77. 77 Inker, L.A., Schmid, C.H., Tighiouart, H., et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367 (2012), 20–29.
78. 78 Earley, A., Miskulin, D., Lamb, E.J., et al. Estimating equations for glomerular filtration rate in the era of creatinine standardization: A systematic review. Ann Intern Med 156 (2012), 785–795 W-270, W-1, W-2, W-3, W-4, W-5, W-6, W-7, W-8.
79. 79 Shlipak, M.G., Sarnak, M.J., Katz, R., et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med 352 (2005), 2049–2060.
80. 80 Peralta, C.A., Katz, R., Sarnak, M.J., et al. Cystatin C identifies chronic kidney disease patients at higher risk for complications. J Am Soc Nephrol 22 (2011), 147–155.
81. 81 Kovesdy, C.P., Lu, J.L., Molnar, M.Z., et al. Observational modeling of strict vs conventional blood pressure control in patients with chronic kidney disease. JAMA Intern Med 174 (2014), 1442–1449.
82. 82 Winkelmayer, W.C., Zhang, Z., Shahinfar, S., et al. Efficacy and safety of angiotensin II receptor blockade in elderly patients with diabetes. Diabetes Care 29 (2006), 2210–2217.
83. 83 Dharmarajan, T.S., Davuluri, S., Medications, renal function, and kidney injury: A complex interplay, wherein prevention is easier than cure!. J Am Med Dir Assoc 15 (2014), 692–696.
84. 84 McMahon, E.J., Bauer, J.D., Hawley, C.M., et al. A randomized trial of dietary sodium restriction in CKD. J Am Soc Nephrol 24 (2013), 2096–2103.
85. 85 Upadhyay, A., Earley, A., Lamont, J.L., et al. Lipid-lowering therapy in persons with chronic kidney disease: A systematic review and meta-analysis. Ann Intern Med 157 (2012), 251–262.
86. 86 Baigent, C., Landray, M.J., Reith, C., et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): A randomised placebo-controlled trial. Lancet 377 (2011), 2181–2192.
87. 87 Palmer, S.C., Craig, J.C., Navaneethan, S.D., et al. Benefits and harms of statin therapy for persons with chronic kidney disease: A systematic review and meta-analysis. Ann Intern Med 157 (2012), 263–275.
88. 88 Davison, R., Sheerin, N.S., Prognosis and management of chronic kidney disease (CKD) at the end of life. Postgrad Med J 90 (2014), 98–105.
89. 89 Musso, C.G., Trigka, K., Dousdampanis, P., Jauregui, J., Therapeutic alternatives and palliative care for advanced renal disease in the very elderly: A review of the literature. Int Urol Nephrol 47 (2015), 647–654.
90. 90 Drinka, P.J., The importance of parathyroid hormone and vitamin D status in the treatment of osteoporosis and renal insufficiency. J Am Med Dir Assoc 5 (2004), 382–386.
91. 91 Riggs, B.L., Melton, L.J. 3rd, Evidence for two distinct syndromes of involutional osteoporosis. Am J Med 75 (1983), 899–901.
92. 92 Ledger, G.A., Burritt, M.F., Kao, P.C., et al. Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption. J Clin Endocrinol Metab 80 (1995), 3304–3310.
93. 93 Gheewala, P.A., Peterson, G.M., Curtain, C.M., et al. Impact of the pharmacist medication review services on drug-related problems and potentially inappropriate prescribing of renally cleared medications in residents of aged care facilities. Drugs Aging 31 (2014), 825–835.
94. 94 Bell, J.S., Blacker, N., Leblanc, V.T., et al. Prescribing for older people with chronic renal impairment. Aust Fam Physician 42 (2013), 24–28.
95. 95 Nderitu, P., Doos, L., Jones, P.W., et al. Non-steroidal anti-inflammatory drugs and chronic kidney disease progression: A systematic review. Fam Pract 30 (2013), 247–255.
96. 96 Sanford, A., Morley, J.E., Are the new guidelines for cholesterol and hypertension age friendly?. J Am Med Dir Assoc 15 (2014), 373–375.
97. 97 Morley, J.E., Treatment of hypertension in older persons: What is the evidence?. Drugs Aging 31 (2014), 331–337.
98. 98 Staessen, J.A., Den Hond, E., Celis, H., et al., Treatment of Hypertension Based on Home or Office Blood Pressure (THIP) Trial Investigators. Antihypertensive treatment based on blood pressure measurement at home or in the physician's office: A randomized controlled trial. JAMA 291 (2004), 955–964.
99. 99 Mossello, E., Pieraccioli, M.C., Zanieri, S., et al. Ambulatory blood pressure monitoring in older nursing home residents: Diagnostic and prognostic role. J Am Med Dir Assoc 13 (2012), 760.e1–760.e5.
100. 100 Kuwajima, I., Hoh, E., Suzuki, Y., et al. Pseudohypertension in the elderly. J Hypertens 8 (1990), 429–432.
101. 101 Morley, J.E., Inappropriate drug prescribing and polypharmacy are major causes of poor outcomes in long-term care. J Am Med Dir Assoc 15 (2014), 780–782.
102. 102 Hein, C., Forgues, A., Piau, A., et al. Impact of polypharmacy on occurrence of delirium in elderly emergency patients. J Am Med Dir Assoc 15 (2014), 850.e11–850.e15.
103. 103 Rolland, Y., Morley, J.E., Editorial: Frailty and polypharmacy. J Nutr Health Aging 20 (2016), 645–646.
104. 104 Jodaitis, L., Vaillant, F., Snacken, M., et al. Orthostatic hypotension and associated conditions in geriatric inpatients. Acta Clin Belg 70 (2015), 251–258.
105. 105 Gorelik, O., Cohen, N., Seated postural hypotension. J Am Soc Hypertens 9 (2015), 985–992.
106. 106 Trahair, L.G., Horowitz, M., Jones, K.L., Postprandial hypotension: A systematic review. J Am Med Dir Assoc 15 (2014), 394–409.
107. 107 Savic, A., Mimica, N., Two cases of loss of consciousness after long-term memantine treatment. J Am Med Dir Assoc 14 (2013), 375–376.
108. 108 Butt, D.A., Harvey, P.J., Benefits and risks of antihypertensive medications in the elderly. J Intern Med 278 (2015), 599–626.
109. 109 Glab, K.L., Wooding, F.G., Tuiskula, K.A., Medication-related falls in the elderly: Mechanisms and prevention strategies. Consult Pharm 29 (2014), 413–417.
110. 110 Lima Ribeiro, S.M., Morley, J.E., Dehydration is difficult to detect and prevent in nursing homes. J Am Med Dir Assoc 16 (2015), 175–176.
111. 111 Bursztyn, M., Jacobs, J.M., Hammerman-Rozenberg, A., Stessman, J., Prevalence of orthostatic hypertension in the very elderly and its relationship to all-cause mortality. J Hypertens 34 (2016), 2053–2058.
112. 112 Hartog, L.C., Hendriks, S.H., Cimzar-Sweelssen, M., et al. Orthostatic changes in blood pressure and mortality in a nursing home population. J Hypertens 34 (2016), 1068–1074.
113. 113 Khera, S., Palaniswamy, C., Aronow, W.S., et al. Predictors of mortality, rehospitalization for syncope, and cardiac syncope in 352 consecutive elderly patients with syncope. J Am Med Dir Assoc 14 (2013), 326–330.
114. 114 Iwancyk, L., Weintraub, N.T., Rubenstein, L.Z., Orthostatic hypotension in the nursing home setting. J Am Med Dir Assoc 7 (2006), 163–167.
115. 115 Agnoletti, D., Valbusa, F., Labat, C., et al., PARTAGE study investigators. Evidence for a prognostic role of orthostatic hypertension on survival in a very old institutionalized population. Hypertension 67 (2016), 191–196.
116. 116 Schultz, M., Rosted, E., Sanders, S., Frailty is associated with a history with more falls in elderly hospitalised patients. Dan Med J, 62, 2015 pii:A5058.
117. 117 Shannon, R.P., Wei, J.Y., Rosa, R.M., et al. The effect of age and sodium depletion on cardiovascular response to orthostasis. Hypertension 8 (1986), 438–443.
118. 118 Morley, J.E., Vellas, B., van Kan, G.A., et al. Frailty consensus: A call to action. J Am Med Dir Assoc 14 (2013), 392–397.
119. 119 Morley, J.E., von Haehling, S., Anker, S.D., Vellas, B., From sarcopenia to frailty: A road less traveled. J Cachexia Sarcopenia Muscle 5 (2014), 5–8.
120. 120 Luo, H., Lum, T.Y., Wong, G.H., et al. Predicting adverse health outcomes in nursing homes: A 9-year longitudinal study and development of the FRAIL-Minimum Data Set (MDS) Quick Screening tool. J Am Med Dir Assoc 16 (2015), 1042–1047.
121. 121 Anker, S.D., Morley, J.E., Cachexia: A nutritional syndrome?. J Cachexia Sarcopenia Muscle 6 (2015), 269–271.
122. 122 Morley, J.E., Anorexia of aging: A true geriatric syndrome. J Nutr Health Aging 16 (2012), 422–425.
123. 123 Ezeoke, C.C., Morley, J.E., Pathophysiology of anorexia in the cancer cachexia syndrome. J Cachexia Sarcopenia Muscle 6 (2015), 287–302.
124. 124 Fernandez, L., Breinbauer, H.A., Delano, P.H., Vertigo and dizziness in the elderly. Front Neurol, 6, 2015, 144.
125. 125 Jahn, K., Kressig, R.W., Bridenbaugh, S.A., et al. Dizziness and unstable gait in old age: Etiology, diagnosis and treatment. Dtsch Arztebl Int 112 (2015), 387–393.
126. 126 Iwasaki, S., Yamasoba, T., Dizziness and imbalance in the elderly: Age-related decline in the vestibular system. Aging Dis 6 (2014), 38–47.
127. 127 AlgAlagiakrishnan, K., Current pharmacological management of hypotensive syndromes in the elderly. Drugs Aging 32 (2015), 337–348.
128. 128 Strassheim, V., Newton, J.L., Tan, M.P., Frith, J., Droxidopa for orthostatic hypotension: A systematic review and meta-analysis. J Hypertens 34 (2016), 1933–1941.
129. 129 Morley, J.E., Editorial: Postprandial hypotension—the ultimate Big Mac attack. J Gerontol A Biol Sci Med Sci 56 (2001), M741–M743.
130. 130 Edwards, B.J., Perry, H.M. 3rd, Kaiser, F.E., et al. Relationship of age and calcitonin gene-related peptide to postprandial hypotension. Mech Ageing Dev 87 (1996), 61–73.
131. 131 Luciano, G.L., Brennan, M.J., Rothberg, M.B., Postprandial hypotension. Am J Med 123 (2010), 281.e1–281.e6.
132. 132 Qiao, W., Li, J., Li, Y., et al. Acarbose, the α-glucosidase inhibitor, attenuates the blood pressure and splanchnic blood flow response to meal in elderly patients with postprandial hypotension concomitant with abnormal glucose metabolism. Blood Press Monit 21 (2016), 38–42.
133. 133 Madden, K.M., Harris, D.E., Meneilly, G.S., Attenuation of postprandial with acarbose in older adults with type 2 diabetes mellitus. J Am Geriatr Soc 63 (2015), 1484–1486.
134. 134 Kenny, R.A., Bhangu, J., King-Kallimanis, B.L., Epidemiology of syncope/collapse in younger and older Western patient populations. Prog Cardiovasc Dis 55 (2013), 357–363.
135. 135 Morley, J.E., Syncope. J Am Med Dir Assoc 14 (2013), 311–312.
136. 136 Solbiati, M., Costantino, G., Casazza, G., et al. Implantable loop recorder versus conventional diagnostic workup for unexplained recurrent syncope. Cochrane Database Syst Rev(4), 2016, CD011637.
137. 137 Elesber, A.A., Decker, W.W., Smars, P.A., et al. Impact of the application of the American College of Emergency Physicians recommendations for the admission of patients with syncope on a retrospectively studied population presenting to the emergency department. Am Heart J 149 (2005), 826–831.
138. 138 Kera, T., Kawai, H., Yoshida, H., et al. Classification of frailty using the Kihon checklist: A cluster analysis of older adults in urban areas. Geriatr Gerontol Int, 2016 Jan 21 [Epub ahead of print].
139. 139 Vellas, B., Implementing frailty screening, assessment, and sustained intervention: The experience of the Gerontopole. J Nutr Health Aging 19 (2015), 673–680.
140. 140 Morley, J.E., Abele, P., The Medicare annual wellness visit in nursing homes. J Am Med Dir Assoc 17 (2016), 567–569.
141. 141 Morley, J.E., Adams, E.V., Rapid geriatric assessment. J Am Med Dir Assoc 16 (2015), 808–812.
142. 142 Rosas-Carrasco, O., Cruz-Arenas, E., Parra-Rodriguez, L., et al. Cross-cultural adaptation and validation of the FRAIL scale to assess frailty in Mexican adults. J Am Med Dir Assoc, 2016 Aug 24 [Epub ahead of print].
143. 143 Li, Y., Zou, Y., Wang, S., et al. A pilot study of the FRAIL scale on predicting outcomes in Chinese elderly people with type 2 diabetes. J Am Med Dir Assoc 16 (2015), 714.e7–714.e12.
144. 144 Woo, J., Yu, R., Wong, M., et al. Frailty screening in the community using the FRAIL scale. J Am Med Dir Assoc 16 (2015), 412–419.
145. 145 Malmstrom, T.K., Miller, D.K., Morley, J.E., A comparison of four failty models. J Am Geriatr Soc 62 (2014), 721–726.
146. 146 Morley, J.E., Malmstrom, T.K., Miller, D.K., A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging 16 (2012), 601–608.
147. 147 Hyde, Z., Flicker, L., Almeida, O.P., et al. Low free testosterone predicts frailty in older men: The health in men study. J Clin Endocrinol Metab 95 (2010), 3165–3172.
148. 148 Malmstrom, T.K., Miller, D.K., Simonsick, E.M., et al. SARC-F: A symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J Cachexia Sarcopenia Muscle 7 (2016), 28–36.
149. 149 Woo, J., Leung, J., Morley, J.E., Defining sarcopenia in terms of incident adverse outcomes. J Am Med Dir Assoc 16 (2015), 247–252.
150. 150 Woo, J., Leung, J., Morley, J.E., Validating the SARC-F: A suitable community screening tool for sarcopenia?. J Am Med Dir Assoc 15 (2014), 630–634.
151. 151 Cao, L., Chen, S., Zou, C., et al. A pilot study of the SARC-F scale on screening sarcopenia and physical disability in the Chinese older people. J Nutr Health Aging 18 (2014), 277–283.
152. 152 Wilson, M.M., Thomas, D.R., Rubenstein, L.Z., et al. Appetite assessment: Simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82 (2005), 1074–1081.
153. 153 Pilgrim, A.L., Baylis, D., Jameson, K.A., et al. Measuring appetite with the Simplified Nutritional Appetite Questionnaire identifies hospitalised older people at risk of worse health outcomes. J Nutr Health Aging 20 (2016), 3–7.
154. 154 Nakatsu, N., Sawa, R., Misu, S., et al. Reliability and validity of the Japanese version of the simplified nutritional appetite questionnaire in community-dwelling older adults. Geriatr Gerontol Int 15 (2015), 1264–1269.
155. 155 Rolland, Y., Perrin, A., Gardette, V., et al. Screening older people at risk of malnutrition or malnourished using the Simplified Nutritional Appetite Questionnaire (SNAQ): A comparison with the Mini-Nutritional Assessment (MNA) tool. J Am Med Dir Assoc 13 (2012), 31–34.
156. 156 Malmstrom, T.K., Voss, V.B., Cruz-Oliver, D.M., et al. The Rapid Cognitive Screen (RCS): A point-of-care screening for dementia and mild cognitive impairment. J Nutr Health Aging 19 (2015), 741–744.
157. 157 Tariq, S.H., Tumosa, N., Chibnall, J.T., et al. Comparison of the Saint Louis University mental status examination and the mini-mental state examination for detecting dementia and mild neurocognitive disorder—a pilot study. Am J Geriatr Psychiatry 14 (2006), 900–910.
158. 158 Cummings-Vaughn, L.A., Chavakula, N.N., Malmstrom, T.K., et al. Veterans Affairs Saint Louis University Mental Status examination compared with the Montreal Cognitive Assessment and the Short Test of Mental Status. J Am Geriatr Soc 62 (2014), 1341–1346.
159. 159 Cruz-Oliver, D.M., Malmstrom, T.K., Allen, C.M., et al. The Veterans Affairs Saint Louis University mental status exam (SLUMS exam) and the Mini-mental status exam as predictors of mortality and institutionalization. J Nutr Health Aging 16 (2012), 636–641.
160. 160 Luger, E., Dorner, T.E., Haider, S., et al. Effects of a home-based and volunteer-administered physical training, nutrition, and social support program on malnutrition and frailty in older persons: A randomized controlled trial. J Am Med Dir Assoc 17 (2016), 671.e9–671.e16.
161. 161 Tarazona-Santabalbina, F.J., Gomez-Cabrera, M.C., Perez-Ros, P., et al. A multicomponent exercise intervention that reverses frailty and improves cognition, emotion, and social networking in the community-dwelling frail elderly: A randomized clinical trial. J Am Med Dir Assoc 17 (2016), 426–433.
162. 162 Bauer, J.M., Verlaan, S., Bautmans, I., et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: A randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 16 (2015), 740–747.
163. 163 Abizanda, P., Lopez, M.D., Garcia, V.P., et al. Effects of an oral nutritional supplementation plus physical exercise intervention in the physical function, nutritional status, and quality of life in frail institutionalized older adults: The ACTIVNES study. J Am Med Dir Assoc 16 (2015), 439.e9–439.e16.
164. 164 Cruz-Oliver, D.M., Malmstrom, T.K., Roegner, M., et al. Cognitive deficit reversal as shown by changes in the Veterans Affairs Saint Louis University Mental Status (SLUMS) examination scores 7.5 years later. J Am Med Dir Assoc 15 (2014), 687.e5–687.e10.
165. 165 Ngandi, T., Lehtisalo, J., Solomon, A., et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial. Lancet 385 (2015), 2255–2263.
166. 166 Volicer, L., Is your nursing home a battlefield?. J Am Med Dir Assoc 13 (2012), 195–196.
167. 167 Volicer, L., Toward better terminology of behavioral symptoms of dementia. J Am Med Dir Assoc 13 (2012), 3–4.
168. 168 Morley, J.E., Dementia-related agitation. J Am Med Dir Assoc 12 (2011), 611–612.e2.
169. 169 Morley, J.E., New horizons in the management of Alzheimer disease. J Am Med Dir Assoc 16 (2015), 1–5.
170. 170 Little, J.T., Satlin, A., Sunderland, T., Volicer, L., Sundown syndrome in severely demented patients with probable Alzheimer's disease. J Geriatr Psychiatry Neurol 8 (1995), 103–106.
171. 171 Ferrazzoli, D., Sica, F., Sancesario, G., Sundowning syndrome: A possible marker of frailty in Alzheimer's disease?. CNS Neurol Disord Drug Targets 12 (2013), 525–528.
172. 172 Flaherty, J.H., Morley, J.E., Delirium in the nursing home. J Am Med Dir Assoc 14 (2013), 632–634.
173. 173 Flaherty, J.H., Shay, K., Weir, C., et al., VA Delirium Working Group. The development of a mental status vital sign for use across the spectrum of care. J Am Med Dir Assoc 10 (2009), 379–380.
174. 174 Flaherty, J.H., Rudolph, J., Shay, K., et al. Delirium is a serious and under-recognized problem: Why assessment of mental status should be the sixth vital sign. J Am Med Dir Assoc 8 (2007), 273–275.
175. 175 Kolanowski, A., Mogle, J., Fick, D.M., et al. Pain, delirium, and physical function in skilled nursing home patients with dementia. J Am Med Dir Assoc 16 (2015), 37–40.
176. 176 Brett, L., Traynor, V., Stapley, P., Effects of physical exercise on health and well-being of individuals living with a dementia in nursing homes: A systematic review. J Am Med Dir Assoc 17 (2016), 104–116.
177. 177 Lam, L.C., Chau, R.C., Wong, B.M., et al. A 1-year randomized controlled trial comparing mind body exercise (Tai Chi) with stretching and toning exercise on cognitive function in older Chinese adults at risk of cognitive decline. J Am Med Dir Assoc 13 (2012), 568.e15–568.e20.
178. 178 Aman, E., Thomas, D.R., Supervised exercise to reduce agitation in severely cognitively impaired persons. J Am Med Dir Assoc 10 (2009), 271–276.
179. 179 Barreto Pde, S., Demougeot, L., Pillard, F., et al. Exercise training for managing behavioral and psychological symptoms in people with dementia: A systematic review and meta-analysis. Ageing Res Rev 24 (2015), 274–285.
180. 180 Yang, Y.P., Lee, F.P., Chao, H.C., et al. Comparing the effects of cognitive stimulation, reminiscence, and aroma-massage on agitation and depressive mood in people with dementia. J Am Med Dir Assoc 17 (2016), 719–724.
181. 181 Berg-Weger, M., Tebb, S., Henderson-Kalb, J., et al. Cognitive stimulation therapy: A tool for your practice with persons with dementia?. J Am Med Dir Assoc 16 (2015), 795–796.
182. 182 D'Amico, F., Rehill, A., Knapp, M., et al. Maintenance cognitive stimulation therapy: An economic evaluation within a randomized controlled trial. J Am Med Dir Assoc 16 (2015), 63–70.
183. 183 Loraine, J., Taylor, S., McAllister, M., Cognitive and physical stimulation therapy. J Am Med Dir Assoc 15 (2014), 140–141.
184. 184 Van Bogaert, P., Van Grinsven, R., Tolson, D., et al. Effects of SolCos model-based individual reminiscence on older adults with mild to moderate dementia due to Alzheimer disease: A pilot study. J Am Med Dir Assoc 14 (2013), 528.e9–528.e13.
185. 185 Wingbermuehle, C., Bryer, D., Berg-Weger, M., et al. Baseball reminiscence league: A model for supporting persons with dementia. J Am Med Dir Assoc 15 (2014), 85–89.
186. 186 Huang, H.C., Chen, Y.T., Chen, P.Y., et al. Reminiscence therapy improves cognitive functions and reduces depressive symptoms in elderly people with dementia: A meta-analysis of randomized controlled trials. J Am Med Dir Assoc 16 (2015), 1087–1094.
187. 187 Strom, B.S., Ytrehus, S., Grov, E.K., Sensory stimulation for persons with dementia: A review of the literature. J Clin Nurs 25 (2016), 1805–1834.
188. 188 Stacpoole, M., Hockley, J., Thompsell, A., et al. The Namaste Care programme can reduce behavioural symptoms in care home residents with advanced dementia. Int J Geriatr Psychiatry 30 (2015), 702–709.
189. 189 Joranson, N., Pedersen, I., Rokstad, A.M., Ihlebaek, C., Effects on symptoms of agitation and depression in persons with dementia participating in robot-assisted activity: A cluster-randomized controlled trial. J Am Med Dir Assoc 16 (2015), 867–873.
190. 190 Bemelmans, R., Gelderblom, G.J., Jonker, P., de Witte, L., Effectiveness of robot Paro in intramural psychogeriatric care: A multicenter quasi-experimental study. J Am Med Dir Assoc 16 (2015), 946–950.
191. 191 Schuurmans, L., Enders-Slegers, M.J., Verheggen, T., Schols, J., Animal-assisted interventions in Dutch nursing homes: A survey. J Am Med Dir Assoc 17 (2016), 647–653.
192. 192 Banks, M.R., Willoughby, L.M., Banks, W.A., Animal-assisted therapy and loneliness in nursing homes: Use of robotic versus living dogs. J Am Med Dir Assoc 9 (2008), 173–177.
193. 193 Morley, J.E., Philpot, C.D., Gill, D., Berg-Weger, M., Meaningful activities in the nursing home. J Am Med Dir Assoc 15 (2014), 79–81.
194. 194 Lam, R.W., Levitt, A.J., Levitan, R.D., et al. Efficacy of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder: A randomized clinical trial. JAMA Psychiatry 73 (2016), 56–63.
195. 195 Royer, M., Ballentine, N.H., Eslinger, P.J., et al. Light therapy for seniors in long term care. J Am Med Dir Assoc 13 (2012), 100–102.
196. 196 Li, H.C., Wang, H.H., Chou, F.H., Chen, K.M., The effect of music therapy on cognitive functioning among older adults: A systematic review and meta-analysis. J Am Med Dir Assoc 16 (2015), 71–77.
197. 197 Ballard, C., Brown, R., Fossey, J., et al. Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial). Am J Geriatr Psychiatry 17 (2009), 726–733.
198. 198 De Mauleon, A., Sourdet, S., Renom-Guiteras, A., et al. Associated factors with antipsychotic use in long-term institutional care in eight European countries: Results from the RightTimePlaceCare study. J Am Med Dir Assoc 15 (2014), 812–818.
199. 199 Thompson Coon, J., Abbott, R., Rogers, M., et al. Interventions to reduce inappropriate prescribing of antipsychotic medications in people with dementia resident in care homes: A systematic review. J Am Med Dir Assoc 15 (2014), 706–718.
200. 200 Snow, V., Beck, D., Budnitz, T., et al. Transitions of Care Consensus policy statement: American College of Physicians, Society of General Internal Medicine, Society of Hospital Medicine, American Geriatrics Society, American College of Emergency Physicians, and Society for Academic Emergency Medicine. J Gen Intern Med, 4, 2009, 364.
201. 201 Gonçalves-Bradley, D.C., Lannin, N.A., Clemson, L.M., et al. Discharge planning from hospital. Cochrane Database Syst Rev(1), 2016, CD000313.
202. 202 Rochester-Eyeguokan, C.D., Pincus, K.J., Patel, R.S., et al. The current landscape of transitions of care practice models: A scoping review. Pharmacotherapy 36 (2016), 117–133.
203. 203 National Transitions of Care Coalition. Available at: http://www.ntocc.org/. Accessed August 29, 2016.
204. 204 Naylor, M.D., Brooten, D.A., Campbell, R.L., et al. Comprehensive discharge planning and home follow-up of hospitalized elders: A randomized clinical trial. JAMA 281 (1999), 613–620.
205. 205 Coleman, E.A., Parry, C., Chalmers, S., Min, S.J., The care transitions intervention: Results of a randomized controlled trial. Arch Intern Med 166 (2006), 1822–1828.
206. 206 Jack, B.W., Chetty, V.K., Anthony, D., et al. A reengineered hospital discharge program to decrease rehospitalization: A randomized trial. Ann Intern Med 150 (2009), 178–187.
207. 207 Hansen, L.O., Greenwald, J.L., Budnitz, T., et al. Project BOOST: Effectiveness of a multihospital effort to reduce rehospitalization. J Hosp Med 8 (2013), 421–427.
208. 208 Ouslander, J., Lamb, G., Tappen, R., et al. Interventions to reduce hospitalizations from nursing homes: Evaluation of the INTERACT II collaborative quality improvement project. J Am Geriatr Soc 59 (2011), 745–753.
209. 209 INTERACT. Interventions to Reduce Acute Care Transfers. INTERACT Version 4.0 Tools. Available at: https://interact2.net/tools_v4.html. Accessed August 30, 2016.
210. 210 Donzé, J., Aujesky, D., Williams, D., Schnipper, J.L., Potentially avoidable 30-day hospital readmissions in medical patients: Derivation and validation of a prediction model. JAMA Intern Med 173 (2013), 632–638.
211. 211 Taha, M., Pal, A., Mahnken, J.D., Rigler, S.K., Derivation and validation of a formula to estimate risk for 30-day readmission in medical patients. Int J Qual Health Care 26 (2014), 271–277.
212. 212 van Walraven, C., Dhalla, I.A., Bell, C., et al. Derivation and validation of an index to predict early death or unplanned readmission after discharge from hospital to the community. CMAJ 182 (2010), 551–557.
213. 213 van Walraven, C., Wong, J., Forster, A.J., LACE+ index: Extension of a validated index to predict early death or urgent readmission after hospital discharge using administrative data. Open Med 6 (2012), e80–e90.
214. 214 McCusker, J., Bellavance, F., Cardin, S., et al. Detection of older people at increased risk of adverse health outcomes after an emergency visit: The ISAR screening tool. J Am Geriatr Soc 47 (1999), 1229–1237.
215. 215 Centers for Medicare and Medicaid Services. Community-based care transitions program. Available at: https://innovation.cms.gov/initiatives/CCTP/. Accessed August 30, 2016.
216. 216 Centers for Medicare and Medicaid Services. Partnership for patients. Available at: https://innovation.cms.gov/initiatives/Partnership-for-Patients/. Accessed August 30, 2016.
217. 217 Centers for Medicare and Medicaid Services. Independence at home demonstration. Available at: https://innovation.cms.gov/initiatives/Independence-at-Home/. Accessed August 30, 2016.
218. 218 Centers for Medicare and Medicaid Services. Initiative to reduce avoidable hospitalizations among nursing facility residents. Available at: https://innovation.cms.gov/initiatives/rahnfr/. Accessed August 30, 2016.