Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial

Journal of the American Medical Directors Association

Volumn 16, Issue 9, 2015, Pages 740-747

  Bauer, Jürgen M ^a   Verlaan, Sjors ^b,c   Bautmans, Ivan ^d   Brandt, Kirsten ^e   Donini, Lorenzo M ^f   Maggio, Marcello ^g   McMurdo, Marion E T ^h   Mets, Tony ^d   Seal, Chris ^e   Wijers, Sander L ^b   Ceda, Gian Paolo ^g   De Vito, Giuseppe ⁱ   Donders, Gilbert ^j   Drey, Michael ^k   Greig, Carolyn ^l   Holmbäck, Ulf ^m   Narici, Marco ⁿ   McPhee, Jamie ^o   Poggiogalle, Eleonora ^f   Power, Dermot ^p   Scafoglieri, Aldo ^d   Schultz, Ralf ^q   Sieber, Cornel C ^r   Cederholm, Tommy ^m   more..

^a UNIVERSITY OF OLDENBURG   (Germany)

^b DANONE NUTRICIA RESEARCH   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g UNIVERSITY HOSPITAL OF PARMA   (Italy)

^h UNIVERSITY OF DUNDEE   (United Kingdom)

ⁱ UNIVERSITY COLLEGE DUBLIN   (Ireland)

^j Femicare   (Belgium)

^k LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^l UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^m UPPSALA UNIVERSITY HOSPITAL   (Sweden)

ⁿ UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^o MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^p MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^q Neurological Therapy Center   (Germany)

^r UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

more..

Author keywords

Lower extremity function; Muscle mass; Nutritional supplementation; Protein; Sarcopenia

Indexed keywords

GLUCOSE; INSULIN; LEUCINE; VITAMIN D; WHEY PROTEIN;

AGED; ARTICLE; ASSESSMENT OF HUMANS; BARTHEL INDEX; BODY MASS; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DIET SUPPLEMENTATION; DIETARY COMPLIANCE; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GRIP STRENGTH; HEMOGLOBIN DETERMINATION; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; MUSCLE MASS; MUSCLE STRENGTH; NUTRITIONAL ASSESSMENT; PHYSICAL ACTIVITY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SARCOPENIA; SHORT PHYSICAL PERFORMANCE BATTERY; TREATMENT DURATION; WALKING SPEED; WHEY; CLINICAL TRIAL; DIETARY SUPPLEMENT; EUROPE; GERIATRIC ASSESSMENT; HAND STRENGTH; PATHOPHYSIOLOGY; PROTEIN-ENERGY MALNUTRITION; TREATMENT OUTCOME; WALKING DIFFICULTY;

AGED; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EUROPE; FEMALE; GERIATRIC ASSESSMENT; HAND STRENGTH; HUMANS; LEUCINE; MALE; MOBILITY LIMITATION; PROTEIN-ENERGY MALNUTRITION; SARCOPENIA; TREATMENT OUTCOME; VITAMIN D; WHEY PROTEINS;

EID: 84940452443     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2015.05.021     Document Type: Article

References (52)

1. Morley J.E., Vellas B., van Kan G.A., et al. Frailty consensus: A call to action. J Am Med Dir Assoc 2013, 14:392-397.
2. Cruz-Jentoft A.J., Baeyens J.P., Bauer J.M., et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010, 39:412-423.
3. Narici M.V., Maffulli N. Sarcopenia: Characteristics, mechanisms and functional significance. Br Med Bull 2010, 95:139-159.
4. Fried L.P., Tangen C.M., Walston J., et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001, 56:M146-M156.
5. Cederholm T., Cruz-Jentoft A.J., Maggi S. Sarcopenia and fragility fractures. Eur J Phys Rehabil Med 2013, 49:111-117.
6. Guralnik J.M., Simonsick E.M., Ferrucci L., et al. A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994, 49:M85-M94.
7. Guralnik J.M., Ferrucci L., Simonsick E.M., et al. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995, 332:556-561.
8. Kalyani R.R., Corriere M., Ferrucci L. Age-related and disease-related muscle loss: The effect of diabetes, obesity, and other diseases. Lancet Diabetes Endocrinol 2014, 2:819-829.
9. Morley J.E., Argiles J.M., Evans W.J., et al. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 2010, 11:391-396.
10. Houston D.K., Nicklas B.J., Ding J., et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: The Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 2008, 87:150-155.
11. Scott D., Blizzard L., Fell J., et al. Associations between dietary nutrient intake and muscle mass and strength in community-dwelling older adults: The Tasmanian Older Adult Cohort Study. J Am Geriatr Soc 2010, 58:2129-2134.
12. Wicherts I.S., van Schoor N.M., Boeke A.J., et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab 2007, 92:2058-2065.
13. Beasley J.M., Wertheim B.C., LaCroix A.Z., et al. Biomarker-calibrated protein intake and physical function in the Women's Health Initiative. J Am Geriatr Soc 2013, 61:1863-1871.
14. Bischoff-Ferrari H.A., Dawson-Hughes B., Willett W.C., et al. Effect of vitamin D on falls: A meta-analysis. JAMA 2004, 291:1999-2006.
15. Boirie Y. Fighting sarcopenia in older frail subjects: Protein fuel for strength, exercise for mass. J Am Med Dir Assoc 2013, 14:140-143.
16. Forbes S.C., Little J.P., Candow D.G. Exercise and nutritional interventions for improving aging muscle health. Endocrine 2012, 42:29-38.
17. Bauer J., Biolo G., Cederholm T., et al. Evidence-based recommendations for optimal dietary protein intake in older people: A position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 2013, 14:542-559.
18. Breen L., Phillips S.M. Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing. Nutr Metab (Lond) 2011, 8:68.
19. Cuthbertson D., Smith K., Babraj J., et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J 2005, 19:422-424.
20. Deutz N.E., Bauer J.M., Barazzoni R., et al. Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group. Clin Nutr 2014, 33:929-936.
21. Chale A., Cloutier G.J., Hau C., et al. Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physical function in mobility-limited older adults. J Gerontol A Biol Sci Med Sci 2013, 68:682-690.
22. Paddon-Jones D., Sheffield-Moore M., Zhang X.J., et al. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab 2004, 286:E321-E328.
23. Kramer I.F., Poeze M., Luiking Y.C., et al. Basal and post-prandial muscle protein synthesis rates are not reduced in sarcopenic elderly. Clin Nutr 2014, 33:S127. [abstract].
24. Janssen I., Heymsfield S.B., Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002, 50:889-896.
25. Schuit A.J., Schouten E.G., Westerterp K.R., Saris W.H. Validity of the Physical Activity Scale for the Elderly (PASE): According to energy expenditure assessed by the doubly labeled water method. J Clin Epidemiol 1997, 50:541-546.
26. Mahoney F.I., Barthel D.W. Functional evaluation: The Barthel Index. Md State Med J 1965, 14:61-65.
27. Euro-Qol, a new facility for the measurement of health-related quality of life. Health Policy 1990, 16:199-208. The EuroQol Group.
28. Bunout B., Barrera G., de la Maza P., et al. Effects of nutritional supplementation and resistance training on muscle strength in free living elders. Results of one year follow. J Nutr Health Aging 2004, 8:68-75.
29. Scognamiglio R., Piccolotto R., Negut C., et al. Oral amino acids in elderly subjects: Effect on myocardial function and walking capacity. Gerontology 2005, 51:302-308.
30. Rejeski W.J., Marsh A.P., Chmelo E., et al. The lifestyle interventions and Independence for elders Pilot (LIFE-P): 2-year follow-up. J Gerontol A Biol Sci Med Sci 2009, 64:462-467.
31. Allison P.D. Handling Missing Data by Maximum Likelihood 2012, SAS Global Forum, Orlando, FL.
32. Kramer I.F., Poeze M., Luiking Y.C., et al. Basal and post-prandial muscle protein synthesis rates are not reduced in sarcopenic elderly 2014, [abstract], 36th ESPEN Congress, Geneva, Switzerland.
33. Luiking Y.C., Deutz N.E., Memelink R.G., et al. Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: A randomized controlled trial. Nutr J 2014, 13:9.
34. Pahor M., Blair S.N., Espeland M., et al. Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci 2006, 61:1157-1165. Life Study Investigators.
35. Latham N.K., Harris B.A., Bean J.F., et al. Effect of a home-based exercise program on functional recovery following rehabilitation after hip fracture: A randomized clinical trial. JAMA 2014, 311:700-708.
36. Pahor M., Guralnik J.M., Ambrosius W.T., et al. Effect of structured physical activity on prevention of major mobility disability in older adults: The LIFE study randomized clinical trial. JAMA 2014, 311:2387-2396.
37. Cruz-Jentoft A.J., Landi F., Schneider S.M., et al. Prevalence of and interventions for sarcopenia in ageing adults: A systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing 2014, 43:748-759.
38. Fiatarone M.A., O'Neill E.F., Ryan N.D., et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 1994, 330:1769-1775.
39. Tieland M., van de Rest O., Dirks M.L., et al. Protein supplementation improves physical performance in frail elderly people: A randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 2012, 13:720-726.
40. Lauretani F., Russo C.R., Bandinelli S., et al. Age-associated changes in skeletal muscles and their effect on mobility: An operational diagnosis of sarcopenia. J Appl Physiol (1985) 2003, 95:1851-1860.
41. Janssen I., Heymsfield S.B., Wang Z.M., Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol (1985) 2000, 89:81-88.
42. Gallagher D., Visser M., De Meersman R.E., et al. Appendicular skeletal muscle mass: Effects of age, gender, and ethnicity. J Appl Physiol (1985) 1997, 83:229-239.
43. Report of the Panel on Macronutrients, Subcommittees on Upper Reference Levels of Nutrients and interpretation and uses of Dietary Reference Intakes, et al. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids 2015, The National Academies Press, Washington, DC.
44. Katsanos C.S., Kobayashi H., Sheffield-Moore M., et al. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 2006, 291:E381-E387.
45. Adamo M.L., Farrar R.P. Resistance training, and IGF involvement in the maintenance of muscle mass during the aging process. Ageing Res Rev 2006, 5:310-331.
46. Bischoff-Ferrari H.A. Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol 2014, 810:500-525.
47. Salles J., Chanet A., Giraudet C., et al. 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. Mol Nutr Food Res 2013, 57:2137-2146.
48. Abizanda P., Navarro J.L., Garcia-Tomas M.I., et al. Validity and usefulness of hand-held dynamometry for measuring muscle strength in community-dwelling older persons. Arch Gerontol Geriatr 2012, 54:21-27.
49. Tieland M., Verdijk L.B., de Groot L.C., van Loon L.J. Handgrip strength does not represent an appropriate measure to evaluate changes in muscle strength during an exercise intervention program in frail older people. Int J Sport Nutr Exerc Metab 2015, 25:27-36.
50. Hardy R., Cooper R., Shah I., et al. Is chair rise performance a useful measure of leg power?. Aging Clin Exp Res 2010, 22:412-418.
51. Cesari M., Kritchevsky S.B., Newman A.B., et al. Added value of physical performance measures in predicting adverse health-related events: Results from the Health, Aging nd Body Composition Study. J Am Geriatr Soc 2009, 57:251-259.
52. Zech A., Drey M., Freiberger E., et al. Residual effects of muscle strength and muscle power training and detraining on physical function in community-dwelling prefrail older adults: A randomized controlled trial. BMC Geriatr 2012, 12:68.