Inappropriate Drug Prescribing and Polypharmacy Are Major Causes of Poor Outcomes in Long-Term Care

Journal of the American Medical Directors Association

Volumn 15, Issue 11, 2014, Pages 780-782

  Morley, John E ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINERGIC RECEPTOR BLOCKING AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PROTON PUMP INHIBITOR; PSYCHOTROPIC AGENT;

BLOOD PRESSURE; BLOOD PRESSURE CUFF; BLOOD PRESSURE MEASUREMENT; DELIRIUM; EDITORIAL; EMERGENCY WARD; HUMAN; HYPERTENSION; INAPPROPRIATE PRESCRIBING; INTERVENTION STUDY; LONG TERM CARE; NURSING HOME; NURSING HOME PATIENT; OUTCOME ASSESSMENT; POLYPHARMACY; PRACTICE GUIDELINE; PRESCRIPTION; SYSTOLIC BLOOD PRESSURE; WEIGHT REDUCTION; HEALTH CARE QUALITY;

HUMANS; INAPPROPRIATE PRESCRIBING; LONG-TERM CARE; NURSING HOMES; POLYPHARMACY; QUALITY OF HEALTH CARE;

EID: 84908244662     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2014.09.003     Document Type: Editorial

References (73)

1. Onder G., Liperoti R., Foebel A., et al. Polypharmacy and mortality among nursing home residents with advanced cognitive impairment: Results from the SHELTER study. JAm Med Dir Assoc 2013, 14:450.e7-450.e12.
2. Little M.O., Morley A. Reducing polypharmacy: Evidence from a simple quality improvement initiative. JAm Med Dir Assoc 2013, 14:152-156.
3. de Souto Barreto P., Lapeyre-Mestre M., Mathieu C., et al. Prevalence and associations of the use of proton-pump inhibitors in nursing homes: A cross-sectional study. JAm Med Dir Assoc 2013, 14:265-269.
4. Cestac P., Tavassoli N., Vellas B., Rolland Y. Improving medication use in the nursing homes: A European perspective. JAm Med Dir Assoc 2013, 14:6-9.
5. De Souto Barreto P., Lapeyre-Mestre M., Mathieu C., et al. Indicators of benzodiazepine use in nursing home residents in France: A cross-sectional study. JAm Med Dir Assoc 2013, 14:29-33.
6. Kojima G., Bell C., Tamura B., et al. Reducing cost by reducing polypharmacy: The polypharmacy outcomes project. JAm Med Dir Assoc 2012, 13:818.e11-818.e15.
7. Bronskill S.E., Gill S.S., Paterson J.M., et al. Exploring variation in rates of polypharmacy across long term care homes. JAm Med Dir Assoc 2012, 13:309.e15-309.e21.
8. Tamura B.K., Cl Bell, Lubimir K., et al. Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes projects. JAm Med Dir Assoc 2011, 12:326-330.
9. Fitzgerald S.P., Bean N.G. An analysis of the interactions between individual comorbidities and their treatments-implications for guidelines and polypharmacy. JAm Med Dir Assoc 2010, 11:475-484.
10. Gokce Kutsal Y., Barak A., Atalay A., et al. Polypharmacy in the elderly: A multicenter study. JAm Med Dir Assoc 2009, 10:486-490.
11. Morley J.E. Polypharmacy in the nursing home. JAm Med Dir Assoc 2009, 10:289-291.
12. Levenson S.A., Saffel D.A. The consultant pharmacist and the physician in the nursing home: Roles, relationships, and a recipe for success. JAm Med Dir Assoc 2007, 8:55-64.
13. Cool C. Potentially inappropriate drug prescribing and associated factors in nursing homes. JAm Med Dir Assoc 2014, 15. (Nov issue).
14. Landi F. Anticholinergic drugs use and negative outcomes among frail elderly population living in nursing home. JAm Med Dir Assoc 2014, 15. (Nov issue).
15. Hein C., Forgues A., Piau A., et al. Impact of polypharmacy on occurrence in elderly emergency patients. JAm Med Dir Assoc 2014, 15. (Nov issue).
16. Grace A., Briggs R., Kieran R.E., et al. Acomparison of Beers and STOPP criteria in assessing potentially inappropriate medications in nursing home residents attending the emergency department. JAm Med Dir Assoc 2014, 15. (Nov issue).
17. Ward K., Eslami M., Garcia M., McCreath H. Do internal medicine residents know enough about skilled nursing facilities to orchestrate a good care transition?. JAm Med Dir Assoc 2014, 15. (Nov issue).
18. Smeets C., Smalbrugge M., Zuidema S., et al. Factors related to psychotropic drug prescription for neuropsychiatric symptoms in nursing home residents with dementia. JAm Med Dir Assoc 2014, 15. (Nov issue).
19. Morandi A., Bellelli G., Vasilevskis E.E., et al. Predictors of rehospitalization among elderly patients admitted to a rehabilitation hospital: The role of polypharmacy, functional status, and length of stay. JAm Med Dir Assoc 2013, 14:761-767.
20. Ouslander J.G., Perloe M., Givens J.H., et al. Reducing potentially avoidable hospitalizations of nursing home residents: Results of a pilot quality improvement project. JAm Med Dir Assoc 2009, 10:644-652.
21. Tena-Nelson R., Santos K., Weingast E., et al. Reducing potentially preventable hospital transfers: Results from a thirty nursing home collaborative. JAm Med Dir Assoc 2012, 13:651-656.
22. Ouslander J.G., Bonner A., Herndon L., Shutes J. The interventions to reduce acute care transfers (INTERACT) quality improvement program: An overview for medical directors and primary care clinicians in long term care. JAm Med Dir Assoc 2014, 15:162-170.
23. Little M.O. Climbing out of the black hole of subacute care. JAm Med Dir Assoc 2012, 13:493-494.
24. Morley J.E., Caplan G., Cesari M., et al. International survey of nursing home research priorities. JAm Med Dir Assoc 2014, 15:309-312.
25. Aaltonen M., Raitanen J., Forma L., et al. Burdensome transitions at the end of life among long-term care residents with dementia. JAm Med Dir Assoc 2014, 15:643-648.
26. Rolland Y., Resnick B., Katz P.R., et al. Nursing home research: The first International Association of Gerontology and Geriatrics (IAGG) research conference. JAm Med Dir Assoc 2014, 15:313-325.
27. Berkowitz R.E., Fang Z., Helfand B.K., et al. Project ReEngineered Discharge (RED) lowers hospital readmissions of patients discharged from a skilled nursing facility. JAm Med Dir Assoc 2013, 14:736-740.
28. Gruneir A., Bronskill S., Bell C., et al. Recent health care transitions and emergency department use by chronic long term care residents: A population-based cohort study. JAm Med Dir Assoc 2012, 13:202-206.
29. Gruneir A., Anderson G.M., Rochon P.A., Bronskill S. Transitions in long-term care and potential implications for quality reporting in Ontario, Canada. JAm Med Dir Assoc 2010, 11:629-635.
30. Morley J.E. Transitions. JAm Med Dir Assoc 2010, 11:607-611.
31. Morley J.E., Vellas B., van Kan G.A., et al. Frailty consensus: A call to action. JAm Med Dir Assoc 2013, 14:392-397.
32. Morley J.E. Frailty, falls, and fractures. JAm Med Dir Assoc 2013, 14:149-151.
33. Morley J.E., Malmstrom T.K., Miller D.K. Asimple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. JNutr Health Aging 2012, 16:601-608.
34. Morley J.E. Frailty screening comes of age. JNutr Health Aging 2014, 18:453-454.
35. Morley J.E., von Haehling S., Anker S.D., Vellas B. From sarcopenia to frailty: A road less traveled. JCachexia Sarcopenia Muscle 2014, 5:5-8.
36. Morley J.E. Frailty: Diagnosis and management. JNutr Health Aging 2011, 15:667-670.
37. Morley J.E. Developing novel therapeutic approaches to frailty. Curr Pharm Des 2009, 15:3384-3395.
38. Reeve E., Wiese M.D., Hendrix I., et al. People's attitudes, beliefs, and experiences regarding polypharmacy and willingness to deprescribe. JAm Geriatric Soc 2013, 61:1508-1514.
39. Fullarton J., Volicer L. Reductions of antipsychotic and hypnotic medications in Namaste Care. JAm Med Dir Assoc 2013, 14:708-709.
40. Volicer L. Is your nursing home a battlefield?. JAm Med Dir Assoc 2012, 13:195-196.
41. Morley J.E., Philpot C.D., Gill D., Berg-Weger M. Meaningful activities in the nursing home. JAm Med Dir Assoc 2014, 15:79-81.
42. Loraine J., Taylor S., McAllister M. Cognitive and physical stimulation therapy. JAm Med Dir Assoc 2014, 15:140-141.
43. Silva R.B., Eslick G.D., Duque G. Exercise for falls and fracture prevention in long term care facilities: A systematic review and meta-analysis. JAm Med Dir Assoc 2013, 14:685-689.e2.
44. Rolland Y., Abellan van Kan G., Vellas B. Physical activity and Alzheimer's disease: From prevention to therapeutic perspectives. JAm Med Dir Assoc 2008, 9:390-405.
45. Degnin F.D. Overmedicating "difficult" patients. JAm Med Dir Assoc 2007, 8:262-264.
46. Rockwood K. Making delirium prevention acceptable in nursing homes. JAm Med Dir Assoc 2014, 15:6-7.
47. Eeles E., Rockwood K. Delirium in the long-term care setting: Clinical and research challenges. JAm Med Dir Assoc 2008, 9:157-161.
48. Boockvar K., Signor D., Ramaswamy R., Hung W. Delirium during acute illness in nursing home residents. JAm Med Dir Assoc 2013, 14:656-660.
49. Flaherty J.H., Morley J.E. Delirium in the nursing home. JAm Med Dir Assoc 2013, 14:632-634.
50. Flaherty J.H., Shay K., Weir C., et al. The development of a mental status vital sign for use across the spectrum of care. JAm Med Dir Assoc 2009, 10:379-380.
51. Fox C., Smith T., Maidment I., et al. Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: A systematic review. Age Ageing 2014, 43:604-615.
52. Takahashi P.Y., North F. Pilot study of inappropriate medications and balance: A study in a continuous care center. JAm Med Dir Assoc 2007, 8:545.
53. Olazarán J., Valle D., Serra J.A., et al. Psychotropic medications and falls in nursing homes: A cross-sectional study. JAm Med Dir Assoc 2013, 14:213-217.
54. Vu M.Q., Weintraub N., Rubenstein L.Z. Falls in the nursing home: Are they preventable?. JAm Med Dir Assoc 2006, 7:S53-S58. 52.
55. Morley J.E., Rolland Y., Tolson D., Vellas B. Increasing awareness of the factors producing falls: The mini falls assessment. JAm Med Dir Assoc 2012, 13:87-90.
56. Gallagher P., Ryan C., Byrne S., et al. STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther 2008, 46:72-83.
57. 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. JAm Geriatr Soc 2012, 60:616-631. The American Geriatrics Society.
58. Michalek C., Wehling M., Schlitzer J., Frohnhofen H. Effects of "Fit fOR The Aged" (FORTA) on pharmacotherapy and clinical endpoints-a pilot randomized controlled study. Eur J Clin Pharmacol 2014, 70:261-267.
59. Bradley M.C., Motterlini N., Padmanabhan S., et al. Potentially inappropriate prescribing among older people in the United Kingdom. BMC Geriatr 2014, 14:72.
60. Psaty B.M., Weiss N.S. 2013 ACC/AHA guideline on the treatment of blood cholesterol: A fresh interpretation of old evidence. JAMA 2014, 311:461-462.
61. Morley J.E., Mahon G. Statins and the nursing home. JAm Med Dir Assoc 2013, 14:853-854.
62. Sanford A., Morley J.E. Are the new guidelines for cholesterol and hypertension age friendly?. JAm Med Dir Assoc 2014, 15:373-375.
63. Morley J.E. Treatment of hypertension in older persons: What is the evidence?. Drugs Aging 2014, 31:331-337.
64. Morley J.E. Systolic hypertension should not be treated in persons age 80 and older until blood pressure is greater than 160 mmHg. JAm Geriatr Soc 2013, 61:1197-1198.
65. Welsh T., Gladman J., Gordon A.L. The treatment of hypertension in care home residents: A systematic review of observational studies. JAm Med Dir Assoc 2014, 15:8-16.
66. Callisaya M.L., Sharman J.E., Close J., et al. Greater daily defined dose of antihypertensive medication increases the risk of falls in older people-a population-based study. JAm Geriatr Soc 2014, 62:1527-1533.
67. Tamura B.K., Bell C.L., Masaki K.H., Amella E.J. Factors associated with weight loss, low BMI, and malnutrition among nursing home patients: A systematic review of the literature. JAm Med Dir Assoc 2013, 14:649-655.
68. Soenen S., Chapman I.M. Body weight, anorexia, and undernutrition in older people. JAm Med Dir Assoc 2013, 14:642-648.
69. Bell C.L., Tamura B.K., Masaki K.H., Amella E.J. Prevalence and measures of nutritional compromise among nursing home patients: Weight loss, low body mass index, malnutrition, and feeding dependency, a systematic review of the literature. JAm Med Dir Assoc 2013, 14:94-100.
70. Morley J.E. Weight loss in older persons: New therapeutic approaches. Curr Pharm Des 2007, 13:3637-3647.
71. Mossello E., Pieraccioli M.C., Zanieri S., et al. Ambulatory blood pressure monitoring in older nursing home residents: Diagnostic and prognostic role. JAm Med Dir Assoc 2012, 13:760.e1-760.e5.
72. Kostas T., Zimmerman K., Salow M., et al. Improving medication management competency of clinical trainees in geriatrics. JAm Geriatr Soc 2014, 62:1568-1574.
73. Tolson D., Rolland Y., Andrieu S., et al. The International Association of Gerontology and Geriatrics: A global agenda for clinical research and quality of care in nursing homes. JAm Med Dir Assoc 2011, 12:184-189.