Current and emerging treatment options for the elderly patient with chronic kidney disease

Clinical Interventions in Aging

Volumn 9, Issue , 2014, Pages 191-199

  Fassett, Robert G ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Dialysis; Elderly; Frailty; Functional status; Kidney transplantation; Palliative care

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIANEMIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BICARBONATE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRBESARTAN; RAMIPRIL; SIRTUIN 1;

AGING; ALBUMINURIA; ANEMIA; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL (TOPIC); COGNITIVE DEFECT; COMMUNITY CARE; COMORBIDITY; CONSERVATIVE TREATMENT; DIABETES CONTROL; DIABETIC NEPHROPATHY; DIALYSIS; DISEASE CLASSIFICATION; DISEASE CONTROL; DISEASE COURSE; DISEASE REGISTRY; DISEASE SEVERITY; END STAGE RENAL DISEASE; EVIDENCE BASED MEDICINE; FAMILY STRESS; FRAIL ELDERLY; FUNCTIONAL ASSESSMENT; FUNCTIONAL STATUS; GLOMERULUS FILTRATION RATE; HEALTH CARE NEED; HUMAN; HYPERTENSION; ILLNESS TRAJECTORY; INFLAMMATION; KIDNEY FUNCTION TEST; KIDNEY TRANSPLANTATION; LIFE EXPECTANCY; PALLIATIVE THERAPY; PRACTICE GUIDELINE; PRESCRIPTION; QUALITY OF LIFE; REHABILITATION CARE; REVIEW; SOCIAL ISOLATION; SODIUM RESTRICTION; TREATMENT INDICATION;

DIALYSIS; ELDERLY; FRAILTY; FUNCTIONAL STATUS; KIDNEY TRANSPLANTATION; PALLIATIVE CARE;

AGE FACTORS; AGED; CLINICAL TRIALS AS TOPIC; HUMANS; PALLIATIVE CARE; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC;

EID: 84892600116     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/CIA.S39763     Document Type: Review

References (89)

1. Australian Bureau of Statistics (2005). Population Projections: 2004-2010. Available from: http://www.abs.gov.au/ausstats/abs@.nsf/Lookup/by%20Subject/1370.0~2010~Chapter~Population%20projections%20(3.4). Accessed January 1, 2014.
2. Grace B, Hurst K, McDonald S. Chapter 2: New patients commencing treatment in 2011. In: 2012 Annual Report-35th Edition. ANZDATA Registry: Adelaide, Australia; 2012.
3. USRDS. 2011 Annual Data Report. Atlas of Chronic Disease and End Stage Renal Disease in the United States, 2011. Available from: http://www.ajkd.org/issues?issue_key=S0272-6386%2811%29X0015-X. Accessed January 1, 2014.
4. Kramer A, Stel V, Zoccali C, etal; ERA-EDTA Registry. An update on renal replacement therapy in Europe: ERA-EDTA Registry data from 1997 to 2006. Nephrol Dial Transplant. 2009;24(12):3557-3566.
5. Locatelli F, Pozzoni P. Chronic kidney disease in the elderly: is it really a premise for overwhelming renal failure? Kidney Int. 2006;69(12): 2118-2120.
6. Bowling CB, Muntner P. Epidemiology of chronic kidney disease among older adults: a focus on the oldest old. J Gerontol A Biol Sci Med Sci. 2012;67(12):1379-1386.
7. The Australian Institute of Health and Welfare. Australia's Health 2012. Canberra, Australia: Australian Institute of Health and Welfare; 2012.
8. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2013;Suppl 3(4):1-150.
9. Dousdampanis P, Trigka K, Fourtounas C. Diagnosis and management of chronic kidney disease in the elderly: a field of ongoing debate. Aging Dis. 2012;3(5):360-372.
10. Johnson DW, Jones GR, Mathew TH, etal; Australasian Proteinuria Consensus Working Group. Chronic kidney disease and measurement of albuminuria or proteinuria: a position statement. Med J Aust. 2012;197(4):224-225.
11. Hallan SI, Matsushita K, Sang Y, etal; Chronic Kidney Disease Prognosis Consortium. Age and association of kidney measures with mortality and end-stage renal disease. JAMA. 2012;308(22):2349-2360.
12. Kidney Health Australia [webpage on the Internet]. Chronic Kidney Disease (CKD) Management in General Practice. Melbourne, Australia: Kidney Health Australia; 2012. Available from: http://www.kidney.org.au//LinkClick.aspx?fileticket=vfDcA4sEUMs%3d&tabid=635&mid=1584. Accessed January 1, 2014.
13. Grams ME, Chow EK, Segev DL, Coresh J. Lifetime incidence of CKD stages 3-5 in the United States. Am J Kidney Dis. 2013;62(2): 245-252.
14. Hemmelgarn BR, Zhang J, Manns BJ, et al. Progression of kidney dysfunction in the community-dwelling elderly. Kidney Int. 2006;69(12): 2155-2161.
15. Lindeman RD, Tobin J, Shock NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 1985;33(4): 278-285.
16. Lamb EJ, O'Riordan SE, Delaney MP. Kidney function in older people: pathology, assessment and management. Clin Chim Acta. 2003;334(1-2):25-40.
17. Drenth-van Maanen AC, Jansen PA, Proost JH, et al. Renal function assessment in older adults. Br J Clin Pharmacol. 2013;76(4):616-623.
18. Flamant M, Haymann JP, Vidal-Petiot E, et al. GFR estimation using the Cockcroft-Gault, MDRD study, and CKD-EPI equations in the elderly. Am J Kidney Dis. 2012;60(5):847-849.
19. Venuthurupalli SK, Hoy WE, Healey HG, Salisbury A, Fassett RG; CKD. QLD group. CKD. QLD: chronic kidney disease surveillance and research in Queensland, Australia. Nephrol Dial Transplant. 2012;27 Suppl 3:iii139-iii145.
20. Lash JP, Go AS, Appel LJ, etal; Chronic Renal Insufficiency Cohort (CRIC) Study Group. Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Clin J Am Soc Nephrol. 2009;4(8):1302-1311.
21. Levin A, Rigatto C, Brendan B, etal; CanPREDDICT investigators. Cohort profile: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT). BMC Nephrol. 2013;14:121.
22. McCullough PA, Vassalotti JA, Collins AJ, Chen SC, Bakris GL, Whaley-Connell AT. National Kidney Foundation's Kidney Early Evaluation Program (KEEP) annual data report 2010: executive summary. Am J Kidney Dis. 2011;57(3 Suppl 2):S1-S3.
23. Spanaus KS, Kollerits B, Ritz E, Hersberger M, Kronenberg F, von Eckardstein A; Mild and Moderate Kidney Disease (MMKD) Study Group. Serum creatinine, cystatin C, and beta-trace protein in diagnostic staging and predicting progression of primary nondiabetic chronic kidney disease. Clin Chem. 2010;56(5):740-749.
24. Landray MJ, Emberson JR, Blackwell L, et al. Prediction of ESRD and death among people with CKD: the Chronic Renal Impairment in Birmingham (CRIB) prospective cohort study. Am J Kidney Dis. 2010;56(6):1082-1094.
25. Marks A, Macleod C, McAteer A, et al. Chronic kidney disease, a useful trigger for proactive primary care? Mortality results from a large UK cohort. Fam Pract. 2013;30(3):282-289.
26. Nair R, Bell JM, Walker PD. Renal biopsy in patients aged 80 years and older. Am J Kidney Dis. 2004;44(4):618-626.
27. Rothwell PM. External validity of randomised controlled trials: "to whom do the results of this trial apply?". Lancet. 2005;365(9453):82-93.
28. Cho S, Lau SW, Tandon V, Kumi K, Pfuma E, Abernethy DR. Geriatric drug evaluation: where are we now and where should we be in the future? Arch Intern Med. 2011;171(10):937-940.
29. Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol. 2004;22(22):4626-4631.
30. Cherubini A, Del Signore S, Ouslander J, Semla T, Michel JP. Fighting against age discrimination in clinical trials. J Am Geriatr Soc. 2010;58(9):1791-1796.
31. Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005;294(6):716-724.
32. Vitry AI, Zhang Y. Quality of Australian clinical guidelines and relevance to the care of older people with multiple comorbid conditions. Med J Aust. 2008;189(7):360-365.
33. Hilmer SN, McLachlan AJ, Le Couteur DG. Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol. 2007;21(3):217-230.
34. Hubbard RE, O'Mahony MS, Woodhouse KW. Medication prescribing in frail older people. Eur J Clin Pharmacol. 2013;69(3):319-326.
35. Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia). Lancet. 1997;349(9069): 1857-1863.
36. Parving HH, Lehnert H, Bröchner-Mortensen J, Gomis R, Andersen S, Arner P; Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria Study Group. The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. 2001;345(12):870-878.
37. Bakris GL, Williams M, Dworkin L, et al. Preserving renal function in adults with hypertension and diabetes: a consensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group. Am J Kidney Dis. 2000;36(3):646-661.
38. Kovesdy CP, Bleyer AJ, Molnar MZ, et al. Blood pressure and mortality in US veterans with chronic kidney disease: a cohort study. Ann Intern Med. 2013;159(4):233-242.
39. Marcum ZA, Fried LF. Aging and antihypertensive medication-related complications in the chronic kidney disease patient. Curr Opin Nephrol Hypertens. 2011;20(5):449-456.
40. Zhou XJ, Rakheja D, Yu X, Saxena R, Vaziri ND, Silva FG. The aging kidney. Kidney Int. 2008;74(6):710-720.
41. Peron EP, Zheng Y, Perera S, etal; Health, Aging, and Body Composition (Health ABC) Study. Antihypertensive drug class use and differential risk of urinary incontinence in community-dwelling older women. J Gerontol A Biol Sci Med Sci. 2012;67(12):1373-1378.
42. Aronow WS, Fleg JL, Pepine CJ, etal; ACCF Task Force. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation. 2011;123(21): 2434-2506.
43. Oliva RV, Bakris GL. Management of hypertension in the elderly population. J Gerontol A Biol Sci Med Sci. 2012;67(12):1343-1351.
44. McMahon EJ, Bauer JD, Hawley CM, et al. The effect of lowering salt intake on ambulatory blood pressure to reduce cardiovascular risk in chronic kidney disease (LowSALT CKD study): protocol of a randomized trial. BMC Nephrol. 2012;13:137.
45. McMahon EJ, Bauer JD, Hawley CM, et al. A randomized trial of dietary sodium restriction in CKD. J Am Soc Nephrol. 2013;24(12): 2096-2103.
46. Shepherd J, Cobbe SM, Ford I, et al. Prevention and coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995;333(20):1301-1307.
47. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344(8934):1383-1389.
48. Shepherd J, Blauw GJ, Murphy MB, etal; PROPSER study group. PROspective Study of Pravastatin in the Elderly at Risk. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet. 2002;360(9346):1623-1630.
49. Wanner C, Krane V, März W, etal; German Diabetes and Dialysis Study Investigators. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N Engl J Med. 2005;353(3):238-248.
50. Baigent C, Landray MJ, Reith C, etal; SHARP Investigators. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet. 2011;377(9784): 2181-2192.
51. Fellström BC, Jardine AG, Schmieder RE, etal; AURORA Study Group. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med. 2009;360(14):1395-1407.
52. Williams ME. Diabetic kidney disease in elderly individuals. Med Clin North Am. 2013;97(1):75-89.
53. Brown AF, Mangione CM, Slabia D, Sarkisian CA; California Healthcare Foundation/American Geriatrics Society Panel on Improving Care for Elders with Diabetes. Guidelines for improving the care of the older person with diabetes mellitus. J Am Geriatr Soc. 2003; 51(5 Suppl Guidelines):S265-S280.
54. Greenwood SA, Lindup H, Taylor K, et al. Evaluation of a pragmatic exercise rehabilitation programme in chronic kidney disease. Nephrol Dial Transplant. 2012;27 Suppl 3:iii126-iii134.
55. Painter P, Marcus RL. Assessing physical function and physical activity in patients with CKD. Clin J Am Soc Nephrol. 2013;8(5):861-872.
56. Gopinath B, Harris DC, Burlutsky G, Mitchell P. Use of community support services and activity limitations among older adults with chronic kidney disease. J Gerontol A Biol Sci Med Sci. 2013;68(6):741-747.
57. Jassal SV, Chiu E, Hladunewich M. Loss of independence in patients starting dialysis at 80 years of age or older. N Engl J Med. 2009;361(16): 1612-1613.
58. Palmer SC, Navaneethan SD, Craig JC, et al. Meta-analysis: erythropoiesis-stimulating agents in patients with chronic kidney disease. Ann Intern Med. 2010;153(1):23-33.
59. Pfeffer MA, Burdmann EA, Chen CY, etal; TREAT Investigators. A trial of darbepoetin alfain type 2 diabetes and chronic kidney disease. N Engl J Med. 2009;361(21):2019-2032.
60. Loniewski I, Wesson DE. Bicarbonate therapy for prevention of chronic kidney disease progression. Kidney Int. Epub October 9, 2013.
61. Mahajan A, Simoni J, Sheather SJ, Broglio KR, Rajab MH, Wesson DE. Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int. 2010;78(3):303-309.
62. Hubbard BP, Gomes AP, Dai H, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science. 2013; 339(6124):1216-1219.
63. Pergola PE, Raskin P, Toto RD, etal; BEAM Study Investigators. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med. 2011;365(4):327-336.
64. Reata Pharmaceuticals [webpage on the Internet]. Company statement: termination of the BEACON trial. Irving, TX: Reata Pharmaceuticals; 2012. Available from: http://www.reatapharma.com/investors-media/news/news-timeline/2012/company-statement-termination-of-beacon-trial.aspx. Accessed January 1, 2014.
65. Australasian Kidney Trials Network [webpage on the Internet]. The CKD-FIX study: a randomised Controlled trial of slowing of Kidney Disease progression From the Inhibition of Xanthine oxidase. Queensland, Australia: Australasian Kidney Trials Network; 2012. Available from: http://www.aktn.org.au/trials/development.php#CKD_FIX. Accessed.
66. Jones SA, Bhandari S. The prevalence of potentially inappropriate medication prescribing in elderly patients with chronic kidney disease. Postgrad Med J. 2013;89(1051):247-250.
67. Thomas MC. Diuretics, ACE inhibitors and NSAIDs-the triple whammy. Med J Aust. 2000;172(4):184-185.
68. Sparke C, Moon L, Green F, et al. Estimating the total incidence of kidney failure in Australia including individuals who are not treated by dialysis or transplantation. Am J Kidney Dis. 2013;61(3):413-419.
69. Rosansky SJ, Eggers P, Jackson K, Glassock R, Clark WF. Early start of hemodialysis may be harmful. Arch Intern Med. 2011;171(5): 396-403.
70. Cooper BA, Branley P, Bulfone L, etal; IDEAL Study. A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med. 2010;363(7):609-619.
71. Vassalotti JA, Jennings WC, Beathard GA, etal; Fistula First Breakthrough Initiative Community Education Committee. Fistula first breakthrough initiative: targeting catheter last in fistula first. Semin Dial. 2012;25(3):303-310.
72. DeSilva RN, Patibandla BK, Vin Y, et al. Fistula first is not always the best strategy for the elderly. J Am Soc Nephrol. 2013;24(8):1297-1304.
73. Winkelmayer WC, Kurella Tamura M. Predialyis nephrology care of older individuals approaching end-stage renal disease. Semin Dial. 2012;25(6):628-632.
74. Eknoyan G, Beck GJ, Cheung AK, etal; Hemodialysis (HEMO) Study Group. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002;347(25):2010-2019.
75. Fassett RG, Robertson IK, Mace R, Youl L, Challenor S, Bull R. Palliative care in end-stage kidney disease. Nephrology (Carlton). 2011;16(1):4-12.
76. Moss AH, Ganjoo J, Sharma S, et al. Utility of the "surprise" question to identify dialysis patients with high mortality. Clin J Am Soc Nephrol. 2008;3(5):1379-1384.
77. Murtagh FE, Marsh JE, Donohoe P, Ekbal NJ, Sheerin NS, Harris FE. Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 5. Nephrol Dial Transplant. 2007;22(7):1955-1962.
78. Kurella Tamura M, Covinsky KE, Chertow GM, Yaffe K, Landefeld CS, McCulloch CE. Functional status of elderly adults before and after initiation of dialysis. N Engl J Med. 2009;361(16):1539-1547.
79. McDonald S. Chapter 3: Deaths. In: 2012 Annual Report-35th Edition. ANZDATA Registry: Adelaide, Australia; 2012. Available from: http://www.anzdata.org.au/anzdata/AnzdataReport/35thReport/2012c03_deaths_v2.9.pdf. Accessed January 1, 2014.
80. Douglas C, Murtagh FE, Chambers EJ, Howse M, Ellershaw J. Symptom management for the adult patient dying with advanced chronic kidney disease: a review of the literature and development of evidence-based guidelines by a United Kingdom Expert Consensus Group. Palliat Med. 2009;23(2):103-110.
81. Impedovo SV, Ditonno P, Ricapito V, et al. Advanced age is not an exclusion criterion for kidney transplantation. Transplant Proc. 2013; 45(7):2650-2653.
82. Lenihan CR, Hurley MP, Tan JC. Comorbidities and kidney transplant evaluation in the elderly. Am J Nephrol. 2013;38(3):204-211.
83. Rodelo JR, Nieto-Ríos JF, Serna-Higuita LM, et al. Survival of renal transplantation patients older than 60 years: a single-center experience. Transplant Proc. 2013;45(4):1402-1409.
84. Rao PS, Merion RM, Ashby VB, Port FK, Wolfe RA, Kayler LK. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation. 2007;83(8):1069-1074.
85. Danovitch G, Savransky E. Challenges in the counseling and management of older kidney transplant candidates. Am J Kidney Dis. 2006;47(4 Suppl 2):S86-S97.
86. USRDS. 2012 Annual Data Report: Annual Data Report. Atlas of Chronic Disease and End Stage Renal Disease in the United States, 2012.
87. Keith DS. Transplantation in the elderly patient. Clin Geriatr Med. 2013;29(3):707-719.
88. Singh P, Germain MJ, Cohen L, Unruh M. The elderly patient on dialysis: geriatric considerations. Nephrol Dial Transplant. Epub June 19, 2013.
89. Meier-Kriesche HU, Ojo AO, Hanson JA, Kaplan B. Exponentially increased risk of infectious death in older renal transplant recipients. Kidney Int. 2001;59(4):1539-1543.