Dizziness and imbalance in the elderly: Age-related decline in the vestibular system

Aging and Disease

Volumn 6, Issue 1, 2015, Pages 38-47

  Iwasaki, Shinichi ^a   Yamasoba, Tatsuya ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Aging; Fall; Rehabilitation; Vestibular

Indexed keywords

AGING; DISEASE ASSOCIATION; DIZZINESS; FALLING; GENETIC PREDISPOSITION; HUMAN; MORBIDITY; MORTALITY; OXIDATIVE STRESS; PHYSICAL DISEASE; POSITIONAL DIZZINESS; PREVALENCE; PUBLIC HEALTH; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; STATISTICAL ANALYSIS; VESTIBULAR DISORDER;

EID: 84936141176     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2014.0128     Document Type: Review

References (84)

1. Tinetti ME, Williams CS, Gill TM (2000). Dizziness among older adults: a possible geriatric syndrome. Ann Intern Med, 132(5): 337-344.
2. Graafmans WC, Ooms ME, Hofstee HM, Bezemer PD, Bouter LM, Lips P (1996). Falls in the elderly: a prospective study of risk factors and risk profiles. Am J Epidemiol, 143(11): 1129-1136.
3. O'Loughlin JL, Boivin JF, Robitaille Y, Suissa S (1994). Falls among the elderly: distinguishing indoor and outdoor risk factors in Canada. J Epidemiol Community Health, 48(5): 488-489.
4. Rubenstein LZ, Josephson KR (2006). Falls and their prevention in elderly people: what does the evidence show? Med Clin North Am, 90(5): 807-824.
5. Stel VS, Pluijm SM, Deeg DJ, Smit JH, Bouter LM, Lips P (2003). A classification tree for predicting recurrent falling in community-dwelling older persons. J Am Geriatr Soc, 51(10): 1356-1364.
6. Delbaere K, Crombez G, Vanderstraeten G, Willems T, Cambier D (2004). Fear-related avoidance of activities, falls and physical frailty. A prospective community-based cohort study. Age Ageing, 33(4): 368-373.
7. Li F, Fisher KJ, Harmer P, McAuley E, Wilson NL (2003). Fear of falling in elderly persons: association with falls, functional ability, and quality of life. J Gerontol B Psychol Sci Soc Sci, 58(5): P283-290.
8. Lawson J, Fitzgerald J, Birchall J, Aldren CP, Kenny RA (1999). Diagnosis of geriatric patients with severe dizziness. J Am Geriatr Soc, 47(1): 12-17.
9. Katsarkas A (1994). Dizziness in aging: a retrospective study of 1194 cases. Otolaryngol Head Neck Surg, 110(3): 296-301.
10. Barin K, Dodson EE (2011). Dizziness in the elderly. Otolaryngol Clin North Am, 44(2): 437-454, x.
11. Colledge NR, Wilson JA, Macintyre CC, MacLennan WJ (1994). The prevalence and characteristics of dizziness in an elderly community. Age Ageing, 23(2): 117-120.
12. Sloane PD, Coeytaux RR, Beck RS, Dallara J (2001). Dizziness: state of the science. Ann Intern Med, 134(9 Pt 2): 823-832.
13. Jonsson R, Sixt E, Landahl S, Rosenhall U (2004). Prevalence of dizziness and vertigo in an urban elderly population. J Vestib Res, 14(1): 47-52.
14. Neuhauser HK, von Brevern M, Radtke A, Lezius F, Feldmann M, Ziese T, Lempert T (2005). Epidemiology of vestibular vertigo: a neurotologic survey of the general population. Neurology, 65(6): 898-904.
15. Davis LE (1994). Dizziness in elderly men. J Am Geriatr Soc, 42(11): 1184-1188.
16. Kroenke K, Lucas CA, Rosenberg ML, Scherokman B, Herbers JE, Jr., Wehrle PA, Boggi JO (1992). Causes of persistent dizziness. A prospective study of 100 patients in ambulatory care. Ann Intern Med, 117(11): 898-904.
17. Belal A, Jr., Glorig A (1986). Dysequilibrium of ageing (presbyastasis). J Laryngol Otol, 100(9): 1037-1041.
18. Colledge NR, Barr-Hamilton RM, Lewis SJ, Sellar RJ, Wilson JA (1996). Evaluation of investigations to diagnose the cause of dizziness in elderly people: a community based controlled study. BMJ, 313(7060): 788-792.
19. Sloane PD, Hartman M, Mitchell CM (1994). Psychological factors associated with chronic dizziness in patients aged 60 and older. J Am Geriatr Soc, 42(8): 847-852.
20. Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T (2001). The interrelations of migraine, vertigo, and migrainous vertigo. Neurology, 56(4): 436-441.
21. Baloh RW, Honrubia V, Jacobson K (1987). Benign positional vertigo: clinical and oculographic features in 240 cases. Neurology, 37(3): 371-378.
22. von Brevern M, Radtke A, Lezius F, Feldmann M, Ziese T, Lempert T, Neuhauser H (2007). Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry, 78(7): 710-715.
23. Neuhauser HK (2007). Epidemiology of vertigo. Curr Opin Neurol, 20(1): 40-46.
24. Dix MR, Hallpike CS (1952). The pathology symptomatology and diagnosis of certain common disorders of the vestibular system. Proc R Soc Med, 45(6): 341-354.
25. Brandt T, Steddin S (1993). Current view of the mechanism of benign paroxysmal positioning vertigo: cupulolithiasis or canalolithiasis? J Vestib Res, 3(4): 373-382.
26. Epley JM (1992). The canalith repositioning procedure: for treatment of benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg, 107(3): 399-404.
27. Iwasaki S, Chihara Y, Ushio M, Ochi A, Murofushi T, Yamasoba T (2011). Effect of the canalith repositioning procedure on subjective visual horizontal in patients with posterior canal benign paroxysmal positional vertigo. Acta Otolaryngol, 131(1): 41-45.
28. Semont A, Freyss G, Vitte E (1988). Curing the BPPV with a liberatory maneuver. Adv Otorhinolaryngol, 42(290-293.
29. Johkura K, Momoo T, Kuroiwa Y (2008). Positional nystagmus in patients with chronic dizziness. J Neurol Neurosurg Psychiatry, 79(12): 1324-1326.
30. Parnes LS, McClure JA (1992). Free-floating endolymph particles: a new operative finding during posterior semicircular canal occlusion. Laryngoscope, 102(9): 988-992.
31. Igarashi M, Saito R, Mizukoshi K, Alford BR (1993). Otoconia in young and elderly persons: a temporal bone study. Acta Otolaryngol Suppl, 504(26-29.
32. Johnsson LG, Hawkins JE, Jr. (1972). Vascular changes in the human inner ear associated with aging. Ann Otol Rhinol Laryngol, 81(3): 364-376.
33. Wladislavosky-Waserman P, Facer GW, Mokri B, Kurland LT (1984). Meniere's disease: a 30-year epidemiologic and clinical study in Rochester, Mn, 1951-1980. Laryngoscope, 94(8): 1098-1102.
34. Ballester M, Liard P, Vibert D, Hausler R (2002). Meniere's disease in the elderly. Otol Neurotol, 23(1): 73-78.
35. Shojaku H, Watanabe Y, Fujisaka M, Tsubota M, Kobayashi K, Yasumura S, Mizukoshi K (2005). Epidemiologic characteristics of definite Meniere's disease in Japan. A long-term survey of Toyama and Niigata prefectures. ORL J Otorhinolaryngol Relat Spec, 67(5): 305-309.
36. Shojaku H, Watanabe Y, Yagi T, Takahashi M, Takeda T, Ikezono T, Ito J, Kubo T, Suzuki M, Takumida M, Takeda N, Furuya N, Yamashita H (2009). Changes in the characteristics of definite Meniere's disease over time in Japan: a long-term survey by the Peripheral Vestibular Disorder Research Committee of Japan, formerly the Meniere's Disease Research Committee of Japan. Acta Otolaryngol, 129(2): 155-160.
37. Guilemany JM, Martinez P, Prades E, Sanudo I, De Espana R, Cuchi A (2004). Clinical and epidemiological study of vertigo at an outpatient clinic. Acta Otolaryngol, 124(1): 49-52.
38. Sekitani T, Imate Y, Noguchi T, Inokuma T (1993). Vestibular neuronitis: epidemiological survey by questionnaire in Japan. Acta Otolaryngol Suppl, 503(9-12.
39. Godemann F, Siefert K, Hantschke-Bruggemann M, Neu P, Seidl R, Strohle A (2005). What accounts for vertigo one year after neuritis vestibularis - anxiety or a dysfunctional vestibular organ? J Psychiatr Res, 39(5): 529-534.
40. Murofushi T, Iwasaki S, Ushio M (2006). Recovery of vestibular evoked myogenic potentials after a vertigo attack due to vestibular neuritis. Acta Otolaryngol, 126(4): 364-367.
41. Okinaka Y, Sekitani T, Okazaki H, Miura M, Tahara T (1993). Progress of caloric response of vestibular neuronitis. Acta Otolaryngol Suppl, 503(18-22.
42. Baloh RW, Jacobson KM, Socotch TM (1993). The effect of aging on visual-vestibuloocular responses. Exp Brain Res, 95(3): 509-516.
43. Paige GD (1992). Senescence of human visualvestibular interactions. 1. Vestibulo-ocular reflex and adaptive plasticity with aging. J Vestib Res, 2(2): 133-151.
44. Peterka RJ, Black FO, Schoenhoff MB (1990). Age-related changes in human vestibulo-ocular reflexes: sinusoidal rotation and caloric tests. J Vestib Res, 1(1): 49-59.
45. Baloh RW, Enrietto J, Jacobson KM, Lin A (2001). Age-related changes in vestibular function: a longitudinal study. Ann N Y Acad Sci, 942(210-219.
46. Chihara Y, Iwasaki S, Ushio M, Murofushi T (2007). Vestibular-evoked extraocular potentials by air-conducted sound: another clinical test for vestibular function. Clin Neurophysiol, 118(12): 2745-2751.
47. Iwasaki S, McGarvie LA, Halmagyi GM, Burgess AM, Kim J, Colebatch JG, Curthoys IS (2007). Head taps evoke a crossed vestibulo-ocular reflex. Neurology, 68(15): 1227-1229.
48. Welgampola MS, Colebatch JG (2005). Characteristics and clinical applications of vestibular-evoked myogenic potentials. Neurology, 64(10): 1682-1688.
49. Murofushi T, Curthoys IS, Topple AN, Colebatch JG, Halmagyi GM (1995). Responses of guinea pig primary vestibular neurons to clicks. Exp Brain Res, 103(1): 174-178.
50. Kushiro K, Zakir M, Sato H, Ono S, Ogawa Y, Meng H, Zhang X, Uchino Y (2000). Saccular and utricular inputs to single vestibular neurons in cats. Exp Brain Res, 131(4): 406-415.
51. Iwasaki S, Chihara Y, Smulders YE, Burgess AM, Halmagyi GM, Curthoys IS, Murofushi T (2009). The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz. Clin Neurophysiol, 120(3): 588-593.
52. Curthoys IS, Iwasaki S, Chihara Y, Ushio M, McGarvie LA, Burgess AM (2011). The ocular vestibular-evoked myogenic potential to airconducted sound; probable superior vestibular nerve origin. Clin Neurophysiol, 122(3): 611-616.
53. Brantberg K, Granath K, Schart N (2007). Agerelated changes in vestibular evoked myogenic potentials. Audiol Neurootol, 12(4): 247-253.
54. Iwasaki S, Smulders YE, Burgess AM, McGarvie LA, Macdougall HG, Halmagyi GM, Curthoys IS (2008). Ocular vestibular evoked myogenic potentials to bone conducted vibration of the midline forehead at Fz in healthy subjects. Clin Neurophysiol, 119(9): 2135-2147.
55. Agrawal Y, Zuniga MG, Davalos-Bichara M, Schubert MC, Walston JD, Hughes J, Carey JP (2012). Decline in semicircular canal and otolith function with age. Otol Neurotol, 33(5): 832-839.
56. Wolfson L, Whipple R, Derby CA, Amerman P, Murphy T, Tobin JN, Nashner L (1992). A dynamic posturography study of balance in healthy elderly. Neurology, 42(11): 2069-2075.
57. Baloh RW, Spain S, Socotch TM, Jacobson KM, Bell T (1995). Posturography and balance problems in older people. J Am Geriatr Soc, 43(6): 638-644.
58. Fujimoto C, Murofushi T, Chihara Y, Ushio M, Sugasawa K, Yamaguchi T, Yamasoba T, Iwasaki S (2009). Assessment of diagnostic accuracy of foam posturography for peripheral vestibular disorders: analysis of parameters related to visual and somatosensory dependence. Clin Neurophysiol, 120(7): 1408-1414.
59. Teasdale N, Stelmach GE, Breunig A (1991). Postural sway characteristics of the elderly under normal and altered visual and support surface conditions. J Gerontol, 46(6): B238-244.
60. Richter E (1980). Quantitative study of human Scarpa's ganglion and vestibular sensory epithelia. Acta Otolaryngol, 90(3-4): 199-208.
61. Rauch SD, Velazquez-Villasenor L, Dimitri PS, Merchant SN (2001). Decreasing hair cell counts in aging humans. Ann N Y Acad Sci, 942(220-227.
62. Merchant SN, Velazquez-Villasenor L, Tsuji K, Glynn RJ, Wall C, 3rd, Rauch SD (2000). Temporal bone studies of the human peripheral vestibular system. Normative vestibular hair cell data. Ann Otol Rhinol Laryngol Suppl, 181(3-13.
63. Lopez I, Ishiyama G, Tang Y, Tokita J, Baloh RW, Ishiyama A (2005). Regional estimates of hair cells and supporting cells in the human crista ampullaris. J Neurosci Res, 82(3): 421-431.
64. Gopen Q, Lopez I, Ishiyama G, Baloh RW, Ishiyama A (2003). Unbiased stereologic type I and type II hair cell counts in human utricular macula. Laryngoscope, 113(7): 1132-1138.
65. Shiga A, Nakagawa T, Nakayama M, Endo T, Iguchi F, Kim TS, Naito Y, Ito J (2005). Aging effects on vestibulo-ocular responses in C57BL/6 mice: comparison with alteration in auditory function. Audiol Neurootol, 10(2): 97-104.
66. Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K (2013). Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways. Hear Res, 303(30-38.
67. Ohlemiller KK (2009). Mechanisms and genes in human strial presbycusis from animal models. Brain Res, 1277:70-83.
68. Schuknecht HF (1955). Presbycusis. Laryngoscope, 65(6): 402-419.
69. Cheng AG, Cunningham LL, Rubel EW (2005). Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg, 13(6): 343-348.
70. Someya S, Yamasoba T, Kujoth GC, Pugh TD, Weindruch R, Tanokura M, Prolla TA (2008). The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma. Neurobiol Aging, 29(7): 1080-1092.
71. Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA (2009). Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A, 106(46): 19432-19437.
72. Uchida Y, Sugiura S, Ando F, Nakashima T, Shimokata H (2011). Molecular genetic epidemiology of age-related hearing impairment. Auris Nasus Larynx, 38(6): 657-665.
73. Le Prell CG, Yamashita D, Minami SB, Yamasoba T, Miller JM (2007). Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hear Res, 226(1-2): 22-43.
74. Cawthorne T (1946). Vestibular injuries. Proc R Soc Lond B Biol Sci, 39(270-273.
75. Yardley L, Beech S, Zander L, Evans T, Weinman J (1998). A randomized controlled trial of exercise therapy for dizziness and vertigo in primary care. Br J Gen Pract, 48(429): 1136-1140.
76. Alrwaily M, Whitney SL (2011). Vestibular rehabilitation of older adults with dizziness. Otolaryngol Clin North Am, 44(2): 473-496, x.
77. Whitney SL, Wrisley DM, Marchetti GF, Furman JM (2002). The effect of age on vestibular rehabilitation outcomes. Laryngoscope, 112(10): 1785-1790.
78. Yardley L, Barker F, Muller I, Turner D, Kirby S, Mullee M, Morris A, Little P (2012). Clinical and cost effectiveness of booklet based vestibular rehabilitation for chronic dizziness in primary care: single blind, parallel group, pragmatic, randomised controlled trial. BMJ, 344:e2237.
79. Yardley L, Donovan-Hall M, Smith HE, Walsh BM, Mullee M, Bronstein AM (2004). Effectiveness of primary care-based vestibular rehabilitation for chronic dizziness. Ann Intern Med, 141(8): 598-605.
80. Wall C, 3rd (2010). Application of vibrotactile feedback of body motion to improve rehabilitation in individuals with imbalance. J Neurol Phys Ther, 34(2): 98-104.
81. Wall C, 3rd, Kentala E (2005). Control of sway using vibrotactile feedback of body tilt in patients with moderate and severe postural control deficits. J Vestib Res, 15(5-6): 313-325.
82. Vuillerme N, Cuisinier R (2009). Sensory supplementation through tongue electrotactile stimulation to preserve head stabilization in space in the absence of vision. Invest Ophthalmol Vis Sci, 50(1): 476-481.
83. Priplata AA, Niemi JB, Harry JD, Lipsitz LA, Collins JJ (2003). Vibrating insoles and balance control in elderly people. Lancet, 362(9390): 1123-1124.
84. Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA (2010). Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell, 143(5): 802-812.