Impact of the Pharmacist Medication Review Services on Drug-Related Problems and Potentially Inappropriate Prescribing of Renally Cleared Medications in Residents of Aged Care Facilities

Drugs and Aging

Volumn 31, Issue 11, 2014, Pages 825-835

  Gheewala, Pankti A ^a   Peterson, Gregory M ^a   Curtain, Colin M ^a   Nishtala, Prasad S ^b   Hannan, Paul J ^c   Castelino, Ronald L ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c Meditrax Pharmacy   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE;

AGED; AGED HOSPITAL PATIENT; ARTICLE; CHRONIC KIDNEY DISEASE; CREATININE BLOOD LEVEL; DIET; DRUG SURVEILLANCE PROGRAM; ELDERLY CARE; FEMALE; GENERAL PRACTITIONER; HUMAN; INAPPROPRIATE PRESCRIBING; KIDNEY CLEARANCE; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MEDICATION THERAPY MANAGEMENT; PHARMACIST; PREVALENCE; RESIDENT; RETROSPECTIVE STUDY; VERY ELDERLY; AUSTRALIA; DRUG USE; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; HOME FOR THE AGED; NURSING HOME; PHARMACY; RENAL INSUFFICIENCY, CHRONIC; STATISTICS AND NUMERICAL DATA;

AGED; AGED, 80 AND OVER; DRUG UTILIZATION REVIEW; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; HOMES FOR THE AGED; HUMANS; INAPPROPRIATE PRESCRIBING; MALE; NEW SOUTH WALES; NURSING HOMES; PHARMACEUTICAL SERVICES; PHARMACISTS; RENAL INSUFFICIENCY, CHRONIC;

EID: 84919915061     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-014-0208-y     Document Type: Article

References (49)

1. Hamilton HJ, Gallagher PF, O’Mahony D. Inappropriate prescribing and adverse drug events in older people. BMC Geriatr. 2009;9:5. doi:10.1186/1471-2318-9-5.
2. Williams M, Peterson GM, Tenni PC, et al. DOCUMENT: a system for classifying drug-related problems in community pharmacy. Int J Clin Pharm. 2012;34(1):43–52. doi:10.1007/s11096-011-9583-1.
3. Fick DM, Cooper JW, Wade WE, et al. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003;163(22):2716–24. doi:10.1001/archinte.163.22.2716.
4. Beyth RJ, Shorr RI. Principles of drug therapy in older patients: rational drug prescribing. Clin Geriatr Med. 2002;18(3):577–92.
5. Walley T, Scott AK. Prescribing in the elderly. Postgrad Med J. 1995;71(838):466–71.
6. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57(1):6–14.
7. ElDesoky ES. Pharmacokinetic-pharmacodynamic crisis in the elderly. Am J Ther. 2007;14(5):488–98. doi:10.1097/01.mjt.0000183719.84390.4d.
8. Stafford AC, Alswayan MS, Tenni PC. Inappropriate prescribing in older residents of Australian care homes. J Clin Pharm Ther. 2011;36(1):33–44. doi:10.1111/j.1365-2710.2009.01151.x.
9. Castelino RL, Bajorek BV, Chen TF. Targeting suboptimal prescribing in the elderly: a review of the impact of pharmacy services. Ann Pharmacother. 2009;43(6):1096–106. doi:10.1345/aph.1L700.
10. Beers MH, Ouslander JG, Fingold SF, et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med. 1992;117(8):684–9.
11. Gill SS, Misiaszek BC, Brymer C. Improving prescribing in the elderly: a study in the long term care setting. Can J Clin Pharmacol. 2001;8(2):78–83.
12. O’Connor MN, Gallagher P, O’Mahony D. Inappropriate prescribing: criteria, detection and prevention. Drugs Aging. 2012;29(6):437–52. doi:10.2165/11632610-000000000-00000.
13. Ruggiero C, Dell’Aquila G, Gasperini B, et al. Potentially inappropriate drug prescriptions and risk of hospitalization among older, Italian, nursing home residents: the ULISSE project. Drugs Aging. 2010;27(9):747–58. doi:10.2165/11538240-000000000-00000.
14. Hanlon JT, Wang X, Handler SM, et al. Potentially inappropriate prescribing of primarily renally cleared medications for older veterans affairs nursing home patients. J Am Med Dir Assoc. 2011;12(5):377–83. doi:10.1016/j.jamda.2010.04.008.
15. Rahimi AR, Kennedy K, Thomason M, et al. Improper renal dosing in long-term care facilities. South Med J. 2008;101(8):802–5. doi:10.1097/SMJ.0b013e31817f1f71.
16. Levey AS, Coresh J, Balk E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003;139(2):137–47.
17. Stevens LA, Coresh J, Greene T, et al. Assessing kidney function: measured and estimated glomerular filtration rate. N Engl J Med. 2006;354(23):2473–83. doi:10.1056/NEJMra054415.
18. Olyaei AJ, Steffl JL. A quantitative approach to drug dosing in chronic kidney disease. Blood Purif. 2011;31(1–3):138–45. doi:10.1159/000321857.
19. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298(17):2038–47. doi:10.1001/jama.298.17.2038.
20. Jose MD, Otahal P, Kirkland G, et al. Chronic kidney disease in Tasmania. Nephrology (Carlton). 2009;14(8):743–9. doi:10.1111/j.1440-1797.2009.01198.x.
21. Rothberg MB, Kehoe ED, Courtemanche AL, et al. Recognition and management of chronic kidney disease in an elderly ambulatory population. J Gen Intern Med. 2008;23(8):1125–30. doi:10.1007/s11606-008-0607-z.
22. Papaioannou A, Clarke JA, Campbell G, et al. Assessment of adherence to renal dosing guidelines in long-term care facilities. J Am Geriatr Soc. 2000;48(11):1470–3.
23. Department of Health. Medication Management Reviews/Residential Medication Management Review. 2013. http://www.health.gov.au/internet/main/publishing.nsf/Content/medication_management_reviews.htm. Accessed 30 Sep 2013.
24. Nishtala PS, Hilmer SN, McLachlan AJ, et al. Impact of residential medication management reviews on drug burden index in aged-care homes: a retrospective analysis. Drugs Aging. 2009;26(8):677–86. doi:10.2165/11316440-000000000-00000.
25. Pharmaceutical Society of Australia. Guidelines for pharmacists providing Residential Medication Management Review (RMMR) and Quality Use of Medicines (QUM). 2011. http://www.psa.org.au/aprc-residential-medication-review/unserstand-service-information. Accessed 30 Sep 2013.
26. Nishtala PS, McLachlan AJ, Bell JS, et al. A retrospective study of drug-related problems in Australian aged care homes: medication reviews involving pharmacists and general practitioners. J Eval Clin Pract. 2011;17(1):97–103. doi:10.1111/j.1365-2753.2010.01374.x.
27. Roberts MS, Stokes JA, King MA, et al. Outcomes of a randomized controlled trial of a clinical pharmacy intervention in 52 nursing homes. Br J Clin Pharmacol. 2001;51(3):257–65.
28. Zermansky AG, Alldred DP, Petty DR, et al. Clinical medication review by a pharmacist of elderly people living in care homes: randomised controlled trial. Age Ageing. 2006;35(6):586–91. doi:10.1093/ageing/afl075.
29. WHO Collaborating Centre for Drug Statistics Mthodology. Anatomical Therapeutic Chemical (ATC) Classification System. Norweigan Institute of Public Health. http://www.whocc.no/atc_ddd_publications/atc_ddd_index/. Accessed 25 Sep 2013.
30. WHO. International Classification of Diseases (ICD)-10, version 2010. http://www.who.int/classifications/icd/en/. Accessed 25 Sep 2013.
31. Stevens LA, Nolin TD, Richardson MM, et al. Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am J Kidney Dis. 2009;54(1):33–42. doi:10.1053/j.ajkd.2009.03.008.
32. Australian Medicines Handbook (AMH). Evidence-based independent medicines reference. 2014. https://shop.amh.net.au/. Accessed 21 July2014.
33. Faull R, Lee L. Prescribing in renal disease. Australian Prescriber. 2007. http://www.australianprescriber.com/magazine/30/1/17/20. Accessed 25 Sep 2013.
34. R Core Team (2013) R: A language for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. http://www.r-project.org/. Accessed 3 Oct 2013.
35. Finkers F, Maring JG, Boersma F, et al. A study of medication reviews to identify drug-related problems of polypharmacy patients in the Dutch nursing home setting. J Clin Pharm Ther. 2007;32(5):469–76. doi:10.1111/j.1365-2710.2007.00849.x.
36. Gurwitz JH, Field TS, Avorn J, et al. Incidence and preventability of adverse drug events in nursing homes. Am J Med. 2000;109(2):87–94.
37. Nguyen JK, Fouts MM, Kotabe SE, et al. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4(1):36–41. doi:10.1016/j.amjopharm.2006.03.002.
38. Gurwitz JH, Field TS, Judge J, et al. The incidence of adverse drug events in two large academic long-term care facilities. Am J Med. 2005;118(3):251–8. doi:10.1016/j.amjmed.2004.09.018.
39. Vlasses PH, Lucarotti RL, Miller DA, et al. Drug therapy review in a skilled nursing facility: an innovative approach. J Am Pharm Assoc. 1977;17(2):92–4.
40. Mandryk JA, Wai A, Mackson JM, et al. Evaluating the impact of educational interventions on use of antithrombotics in Australia. Pharmacoepidemiol Drug Saf. 2008;17(2):160–71. doi:10.1002/pds.1536.
41. Schoen C, Osborn R, Huynh PT, et al. Taking the pulse of health care systems: experiences of patients with health problems in six countries. Health Aff (Millwood). 2005;Suppl Web Exclusives:W5-509-25. doi:10.1377/hlthaff.w5.509.
42. Harding G, Wilcock M. Community pharmacists’ perceptions of medicines use reviews and quality assurance by peer review. Pharm World Sci. 2010;32(3):381–5. doi:10.1007/s11096-010-9381-1.
43. McClellan WM, Resnick B, Lei L, et al. Prevalence and severity of chronic kidney disease and anemia in the nursing home population. J Am Med Dir Assoc. 2010;11(1):33–41. doi:10.1016/j.jamda.2009.07.003.
44. Khanal A, Castelino RL, Peterson GM, et al. Dose adjustment guidelines for medications in patients with renal impairment: how consistent are drug information sources? Intern Med J. 2014;44(1):77–85. doi:10.1111/imj.12291.
45. Sweileh WM, Janem SA, Sawalha AF, et al. Medication dosing errors in hospitalized patients with renal impairment: a study in Palestine. Pharmacoepidemiol Drug Saf. 2007;16(8):908–12. doi:10.1002/pds.1412.
46. Decloedt E, Leisegang R, Blockman M, et al. Dosage adjustment in medical patients with renal impairment at Groote Schuur Hospital. S Afr Med J. 2010;100(5):304–6.
47. Khanal A, Peterson GM, Castelino RL, et al. Renal drug dosing recommendations: evaluation of product information for brands of the same drug. Intern Med J. 2014;44(6):591–6. doi:10.1111/imj.12446.
48. Hanlon JT, Aspinall SL, Semla TP, et al. Consensus guidelines for oral dosing of primarily renally cleared medications in older adults. J Am Geriatr Soc. 2009;57(2):335–40. doi:10.1111/j.1532-5415.2008.02098.x.
49. Desrochers JF, Lemieux JP, Morin-Belanger C, et al. Development and validation of the PAIR (Pharmacotherapy Assessment in Chronic Renal Disease) criteria to assess medication safety and use issues in patients with CKD. Am J Kidney Dis. 2011;58(4):527–35. doi:10.1053/j.ajkd.2011.04.020.