Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1859, Issue 11, 2016, Pages 1440-1448

  Anastasina, Maria ^a,c   Le May, Nicolas ^b   Bugai, Andrii ^a   Fu, Yu ^a   Söderholm, Sandra ^c   Gaelings, Lana ^a   Ohman, Tiina ^c   Tynell, Janne ^d   Kyttänen, Suvi ^a   Barboric, Matjaz ^a   Nyman, Tuula A ^c,e   Matikainen, Sampsa ^a   Julkunen, Ilkka ^d,f   Butcher, Sarah J ^c   Egly, Jean Marc ^b   Kainov, Denis E ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c UNIVERSITY OF HELSINKI   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e OSLO UNIVERSITY HOSPITAL   (Norway)

^f UNIVERSITY OF TURKU   (Finland)

Author keywords

Antiviral responses; Influenza A virus; Innate immunity; Regulation of gene expression; Viral counter responses

Indexed keywords

BAMBI PROTEIN; BETA1 INTERFERON; CELL DNA; CH25H PROTEIN; DDX60L PROTEIN; EIF2AK2 PROTEIN; HISTONE H1; HISTONE H3; IDO PROTEIN; IFIH1 PROTEIN; INTERFERON; NONSTRUCTURAL PROTEIN 1; OAS1 PROTEIN; OAS3 PROTEIN; PROTEIN; PTGS2 PROTEIN; RNA POLYMERASE II; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG; CHROMATIN; DNA; INS1 PROTEIN, INFLUENZA VIRUS; PROTEIN BINDING; VIRAL PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLUENZA A; INFLUENZA A VIRUS; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA VIRUS; VIRUS GENE; ANIMAL; CELL LINE; CHROMATIN; METABOLISM; PHYSIOLOGY; VIRUS REPLICATION;

ANIMALS; CELL LINE; CHROMATIN; DNA; HUMANS; INFLUENZA A VIRUS; PROTEIN BINDING; TRANSCRIPTION, GENETIC; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84992089021     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2016.09.005     Document Type: Article

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