The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice

Journal of General Virology

Volumn 96, Issue 8, 2015, Pages 2086-2091

  Anastasina, Maria ^a   Schepens, Bert ^b,c   Söderholm, Sandra ^a,d   Nyman, Tuula A ^a   Matikaine, Sampsa ^d   Saksela, Kalle ^e   Saelens, Xavier ^b,c   Kainov, Denis E ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONIN 60; INTERLEUKIN 6; INTERLEUKIN 8; NONSTRUCTURAL PROTEIN 1; STAT3 PROTEIN; INS1 PROTEIN, INFLUENZA VIRUS; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA A VIRUS (H1N1); MACROPHAGE; MOUSE; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE GENETICS; VIRUS EXPRESSION; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; FEMALE; GENETICS; IMMUNOLOGY; INFLUENZA; PHYSIOLOGY; PROTEIN MOTIF; VIROLOGY;

INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

AMINO ACID MOTIFS; ANIMALS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MACROPHAGES; MICE; MICE, INBRED BALB C; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84940208073     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.000171     Document Type: Article

References (14)

1. Ayllon, J. & García-Sastre, A. (2015). The NS1 protein: a multitasking virulence factor. Curr Top Microbiol Immunol 386, 73-107.
2. Denisova, O. V., Kakkola, L., Feng, L., Stenman, J., Nagaraj, A., Lampe, J., Yadav, B., Aittokallio, T. & Kaukinen, P. (2012). Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. J Biol Chem 287, 35324-35332.
3. Denisova, O. V., Soderholm, S., Virtanen, S., Von Schantz, C., Bychkov, D., Vashchinkina, E., Desloovere, J., Tynell, J. & Ikonen, N. (2014). Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. Antimicrob Agents Chemother 58, 3689-3696
4. Dundon, W. G. & Capua, I. (2009). A closer look at the NS1 of influenza virus. Viruses 1, 1057-1072.
5. Hale, B. G., Randall, R. E., Ortín, J. & Jackson, D. (2008). The multifunctional NS1 protein of influenza A viruses. J Gen Virol 89, 2359-2376
6. Hoffmann, E., Neumann, G., Kawaoka, Y., Hobom, G. & Webster, R. G. (2000). A DNA transfection system for generation of influenza A virus from eight plasmids. Proc Natl Acad Sci U S A 97, 6108-6113
7. Jackson, D., Hossain, M. J., Hickman, D., Perez, D. R. & Lamb, R. A. (2008). A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci USA105,4381-4386.
8. Jalovaara, P., Bychkov, D., Ahtiainen, L., Kallio-Kokko, H., Valkonen, M., Kantele, A., Mattila, P., Almusa, H., Kallioniemi, O. & Kainov, D. (2014). Genetic instability of influenza pH1N1 viruses. Genome Announc 2, e00841-14
9. Kakkola, L., Denisova, O. V., Tynell, J., Viiliainen, J., Ysenbaert, T., Matos, R. C., Nagaraj, A., Ohman, T. & Kuivanen, S. (2013). Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice. Cell Death Dis 4, e742
10. Kong, W., Liu, L., Wang, Y., He, Q., Wu, S., Qin, Z., Wang, J., Sun, H. & Sun, Y. (2015). C-terminal elongation of NS1 of H9N2 influenza virus induces a high level of inflammatory cytokines and increases transmission. J Gen Virol 96, 259-268
11. Lakspere, T., Tynell, J., Kaloinen, M., Vanlede, M., Parsons, A., Ikonen, N., Kallio-Kokko, H., Kantele, A. & Mattila, P. (2014). Full- genome sequences of influenza A(H1N1)pdm09 viruses isolated from Finnish patients from 2009 to 2013. Genome Announc 2, e01004-e01013
12. Muller, K. H., Kakkola, L., Nagaraj, A. S., Cheltsov, A. V., Anastasina, M. & Kainov, D. E. (2012) Emerging cellular targets for influenza antiviral agents. Trends Pharmacol Sci 33, 89-99
13. Richt, J. A. & García-Sastre, A. (2009) Attenuated influenza virus vaccines with modified NS1 proteins. Curr Top Microbiol Immunol 333, 177-195
14. Soubies, S. M., Volmer, C., Guérin, J. L. & Volmer, R. (2010) Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells. Avian Dis 54 (Suppl), 527-531.