Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis

Acta Neuropathologica

Volumn 133, Issue 1, 2017, Pages 79-90

  Braak, Heiko ^a   Ludolph, Albert C ^a   Neumann, Manuela ^b,c   Ravits, John ^d   Del Tredici, Kelly ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyotrophic lateral sclerosis; Betz cells; Motor neuron disease; Primary motor cortex; TAR DNA binding protein; TDP 43; Therapeutics; Transsynaptic spreading; Motoneurons

Indexed keywords

TAR DNA BINDING PROTEIN; DNA BINDING PROTEIN; TDP-43 PROTEIN, HUMAN;

ADULT; AGED; ALPHA NERVE FIBER; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BRAIN STEM; CELL INCLUSION; CELL LOSS; CELL NUCLEUS; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; FEMALE; HUMAN; HUMAN TISSUE; HYPOGLOSSAL NUCLEUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MIDDLE AGED; MOLECULAR PATHOLOGY; NEOCORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PYRAMIDAL NERVE CELL; RETROSPECTIVE STUDY; SPINAL CORD; SPORADIC AMYOTROPHIC LATERAL SCLEROSIS; TISSUE SECTION; COHORT ANALYSIS; METABOLISM; MOTONEURON; MOTOR CORTEX; PATHOLOGY; PROTEINOSIS;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN STEM; COHORT STUDIES; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOTOR CORTEX; MOTOR NEURONS; PROTEIN AGGREGATION, PATHOLOGICAL; PYRAMIDAL CELLS; SPINAL CORD;

EID: 84991704762     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-016-1633-2     Document Type: Article

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