Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43

Acta Neuropathologica Communications

Volumn 2, Issue 1, 2014, Pages

  Tan, Rachel H ^a   Shepherd, Claire E ^a,b   Kril, Jillian J ^c   McCann, Heather ^a   McGeachie, Andrew ^a,b   McGinley, Ciara ^c   Affleck, Andrew ^a,b   Halliday, Glenda M ^a,b  

^a NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Frontotemporal dementia; Pathological classification; TDP43

Indexed keywords

EID: 85005917048     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/2051-5960-1-33     Document Type: Article

References (27)

1. Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T: TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2006, 351: 602-611. 10.1016/j.bbrc.2006.10.093
2. Mackenzie IR, Baborie A, Pickering-Brown S, Du Plessis D, Jaros E, Perry RH, Neary D, Snowden JS, Mann DM: Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype. Acta Neuropathol 2006, 112: 539-549. 10.1007/s00401-006-0138-9
3. Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, Perry RH, Trojanowski JQ, Mann DM, Lee VM: A harmonized classification system for FTLD-TDP pathology. Acta Neuropathol 2011, 122: 111-113. 10.1007/s00401-011-0845-8
4. Sampathu DM, Neumann M, Kwong LK, Chou TT, Micsenyi M, Truax A, Bruce J, Grossman M, Trojanowski JQ, Lee VM: Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. Am J Pathol 2006, 169: 1343-1352. 10.2353/ajpath.2006.060438
5. Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM: Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol 2009, 117: 137-149. 10.1007/s00401-008-0477-9
6. Onodera O, Sugai A, Konno T, Tada M, Koyama A, Nishizawa M: What is the key player in TDP-43 pathology in ALS: disappearance from the nucleus or inclusion formation in the cytoplasm? Neurol Clin Neurophysiol 2013, 1: 11-17.
7. Davidson Y, Kelley T, Mackenzie IR, Pickering-Brown S, Du Plessis D, Neary D, Snowden JS, Mann DM: Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43. Acta Neuropathol 2007, 113: 521-533. 10.1007/s00401-006-0189-y
8. Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, et al.: Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann Neurol 2008, 64: 60-70. 10.1002/ana.21425
9. Olive M, Janue A, Moreno D, Gamez J, Torrejon-Escribano B, Ferrer I: TAR DNA-Binding protein 43 accumulation in protein aggregate myopathies. J Neuropathol Exp Neurol 2009, 68: 262-273. 10.1097/NEN.0b013e3181996d8f
10. Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL: TDP-43 pathology in familial British dementia. Acta Neuropathol 2009, 118: 303-311. 10.1007/s00401-009-0514-3
11. Grossman M, Wood EM, Moore P, Neumann M, Kwong L, Forman MS, Clark CM, McCluskey LF, Miller BL, Lee VM, Trojanowski JQ: TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions. Arch Neurol 2007, 64: 1449-1454. 10.1001/archneur.64.10.1449
12. Josephs KA, Stroh A, Dugger B, Dickson DW: Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes. Acta Neuropathol 2009, 118: 349-358. 10.1007/s00401-009-0547-7
13. Snowden J, Neary D, Mann D: Frontotemporal lobar degeneration: clinical and pathological relationships. Acta Neuropathol 2007, 114: 31-38. 10.1007/s00401-007-0236-3
14. Josephs KA, Hodges JR, Snowden JS, Mackenzie IR, Neumann M, Mann DM, Dickson DW: Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathol 2011, 122: 137-153. 10.1007/s00401-011-0839-6
15. Armstrong RA, Ellis W, Hamilton RL, Mackenzie IR, Hedreen J, Gearing M, Montine T, Vonsattel JP, Head E, Lieberman AP, Cairns NJ: Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. J Neural Transm 2010, 117: 227-239. 10.1007/s00702-009-0350-6
16. Armstrong RA, Carter D, Cairns NJ: A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP). Neuropathol Appl Neurobiol 2012, 38: 25-38. 10.1111/j.1365-2990.2011.01188.x
17. Bieniek KF, Murray ME, Rutherford NJ, Castanedes-Casey M, DeJesus-Hernandez M, Liesinger AM, Baker MC, Boylan KB, Rademakers R, Dickson DW: Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion. Acta Neuropathol 2013, 125: 289-302. 10.1007/s00401-012-1048-7
18. Murray ME, DeJesus-Hernandez M, Rutherford NJ, Baker M, Duara R, Graff-Radford NR, Wszolek ZK, Ferman TJ, Josephs KA, Boylan KB, et al.: Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72. Acta Neuropathol 2011, 122: 673-690. 10.1007/s00401-011-0907-y
19. Kadokura A, Yamazaki T, Kakuda S, Makioka K, Lemere CA, Fujita Y, Takatama M, Okamoto K: Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration. Neurosci Lett 2009, 463: 87-92. 10.1016/j.neulet.2009.06.024
20. Arai T, Mackenzie IR, Hasegawa M, Nonoka T, Niizato K, Tsuchiya K, Iritani S, Onaya M, Akiyama H: Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol 2009, 117: 125-136. 10.1007/s00401-008-0480-1
21. Dobson-Stone C, Hallupp M, Bartley L, Shepherd CE, Halliday GM, Schofield PR, Hodges JR, Kwok JB: C9ORF72 repeat expansion in clinical and neuropathologic frontotemporal dementia cohorts. Neurology 2012, 79: 995-1001. 10.1212/WNL.0b013e3182684634
22. Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, et al.: Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol 2010, 119: 1-4. 10.1007/s00401-009-0612-2
23. Luty AA, Kwok JB, Thompson EM, Blumbergs P, Brooks WS, Loy CT, Dobson-Stone C, Panegyres PK, Hecker J, Nicholson GA, et al.: Pedigree with frontotemporal lobar degeneration-motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9. BMC Neurol 2008, 8: 32. 10.1186/1471-2377-8-32
24. Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, et al.: Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann Neurol 2007, 61: 427-434. 10.1002/ana.21147
25. Fleiss J: Measuring nominal scale agreement among many raters. Psychol Bull 1971, 76: 378-382.
26. Hartmann DP: Considerations in the choice of interobserver reliability estimates. J Appl Behav Anal 1977, 10: 103-116. 10.1901/jaba.1977.10-103
27. Landis J, Koch G: The measurement of observer agreement for categorical data. Biometrics 1977, 33: 159-174. 10.2307/2529310