Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity

Biochemistry

Volumn 55, Issue 4, 2016, Pages 675-685

  Lam, Huy T ^a   Graber, Michael C ^a   Gentry, Katherine A ^a   Bieschke, Jan ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; GLYCOPROTEINS; MOLECULES; NEURODEGENERATIVE DISEASES; OLIGOMERS; PROTEINS; SODIUM DODECYL SULFATE; SODIUM SULFATE; STABILIZATION; TOXICITY;

AGGREGATE FORMATION; ALZHEIMER'S DISEASE; NATURAL COMPOUNDS; PARKINSON'S DISEASE; PROTEIN MISFOLDING; REDUCED TOXICITY; SMALL MOLECULES; THERAPEUTIC STRATEGY;

DIAGNOSIS;

ALPHA SYNUCLEIN; DODECYL SULFATE SODIUM; PROTEINASE K; THIOFLAVINE; AMYLOID; SNCA PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL; NEUROBLASTOMA CELL; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; ALZHEIMER DISEASE; CHEMISTRY; METABOLISM; PROTEIN FOLDING; PROTEIN STABILITY; PROTEINOSIS;

ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMYLOID; HUMANS; PARKINSON DISEASE; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN FOLDING; PROTEIN STABILITY;

EID: 84956969211     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b01168     Document Type: Article

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