SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 41, 2016, Pages E6271-E6280

  Summers, Daniel W ^a   Gibson, Daniel A ^a   DiAntonio, Aaron ^a   Milbrandt, Jeffrey ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axon degeneration; Cell death; NAD; SARM; Sarmoptosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; HOMODIMER; INTERLEUKIN RECEPTOR; LAMININ; MYELOID DIFFERENTIATION FACTOR 88; NICOTINAMIDE ADENINE DINUCLEOTIDE; PEPTIDES AND PROTEINS; POLY DEXTRO LYSINE; RAPAMYCIN; STERILE ALPHA AND TOLL INTERLEUKIN RECEPTOR MOTIF CONTAINING PROTEIN 1; UNCLASSIFIED DRUG; VINCRISTINE; ARMADILLO DOMAIN PROTEIN; CYTOSKELETON PROTEIN; SARM1 PROTEIN, HUMAN;

ALPHA HELIX; ANIMAL CELL; ARTICLE; AXON; AXONAL INJURY; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DIMERIZATION; EMBRYO; MOUSE; MUTAGENESIS; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; SENSORY NERVE CELL; SEQUENCE ALIGNMENT; SPINAL GANGLION; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CELL DEATH; CELL LINE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOLECULAR MODEL; MUTATION; NERVE CELL; NERVE REGENERATION; PHYSIOLOGY; PRIMARY CELL CULTURE; PROTEIN MULTIMERIZATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARMADILLO DOMAIN PROTEINS; AXONS; CELL DEATH; CELL LINE; CYTOSKELETAL PROTEINS; GANGLIA, SPINAL; GENE EXPRESSION; HUMANS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; NAD; NERVE REGENERATION; NEURONS; PRIMARY CELL CULTURE; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84991447123     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1601506113     Document Type: Article

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