Depletion of the Central Metabolite NAD leads to oncosismediated cell death

Journal of Biological Chemistry

Volumn 289, Issue 51, 2014, Pages 35182-35192

  Nagro, Christopher Del ^a   Xiao, Yang ^a   Rangell, Linda ^a   Reichelt, Mike ^a   O'Brien, Thomas ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; CELL CULTURE; CELL MEMBRANES; CELL PROLIFERATION; METABOLITES;

ATP DEPLETION; CELL LINES; HISTONE H3; METABOLIC DEFECTS; RATE-LIMITING ENZYMES; SEQUENCE OF EVENTS; SMALL MOLECULE INHIBITOR; THERAPEUTIC STRATEGY;

CELL DEATH;

ADENOSINE TRIPHOSPHATE; ALPHA TUBULIN; CASPASE 3; CELL ENZYME; ENZYME INHIBITOR; HISTONE H3; LYSINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE DEPENDENT DEACETYLASE; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; GNE-617; HISTONE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SULFONE; TUBULIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; BIOSYNTHESIS; CELL FUNCTION; CELL MEMBRANE; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HOMEOSTASIS; HUMAN; HUMAN CELL; METABOLITE; MOLECULAR PROBE; NUCLEOTIDE METABOLISM; PROTEIN DEPLETION; ACETYLATION; ANTAGONISTS AND INHIBITORS; CELL DEATH; CELL MOTION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HCT116 CELL LINE; METABOLISM; TIME FACTOR; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; WESTERN BLOTTING;

ACETYLATION; ADENOSINE TRIPHOSPHATE; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CASPASE 3; CELL DEATH; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; HCT116 CELLS; HETEROCYCLIC COMPOUNDS, 2-RING; HISTONES; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; NAD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SULFONES; TIME FACTORS; TUBULIN;

EID: 84919363649     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.580159     Document Type: Article

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