T-cell death following immune activation is mediated by mitochondria-localized SARM

Cell Death and Differentiation

Volumn 20, Issue 3, 2013, Pages 478-489

  Panneerselvam, P ^a,b   Singh, L P ^b   Selvarajan, V ^c   Chng, W J ^c,d   Ng, S B ^c   Tan, N S ^e,f   Ho, B ^g   Chen, J ^a,h,i   Ding, J L ^a,b  

^a SINGAPORE MIT ALLIANCE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^f INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

ⁱ MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

adoptive transfer mouse model; influenza infection; intrinsic T cell death by SARM; neglect and activation induced cell death; NK T cell lymphoma

Indexed keywords

ARMADILLO DOMAIN PROTEIN; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STERILE ALPHA AND HEAT ARMADILLO MOTIF CONTAINING PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER PATIENT; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INFLUENZA; LYMPHOCYTE PROLIFERATION; MITOCHONDRION; NK T CELL LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; APOPTOSIS; ARMADILLO DOMAIN PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 9; CELLS, CULTURED; CYTOSKELETAL PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOMA, T-CELL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TRANSFECTION;

ARMADILLO;

EID: 84873723800     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.144     Document Type: Article

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