SARM1 activation triggers axon degeneration locally via NAD+ destruction

Science

Volumn 348, Issue 6233, 2015, Pages 453-457

  Gerdts, Josiah ^a   Brace, E J ^a   Sasaki, Yo ^a   DiAntonio, Aaron ^a   Milbrandt, Jeffrey ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; STERILE ALPHA AND TIR MOTIF CONTAINING 1 PROTEIN; UNCLASSIFIED DRUG; ARMADILLO DOMAIN PROTEIN; CYTOSKELETON PROTEIN; SARM PROTEIN, MOUSE;

BIOENGINEERING; INJURY; MUTATION; NEUROLOGY; RODENT;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AXONAL INJURY; CONTROLLED STUDY; ELECTROPORATION; GEL ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MOUSE; NERVE FIBER DEGENERATION; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; WILD TYPE; ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; NERVE FIBER; PATHOLOGY; PERIPHERAL NERVE INJURY; PROTEIN MULTIMERIZATION; WALLERIAN DEGENERATION;

MUS; WALLERIA;

ANIMALS; ARMADILLO DOMAIN PROTEINS; AXONS; CYTOSKELETAL PROTEINS; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; NAD; NEURONS; PERIPHERAL NERVE INJURIES; PROTEIN MULTIMERIZATION; WALLERIAN DEGENERATION;

EID: 84928411460     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1258366     Document Type: Article

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