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Volumn 44, Issue 7, 2016, Pages 662-672

Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; ENEMA; INULIN; INULIN PROPIONATE ESTER 27; INULIN PROPIONATE ESTER 54; PROPIONIC ACID; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG; ESTER; PROPIONIC ACID DERIVATIVE; VOLATILE FATTY ACID;

EID: 84991387364     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.13749     Document Type: Article
Times cited : (38)

References (51)
  • 1
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013; 504: 451–5.
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3
  • 2
    • 84892814749 scopus 로고    scopus 로고
    • Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
    • De Vadder F, Kovatcheva-Datchary P, Goncalves D, et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 2014; 156: 84–96.
    • (2014) Cell , vol.156 , pp. 84-96
    • De Vadder, F.1    Kovatcheva-Datchary, P.2    Goncalves, D.3
  • 3
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013; 341: 569–73.
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3
  • 4
    • 84893704050 scopus 로고    scopus 로고
    • Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
    • Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20: 159–66.
    • (2014) Nat Med , vol.20 , pp. 159-166
    • Trompette, A.1    Gollwitzer, E.S.2    Yadava, K.3
  • 5
    • 84899816854 scopus 로고    scopus 로고
    • Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention
    • Zeng H, Lazarova DL, Bordonaro M. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World J Gastrointest Oncol 2014; 6: 41–51.
    • (2014) World J Gastrointest Oncol , vol.6 , pp. 41-51
    • Zeng, H.1    Lazarova, D.L.2    Bordonaro, M.3
  • 6
    • 0038363378 scopus 로고    scopus 로고
    • The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • Brown AJ, Goldsworthy SM, Barnes AA, et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 2003; 278: 11312–9.
    • (2003) J Biol Chem , vol.278 , pp. 11312-11319
    • Brown, A.J.1    Goldsworthy, S.M.2    Barnes, A.A.3
  • 7
    • 0038491435 scopus 로고    scopus 로고
    • Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
    • Le Poul E, Loison C, Struyf S, et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003; 278: 25481–9.
    • (2003) J Biol Chem , vol.278 , pp. 25481-25489
    • Le Poul, E.1    Loison, C.2    Struyf, S.3
  • 8
    • 0037453280 scopus 로고    scopus 로고
    • Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
    • Nilsson NE, Kotarsky K, Owman C, Olde B. Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 2003; 303: 1047–52.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 1047-1052
    • Nilsson, N.E.1    Kotarsky, K.2    Owman, C.3    Olde, B.4
  • 9
    • 44949099525 scopus 로고    scopus 로고
    • Impact of resistant starch on body fat patterning and central appetite regulation
    • So PW, Yu WS, Kuo YT, et al. Impact of resistant starch on body fat patterning and central appetite regulation. PLoS ONE 2007; 2: e1309.
    • (2007) PLoS ONE , vol.2
    • So, P.W.1    Yu, W.S.2    Kuo, Y.T.3
  • 10
    • 66849129539 scopus 로고    scopus 로고
    • Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults
    • Parnell JA, Reimer RA. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 2009; 89: 1751–9.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1751-1759
    • Parnell, J.A.1    Reimer, R.A.2
  • 11
    • 33745126131 scopus 로고    scopus 로고
    • Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor
    • Cani PD, Knauf C, Iglesias MA, Drucker DJ, Delzenne NM, Burcelin R. Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 2006; 55: 1484–90.
    • (2006) Diabetes , vol.55 , pp. 1484-1490
    • Cani, P.D.1    Knauf, C.2    Iglesias, M.A.3    Drucker, D.J.4    Delzenne, N.M.5    Burcelin, R.6
  • 12
    • 27244434038 scopus 로고    scopus 로고
    • Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism
    • Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr 2005; 82: 559–67.
    • (2005) Am J Clin Nutr , vol.82 , pp. 559-567
    • Robertson, M.D.1    Bickerton, A.S.2    Dennis, A.L.3    Vidal, H.4    Frayn, K.N.5
  • 13
    • 6944239073 scopus 로고    scopus 로고
    • Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
    • Cani PD, Dewever C, Delzenne NM. Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 2004; 92: 521–6.
    • (2004) Br J Nutr , vol.92 , pp. 521-526
    • Cani, P.D.1    Dewever, C.2    Delzenne, N.M.3
  • 14
    • 84901605077 scopus 로고    scopus 로고
    • The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity
    • Daud NM, Ismail NA, Thomas EL, et al. The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. Obesity (Silver Spring) 2014; 22: 1430–8.
    • (2014) Obesity (Silver Spring) , vol.22 , pp. 1430-1438
    • Daud, N.M.1    Ismail, N.A.2    Thomas, E.L.3
  • 15
    • 0032445520 scopus 로고    scopus 로고
    • Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat
    • Cherbut C, Ferrier L, Roze C, et al. Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. Am J Physiol 1998; 275(6 Pt 1): G1415–22.
    • (1998) Am J Physiol , vol.275 , Issue.6 , pp. G1415-G1422
    • Cherbut, C.1    Ferrier, L.2    Roze, C.3
  • 16
    • 84856509724 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
    • Tolhurst G, Heffron H, Lam YS, et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 2012; 61: 364–71.
    • (2012) Diabetes , vol.61 , pp. 364-371
    • Tolhurst, G.1    Heffron, H.2    Lam, Y.S.3
  • 17
    • 77449157340 scopus 로고    scopus 로고
    • Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha
    • Freeland KR, Wolever TM. Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha. Br J Nutr 2010; 103: 460–6.
    • (2010) Br J Nutr , vol.103 , pp. 460-466
    • Freeland, K.R.1    Wolever, T.M.2
  • 20
    • 0029818453 scopus 로고    scopus 로고
    • Influence of orally and rectally administered propionate on cholesterol and glucose metabolism in obese rats
    • Berggren AM, Nyman EM, Lundquist I, Bjorck IM. Influence of orally and rectally administered propionate on cholesterol and glucose metabolism in obese rats. Br J Nutr 1996; 76: 287–94.
    • (1996) Br J Nutr , vol.76 , pp. 287-294
    • Berggren, A.M.1    Nyman, E.M.2    Lundquist, I.3    Bjorck, I.M.4
  • 21
    • 0037329435 scopus 로고    scopus 로고
    • The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal
    • Frost GS, Brynes AE, Dhillo WS, Bloom SR, McBurney MI. The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal. Eur J Clin Nutr 2003; 57: 293–8.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 293-298
    • Frost, G.S.1    Brynes, A.E.2    Dhillo, W.S.3    Bloom, S.R.4    McBurney, M.I.5
  • 22
    • 84945202481 scopus 로고    scopus 로고
    • Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
    • Chambers E, Viardot A, Psichas A, et al. Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 2015; 64: 1744–54.
    • (2015) Gut , vol.64 , pp. 1744-1754
    • Chambers, E.1    Viardot, A.2    Psichas, A.3
  • 23
    • 0036791174 scopus 로고    scopus 로고
    • Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose-coated hydroxypropylmethylcellulose capsules
    • Tuleu C, Basit AW, Waddington WA, Ell PJ, Newton JM. Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose-coated hydroxypropylmethylcellulose capsules. Aliment Pharmacol Ther 2002; 16: 1771–9.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1771-1779
    • Tuleu, C.1    Basit, A.W.2    Waddington, W.A.3    Ell, P.J.4    Newton, J.M.5
  • 24
    • 84941343967 scopus 로고    scopus 로고
    • Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets
    • Maurer JM, Schellekens RC, van Rieke HM, et al. Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets. PLoS ONE 2015; 10: e0129076.
    • (2015) PLoS ONE , vol.10
    • Maurer, J.M.1    Schellekens, R.C.2    van Rieke, H.M.3
  • 26
    • 0023276469 scopus 로고
    • Short chain fatty acids in human large intestine, portal, hepatic and venous blood
    • Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 1987; 28: 1221–7.
    • (1987) Gut , vol.28 , pp. 1221-1227
    • Cummings, J.H.1    Pomare, E.W.2    Branch, W.J.3    Naylor, C.P.4    Macfarlane, G.T.5
  • 27
    • 0034959553 scopus 로고    scopus 로고
    • Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides
    • Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 2001; 81: 1031–64.
    • (2001) Physiol Rev , vol.81 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 28
    • 79957933330 scopus 로고    scopus 로고
    • An oral colon-targeting controlled release system based on resistant starch acetate: synthetization, characterization, and preparation of film-coating pellets
    • Pu H, Chen L, Li X, Xie F, Yu L, Li L. An oral colon-targeting controlled release system based on resistant starch acetate: synthetization, characterization, and preparation of film-coating pellets. J Agric Food Chem 2011; 59: 5738–45.
    • (2011) J Agric Food Chem , vol.59 , pp. 5738-5745
    • Pu, H.1    Chen, L.2    Li, X.3    Xie, F.4    Yu, L.5    Li, L.6
  • 29
    • 80055023996 scopus 로고    scopus 로고
    • Butyrate esterified to starch is released in the human gastrointestinal tract
    • Clarke JM, Topping DL, Christophersen CT, et al. Butyrate esterified to starch is released in the human gastrointestinal tract. Am J Clin Nutr 2011; 94: 1276–83.
    • (2011) Am J Clin Nutr , vol.94 , pp. 1276-1283
    • Clarke, J.M.1    Topping, D.L.2    Christophersen, C.T.3
  • 30
    • 0344417063 scopus 로고    scopus 로고
    • Nondigestibility characteristics of inulin and oligofructose in humans
    • Andersson HB, Ellegard LH, Bosaeus IG. Nondigestibility characteristics of inulin and oligofructose in humans. J Nutr 1999; 129(7 Suppl.): 1428s–30s.
    • (1999) J Nutr , vol.129 , Issue.7 , pp. 30s-1428s
    • Andersson, H.B.1    Ellegard, L.H.2    Bosaeus, I.G.3
  • 31
    • 0024211322 scopus 로고
    • Availability of cereal fructans and inulin in the rat intestinal tract
    • Nilsson U, Bjorck I. Availability of cereal fructans and inulin in the rat intestinal tract. J Nutr 1988; 118: 1482–6.
    • (1988) J Nutr , vol.118 , pp. 1482-1486
    • Nilsson, U.1    Bjorck, I.2
  • 32
    • 0016056087 scopus 로고
    • Activated carbon adsorption of petrochemicals
    • Giusti DM, Conway RA, CT L. Activated carbon adsorption of petrochemicals. J Water Pollut Control Fed 1974; 46: 249–53.
    • (1974) J Water Pollut Control Fed , vol.46 , pp. 249-253
    • Giusti, D.M.1    Conway, R.A.2
  • 33
    • 0030936474 scopus 로고    scopus 로고
    • In vitro fermentation of carbohydrate by breast fed and formula fed infants
    • Parrett AM, Edwards CA. In vitro fermentation of carbohydrate by breast fed and formula fed infants. Arch Dis Child 1997; 76: 249–53.
    • (1997) Arch Dis Child , vol.76 , pp. 249-253
    • Parrett, A.M.1    Edwards, C.A.2
  • 34
    • 0031595030 scopus 로고    scopus 로고
    • Importance of measuring CO2-production rate when using 13C-breath tests to measure fat digestion
    • Amarri S, Coward WA, Harding M, Weaver LT. Importance of measuring CO2-production rate when using 13C-breath tests to measure fat digestion. Br J Nutr 1998; 79: 541–5.
    • (1998) Br J Nutr , vol.79 , pp. 541-545
    • Amarri, S.1    Coward, W.A.2    Harding, M.3    Weaver, L.T.4
  • 35
    • 0026458519 scopus 로고
    • Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber)
    • Cummings JH, Bingham SA, Heaton KW, Eastwood MA. Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber). Gastroenterology 1992; 103: 1783–9.
    • (1992) Gastroenterology , vol.103 , pp. 1783-1789
    • Cummings, J.H.1    Bingham, S.A.2    Heaton, K.W.3    Eastwood, M.A.4
  • 36
    • 0026468155 scopus 로고
    • Classification and measurement of nutritionally important starch fractions
    • Englyst HN, Kingman SM, Cummings JH. Classification and measurement of nutritionally important starch fractions. Eur J Clin Nutr 1992; 46(Suppl. 2): S33–50.
    • (1992) Eur J Clin Nutr , vol.46 , pp. S33-50
    • Englyst, H.N.1    Kingman, S.M.2    Cummings, J.H.3
  • 37
    • 0021687406 scopus 로고
    • Short-chain fatty acid fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes
    • Anderson JW, Bridges SR. Short-chain fatty acid fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes. Proc Soc Exp Biol Med 1984; 177: 372–6.
    • (1984) Proc Soc Exp Biol Med , vol.177 , pp. 372-376
    • Anderson, J.W.1    Bridges, S.R.2
  • 38
    • 0029117567 scopus 로고
    • Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture
    • Lin Y, Vonk RJ, Slooff MJ, Kuipers F, Smit MJ. Differences in propionate-induced inhibition of cholesterol and triacylglycerol synthesis between human and rat hepatocytes in primary culture. Br J Nutr 1995; 74: 197–207.
    • (1995) Br J Nutr , vol.74 , pp. 197-207
    • Lin, Y.1    Vonk, R.J.2    Slooff, M.J.3    Kuipers, F.4    Smit, M.J.5
  • 40
    • 0029038118 scopus 로고
    • Recovery of inulin from Jerusalem artichoke (Helianthus tuberosus L.) in the small intestine of man
    • Bach Knudsen KE, Hessov I. Recovery of inulin from Jerusalem artichoke (Helianthus tuberosus L.) in the small intestine of man. Br J Nutr 1995; 74: 101–13.
    • (1995) Br J Nutr , vol.74 , pp. 101-113
    • Bach Knudsen, K.E.1    Hessov, I.2
  • 41
    • 0029840195 scopus 로고    scopus 로고
    • Digestion, excretion, and energy value of fructooligosaccharides in healthy humans
    • Molis C, Flourie B, Ouarne F, et al. Digestion, excretion, and energy value of fructooligosaccharides in healthy humans. Am J Clin Nutr 1996; 64: 324–8.
    • (1996) Am J Clin Nutr , vol.64 , pp. 324-328
    • Molis, C.1    Flourie, B.2    Ouarne, F.3
  • 42
    • 84941183248 scopus 로고    scopus 로고
    • The Role of Short Chain Fatty Acids in Appetite Regulation and Energy Homeostasis
    • Byrne C, Chambers E, Morrison DJ, Frost G. The Role of Short Chain Fatty Acids in Appetite Regulation and Energy Homeostasis. Int J Obes 2015; 39: 1331–38.
    • (2015) Int J Obes , vol.39 , pp. 1331-1338
    • Byrne, C.1    Chambers, E.2    Morrison, D.J.3    Frost, G.4
  • 43
    • 84937542675 scopus 로고    scopus 로고
    • Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?
    • Chambers ES, Morrison DJ, Frost G. Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms? Proc Nutr Soc 2015; 74: 328–36.
    • (2015) Proc Nutr Soc , vol.74 , pp. 328-336
    • Chambers, E.S.1    Morrison, D.J.2    Frost, G.3
  • 44
    • 84961200851 scopus 로고    scopus 로고
    • Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
    • Morrison DJ, Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes 2016; 7: 189–200.
    • (2016) Gut Microbes , vol.7 , pp. 189-200
    • Morrison, D.J.1    Preston, T.2
  • 45
    • 84941879755 scopus 로고    scopus 로고
    • Short-chain fatty acids in control of body weight and insulin sensitivity
    • Canfora EE, Jocken JW, Blaak EE. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol 2015; 11: 577–91.
    • (2015) Nat Rev Endocrinol , vol.11 , pp. 577-591
    • Canfora, E.E.1    Jocken, J.W.2    Blaak, E.E.3
  • 46
    • 33748423680 scopus 로고    scopus 로고
    • Effects of GI and content of indigestible carbohydrates of cereal-based evening meals on glucose tolerance at a subsequent standardised breakfast
    • Nilsson A, Granfeldt Y, Ostman E, Preston T, Bjorck I. Effects of GI and content of indigestible carbohydrates of cereal-based evening meals on glucose tolerance at a subsequent standardised breakfast. Eur J Clin Nutr 2006; 60: 1092–9.
    • (2006) Eur J Clin Nutr , vol.60 , pp. 1092-1099
    • Nilsson, A.1    Granfeldt, Y.2    Ostman, E.3    Preston, T.4    Bjorck, I.5
  • 47
    • 44949130778 scopus 로고    scopus 로고
    • Effects of GI vs content of cereal fibre of the evening meal on glucose tolerance at a subsequent standardized breakfast
    • Nilsson A, Ostman E, Preston T, Bjorck I. Effects of GI vs content of cereal fibre of the evening meal on glucose tolerance at a subsequent standardized breakfast. Eur J Clin Nutr 2008; 62: 712–20.
    • (2008) Eur J Clin Nutr , vol.62 , pp. 712-720
    • Nilsson, A.1    Ostman, E.2    Preston, T.3    Bjorck, I.4
  • 48
    • 41549105513 scopus 로고    scopus 로고
    • Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast
    • Nilsson AC, Ostman EM, Holst JJ, Bjorck IM. Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast. J Nutr 2008; 138: 732–9.
    • (2008) J Nutr , vol.138 , pp. 732-739
    • Nilsson, A.C.1    Ostman, E.M.2    Holst, J.J.3    Bjorck, I.M.4
  • 49
    • 0028566412 scopus 로고
    • Gastric emptying of liquid meals measured noninvasively in humans with [13C]acetate breath test
    • Mossi S, Meyer-Wyss B, Beglinger C, et al. Gastric emptying of liquid meals measured noninvasively in humans with [13C]acetate breath test. Dig Dis Sci 1994; 39(12 Suppl.): 107s–9s.
    • (1994) Dig Dis Sci , vol.39 , Issue.12 , pp. 9s-107s
    • Mossi, S.1    Meyer-Wyss, B.2    Beglinger, C.3
  • 50
    • 84888037176 scopus 로고    scopus 로고
    • Effect of short-chain fatty acids and acidification on the phasic and tonic motor activity of the human colon
    • Jouet P, Moussata D, Duboc H, et al. Effect of short-chain fatty acids and acidification on the phasic and tonic motor activity of the human colon. Neurogastroenterol Motil 2013; 25: 943–9.
    • (2013) Neurogastroenterol Motil , vol.25 , pp. 943-949
    • Jouet, P.1    Moussata, D.2    Duboc, H.3
  • 51
    • 79954417472 scopus 로고    scopus 로고
    • Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery
    • Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. AAPS PharmSciTech 2011; 12: 62–76.
    • (2011) AAPS PharmSciTech , vol.12 , pp. 62-76
    • Das, S.1    Chaudhury, A.2


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