메뉴 건너뛰기




Volumn 2, Issue 3, 2015, Pages 257-267

Non-eosinophilic Asthma Endotypes

Author keywords

Asthma; Endotypes; Induced sputum; Innate immunity; Neutrophilic inflammation; Non eosinophilic; Th17

Indexed keywords


EID: 84990970084     PISSN: None     EISSN: 21963053     Source Type: Journal    
DOI: 10.1007/s40521-015-0052-2     Document Type: Review
Times cited : (12)

References (69)
  • 1
    • 33645101537 scopus 로고    scopus 로고
    • Inflammatory subtypes in asthma: assessment and identification using induced sputum
    • PID: 16423202, Pivotal study describing the major inflammatory phenotypes of asthma using induced sputum
    • Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology. 2006;11:54–61. Pivotal study describing the major inflammatory phenotypes of asthma using induced sputum.
    • (2006) Respirology , vol.11 , pp. 54-61
    • Simpson, J.L.1    Scott, R.2    Boyle, M.J.3    Gibson, P.G.4
  • 2
    • 76149146032 scopus 로고    scopus 로고
    • National heart, lung, and blood institute’s severe asthma research program. Identification of asthma phenotypes using cluster analysis in the severe asthma research program
    • PID: 19892860
    • Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. National heart, lung, and blood institute’s severe asthma research program. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med. 2010;181:315–23.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3    Teague, W.G.4    Li, H.5    Li, X.6
  • 3
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • PID: 19483109, COI: 1:CAS:528:DC%2BD1MXhtFOju7vI
    • Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009;180(5):388–95.
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.5 , pp. 388-395
    • Woodruff, P.G.1    Modrek, B.2    Choy, D.F.3    Jia, G.4    Abbas, A.R.5    Ellwanger, A.6
  • 4
    • 78650864775 scopus 로고    scopus 로고
    • Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    • PID: 21211650, COI: 1:CAS:528:DC%2BC3MXjs1ehtg%3D%3D
    • Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol. 2011;127(1):153–60.
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.1 , pp. 153-160
    • Baines, K.J.1    Simpson, J.L.2    Wood, L.G.3    Scott, R.J.4    Gibson, P.G.5
  • 6
    • 0028791194 scopus 로고
    • Exacerbations of asthma without sputum eosinophilia
    • PID: 7491553, COI: 1:STN:280:DyaK28%2Fps1Klsw%3D%3D
    • Turner MO, Hussack P, Sears MR, Dolovich J, Hargreave FE. Exacerbations of asthma without sputum eosinophilia. Thorax. 1995;50:1057–61.
    • (1995) Thorax , vol.50 , pp. 1057-1061
    • Turner, M.O.1    Hussack, P.2    Sears, M.R.3    Dolovich, J.4    Hargreave, F.E.5
  • 7
    • 84864022085 scopus 로고    scopus 로고
    • Sputum inflammatory phenotypes are not stable in children with asthma
    • PID: 22379070
    • Fleming L, Tsartsali L, Wilson N, Regamey N, Bush A. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax. 2012;67(8):675–81.
    • (2012) Thorax , vol.67 , Issue.8 , pp. 675-681
    • Fleming, L.1    Tsartsali, L.2    Wilson, N.3    Regamey, N.4    Bush, A.5
  • 8
    • 79959715323 scopus 로고    scopus 로고
    • Different inflammatory phenotypes in adults and children with acute asthma
    • PID: 21233265, COI: 1:STN:280:DC%2BC3MfgtlWlug%3D%3D
    • Wang F, He XY, Baines KJ, Gunawardhana LP, Simpson JL, Li F, et al. Different inflammatory phenotypes in adults and children with acute asthma. Eur Respir J. 2011;38(3):567–74.
    • (2011) Eur Respir J , vol.38 , Issue.3 , pp. 567-574
    • Wang, F.1    He, X.Y.2    Baines, K.J.3    Gunawardhana, L.P.4    Simpson, J.L.5    Li, F.6
  • 9
    • 84870997202 scopus 로고    scopus 로고
    • Clinical characteristics of eosinophilic and noneosinophilic asthma in children
    • PID: 23113613
    • Lee YJ, Kim KW, Choi BS, Sohn MH, Kim KE. Clinical characteristics of eosinophilic and noneosinophilic asthma in children. Acta Paediatr. 2013;102(1):53–7.
    • (2013) Acta Paediatr , vol.102 , Issue.1 , pp. 53-57
    • Lee, Y.J.1    Kim, K.W.2    Choi, B.S.3    Sohn, M.H.4    Kim, K.E.5
  • 11
    • 84879521824 scopus 로고    scopus 로고
    • Airway and systemic inflammation in obese children with asthma
    • PID: 23349447, COI: 1:CAS:528:DC%2BC3sXhslWnsbzE
    • Jensen ME, Gibson PG, Collins CE, Wood LG. Airway and systemic inflammation in obese children with asthma. Eur Respir J. 2013;42(4):1012–9.
    • (2013) Eur Respir J , vol.42 , Issue.4 , pp. 1012-1019
    • Jensen, M.E.1    Gibson, P.G.2    Collins, C.E.3    Wood, L.G.4
  • 12
    • 84899671419 scopus 로고    scopus 로고
    • Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD
    • PID: 24641293, Comprehensive evaluation of risk factors and clinical features of neutrophilic asthma
    • Simpson JL, Baines KJ, Ryan N, Gibson PG. Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD. Asian Pac J Allergy Immunol. 2014;32(1):66–74. Comprehensive evaluation of risk factors and clinical features of neutrophilic asthma.
    • (2014) Asian Pac J Allergy Immunol , vol.32 , Issue.1 , pp. 66-74
    • Simpson, J.L.1    Baines, K.J.2    Ryan, N.3    Gibson, P.G.4
  • 13
    • 80053087268 scopus 로고    scopus 로고
    • Noneosinophilic asthma in children: relation with airway remodelling
    • PID: 21310879, COI: 1:STN:280:DC%2BC3MfgtlaisA%3D%3D
    • Baraldo S, Turato G, Bazzan E, Ballarin A, Damin M, Balestro E, et al. Noneosinophilic asthma in children: relation with airway remodelling. Eur Respir J. 2011;38(3):575–83.
    • (2011) Eur Respir J , vol.38 , Issue.3 , pp. 575-583
    • Baraldo, S.1    Turato, G.2    Bazzan, E.3    Ballarin, A.4    Damin, M.5    Balestro, E.6
  • 14
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • PID: 12324674, COI: 1:STN:280:DC%2BD38vovV2qtw%3D%3D
    • Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax. 2002;57:875–9.
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Woltmann, G.3
  • 15
    • 84862024217 scopus 로고    scopus 로고
    • Untangling asthma phenotypes and endotypes
    • PID: 22594878, COI: 1:CAS:528:DC%2BC38Xht1Gmu7vF
    • Agache I, Akdis C, Jutel M, Virchow JC. Untangling asthma phenotypes and endotypes. Allergy. 2012;67(7):835–46.
    • (2012) Allergy , vol.67 , Issue.7 , pp. 835-846
    • Agache, I.1    Akdis, C.2    Jutel, M.3    Virchow, J.C.4
  • 16
    • 84876894419 scopus 로고    scopus 로고
    • From phenotypes to endotypes to asthma treatment
    • PID: 23587683, COI: 1:CAS:528:DC%2BC3sXmsVaitbY%3D
    • Agache IO. From phenotypes to endotypes to asthma treatment. Curr Opin Allergy Clin Immunol. 2013;13(3):249–56.
    • (2013) Curr Opin Allergy Clin Immunol , vol.13 , Issue.3 , pp. 249-256
    • Agache, I.O.1
  • 17
    • 84937413585 scopus 로고    scopus 로고
    • Endotype driven treatment of asthma
    • Description of the endotype-driven therapeutic strategies Th2 and non-Th2 asthma
    • Agache IO. Endotype driven treatment of asthma. Curr Treat Options Allergy. 2014;1:198–212. Description of the endotype-driven therapeutic strategies in Th2 and non-Th2 asthma.
    • (2014) Curr Treat Options Allergy , vol.1 , pp. 198-212
    • Agache, I.O.1
  • 18
    • 85097786872 scopus 로고    scopus 로고
    • Current treatment options in allergy. The complex type 2 endotype in allergy and asthma: From laboratory to bedside
    • in press. The first paper to describe the concept of a complex endotype and to pinpoint the major subendotypes of Th2 asthma
    • Agache I, Sugita K, Morita H, Akdis M, Akdis CA. Current treatment options in allergy. The complex type 2 endotype in allergy and asthma: from laboratory to bedside. Curr Allergy Asthma Rep. 2015, in press. The first paper to describe the concept of a complex endotype and to pinpoint the major subendotypes of Th2 asthma.
    • (2015) Curr Allergy Asthma Rep
    • Agache, I.1    Sugita, K.2    Morita, H.3    Akdis, M.4    Akdis, C.A.5
  • 19
  • 20
    • 79955437252 scopus 로고    scopus 로고
    • Insights into asthmatic airway remodelling through murine models
    • PID: 21435099
    • Al Heialy S, McGovern TK, Martin JG. Insights into asthmatic airway remodelling through murine models. Respirology. 2011;16:589–97.
    • (2011) Respirology , vol.16 , pp. 589-597
    • Al Heialy, S.1    McGovern, T.K.2    Martin, J.G.3
  • 21
    • 56149097181 scopus 로고    scopus 로고
    • TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
    • PID: 18768865, COI: 1:CAS:528:DC%2BD1cXhtVKntb%2FK
    • McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol. 2008;181:4089–97.
    • (2008) J Immunol , vol.181 , pp. 4089-4097
    • McKinley, L.1    Alcorn, J.F.2    Peterson, A.3    Dupont, R.B.4    Kapadia, S.5    Logar, A.6
  • 22
    • 65249179610 scopus 로고    scopus 로고
    • Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways
    • PID: 19342691, COI: 1:CAS:528:DC%2BD1MXjvFOitr4%3D
    • Yang M, Kumar RK, Foster PS. Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways. J Immunol. 2009;182:5107–15.
    • (2009) J Immunol , vol.182 , pp. 5107-5115
    • Yang, M.1    Kumar, R.K.2    Foster, P.S.3
  • 23
    • 84872399801 scopus 로고    scopus 로고
    • PI3K and MAPKs regulate neutrophil migration toward the airways in heaves
    • PID: 23194017, COI: 1:STN:280:DC%2BC3s7nsVCnsg%3D%3D
    • Bullone M, Moran K, Lavoie-Lamoureux A, Lavoie JP. PI3K and MAPKs regulate neutrophil migration toward the airways in heaves. J Vet Intern Med. 2013;27(1):164–70.
    • (2013) J Vet Intern Med , vol.27 , Issue.1 , pp. 164-170
    • Bullone, M.1    Moran, K.2    Lavoie-Lamoureux, A.3    Lavoie, J.P.4
  • 24
    • 84888054553 scopus 로고    scopus 로고
    • Real time RT-PCR analysis of inflammatory mediator expression in recurrent airway obstruction-affected horses
    • PID: 24176614, COI: 1:CAS:528:DC%2BC3sXhslSlsbjN
    • Padoan E, Ferraresso S, Pegolo S, Castagnaro M, Barnini C, Bargelloni L. Real time RT-PCR analysis of inflammatory mediator expression in recurrent airway obstruction-affected horses. Vet Immunol Immunopathol. 2013;156(3–4):190–9.
    • (2013) Vet Immunol Immunopathol , vol.156 , Issue.3-4 , pp. 190-199
    • Padoan, E.1    Ferraresso, S.2    Pegolo, S.3    Castagnaro, M.4    Barnini, C.5    Bargelloni, L.6
  • 25
    • 74549186515 scopus 로고    scopus 로고
    • Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
    • PID: 19922242, COI: 1:CAS:528:DC%2BC3cXlvFahsw%3D%3D
    • Wood LG, Simpson JL, Hansbro P, Gibson PG. Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia. Free Radic Res. 2010;44:146–54.
    • (2010) Free Radic Res , vol.44 , pp. 146-154
    • Wood, L.G.1    Simpson, J.L.2    Hansbro, P.3    Gibson, P.G.4
  • 26
    • 84875544510 scopus 로고    scopus 로고
    • Extracellular vesicles, especially derived from gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses
    • PID: 23517040, COI: 1:CAS:528:DC%2BC3sXksFOhsr8%3D
    • Kim YS, Choi EJ, Lee WH, Choi SJ, Roh TY, Park J, et al. Extracellular vesicles, especially derived from gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses. Clin Exp Allergy. 2013;43(4):443–54.
    • (2013) Clin Exp Allergy , vol.43 , Issue.4 , pp. 443-454
    • Kim, Y.S.1    Choi, E.J.2    Lee, W.H.3    Choi, S.J.4    Roh, T.Y.5    Park, J.6
  • 29
    • 84897434505 scopus 로고    scopus 로고
    • Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    • PID: 24582314, COI: 1:CAS:528:DC%2BC2cXjs1Onurg%3D, Very elegant demonstration of the discriminatory capacity between eosinophilic and non-eosinophilic asthma of the six gene signature
    • Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al. Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes. J Allergy Clin Immunol. 2014;133(4):997–1007. Very elegant demonstration of the discriminatory capacity between eosinophilic and non-eosinophilic asthma of the six gene signature.
    • (2014) J Allergy Clin Immunol , vol.133 , Issue.4 , pp. 997-1007
    • Baines, K.J.1    Simpson, J.L.2    Wood, L.G.3    Scott, R.J.4    Fibbens, N.L.5    Powell, H.6
  • 30
    • 84945188133 scopus 로고    scopus 로고
    • Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation
    • Dejager L, Dendoncker K, Eggermont M, Souffriau J, Van Hauwermeiren F, Willart M, et al. Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation. Mucosal Immunol. 2015. doi:10.1038/mi.2015.12. DOI: 10.1038/mi.2015.12
    • (2015) Mucosal Immunol
    • Dejager, L.1    Dendoncker, K.2    Eggermont, M.3    Souffriau, J.4    Van Hauwermeiren, F.5    Willart, M.6
  • 31
    • 84917735175 scopus 로고    scopus 로고
    • Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells
    • PID: 25501580
    • Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, et al. Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells. PLoS One. 2014;9(12), e114791.
    • (2014) PLoS One , vol.9 , Issue.12
    • Mikami, Y.1    Matsuzaki, H.2    Horie, M.3    Noguchi, S.4    Jo, T.5    Narumoto, O.6
  • 32
    • 77951155473 scopus 로고    scopus 로고
    • Differential gene expression and cytokine production from neutrophils in asthma phenotypes
    • PID: 19797135, COI: 1:CAS:528:DC%2BC3cXksVGnsb8%3D
    • Baines KJ, Simpson JL, Bowden NA, Scott RJ, Gibson PG. Differential gene expression and cytokine production from neutrophils in asthma phenotypes. Eur Respir J. 2010;35(3):522–31.
    • (2010) Eur Respir J , vol.35 , Issue.3 , pp. 522-531
    • Baines, K.J.1    Simpson, J.L.2    Bowden, N.A.3    Scott, R.J.4    Gibson, P.G.5
  • 33
    • 84927711820 scopus 로고    scopus 로고
    • Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1ß
    • PID: 25616863, COI: 1:CAS:528:DC%2BC2MXjtlKjsro%3D
    • Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al. Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1ß. Respir Res. 2015;16(1):5.
    • (2015) Respir Res , vol.16 , Issue.1 , pp. 5
    • Gao, P.1    Gibson, P.G.2    Baines, K.J.3    Yang, I.A.4    Upham, J.W.5    Reynolds, P.N.6
  • 34
    • 84911102298 scopus 로고    scopus 로고
    • Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion
    • PID: 25173346, COI: 1:CAS:528:DC%2BC2cXhsVCrtLnM, Description of the interaction between a newly described phenotype of neutrophils (N2) and macrophages the context of a type 2 immune response the lungs of nematode infected animals
    • Chen F, Wu W, Millman A, Craft JF, Chen E, Patel N, et al. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat Immunol. 2014;15(10):938–46. Description of the interaction between a newly described phenotype of neutrophils (N2) and macrophages in the context of a type 2 immune response in the lungs of nematode infected animals.
    • (2014) Nat Immunol , vol.15 , Issue.10 , pp. 938-946
    • Chen, F.1    Wu, W.2    Millman, A.3    Craft, J.F.4    Chen, E.5    Patel, N.6
  • 36
    • 24144482766 scopus 로고    scopus 로고
    • Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
    • PID: 15901607
    • Simpson JL, Scott RJ, Boyle MJ, Gibson PG. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Resp Crit Care Med. 2005;172:559–65.
    • (2005) Am J Resp Crit Care Med , vol.172 , pp. 559-565
    • Simpson, J.L.1    Scott, R.J.2    Boyle, M.J.3    Gibson, P.G.4
  • 37
    • 65349121194 scopus 로고    scopus 로고
    • IL-17-producing T cells in lung immunity and inflammation
    • PID: 19410688, COI: 1:CAS:528:DC%2BD1MXltlyhsrw%3D
    • Nembrini C, Marsland BJ, Kopf M. IL-17-producing T cells in lung immunity and inflammation. J Allergy Clin Immunol. 2009;123:986–94.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 986-994
    • Nembrini, C.1    Marsland, B.J.2    Kopf, M.3
  • 39
    • 84891889644 scopus 로고    scopus 로고
    • Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
    • PID: 24336249, COI: 1:CAS:528:DC%2BC3sXhvFentb%2FE
    • Kim HY, Lee HJ, Chang Y-J, Pichavant M, Shore SA, Fitzgerald KA, et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2014;20:54–61.
    • (2014) Nat Med , vol.20 , pp. 54-61
    • Kim, H.Y.1    Lee, H.J.2    Chang, Y.-J.3    Pichavant, M.4    Shore, S.A.5    Fitzgerald, K.A.6
  • 40
    • 84922410788 scopus 로고    scopus 로고
    • Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis
    • PID: 25599143, COI: 1:CAS:528:DC%2BC2MXitFCis7g%3D
    • Mease PJ. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. Curr Opin Rheumatol. 2015;27(2):127–33.
    • (2015) Curr Opin Rheumatol , vol.27 , Issue.2 , pp. 127-133
    • Mease, P.J.1
  • 41
    • 70349871248 scopus 로고    scopus 로고
    • Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness
    • PID: 19661246, COI: 1:CAS:528:DC%2BD1MXhtlGgtbjE
    • Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009;180:720–30.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 720-730
    • Wilson, R.H.1    Whitehead, G.S.2    Nakano, H.3    Free, M.E.4    Kolls, J.K.5    Cook, D.N.6
  • 42
    • 84874088635 scopus 로고    scopus 로고
    • Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance an contribute to airway remodeling
    • PID: 22892938, COI: 1:CAS:528:DC%2BC38XhtF2rt7bO
    • Zhao J, Lloyd CM, Noble A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance an contribute to airway remodeling. Mucosal Immunol. 2013;6:335–46.
    • (2013) Mucosal Immunol , vol.6 , pp. 335-346
    • Zhao, J.1    Lloyd, C.M.2    Noble, A.3
  • 43
    • 33751180809 scopus 로고    scopus 로고
    • IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
    • PID: 17083726
    • Bullens DM, Truyen E, Coteur L, Dilissen E, Hellings PW, Dupont LJ, et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res. 2006;7:135.
    • (2006) Respir Res , vol.7 , pp. 135
    • Bullens, D.M.1    Truyen, E.2    Coteur, L.3    Dilissen, E.4    Hellings, P.W.5    Dupont, L.J.6
  • 44
    • 77953913216 scopus 로고    scopus 로고
    • Increased serum IL-17 is an independent risk factor for severe asthma
    • PID: 20338742
    • Agache I, Ciobanu C, Agache C, Anghel M. Increased serum IL-17 is an independent risk factor for severe asthma. Respir Med. 2010;104:1131–7.
    • (2010) Respir Med , vol.104 , pp. 1131-1137
    • Agache, I.1    Ciobanu, C.2    Agache, C.3    Anghel, M.4
  • 45
    • 0034833339 scopus 로고    scopus 로고
    • IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
    • PID: 11544464, COI: 1:CAS:528:DC%2BD3MXnsFGntb8%3D
    • Molet S, Hamid Q, Davoine F, Nutku E, Taha R, Pagé N, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol. 2001;108:430–8.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 430-438
    • Molet, S.1    Hamid, Q.2    Davoine, F.3    Nutku, E.4    Taha, R.5    Pagé, N.6
  • 46
    • 0037636682 scopus 로고    scopus 로고
    • Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
    • PID: 12814161, COI: 1:STN:280:DC%2BD3s3os1Kitw%3D%3D
    • Barczyk A, Pierzchala W, Sozañska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med. 2003;97:726–33.
    • (2003) Respir Med , vol.97 , pp. 726-733
    • Barczyk, A.1    Pierzchala, W.2    Sozañska, E.3
  • 47
    • 84882771510 scopus 로고    scopus 로고
    • Increased IL-17A secreting CD41 T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity
    • PID: 23957337, COI: 1:CAS:528:DC%2BC3sXhtlaitb7P
    • Chien JW, Lin CY, Yang KD, Lin CH, Kao JK, Tsai YG. Increased IL-17A secreting CD41 T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity. Clin Exp Allergy. 2013;43:1018–26.
    • (2013) Clin Exp Allergy , vol.43 , pp. 1018-1026
    • Chien, J.W.1    Lin, C.Y.2    Yang, K.D.3    Lin, C.H.4    Kao, J.K.5    Tsai, Y.G.6
  • 48
    • 84920369993 scopus 로고    scopus 로고
    • Identification of novel immune phenotypes for allergic and non-allergic childhood asthma
    • PID: 25226851, COI: 1:CAS:528:DC%2BC2MXhtVClt7k%3D
    • Raedler D, Ballenberger N, Klucker E, Böck A, Otto R, Prazeres da Costa O, et al. Identification of novel immune phenotypes for allergic and non-allergic childhood asthma. J Allergy Clin Immunol. 2015;135(1):81–91.
    • (2015) J Allergy Clin Immunol , vol.135 , Issue.1 , pp. 81-91
    • Raedler, D.1    Ballenberger, N.2    Klucker, E.3    Böck, A.4    Otto, R.5    Prazeres da Costa, O.6
  • 49
    • 84901026697 scopus 로고    scopus 로고
    • Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma
    • PID: 24347461
    • Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, et al. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax. 2014;69:508–15.
    • (2014) Thorax , vol.69 , pp. 508-515
    • Gupta, A.1    Dimeloe, S.2    Richards, D.F.3    Chambers, E.S.4    Black, C.5    Urry, Z.6
  • 50
    • 73149118287 scopus 로고    scopus 로고
    • Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4
    • PID: 20109749, COI: 1:CAS:528:DC%2BC3cXosV2r
    • Cosmi L, Maggi L, Santarlasci V, Capone M, Cardilicchia E, Frosali F, et al. Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J Allergy Clin Immunol. 2010;125(1):222–30.
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.1 , pp. 222-230
    • Cosmi, L.1    Maggi, L.2    Santarlasci, V.3    Capone, M.4    Cardilicchia, E.5    Frosali, F.6
  • 51
    • 84913530341 scopus 로고    scopus 로고
    • Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
    • PID: 25042748, COI: 1:CAS:528:DC%2BC2cXhtF2ks7bL, First study proving the existence of dual-positive Th2/Th17 cells the airways and their association with asthma severity
    • Irvin C, Zafar I, Good J, Rollins D, Christianson C, Gorska MM, et al. Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J Allergy Clin Immunol. 2014;134:1175–86. First study proving the existence of dual-positive Th2/Th17 cells in the airways and their association with asthma severity.
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 1175-1186
    • Irvin, C.1    Zafar, I.2    Good, J.3    Rollins, D.4    Christianson, C.5    Gorska, M.M.6
  • 52
    • 84904440406 scopus 로고    scopus 로고
    • IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models
    • PID: 24480880, COI: 1:CAS:528:DC%2BC2cXjt1WmsrY%3D
    • Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga CS, et al. IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models. J Invest Dermatol. 2014;134(8):2122–30.
    • (2014) J Invest Dermatol , vol.134 , Issue.8 , pp. 2122-2130
    • Nakajima, S.1    Kitoh, A.2    Egawa, G.3    Natsuaki, Y.4    Nakamizo, S.5    Moniaga, C.S.6
  • 53
    • 84901289099 scopus 로고    scopus 로고
    • CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis
    • PID: 24729611, COI: 1:CAS:528:DC%2BC2cXntlGhu70%3D
    • Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM, Russo JM, et al. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. J Immunol. 2014;192:4655–65.
    • (2014) J Immunol , vol.192 , pp. 4655-4665
    • Ponichtera, H.E.1    Shainheit, M.G.2    Liu, B.C.3    Raychowdhury, R.4    Larkin, B.M.5    Russo, J.M.6
  • 54
    • 84911143445 scopus 로고    scopus 로고
    • Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage
    • PID: 25326751, COI: 1:CAS:528:DC%2BC2cXhslKrt7%2FP
    • Sutherland TE, Logan N, Rückerl D, Humbles AA, Allan SM, Papayannopoulos V, et al. Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage. Nat Immunol. 2014;15(12):1116–25.
    • (2014) Nat Immunol , vol.15 , Issue.12 , pp. 1116-1125
    • Sutherland, T.E.1    Logan, N.2    Rückerl, D.3    Humbles, A.A.4    Allan, S.M.5    Papayannopoulos, V.6
  • 55
    • 84896711467 scopus 로고    scopus 로고
    • IL-17A promotes the exacerbation of IL-33-induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice
    • PID: 24446518, COI: 1:CAS:528:DC%2BC2cXitFWnur4%3D
    • Mizutani N, Nabe T, Yoshino S. IL-17A promotes the exacerbation of IL-33-induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice. J Immunol. 2014;192(4):1372–84.
    • (2014) J Immunol , vol.192 , Issue.4 , pp. 1372-1384
    • Mizutani, N.1    Nabe, T.2    Yoshino, S.3
  • 57
    • 84994700720 scopus 로고    scopus 로고
    • Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids
    • Furukawa T, Sakagami T, Koya T, Hasegawa T, Kawakami H, Kimura Y, et al. Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids. J Asthma. 2014;11:1–6.
    • (2014) J Asthma , vol.11 , pp. 1-6
    • Furukawa, T.1    Sakagami, T.2    Koya, T.3    Hasegawa, T.4    Kawakami, H.5    Kimura, Y.6
  • 58
    • 84911481328 scopus 로고    scopus 로고
    • Non-eosinophilic airway hyper-reactivity in mice, induced by IFN-γ producing CD4(+) and CD8(+) lung T cells, is responsive to steroid treatment
    • PID: 25124713, COI: 1:CAS:528:DC%2BC2cXhslylt7rF
    • Stein J, Maxeiner JH, Montermann E, Höhn Y, Raker V, Taube C, et al. Non-eosinophilic airway hyper-reactivity in mice, induced by IFN-γ producing CD4(+) and CD8(+) lung T cells, is responsive to steroid treatment. Scand J Immunol. 2014;80(5):327–38.
    • (2014) Scand J Immunol , vol.80 , Issue.5 , pp. 327-338
    • Stein, J.1    Maxeiner, J.H.2    Montermann, E.3    Höhn, Y.4    Raker, V.5    Taube, C.6
  • 59
    • 84938737977 scopus 로고    scopus 로고
    • MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity
    • Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, et al. MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. J Allergy Clin Immunol. 2015. doi:10.1016/j.jaci.2014.11.044. DOI: 10.1016/j.jaci.2014.11.044
    • (2015) J Allergy Clin Immunol
    • Li, J.J.1    Tay, H.L.2    Maltby, S.3    Xiang, Y.4    Eyers, F.5    Hatchwell, L.6
  • 61
    • 84862821428 scopus 로고    scopus 로고
    • Age-related differences in clinical outcomes for acute asthma in the United States, 2006–2008
    • PID: 22385630
    • Tsai CL, Lee WY, Hanania NA, Camargo Jr CA. Age-related differences in clinical outcomes for acute asthma in the United States, 2006–2008. J Allergy Clin Immunol. 2012;129:1252–8.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 1252-1258
    • Tsai, C.L.1    Lee, W.Y.2    Hanania, N.A.3    Camargo, C.A.4
  • 62
    • 84879327324 scopus 로고    scopus 로고
    • Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics
    • PID: 23490307, First study showing a relation between increasing age and increasing sputum neutrophils, both healthy and asthmatics
    • Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL. Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics. Respirology. 2013;18(5):857–65. First study showing a relation between increasing age and increasing sputum neutrophils, both in healthy and in asthmatics.
    • (2013) Respirology , vol.18 , Issue.5 , pp. 857-865
    • Brooks, C.R.1    Gibson, P.G.2    Douwes, J.3    Van Dalen, C.J.4    Simpson, J.L.5
  • 63
    • 84875219719 scopus 로고    scopus 로고
    • Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial
    • PID: 23291349
    • Brusselle GG, Vanderstichele C, Jordens P, Deman R, Slabbynck H, Ringoet V, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax. 2013;68(4):322–9.
    • (2013) Thorax , vol.68 , Issue.4 , pp. 322-329
    • Brusselle, G.G.1    Vanderstichele, C.2    Jordens, P.3    Deman, R.4    Slabbynck, H.5    Ringoet, V.6
  • 64
    • 84926407544 scopus 로고    scopus 로고
    • Macrolide antibiotics for treatment of asthma in adults: A meta-analysis of 18 randomized controlled clinical studies
    • PID: 25252142, COI: 1:CAS:528:DC%2BC2cXhs1Gms77M
    • Tong X, Guo T, Liu S, Peng S, Yan Z, Yang X, et al. Macrolide antibiotics for treatment of asthma in adults: A meta-analysis of 18 randomized controlled clinical studies. Pulm Pharmacol Ther. 2015;31:99–108.
    • (2015) Pulm Pharmacol Ther , vol.31 , pp. 99-108
    • Tong, X.1    Guo, T.2    Liu, S.3    Peng, S.4    Yan, Z.5    Yang, X.6
  • 65
    • 84902147234 scopus 로고    scopus 로고
    • The impact of azithromycin therapy on the airway microbiota in asthma
    • PID: 24287164, This is the first study to examine longitudinal changes airway microbiota following antibiotic treatment asthma
    • Slater M, Rivett DW, Williams L, Martin M, Harrison T, Sayers I, et al. The impact of azithromycin therapy on the airway microbiota in asthma. Thorax. 2014;69(7):673–4. This is the first study to examine longitudinal changes in airway microbiota following antibiotic treatment in asthma.
    • (2014) Thorax , vol.69 , Issue.7 , pp. 673-674
    • Slater, M.1    Rivett, D.W.2    Williams, L.3    Martin, M.4    Harrison, T.5    Sayers, I.6
  • 66
    • 84929457101 scopus 로고    scopus 로고
    • Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma
    • Essilfie AT, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al. Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma. Thorax. 2015. doi:10.1136/thoraxjnl-2014-206067. DOI: 10.1136/thoraxjnl-2014-206067
    • (2015) Thorax
    • Essilfie, A.T.1    Horvat, J.C.2    Kim, R.Y.3    Mayall, J.R.4    Pinkerton, J.W.5    Beckett, E.L.6
  • 67
    • 84890026323 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
    • PID: 24200404, COI: 1:CAS:528:DC%2BC2cXhtVKqs7c%3D, First large clinical trial to evaluate the efficacy and safety of anti-IL-17 targeted intervention asthma and delineating a possible responder subgroup
    • Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med. 2013;188:1294–302. First large clinical trial to evaluate the efficacy and safety of anti-IL-17 targeted intervention in asthma and delineating a possible responder subgroup.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 1294-1302
    • Busse, W.W.1    Holgate, S.2    Kerwin, E.3    Chon, Y.4    Feng, J.5    Lin, J.6
  • 68
    • 84862519263 scopus 로고    scopus 로고
    • Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
    • PID: 22702508, COI: 1:CAS:528:DC%2BC38Xht1Kkt7nJ
    • Nair P, Gaga M, Zervas E, Alagha K, Hargreave FE, O’Byrne PM, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2012;42(7):1097–103.
    • (2012) Clin Exp Allergy , vol.42 , Issue.7 , pp. 1097-1103
    • Nair, P.1    Gaga, M.2    Zervas, E.3    Alagha, K.4    Hargreave, F.E.5    O’Byrne, P.M.6
  • 69
    • 84925059188 scopus 로고    scopus 로고
    • Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists
    • PID: 25708618, COI: 1:CAS:528:DC%2BC2MXitl2ktrk%3D
    • Austin RP, Bennion C, Bonnert RV, Cheema L, Cook AR, Cox RJ, et al. Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists. Bioorg Med Chem Lett. 2015;25(7):1616–20.
    • (2015) Bioorg Med Chem Lett , vol.25 , Issue.7 , pp. 1616-1620
    • Austin, R.P.1    Bennion, C.2    Bonnert, R.V.3    Cheema, L.4    Cook, A.R.5    Cox, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.