-
1
-
-
33645101537
-
Inflammatory subtypes in asthma: assessment and identification using induced sputum
-
PID: 16423202, Pivotal study describing the major inflammatory phenotypes of asthma using induced sputum
-
Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology. 2006;11:54–61. Pivotal study describing the major inflammatory phenotypes of asthma using induced sputum.
-
(2006)
Respirology
, vol.11
, pp. 54-61
-
-
Simpson, J.L.1
Scott, R.2
Boyle, M.J.3
Gibson, P.G.4
-
2
-
-
76149146032
-
National heart, lung, and blood institute’s severe asthma research program. Identification of asthma phenotypes using cluster analysis in the severe asthma research program
-
PID: 19892860
-
Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. National heart, lung, and blood institute’s severe asthma research program. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med. 2010;181:315–23.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 315-323
-
-
Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
Teague, W.G.4
Li, H.5
Li, X.6
-
3
-
-
69249150516
-
T-helper type 2-driven inflammation defines major subphenotypes of asthma
-
PID: 19483109, COI: 1:CAS:528:DC%2BD1MXhtFOju7vI
-
Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009;180(5):388–95.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, Issue.5
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
Jia, G.4
Abbas, A.R.5
Ellwanger, A.6
-
4
-
-
78650864775
-
Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
-
PID: 21211650, COI: 1:CAS:528:DC%2BC3MXjs1ehtg%3D%3D
-
Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J Allergy Clin Immunol. 2011;127(1):153–60.
-
(2011)
J Allergy Clin Immunol
, vol.127
, Issue.1
, pp. 153-160
-
-
Baines, K.J.1
Simpson, J.L.2
Wood, L.G.3
Scott, R.J.4
Gibson, P.G.5
-
5
-
-
84858273561
-
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
-
PID: 22268133, COI: 1:CAS:528:DC%2BC38XmtVehtbk%3D
-
McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM, et al. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med. 2012;185:612–9.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 612-619
-
-
McGrath, K.W.1
Icitovic, N.2
Boushey, H.A.3
Lazarus, S.C.4
Sutherland, E.R.5
Chinchilli, V.M.6
-
6
-
-
0028791194
-
Exacerbations of asthma without sputum eosinophilia
-
PID: 7491553, COI: 1:STN:280:DyaK28%2Fps1Klsw%3D%3D
-
Turner MO, Hussack P, Sears MR, Dolovich J, Hargreave FE. Exacerbations of asthma without sputum eosinophilia. Thorax. 1995;50:1057–61.
-
(1995)
Thorax
, vol.50
, pp. 1057-1061
-
-
Turner, M.O.1
Hussack, P.2
Sears, M.R.3
Dolovich, J.4
Hargreave, F.E.5
-
7
-
-
84864022085
-
Sputum inflammatory phenotypes are not stable in children with asthma
-
PID: 22379070
-
Fleming L, Tsartsali L, Wilson N, Regamey N, Bush A. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax. 2012;67(8):675–81.
-
(2012)
Thorax
, vol.67
, Issue.8
, pp. 675-681
-
-
Fleming, L.1
Tsartsali, L.2
Wilson, N.3
Regamey, N.4
Bush, A.5
-
8
-
-
79959715323
-
Different inflammatory phenotypes in adults and children with acute asthma
-
PID: 21233265, COI: 1:STN:280:DC%2BC3MfgtlWlug%3D%3D
-
Wang F, He XY, Baines KJ, Gunawardhana LP, Simpson JL, Li F, et al. Different inflammatory phenotypes in adults and children with acute asthma. Eur Respir J. 2011;38(3):567–74.
-
(2011)
Eur Respir J
, vol.38
, Issue.3
, pp. 567-574
-
-
Wang, F.1
He, X.Y.2
Baines, K.J.3
Gunawardhana, L.P.4
Simpson, J.L.5
Li, F.6
-
9
-
-
84870997202
-
Clinical characteristics of eosinophilic and noneosinophilic asthma in children
-
PID: 23113613
-
Lee YJ, Kim KW, Choi BS, Sohn MH, Kim KE. Clinical characteristics of eosinophilic and noneosinophilic asthma in children. Acta Paediatr. 2013;102(1):53–7.
-
(2013)
Acta Paediatr
, vol.102
, Issue.1
, pp. 53-57
-
-
Lee, Y.J.1
Kim, K.W.2
Choi, B.S.3
Sohn, M.H.4
Kim, K.E.5
-
11
-
-
84879521824
-
Airway and systemic inflammation in obese children with asthma
-
PID: 23349447, COI: 1:CAS:528:DC%2BC3sXhslWnsbzE
-
Jensen ME, Gibson PG, Collins CE, Wood LG. Airway and systemic inflammation in obese children with asthma. Eur Respir J. 2013;42(4):1012–9.
-
(2013)
Eur Respir J
, vol.42
, Issue.4
, pp. 1012-1019
-
-
Jensen, M.E.1
Gibson, P.G.2
Collins, C.E.3
Wood, L.G.4
-
12
-
-
84899671419
-
Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD
-
PID: 24641293, Comprehensive evaluation of risk factors and clinical features of neutrophilic asthma
-
Simpson JL, Baines KJ, Ryan N, Gibson PG. Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD. Asian Pac J Allergy Immunol. 2014;32(1):66–74. Comprehensive evaluation of risk factors and clinical features of neutrophilic asthma.
-
(2014)
Asian Pac J Allergy Immunol
, vol.32
, Issue.1
, pp. 66-74
-
-
Simpson, J.L.1
Baines, K.J.2
Ryan, N.3
Gibson, P.G.4
-
13
-
-
80053087268
-
Noneosinophilic asthma in children: relation with airway remodelling
-
PID: 21310879, COI: 1:STN:280:DC%2BC3MfgtlaisA%3D%3D
-
Baraldo S, Turato G, Bazzan E, Ballarin A, Damin M, Balestro E, et al. Noneosinophilic asthma in children: relation with airway remodelling. Eur Respir J. 2011;38(3):575–83.
-
(2011)
Eur Respir J
, vol.38
, Issue.3
, pp. 575-583
-
-
Baraldo, S.1
Turato, G.2
Bazzan, E.3
Ballarin, A.4
Damin, M.5
Balestro, E.6
-
14
-
-
0036795111
-
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
-
PID: 12324674, COI: 1:STN:280:DC%2BD38vovV2qtw%3D%3D
-
Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax. 2002;57:875–9.
-
(2002)
Thorax
, vol.57
, pp. 875-879
-
-
Green, R.H.1
Brightling, C.E.2
Woltmann, G.3
-
15
-
-
84862024217
-
Untangling asthma phenotypes and endotypes
-
PID: 22594878, COI: 1:CAS:528:DC%2BC38Xht1Gmu7vF
-
Agache I, Akdis C, Jutel M, Virchow JC. Untangling asthma phenotypes and endotypes. Allergy. 2012;67(7):835–46.
-
(2012)
Allergy
, vol.67
, Issue.7
, pp. 835-846
-
-
Agache, I.1
Akdis, C.2
Jutel, M.3
Virchow, J.C.4
-
16
-
-
84876894419
-
From phenotypes to endotypes to asthma treatment
-
PID: 23587683, COI: 1:CAS:528:DC%2BC3sXmsVaitbY%3D
-
Agache IO. From phenotypes to endotypes to asthma treatment. Curr Opin Allergy Clin Immunol. 2013;13(3):249–56.
-
(2013)
Curr Opin Allergy Clin Immunol
, vol.13
, Issue.3
, pp. 249-256
-
-
Agache, I.O.1
-
17
-
-
84937413585
-
Endotype driven treatment of asthma
-
Description of the endotype-driven therapeutic strategies Th2 and non-Th2 asthma
-
Agache IO. Endotype driven treatment of asthma. Curr Treat Options Allergy. 2014;1:198–212. Description of the endotype-driven therapeutic strategies in Th2 and non-Th2 asthma.
-
(2014)
Curr Treat Options Allergy
, vol.1
, pp. 198-212
-
-
Agache, I.O.1
-
18
-
-
85097786872
-
Current treatment options in allergy. The complex type 2 endotype in allergy and asthma: From laboratory to bedside
-
in press. The first paper to describe the concept of a complex endotype and to pinpoint the major subendotypes of Th2 asthma
-
Agache I, Sugita K, Morita H, Akdis M, Akdis CA. Current treatment options in allergy. The complex type 2 endotype in allergy and asthma: from laboratory to bedside. Curr Allergy Asthma Rep. 2015, in press. The first paper to describe the concept of a complex endotype and to pinpoint the major subendotypes of Th2 asthma.
-
(2015)
Curr Allergy Asthma Rep
-
-
Agache, I.1
Sugita, K.2
Morita, H.3
Akdis, M.4
Akdis, C.A.5
-
19
-
-
33846141819
-
Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms
-
PID: 17008432
-
Wagers SS, Haverkamp HC, Bates JH, Norton RJ, Thompson-Figueroa JA, Sullivan MJ, et al. Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms. J Appl Physiol. 2007;102:221–30.
-
(2007)
J Appl Physiol
, vol.102
, pp. 221-230
-
-
Wagers, S.S.1
Haverkamp, H.C.2
Bates, J.H.3
Norton, R.J.4
Thompson-Figueroa, J.A.5
Sullivan, M.J.6
-
20
-
-
79955437252
-
Insights into asthmatic airway remodelling through murine models
-
PID: 21435099
-
Al Heialy S, McGovern TK, Martin JG. Insights into asthmatic airway remodelling through murine models. Respirology. 2011;16:589–97.
-
(2011)
Respirology
, vol.16
, pp. 589-597
-
-
Al Heialy, S.1
McGovern, T.K.2
Martin, J.G.3
-
21
-
-
56149097181
-
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
-
PID: 18768865, COI: 1:CAS:528:DC%2BD1cXhtVKntb%2FK
-
McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol. 2008;181:4089–97.
-
(2008)
J Immunol
, vol.181
, pp. 4089-4097
-
-
McKinley, L.1
Alcorn, J.F.2
Peterson, A.3
Dupont, R.B.4
Kapadia, S.5
Logar, A.6
-
22
-
-
65249179610
-
Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways
-
PID: 19342691, COI: 1:CAS:528:DC%2BD1MXjvFOitr4%3D
-
Yang M, Kumar RK, Foster PS. Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways. J Immunol. 2009;182:5107–15.
-
(2009)
J Immunol
, vol.182
, pp. 5107-5115
-
-
Yang, M.1
Kumar, R.K.2
Foster, P.S.3
-
23
-
-
84872399801
-
PI3K and MAPKs regulate neutrophil migration toward the airways in heaves
-
PID: 23194017, COI: 1:STN:280:DC%2BC3s7nsVCnsg%3D%3D
-
Bullone M, Moran K, Lavoie-Lamoureux A, Lavoie JP. PI3K and MAPKs regulate neutrophil migration toward the airways in heaves. J Vet Intern Med. 2013;27(1):164–70.
-
(2013)
J Vet Intern Med
, vol.27
, Issue.1
, pp. 164-170
-
-
Bullone, M.1
Moran, K.2
Lavoie-Lamoureux, A.3
Lavoie, J.P.4
-
24
-
-
84888054553
-
Real time RT-PCR analysis of inflammatory mediator expression in recurrent airway obstruction-affected horses
-
PID: 24176614, COI: 1:CAS:528:DC%2BC3sXhslSlsbjN
-
Padoan E, Ferraresso S, Pegolo S, Castagnaro M, Barnini C, Bargelloni L. Real time RT-PCR analysis of inflammatory mediator expression in recurrent airway obstruction-affected horses. Vet Immunol Immunopathol. 2013;156(3–4):190–9.
-
(2013)
Vet Immunol Immunopathol
, vol.156
, Issue.3-4
, pp. 190-199
-
-
Padoan, E.1
Ferraresso, S.2
Pegolo, S.3
Castagnaro, M.4
Barnini, C.5
Bargelloni, L.6
-
25
-
-
74549186515
-
Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
-
PID: 19922242, COI: 1:CAS:528:DC%2BC3cXlvFahsw%3D%3D
-
Wood LG, Simpson JL, Hansbro P, Gibson PG. Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia. Free Radic Res. 2010;44:146–54.
-
(2010)
Free Radic Res
, vol.44
, pp. 146-154
-
-
Wood, L.G.1
Simpson, J.L.2
Hansbro, P.3
Gibson, P.G.4
-
26
-
-
84875544510
-
Extracellular vesicles, especially derived from gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses
-
PID: 23517040, COI: 1:CAS:528:DC%2BC3sXksFOhsr8%3D
-
Kim YS, Choi EJ, Lee WH, Choi SJ, Roh TY, Park J, et al. Extracellular vesicles, especially derived from gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses. Clin Exp Allergy. 2013;43(4):443–54.
-
(2013)
Clin Exp Allergy
, vol.43
, Issue.4
, pp. 443-454
-
-
Kim, Y.S.1
Choi, E.J.2
Lee, W.H.3
Choi, S.J.4
Roh, T.Y.5
Park, J.6
-
27
-
-
84858662552
-
Association between proximity to major roads and sputum cell counts
-
PID: 21369545
-
Wallace J, D’Silva L, Brannan J, Hargreave FE, Kanaroglou P, Nair P. Association between proximity to major roads and sputum cell counts. Can Respir J. 2011;18(1):13–8.
-
(2011)
Can Respir J
, vol.18
, Issue.1
, pp. 13-18
-
-
Wallace, J.1
D’Silva, L.2
Brannan, J.3
Hargreave, F.E.4
Kanaroglou, P.5
Nair, P.6
-
28
-
-
33947588653
-
Innate immune activation in neutrophilic asthma and bronchiectasis
-
PID: 16844729
-
Simpson JL, Grissell TV, Douwes J, Scott RJ, Boyle MJ, Gibson PG. Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax. 2007;62:211–8.
-
(2007)
Thorax
, vol.62
, pp. 211-218
-
-
Simpson, J.L.1
Grissell, T.V.2
Douwes, J.3
Scott, R.J.4
Boyle, M.J.5
Gibson, P.G.6
-
29
-
-
84897434505
-
Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
-
PID: 24582314, COI: 1:CAS:528:DC%2BC2cXjs1Onurg%3D, Very elegant demonstration of the discriminatory capacity between eosinophilic and non-eosinophilic asthma of the six gene signature
-
Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al. Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes. J Allergy Clin Immunol. 2014;133(4):997–1007. Very elegant demonstration of the discriminatory capacity between eosinophilic and non-eosinophilic asthma of the six gene signature.
-
(2014)
J Allergy Clin Immunol
, vol.133
, Issue.4
, pp. 997-1007
-
-
Baines, K.J.1
Simpson, J.L.2
Wood, L.G.3
Scott, R.J.4
Fibbens, N.L.5
Powell, H.6
-
30
-
-
84945188133
-
Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation
-
Dejager L, Dendoncker K, Eggermont M, Souffriau J, Van Hauwermeiren F, Willart M, et al. Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation. Mucosal Immunol. 2015. doi:10.1038/mi.2015.12. DOI: 10.1038/mi.2015.12
-
(2015)
Mucosal Immunol
-
-
Dejager, L.1
Dendoncker, K.2
Eggermont, M.3
Souffriau, J.4
Van Hauwermeiren, F.5
Willart, M.6
-
31
-
-
84917735175
-
Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells
-
PID: 25501580
-
Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, et al. Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells. PLoS One. 2014;9(12), e114791.
-
(2014)
PLoS One
, vol.9
, Issue.12
-
-
Mikami, Y.1
Matsuzaki, H.2
Horie, M.3
Noguchi, S.4
Jo, T.5
Narumoto, O.6
-
32
-
-
77951155473
-
Differential gene expression and cytokine production from neutrophils in asthma phenotypes
-
PID: 19797135, COI: 1:CAS:528:DC%2BC3cXksVGnsb8%3D
-
Baines KJ, Simpson JL, Bowden NA, Scott RJ, Gibson PG. Differential gene expression and cytokine production from neutrophils in asthma phenotypes. Eur Respir J. 2010;35(3):522–31.
-
(2010)
Eur Respir J
, vol.35
, Issue.3
, pp. 522-531
-
-
Baines, K.J.1
Simpson, J.L.2
Bowden, N.A.3
Scott, R.J.4
Gibson, P.G.5
-
33
-
-
84927711820
-
Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1ß
-
PID: 25616863, COI: 1:CAS:528:DC%2BC2MXjtlKjsro%3D
-
Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al. Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1ß. Respir Res. 2015;16(1):5.
-
(2015)
Respir Res
, vol.16
, Issue.1
, pp. 5
-
-
Gao, P.1
Gibson, P.G.2
Baines, K.J.3
Yang, I.A.4
Upham, J.W.5
Reynolds, P.N.6
-
34
-
-
84911102298
-
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion
-
PID: 25173346, COI: 1:CAS:528:DC%2BC2cXhsVCrtLnM, Description of the interaction between a newly described phenotype of neutrophils (N2) and macrophages the context of a type 2 immune response the lungs of nematode infected animals
-
Chen F, Wu W, Millman A, Craft JF, Chen E, Patel N, et al. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat Immunol. 2014;15(10):938–46. Description of the interaction between a newly described phenotype of neutrophils (N2) and macrophages in the context of a type 2 immune response in the lungs of nematode infected animals.
-
(2014)
Nat Immunol
, vol.15
, Issue.10
, pp. 938-946
-
-
Chen, F.1
Wu, W.2
Millman, A.3
Craft, J.F.4
Chen, E.5
Patel, N.6
-
35
-
-
84871706214
-
Impaired macrophage phagocytosis in non-eosinophilic asthma
-
PID: 23278878, COI: 1:STN:280:DC%2BC3s3lslOntw%3D%3D
-
Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, et al. Impaired macrophage phagocytosis in non-eosinophilic asthma. Clin Exp Allergy. 2013;43:29–35.
-
(2013)
Clin Exp Allergy
, vol.43
, pp. 29-35
-
-
Simpson, J.L.1
Gibson, P.G.2
Yang, I.A.3
Upham, J.4
James, A.5
Reynolds, P.N.6
-
36
-
-
24144482766
-
Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
-
PID: 15901607
-
Simpson JL, Scott RJ, Boyle MJ, Gibson PG. Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma. Am J Resp Crit Care Med. 2005;172:559–65.
-
(2005)
Am J Resp Crit Care Med
, vol.172
, pp. 559-565
-
-
Simpson, J.L.1
Scott, R.J.2
Boyle, M.J.3
Gibson, P.G.4
-
37
-
-
65349121194
-
IL-17-producing T cells in lung immunity and inflammation
-
PID: 19410688, COI: 1:CAS:528:DC%2BD1MXltlyhsrw%3D
-
Nembrini C, Marsland BJ, Kopf M. IL-17-producing T cells in lung immunity and inflammation. J Allergy Clin Immunol. 2009;123:986–94.
-
(2009)
J Allergy Clin Immunol
, vol.123
, pp. 986-994
-
-
Nembrini, C.1
Marsland, B.J.2
Kopf, M.3
-
38
-
-
84897146503
-
Innate lymphoid cells and asthma
-
PID: 24679467, COI: 1:CAS:528:DC%2BC2cXmtVCgsLo%3D
-
Yu S, Kim HY, Chang Y-J, DeKruyff RH, Umetsu DT. Innate lymphoid cells and asthma. J Allergy Clin Immunol. 2014;133:943–50.
-
(2014)
J Allergy Clin Immunol
, vol.133
, pp. 943-950
-
-
Yu, S.1
Kim, H.Y.2
Chang, Y.-J.3
DeKruyff, R.H.4
Umetsu, D.T.5
-
39
-
-
84891889644
-
Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity
-
PID: 24336249, COI: 1:CAS:528:DC%2BC3sXhvFentb%2FE
-
Kim HY, Lee HJ, Chang Y-J, Pichavant M, Shore SA, Fitzgerald KA, et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2014;20:54–61.
-
(2014)
Nat Med
, vol.20
, pp. 54-61
-
-
Kim, H.Y.1
Lee, H.J.2
Chang, Y.-J.3
Pichavant, M.4
Shore, S.A.5
Fitzgerald, K.A.6
-
40
-
-
84922410788
-
Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis
-
PID: 25599143, COI: 1:CAS:528:DC%2BC2MXitFCis7g%3D
-
Mease PJ. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. Curr Opin Rheumatol. 2015;27(2):127–33.
-
(2015)
Curr Opin Rheumatol
, vol.27
, Issue.2
, pp. 127-133
-
-
Mease, P.J.1
-
41
-
-
70349871248
-
Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness
-
PID: 19661246, COI: 1:CAS:528:DC%2BD1MXhtlGgtbjE
-
Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med. 2009;180:720–30.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 720-730
-
-
Wilson, R.H.1
Whitehead, G.S.2
Nakano, H.3
Free, M.E.4
Kolls, J.K.5
Cook, D.N.6
-
42
-
-
84874088635
-
Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance an contribute to airway remodeling
-
PID: 22892938, COI: 1:CAS:528:DC%2BC38XhtF2rt7bO
-
Zhao J, Lloyd CM, Noble A. Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance an contribute to airway remodeling. Mucosal Immunol. 2013;6:335–46.
-
(2013)
Mucosal Immunol
, vol.6
, pp. 335-346
-
-
Zhao, J.1
Lloyd, C.M.2
Noble, A.3
-
43
-
-
33751180809
-
IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
-
PID: 17083726
-
Bullens DM, Truyen E, Coteur L, Dilissen E, Hellings PW, Dupont LJ, et al. IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res. 2006;7:135.
-
(2006)
Respir Res
, vol.7
, pp. 135
-
-
Bullens, D.M.1
Truyen, E.2
Coteur, L.3
Dilissen, E.4
Hellings, P.W.5
Dupont, L.J.6
-
44
-
-
77953913216
-
Increased serum IL-17 is an independent risk factor for severe asthma
-
PID: 20338742
-
Agache I, Ciobanu C, Agache C, Anghel M. Increased serum IL-17 is an independent risk factor for severe asthma. Respir Med. 2010;104:1131–7.
-
(2010)
Respir Med
, vol.104
, pp. 1131-1137
-
-
Agache, I.1
Ciobanu, C.2
Agache, C.3
Anghel, M.4
-
45
-
-
0034833339
-
IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
-
PID: 11544464, COI: 1:CAS:528:DC%2BD3MXnsFGntb8%3D
-
Molet S, Hamid Q, Davoine F, Nutku E, Taha R, Pagé N, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol. 2001;108:430–8.
-
(2001)
J Allergy Clin Immunol
, vol.108
, pp. 430-438
-
-
Molet, S.1
Hamid, Q.2
Davoine, F.3
Nutku, E.4
Taha, R.5
Pagé, N.6
-
46
-
-
0037636682
-
Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
-
PID: 12814161, COI: 1:STN:280:DC%2BD3s3os1Kitw%3D%3D
-
Barczyk A, Pierzchala W, Sozañska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med. 2003;97:726–33.
-
(2003)
Respir Med
, vol.97
, pp. 726-733
-
-
Barczyk, A.1
Pierzchala, W.2
Sozañska, E.3
-
47
-
-
84882771510
-
Increased IL-17A secreting CD41 T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity
-
PID: 23957337, COI: 1:CAS:528:DC%2BC3sXhtlaitb7P
-
Chien JW, Lin CY, Yang KD, Lin CH, Kao JK, Tsai YG. Increased IL-17A secreting CD41 T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity. Clin Exp Allergy. 2013;43:1018–26.
-
(2013)
Clin Exp Allergy
, vol.43
, pp. 1018-1026
-
-
Chien, J.W.1
Lin, C.Y.2
Yang, K.D.3
Lin, C.H.4
Kao, J.K.5
Tsai, Y.G.6
-
48
-
-
84920369993
-
Identification of novel immune phenotypes for allergic and non-allergic childhood asthma
-
PID: 25226851, COI: 1:CAS:528:DC%2BC2MXhtVClt7k%3D
-
Raedler D, Ballenberger N, Klucker E, Böck A, Otto R, Prazeres da Costa O, et al. Identification of novel immune phenotypes for allergic and non-allergic childhood asthma. J Allergy Clin Immunol. 2015;135(1):81–91.
-
(2015)
J Allergy Clin Immunol
, vol.135
, Issue.1
, pp. 81-91
-
-
Raedler, D.1
Ballenberger, N.2
Klucker, E.3
Böck, A.4
Otto, R.5
Prazeres da Costa, O.6
-
49
-
-
84901026697
-
Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma
-
PID: 24347461
-
Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, et al. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax. 2014;69:508–15.
-
(2014)
Thorax
, vol.69
, pp. 508-515
-
-
Gupta, A.1
Dimeloe, S.2
Richards, D.F.3
Chambers, E.S.4
Black, C.5
Urry, Z.6
-
50
-
-
73149118287
-
Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4
-
PID: 20109749, COI: 1:CAS:528:DC%2BC3cXosV2r
-
Cosmi L, Maggi L, Santarlasci V, Capone M, Cardilicchia E, Frosali F, et al. Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J Allergy Clin Immunol. 2010;125(1):222–30.
-
(2010)
J Allergy Clin Immunol
, vol.125
, Issue.1
, pp. 222-230
-
-
Cosmi, L.1
Maggi, L.2
Santarlasci, V.3
Capone, M.4
Cardilicchia, E.5
Frosali, F.6
-
51
-
-
84913530341
-
Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
-
PID: 25042748, COI: 1:CAS:528:DC%2BC2cXhtF2ks7bL, First study proving the existence of dual-positive Th2/Th17 cells the airways and their association with asthma severity
-
Irvin C, Zafar I, Good J, Rollins D, Christianson C, Gorska MM, et al. Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J Allergy Clin Immunol. 2014;134:1175–86. First study proving the existence of dual-positive Th2/Th17 cells in the airways and their association with asthma severity.
-
(2014)
J Allergy Clin Immunol
, vol.134
, pp. 1175-1186
-
-
Irvin, C.1
Zafar, I.2
Good, J.3
Rollins, D.4
Christianson, C.5
Gorska, M.M.6
-
52
-
-
84904440406
-
IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models
-
PID: 24480880, COI: 1:CAS:528:DC%2BC2cXjt1WmsrY%3D
-
Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga CS, et al. IL-17A as an inducer for Th2 immune responses in murine atopic dermatitis models. J Invest Dermatol. 2014;134(8):2122–30.
-
(2014)
J Invest Dermatol
, vol.134
, Issue.8
, pp. 2122-2130
-
-
Nakajima, S.1
Kitoh, A.2
Egawa, G.3
Natsuaki, Y.4
Nakamizo, S.5
Moniaga, C.S.6
-
53
-
-
84901289099
-
CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis
-
PID: 24729611, COI: 1:CAS:528:DC%2BC2cXntlGhu70%3D
-
Ponichtera HE, Shainheit MG, Liu BC, Raychowdhury R, Larkin BM, Russo JM, et al. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. J Immunol. 2014;192:4655–65.
-
(2014)
J Immunol
, vol.192
, pp. 4655-4665
-
-
Ponichtera, H.E.1
Shainheit, M.G.2
Liu, B.C.3
Raychowdhury, R.4
Larkin, B.M.5
Russo, J.M.6
-
54
-
-
84911143445
-
Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage
-
PID: 25326751, COI: 1:CAS:528:DC%2BC2cXhslKrt7%2FP
-
Sutherland TE, Logan N, Rückerl D, Humbles AA, Allan SM, Papayannopoulos V, et al. Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage. Nat Immunol. 2014;15(12):1116–25.
-
(2014)
Nat Immunol
, vol.15
, Issue.12
, pp. 1116-1125
-
-
Sutherland, T.E.1
Logan, N.2
Rückerl, D.3
Humbles, A.A.4
Allan, S.M.5
Papayannopoulos, V.6
-
55
-
-
84896711467
-
IL-17A promotes the exacerbation of IL-33-induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice
-
PID: 24446518, COI: 1:CAS:528:DC%2BC2cXitFWnur4%3D
-
Mizutani N, Nabe T, Yoshino S. IL-17A promotes the exacerbation of IL-33-induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice. J Immunol. 2014;192(4):1372–84.
-
(2014)
J Immunol
, vol.192
, Issue.4
, pp. 1372-1384
-
-
Mizutani, N.1
Nabe, T.2
Yoshino, S.3
-
56
-
-
84932603680
-
Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation
-
McAlees JW, Whitehead GS, Harley IT, Cappelletti M, Rewerts CL, Holdcroft AM, et al. Distinct Tlr4-expressing cell compartments control neutrophilic and eosinophilic airway inflammation. Mucosal Immunol. 2014. doi:10.1038/mi.2014.117. DOI: 10.1038/mi.2014.117
-
(2014)
Mucosal Immunol
-
-
McAlees, J.W.1
Whitehead, G.S.2
Harley, I.T.3
Cappelletti, M.4
Rewerts, C.L.5
Holdcroft, A.M.6
-
57
-
-
84994700720
-
Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids
-
Furukawa T, Sakagami T, Koya T, Hasegawa T, Kawakami H, Kimura Y, et al. Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids. J Asthma. 2014;11:1–6.
-
(2014)
J Asthma
, vol.11
, pp. 1-6
-
-
Furukawa, T.1
Sakagami, T.2
Koya, T.3
Hasegawa, T.4
Kawakami, H.5
Kimura, Y.6
-
58
-
-
84911481328
-
Non-eosinophilic airway hyper-reactivity in mice, induced by IFN-γ producing CD4(+) and CD8(+) lung T cells, is responsive to steroid treatment
-
PID: 25124713, COI: 1:CAS:528:DC%2BC2cXhslylt7rF
-
Stein J, Maxeiner JH, Montermann E, Höhn Y, Raker V, Taube C, et al. Non-eosinophilic airway hyper-reactivity in mice, induced by IFN-γ producing CD4(+) and CD8(+) lung T cells, is responsive to steroid treatment. Scand J Immunol. 2014;80(5):327–38.
-
(2014)
Scand J Immunol
, vol.80
, Issue.5
, pp. 327-338
-
-
Stein, J.1
Maxeiner, J.H.2
Montermann, E.3
Höhn, Y.4
Raker, V.5
Taube, C.6
-
59
-
-
84938737977
-
MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity
-
Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, et al. MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. J Allergy Clin Immunol. 2015. doi:10.1016/j.jaci.2014.11.044. DOI: 10.1016/j.jaci.2014.11.044
-
(2015)
J Allergy Clin Immunol
-
-
Li, J.J.1
Tay, H.L.2
Maltby, S.3
Xiang, Y.4
Eyers, F.5
Hatchwell, L.6
-
60
-
-
84929682949
-
CXCL8 Histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET
-
Clifford RL, Patel JK, John AE, Tatler AL, Mazengarb L, Brightling CE, et al. CXCL8 Histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET. Am J Physiol Lung Cell Mol Physiol. 2015. doi:10.1152/ajplung.00021.2015. DOI: 10.1152/ajplung.00021.2015
-
(2015)
Am J Physiol Lung Cell Mol Physiol
-
-
Clifford, R.L.1
Patel, J.K.2
John, A.E.3
Tatler, A.L.4
Mazengarb, L.5
Brightling, C.E.6
-
61
-
-
84862821428
-
Age-related differences in clinical outcomes for acute asthma in the United States, 2006–2008
-
PID: 22385630
-
Tsai CL, Lee WY, Hanania NA, Camargo Jr CA. Age-related differences in clinical outcomes for acute asthma in the United States, 2006–2008. J Allergy Clin Immunol. 2012;129:1252–8.
-
(2012)
J Allergy Clin Immunol
, vol.129
, pp. 1252-1258
-
-
Tsai, C.L.1
Lee, W.Y.2
Hanania, N.A.3
Camargo, C.A.4
-
62
-
-
84879327324
-
Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics
-
PID: 23490307, First study showing a relation between increasing age and increasing sputum neutrophils, both healthy and asthmatics
-
Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL. Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics. Respirology. 2013;18(5):857–65. First study showing a relation between increasing age and increasing sputum neutrophils, both in healthy and in asthmatics.
-
(2013)
Respirology
, vol.18
, Issue.5
, pp. 857-865
-
-
Brooks, C.R.1
Gibson, P.G.2
Douwes, J.3
Van Dalen, C.J.4
Simpson, J.L.5
-
63
-
-
84875219719
-
Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial
-
PID: 23291349
-
Brusselle GG, Vanderstichele C, Jordens P, Deman R, Slabbynck H, Ringoet V, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax. 2013;68(4):322–9.
-
(2013)
Thorax
, vol.68
, Issue.4
, pp. 322-329
-
-
Brusselle, G.G.1
Vanderstichele, C.2
Jordens, P.3
Deman, R.4
Slabbynck, H.5
Ringoet, V.6
-
64
-
-
84926407544
-
Macrolide antibiotics for treatment of asthma in adults: A meta-analysis of 18 randomized controlled clinical studies
-
PID: 25252142, COI: 1:CAS:528:DC%2BC2cXhs1Gms77M
-
Tong X, Guo T, Liu S, Peng S, Yan Z, Yang X, et al. Macrolide antibiotics for treatment of asthma in adults: A meta-analysis of 18 randomized controlled clinical studies. Pulm Pharmacol Ther. 2015;31:99–108.
-
(2015)
Pulm Pharmacol Ther
, vol.31
, pp. 99-108
-
-
Tong, X.1
Guo, T.2
Liu, S.3
Peng, S.4
Yan, Z.5
Yang, X.6
-
65
-
-
84902147234
-
The impact of azithromycin therapy on the airway microbiota in asthma
-
PID: 24287164, This is the first study to examine longitudinal changes airway microbiota following antibiotic treatment asthma
-
Slater M, Rivett DW, Williams L, Martin M, Harrison T, Sayers I, et al. The impact of azithromycin therapy on the airway microbiota in asthma. Thorax. 2014;69(7):673–4. This is the first study to examine longitudinal changes in airway microbiota following antibiotic treatment in asthma.
-
(2014)
Thorax
, vol.69
, Issue.7
, pp. 673-674
-
-
Slater, M.1
Rivett, D.W.2
Williams, L.3
Martin, M.4
Harrison, T.5
Sayers, I.6
-
66
-
-
84929457101
-
Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma
-
Essilfie AT, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al. Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma. Thorax. 2015. doi:10.1136/thoraxjnl-2014-206067. DOI: 10.1136/thoraxjnl-2014-206067
-
(2015)
Thorax
-
-
Essilfie, A.T.1
Horvat, J.C.2
Kim, R.Y.3
Mayall, J.R.4
Pinkerton, J.W.5
Beckett, E.L.6
-
67
-
-
84890026323
-
Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
-
PID: 24200404, COI: 1:CAS:528:DC%2BC2cXhtVKqs7c%3D, First large clinical trial to evaluate the efficacy and safety of anti-IL-17 targeted intervention asthma and delineating a possible responder subgroup
-
Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med. 2013;188:1294–302. First large clinical trial to evaluate the efficacy and safety of anti-IL-17 targeted intervention in asthma and delineating a possible responder subgroup.
-
(2013)
Am J Respir Crit Care Med
, vol.188
, pp. 1294-1302
-
-
Busse, W.W.1
Holgate, S.2
Kerwin, E.3
Chon, Y.4
Feng, J.5
Lin, J.6
-
68
-
-
84862519263
-
Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
-
PID: 22702508, COI: 1:CAS:528:DC%2BC38Xht1Kkt7nJ
-
Nair P, Gaga M, Zervas E, Alagha K, Hargreave FE, O’Byrne PM, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2012;42(7):1097–103.
-
(2012)
Clin Exp Allergy
, vol.42
, Issue.7
, pp. 1097-1103
-
-
Nair, P.1
Gaga, M.2
Zervas, E.3
Alagha, K.4
Hargreave, F.E.5
O’Byrne, P.M.6
-
69
-
-
84925059188
-
Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists
-
PID: 25708618, COI: 1:CAS:528:DC%2BC2MXitl2ktrk%3D
-
Austin RP, Bennion C, Bonnert RV, Cheema L, Cook AR, Cox RJ, et al. Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists. Bioorg Med Chem Lett. 2015;25(7):1616–20.
-
(2015)
Bioorg Med Chem Lett
, vol.25
, Issue.7
, pp. 1616-1620
-
-
Austin, R.P.1
Bennion, C.2
Bonnert, R.V.3
Cheema, L.4
Cook, A.R.5
Cox, R.J.6
|