Heterogeneity of lower airway inflammation in children with severe-persistent asthma

Pediatric Pulmonology

Volumn 50, Issue 12, 2015, Pages 1200-1204

  O'Brien, Caitlin E ^a   Tsirilakis, Kalliope ^b   Santiago, Maria Teresa ^b   Goldman, David L ^c   Vicencio, Alfin G ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HOFSTRA UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL AT MONTEFIORE   (United States)

Author keywords

asthma ; bronchoscopy; early wheeze; eosinophil; immunoglobulin E

Indexed keywords

IMMUNOGLOBULIN E;

ARTICLE; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CHILD; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FEMALE; GRANULOCYTE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY TRACT INFLAMMATION; BLOOD; CYTOLOGY; INFLAMMATION; METABOLISM; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX;

ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CHILD; EOSINOPHILS; FEMALE; GRANULOCYTES; HUMANS; IMMUNOGLOBULIN E; INFLAMMATION; MALE; NEUTROPHILS; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 84955185795     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.23165     Document Type: Article

References (32)

1. Akinbami LJ, Moorman JE, Liu X,. Asthma prevalence, health care use, and mortality: United States, 2005-2009. Natl Health Stat Report 2011; 1-14.
2. Chips B,. Asthma in infants and children. Clin Cornerstone 2008; 8: 44-61.
3. Chips BE, Zeiger RS, Borish L, Wenzel SE, Yegin A, Hayden ML, Miller DP, Bleecker ER, Simons FER, Szefler SJ, et al., Key findings and clinical implications from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. J Allergy Clin Immunol 2012; 130: 332-342.
4. Szefler SJ, Zeiger RS, Haselkorn T, Mink DR, Kamath TV, Fish JE, Chipps BE,. Economic burden of impairment in children with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2011; 107: 110-119. e111.
5. National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol 2007; 120: S94-138.
6. Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fahy JV, et al., The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol 2007; 119: 73-80.
7. Konradsen JR, Nordlund B, Lidegran M, Pedroletti C, Gronlund H, van Hage M, Dahlen B, Hedlin G,. Problematic severe asthma: a proposed approach to identifying children who are severely resistant to therapy. Pediatr Allergy Immunol 2011; 22: 9-18.
8. Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, et al., Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 2002; 109: 410-418.
9. Wenzel S, Schwartz L, Langmack E, Halliday J, Trudeau J, Gibbs R, Chu H,. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct phusiologic and clinical characteristics. Am J Respir Crit Care Med 1999; 160: 1001-1008.
10. Bell MC, Busse WW,. Severe asthma: an expanding and mounting clinical challenge. J Allergy Clin Immunol Pract 2013; 1: 110-121. quiz 122.
11. Payne DN, Wilson NM, James A, Hablas H, Agrafioti C, Bush A,. Evidence for different subgroups of difficult asthma in children. Thorax 2001; 56: 345-350.
12. Fitzpatrick AM, Teague WG,. Severe asthma in children: insights from the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Pediatr Allergy Immunol Pulmonol 2010; 23: 131-138.
13. Fitzpatrick AM, Teague WG, Meyers DA, Peters SP, Li X, Li H, Wenzel SE, Aujla S, Castro M, Bacharier LB, et al., Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011; 127: 382-389.
14. Good J, Kolakowski C, Groshong S, Murphy J, Martin R,. Refractory asthma: importance of bronchoscopy to identify phenotypes and direct therapy. Chest 2012; 141: 599-606.
15. Sherrill DL, Lebowitz MD, Halonen M, Barbee RA, Burrows B,. Longitudinal evaluation of the association between pulmonary function and total serum IgE. Am J Respir Crit Care Med 1995; 152: 98-102.
16. Ullmann N, Bossley CJ, Fleming L, Silvestri M, Bush A, Saglani S,. Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma. Allergy 2013; 68: 402-406.
17. Lama M, Chatterjee M, Chaudhuri TK,. Total serum immunoglobulin e in children with asthma. Indian J Clin Biochem 2013; 28: 197-200.
18. Jang WN, Park IS, Choi CH, Bauer S, Harmin S, Seo SC, Choi IS, Choung JT, Yoo Y,. Relationships between exhaled nitric oxide and atopy profiles in children with asthma. Allergy Asthma Immunol Res 2013; 5: 155-161.
19. Patel KK, Vicencio AG, Du Z, Tsirilakis K, Salva PS, Webley WC,. Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. Pediatr Infect Dis J 2010; 29: 1093-1098.
20. Goldman DL, Li X, Tsirilakis K, Andrade C, Casadevall A, Vicencio AG,. Increased chitinase expression and fungal-specific antibodies in the bronchoalveolar lavage fluid of asthmatic children. Clin Exp Allergy 2012; 42: 523-530.
21. de Blic J, Midulla F, Barbato A, Clement A, Dab I, Eber E, Green C, Grigg J, Kotecha S, Kurland G, et al., Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. Eur Respir J 2000; 15: 217-231.
22. Brusselle GG, Vanderstichele C, Jordens P, Deman R, Slabbynck H, Ringoet V, Verleden G, Demedts IK, Verhamme K, Delporte A, et al., Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax 2013; 68: 322-329.
23. Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG,. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 2008; 177: 148-155.
24. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH,. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med 2006; 203: 2907-2917.
25. Djukanovic R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, Bao W, Fowler-Taylor A, Matthews J, Busse WW, et al., Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med 2004; 170: 583-593.
26. Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P,. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380: 651-659.
27. Vicencio AG, Muzumdar H, Tsirilakis K, Kessel A, Nandalike K, Goldman DL,. Severe asthma with fungal sensitization in a child: response to itraconazole therapy. Pediatrics 2010; 125: e1255-1258.
28. Campos LE, Pereira LF,. Pulmonary eosinophilia. J Bras Pneumol 2009; 35: 561-573.
29. Denning DW, O'Driscoll BR, Powell G, Chew F, Atherton GT, Vyas A, Miles J, Morris J, Niven RM,. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: the Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med 2009; 179: 11-18.
30. Vicencio AG, Chupp GL, Tsirilakis K, He X, Kessel A, Nandalike K, Veler H, Kipperman S, Young MC, Goldman DL,. CHIT1 mutations: genetic risk factor for severe asthma with fungal sensitization. Pediatrics 2010; 126: e982-985.
31. Worgall TS, Veerappan A, Sung B, Kim BI, Weiner E, Bholah R, Silver RB, Jiang XC, Worgall S,. Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity. Sci Transl Med 2013; 5: 186ra167.
32. Ono JG, Worgall TS, Worgall S,. 17q21 locus and ORMDL3: an increased risk for childhood asthma. Pediatr Res 2014; 75: 165-170.