CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: Regulation by BET

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 308, Issue 9, 2015, Pages L962-L972

  Clifford, Rachel L ^a   Patel, Jamie K ^a   John, Alison E ^a   Tatler, Amanda L ^a   Mazengarb, Lisa ^a   Brightling, Christopher E ^b   Knox, Alan J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Airway smooth muscle; Asthma; BET protein; Bromodomain; CXCl8; Histone acetylation

Indexed keywords

ALPHA CHEMOKINE; HISTONE ACETYLTRANSFERASE; HISTONE H3; INTERLEUKIN 8; PROTEIN; PROTEIN BRD3; PROTEIN BRD4; PROTEIN INHIBITOR; RNA POLYMERASE II; STEROID; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG; BRD3 PROTEIN, HUMAN; BRD4 PROTEIN, HUMAN; CCAAT ENHANCER BINDING PROTEIN BETA; CEBPB PROTEIN, HUMAN; DNA BINDING PROTEIN; HISTONE; HISTONE ACETYLTRANSFERASE PCAF; IL8 PROTEIN, HUMAN; NERVE PROTEIN; NUCLEAR PROTEIN; P300-CBP-ASSOCIATED FACTOR; PROTEIN BINDING; RELA PROTEIN, HUMAN; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA;

ACETYLATION; AIRWAY SMOOTH MUSCLE CELL; ARTICLE; ASTHMA; CELL ISOLATION; CONTROLLED STUDY; DNA METHYLATION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SECRETION; RESPIRATORY TRACT INFLAMMATION; SMOOTH MUSCLE; TRANSCRIPTION REGULATION; AIRWAY REMODELING; ANTAGONISTS AND INHIBITORS; CELL CULTURE; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; PRIMARY CELL CULTURE; SMOOTH MUSCLE CELL;

ACETYLATION; AIRWAY REMODELING; ASTHMA; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; DNA METHYLATION; DNA-BINDING PROTEINS; HISTONES; HUMANS; INFLAMMATION; INTERLEUKIN-8; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; P300-CBP TRANSCRIPTION FACTORS; PRIMARY CELL CULTURE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA POLYMERASE II; RNA-BINDING PROTEINS; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84929682949     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00021.2015     Document Type: Article

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