Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Mikami, Yu ^a   Matsuzaki, Hirotaka ^a   Horie, Masafumi ^a   Noguchi, Satoshi ^a   Jo, Taisuke ^a   Narumoto, Osamu ^a   Kohyama, Tadashi ^b   Takizawa, Hajime ^c   Nagase, Takahide ^a   Yamauchi, Yasuhiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TEIKYO UNIVERSITY MIZONOKUCHI HOSPITAL   (Japan)

^c KYORIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; GROWTH REGULATED PROTEIN ALPHA; HERPESVIRUS ENTRY MEDIATOR LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LYMPHOTOXIN BETA RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; ONCOSTATIN M; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; IL6 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE P38; TNFSF14 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ARTICLE; CELL CULTURE; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ASTHMA; BIOSYNTHESIS; BRONCHUS; EPITHELIUM CELL; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY;

HERPESVIRIDAE;

ASTHMA; BRONCHI; EPITHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; LYMPHOTOXIN BETA RECEPTOR; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84917735175     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114791     Document Type: Article

References (42)

1. Goleva E, Li LB, Eves PT, Strand MJ, Martin RJ, et al. (2006) Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 173: 607-616.
2. Locksley RM (2010) Asthma and allergic inflammation. Cell 140: 777-783.
3. Ward C, Pais M, Bish R, Reid D, Feltis B, et al. (2002) Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 57: 309-316.
4. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, et al. (2014) International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 43: 343-373.
5. European Network for Understanding Mechanisms of Severe Asthma (2003) The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J 22: 470-477.
6. Fahy JV (2009) Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 6: 256-259.
7. Godaly G, Proudfoot AE, Offord RE, Svanborg C, Agace WW (1997) Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration. Infect Immun 65: 3451-3456.
8. Nakagome K, Matsushita S, Nagata M (2012) Neutrophilic inflammation in severe asthma. Int Arch Allergy Immunol 158 Suppl 1: 96-102.
9. Barnes PJ (2008) Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol 8: 183-192.
10. Barnes PJ (2007) New molecular targets for the treatment of neutrophilic diseases. J Allergy Clin Immunol 119: 1055-1062; quiz, 1063-1054.
11. Zhai Y, Guo R, Hsu TL, Yu GL, Ni J, et al. (1998) LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest 102: 1142-1151.
12. Aggarwal BB (2003) Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3: 745-756.
13. Cheung TC (2009) Modulation of T cell proliferation through the LIGHT-HVEM-BTLA cosignaling pathway. Recent Pat DNA Gene Seq 3: 177-182.
14. Rooney IA, Butrovich KD, Glass AA, Borboroglu S, Benedict CA, et al. (2000) The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J Biol Chem 275: 14307-14315.
15. Wang J, Foster A, Chin R, Yu P, Sun Y, et al. (2002) The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function. Eur J Immunol 32: 1969-1979.
16. Ishida S, Yamane S, Ochi T, Nakano S, Mori T, et al. (2008) LIGHT induces cell proliferation and inflammatory responses of rheumatoid arthritis synovial fibroblasts via lymphotoxin beta receptor. J Rheumatol 35: 960-968.
17. Wang J, Anders RA, Wu Q, Peng D, Cho JH, et al. (2004) Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest 113: 826-835.
18. Mikami Y, Yamauchi Y, Horie M, Kase M, Jo T, et al. (2012) Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells. Biochem Biophys Res Commun 428: 451-457.
19. Doherty TA, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, et al. (2011) The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat Med 17: 596-603.
20. Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, et al. (2010) Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 125: 1028-1036 e1013.
21. Lechner JF, LaVeck MA (1985) A serum-free method for culturing normal human bronchial epithelial cells at clonal density. Journal of tissue culture methods 9: 43-48.
22. The FANTOM Consortium, RIKEN PMI, CLST (DGT) (2014) A promoter-level mammalian expression atlas. Nature 507: 462-470.
23. Snelgrove RJ (2011) Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic strategy to alleviate chronic neutrophilic lung diseases. Eur J Pharmacol 667: 1-5.
24. Kaur M, Singh D (2013) Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2. J Pharmacol Exp Ther 347: 173-180.
25. Feng E, Wan R, Yang S, Yan Z, Wang S, et al. (2013) Expression levels of induced sputum IL-8 and IL-10 and drug intervention effects in patients with acute exacerbated COPD complicated with chronic cor pulmonale at high altitude. Exp Ther Med 6: 747-752.
26. Konrad FM, Reutershan J (2012) CXCR2 in acute lung injury. Mediators Inflamm 2012: 740987.
27. Pepe C, Foley S, Shannon J, Lemiere C, Olivenstein R, et al. (2005) Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol 116: 544-549.
28. Ware CF, Sedy JR (2011) TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14). Curr Opin Immunol 23: 627-631.
29. Plant SR, Iocca HA, Wang Y, Thrash JC, O'Connor BP, et al. (2007) Lymphotoxin beta receptor (Lt betaR): dual roles in demyelination and remyelination and successful therapeutic intervention using Lt betaR-Ig protein. J Neurosci 27: 7429-7437.
30. del Rio ML, Lucas CL, Buhler L, Rayat G, Rodriguez-Barbosa JI (2010) HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation. J Leukoc Biol 87: 223-235.
31. Duhen T, Pasero C, Mallet F, Barbarat B, Olive D, et al. (2004) LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation. Eur J Immunol 34: 3534-3541.
32. Shi JX, Su X, Xu J, Zhang WY, Shi Y (2012) MK2 posttranscriptionally regulates TNF-alpha-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 302: L793-799.
33. Robins S, Roussel L, Schachter A, Risse PA, Mogas AK, et al. (2011) Steroid-insensitive ERK1/2 activity drives CXCL8 synthesis and neutrophilia by airway smooth muscle. Am J Respir Cell Mol Biol 45: 984-990.
34. Chang YH, Hsieh SL, Chen MC, Lin WW (2002) Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation. Exp Cell Res 278: 166-174.
35. Lin CH, Cheng HW, Ma HP, Wu CH, Hong CY, et al. (2011) Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway. J Biol Chem 286: 10483-10494.
36. Mukaida N, Morita M, Ishikawa Y, Rice N, Okamoto S, et al. (1994) Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem 269: 13289-13295.
37. Cavigelli M, Dolfi F, Claret FX, Karin M (1995) Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J 14: 5957-5964.
38. Takata M, Urakaze M, Temaru R, Yamazaki K, Nakamura N, et al. (2001) Pravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinase. Br J Pharmacol 134: 753-762.
39. Matsushima K, Baldwin ET, Mukaida N (1992) Interleukin-8 and MCAF: novel leukocyte recruitment and activating cytokines. Chem Immunol 51: 236-265.
40. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8: 205-215.
41. Beinke S, Ley SC (2004) Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J 382: 393-409.
42. Sun SC (2011) Non-canonical NF-kappaB signaling pathway. Cell Res 21: 71-85.