Caspase-2 cleavage of tau reversibly impairs memory

Nature Medicine

Volumn 22, Issue 11, 2016, Pages 1268-1276

  Zhao, Xiaohui ^a,b   Kotilinek, Linda A ^a,b   Smith, Benjamin ^a,b   Hlynialuk, Chris ^a,b   Zahs, Kathleen ^a,b   Ramsden, Martin ^a,b,d   Cleary, James ^a,b,c   Ashe, Karen H ^a,b,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d R and D Systems Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CASPASE 10; CASPASE 2; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; GLUTAMATE RECEPTOR; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; POSTSYNAPTIC DENSITY PROTEIN 95; TAU PROTEIN; CASP2 PROTEIN, MOUSE; CASPASE; MAPT PROTEIN, HUMAN; MORPHOLINO OLIGONUCLEOTIDE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELLULAR DISTRIBUTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DENDRITIC SPINE; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HIPPOCAMPAL CA1 REGION; HUMAN; IN VITRO STUDY; LEARNING DISORDER; LONG TERM MEMORY; MALE; MEMORY DISORDER; MILD COGNITIVE IMPAIRMENT; MOUSE; NERVE CELL; NERVE CELL CULTURE; NERVE DEGENERATION; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; REFERENCE MEMORY; SPATIAL LEARNING; SYNAPSE; SYNAPTIC TRANSMISSION; TAUOPATHY; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; GENETICS; HIPPOCAMPUS; MEMORY; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; CASPASE 2; CASPASES; CELLS, CULTURED; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; HUMANS; MEMORY; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MORPHOLINOS; NEURONS; ORGAN SIZE; RECEPTORS, GLUTAMATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNAPSES; TAU PROTEINS;

EID: 84990966921     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4199     Document Type: Article

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