메뉴 건너뛰기




Volumn 138, Issue 1, 2016, Pages 3-14

The role of the inflammasome in patients with autoinflammatory diseases

Author keywords

Autoinflammation; inflammasome; innate immunity

Indexed keywords

BIOLOGICAL PRODUCT; INFLAMMASOME; ANTIINFLAMMATORY AGENT; IMMUNOLOGIC FACTOR;

EID: 84990874037     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.05.001     Document Type: Review
Times cited : (59)

References (84)
  • 1
    • 84938383400 scopus 로고    scopus 로고
    • Autoimmunity and immune dysregulation in primary immune deficiency disorders
    • 1 Lehman, H.K., Autoimmunity and immune dysregulation in primary immune deficiency disorders. Curr Allergy Asthma Rep, 15, 2015, 53.
    • (2015) Curr Allergy Asthma Rep , vol.15 , pp. 53
    • Lehman, H.K.1
  • 2
    • 84887931088 scopus 로고    scopus 로고
    • Inflammasome-microbiota interplay in host physiologies
    • 2 Ayres, J.S., Inflammasome-microbiota interplay in host physiologies. Cell Host Microbe 14 (2013), 491–497.
    • (2013) Cell Host Microbe , vol.14 , pp. 491-497
    • Ayres, J.S.1
  • 3
    • 33748367018 scopus 로고    scopus 로고
    • A proposed classification of the immunological diseases
    • 3 McGonagle, D., McDermott, M.F., A proposed classification of the immunological diseases. PLoS Med, 3, 2006, e297.
    • (2006) PLoS Med , vol.3 , pp. e297
    • McGonagle, D.1    McDermott, M.F.2
  • 5
    • 0033515520 scopus 로고    scopus 로고
    • Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
    • 5 McDermott, M.F., Aksentijevich, I., Galon, J., McDermott, E.M., Ogunkolade, B.W., Centola, M., et al. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97 (1999), 133–144.
    • (1999) Cell , vol.97 , pp. 133-144
    • McDermott, M.F.1    Aksentijevich, I.2    Galon, J.3    McDermott, E.M.4    Ogunkolade, B.W.5    Centola, M.6
  • 6
    • 16944365196 scopus 로고    scopus 로고
    • A candidate gene for familial Mediterranean fever
    • 6 French FMF Consortium. A candidate gene for familial Mediterranean fever. Nat Genet 17 (1997), 25–31.
    • (1997) Nat Genet , vol.17 , pp. 25-31
  • 7
    • 0030745449 scopus 로고    scopus 로고
    • Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever
    • 7 International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90 (1997), 797–807.
    • (1997) Cell , vol.90 , pp. 797-807
  • 8
    • 0036899758 scopus 로고    scopus 로고
    • De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases
    • 8 Aksentijevich, I., Nowak, M., Mallah, M., Chae, J.J., Watford, W.T., Hofmann, S.R., et al. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum 46 (2002), 3340–3348.
    • (2002) Arthritis Rheum , vol.46 , pp. 3340-3348
    • Aksentijevich, I.1    Nowak, M.2    Mallah, M.3    Chae, J.J.4    Watford, W.T.5    Hofmann, S.R.6
  • 9
    • 0034774916 scopus 로고    scopus 로고
    • Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever
    • 9 Hoffman, H.M., Wanderer, A.A., Broide, D.H., Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol 108 (2001), 615–620.
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 615-620
    • Hoffman, H.M.1    Wanderer, A.A.2    Broide, D.H.3
  • 10
    • 79956299492 scopus 로고    scopus 로고
    • Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1beta activation and severe autoinflammation in mice
    • 10 Chae, J.J., Cho, Y.H., Lee, G.S., Cheng, J., Liu, P.P., Feigenbaum, L., et al. Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1beta activation and severe autoinflammation in mice. Immunity 34 (2011), 755–768.
    • (2011) Immunity , vol.34 , pp. 755-768
    • Chae, J.J.1    Cho, Y.H.2    Lee, G.S.3    Cheng, J.4    Liu, P.P.5    Feigenbaum, L.6
  • 11
  • 12
    • 84922464191 scopus 로고    scopus 로고
    • Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
    • 12 Nakagawa, K., Gonzalez-Roca, E., Souto, A., Kawai, T., Umebayashi, H., Campistol, J.M., et al. Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes. Ann Rheum Dis 74 (2015), 603–610.
    • (2015) Ann Rheum Dis , vol.74 , pp. 603-610
    • Nakagawa, K.1    Gonzalez-Roca, E.2    Souto, A.3    Kawai, T.4    Umebayashi, H.5    Campistol, J.M.6
  • 13
    • 80155148684 scopus 로고    scopus 로고
    • High incidence of NLRP3 somatic mosaicism in chronic infantile neurological cutaneous and articular syndrome patients: the results of an international multicenter collaborative study
    • 13 Tanaka, N., Izawa, K., Saito, M.K., Sakuma, M., Oshima, K., Ohara, O., et al. High incidence of NLRP3 somatic mosaicism in chronic infantile neurological cutaneous and articular syndrome patients: the results of an international multicenter collaborative study. Arthritis Rheum 63 (2011), 3625–3632.
    • (2011) Arthritis Rheum , vol.63 , pp. 3625-3632
    • Tanaka, N.1    Izawa, K.2    Saito, M.K.3    Sakuma, M.4    Oshima, K.5    Ohara, O.6
  • 14
    • 84937609176 scopus 로고    scopus 로고
    • Brief report: cryopyrin-associated periodic syndrome caused by a myeloid-restricted somatic NLRP3 mutation
    • 14 Zhou, Q., Aksentijevich, I., Wood, G.M., Walts, A.D., Hoffmann, P., Remmers, E.F., et al. Brief report: cryopyrin-associated periodic syndrome caused by a myeloid-restricted somatic NLRP3 mutation. Arthritis Rheumatol 67 (2015), 2482–2486.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2482-2486
    • Zhou, Q.1    Aksentijevich, I.2    Wood, G.M.3    Walts, A.D.4    Hoffmann, P.5    Remmers, E.F.6
  • 15
    • 84868475244 scopus 로고    scopus 로고
    • Clinical impact of MEFV mutations in children with periodic fever in a prevalent western European Caucasian population
    • 15 Federici, S., Calcagno, G., Finetti, M., Gallizzi, R., Meini, A., Vitale, A., et al. Clinical impact of MEFV mutations in children with periodic fever in a prevalent western European Caucasian population. Ann Rheum Dis 71 (2012), 1961–1965.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1961-1965
    • Federici, S.1    Calcagno, G.2    Finetti, M.3    Gallizzi, R.4    Meini, A.5    Vitale, A.6
  • 16
    • 84921454539 scopus 로고    scopus 로고
    • A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants
    • 16 Rieber, N., Gavrilov, A., Hofer, L., Singh, A., Oz, H., Endres, T., et al. A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants. Clin Immunol 157 (2015), 56–64.
    • (2015) Clin Immunol , vol.157 , pp. 56-64
    • Rieber, N.1    Gavrilov, A.2    Hofer, L.3    Singh, A.4    Oz, H.5    Endres, T.6
  • 17
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • 17 Martinon, F., Burns, K., Tschopp, J., The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10 (2002), 417–426.
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 19
    • 0034520137 scopus 로고    scopus 로고
    • The PYRIN domain: a novel motif found in apoptosis and inflammation proteins
    • 19 Bertin, J., DiStefano, P.S., The PYRIN domain: a novel motif found in apoptosis and inflammation proteins. Cell Death Differ 7 (2000), 1273–1274.
    • (2000) Cell Death Differ , vol.7 , pp. 1273-1274
    • Bertin, J.1    DiStefano, P.S.2
  • 20
    • 0035916324 scopus 로고    scopus 로고
    • The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation
    • 20 Martinon, F., Hofmann, K., Tschopp, J., The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol 11 (2001), R118–R120.
    • (2001) Curr Biol , vol.11 , pp. R118-R120
    • Martinon, F.1    Hofmann, K.2    Tschopp, J.3
  • 21
    • 0037108346 scopus 로고    scopus 로고
    • Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains
    • 21 Harton, J.A., Linhoff, M.W., Zhang, J., Ting, J.P., Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol 169 (2002), 4088–4093.
    • (2002) J Immunol , vol.169 , pp. 4088-4093
    • Harton, J.A.1    Linhoff, M.W.2    Zhang, J.3    Ting, J.P.4
  • 22
    • 80051650525 scopus 로고    scopus 로고
    • Defects of pattern recognition: primary immunodeficiencies of the innate immune system
    • 22 Netea, M.G., van de Veerdonk, F.L., van Deuren, M., van der Meer, J.W., Defects of pattern recognition: primary immunodeficiencies of the innate immune system. Curr Opin Pharmacol 11 (2011), 412–422.
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 412-422
    • Netea, M.G.1    van de Veerdonk, F.L.2    van Deuren, M.3    van der Meer, J.W.4
  • 23
    • 85018193025 scopus 로고    scopus 로고
    • Why does the gout attack stop? A roadmap for the immune pathogenesis of gout
    • 23 Schett, G., Schauer, C., Hoffmann, M., Herrmann, M., Why does the gout attack stop? A roadmap for the immune pathogenesis of gout. RMD Open, 1, 2015, e000046.
    • (2015) RMD Open , vol.1 , pp. e000046
    • Schett, G.1    Schauer, C.2    Hoffmann, M.3    Herrmann, M.4
  • 24
    • 84904692363 scopus 로고    scopus 로고
    • The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation
    • 24 Franklin, B.S., Bossaller, L., De Nardo, D., Ratter, J.M., Stutz, A., Engels, G., et al. The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation. Nat Immunol 15 (2014), 727–737.
    • (2014) Nat Immunol , vol.15 , pp. 727-737
    • Franklin, B.S.1    Bossaller, L.2    De Nardo, D.3    Ratter, J.M.4    Stutz, A.5    Engels, G.6
  • 26
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • 26 Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J., Alnemri, E.S., AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458 (2009), 509–513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 27
    • 63649133278 scopus 로고    scopus 로고
    • AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    • 27 Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D.R., et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458 (2009), 514–518.
    • (2009) Nature , vol.458 , pp. 514-518
    • Hornung, V.1    Ablasser, A.2    Charrel-Dennis, M.3    Bauernfeind, F.4    Horvath, G.5    Caffrey, D.R.6
  • 28
    • 84907270863 scopus 로고    scopus 로고
    • Innate immune sensing of bacterial modifications of Rho GTPases by the pyrin inflammasome
    • 28 Xu, H., Yang, J., Gao, W., Li, L., Li, P., Zhang, L., et al. Innate immune sensing of bacterial modifications of Rho GTPases by the pyrin inflammasome. Nature 513 (2014), 237–241.
    • (2014) Nature , vol.513 , pp. 237-241
    • Xu, H.1    Yang, J.2    Gao, W.3    Li, L.4    Li, P.5    Zhang, L.6
  • 29
    • 37549041954 scopus 로고    scopus 로고
    • Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
    • 29 Sutterwala, F.S., Mijares, L.A., Li, L., Ogura, Y., Kazmierczak, B.I., Flavell, R.A., Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med 204 (2007), 3235–3245.
    • (2007) J Exp Med , vol.204 , pp. 3235-3245
    • Sutterwala, F.S.1    Mijares, L.A.2    Li, L.3    Ogura, Y.4    Kazmierczak, B.I.5    Flavell, R.A.6
  • 30
    • 34247252063 scopus 로고    scopus 로고
    • The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model
    • 30 Aksentijevich, I., D Putnam, C., Remmers, E.F., Mueller, J.L., Le, J., Kolodner, R.D., et al. The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum 56 (2007), 1273–1285.
    • (2007) Arthritis Rheum , vol.56 , pp. 1273-1285
    • Aksentijevich, I.1    D Putnam, C.2    Remmers, E.F.3    Mueller, J.L.4    Le, J.5    Kolodner, R.D.6
  • 31
    • 84922375101 scopus 로고    scopus 로고
    • Myeloid lineage-restricted somatic mosaicism of NLRP3 mutations in patients with variant Schnitzler syndrome
    • 31 de Koning, H.D., van Gijn, M.E., Stoffels, M., Jongekrijg, J., Zeeuwen, P.L., Elferink, M.G., et al. Myeloid lineage-restricted somatic mosaicism of NLRP3 mutations in patients with variant Schnitzler syndrome. J Allergy Clin Immunol 135 (2015), 561–564.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 561-564
    • de Koning, H.D.1    van Gijn, M.E.2    Stoffels, M.3    Jongekrijg, J.4    Zeeuwen, P.L.5    Elferink, M.G.6
  • 32
    • 23444439667 scopus 로고    scopus 로고
    • IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients
    • 32 Stack, J.H., Beaumont, K., Larsen, P.D., Straley, K.S., Henkel, G.W., Randle, J.C., et al. IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol 175 (2005), 2630–2634.
    • (2005) J Immunol , vol.175 , pp. 2630-2634
    • Stack, J.H.1    Beaumont, K.2    Larsen, P.D.3    Straley, K.S.4    Henkel, G.W.5    Randle, J.C.6
  • 33
    • 77953105116 scopus 로고    scopus 로고
    • Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretion
    • 33 Tassi, S., Carta, S., Delfino, L., Caorsi, R., Martini, A., Gattorno, M., et al. Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretion. Proc Natl Acad Sci U S A 107 (2010), 9789–9794.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9789-9794
    • Tassi, S.1    Carta, S.2    Delfino, L.3    Caorsi, R.4    Martini, A.5    Gattorno, M.6
  • 34
    • 66949115474 scopus 로고    scopus 로고
    • Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
    • 34 Brydges, S.D., Mueller, J.L., McGeough, M.D., Pena, C.A., Misaghi, A., Gandhi, C., et al. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30 (2009), 875–887.
    • (2009) Immunity , vol.30 , pp. 875-887
    • Brydges, S.D.1    Mueller, J.L.2    McGeough, M.D.3    Pena, C.A.4    Misaghi, A.5    Gandhi, C.6
  • 35
    • 66949175347 scopus 로고    scopus 로고
    • A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
    • 35 Meng, G., Zhang, F., Fuss, I., Kitani, A., Strober, W., A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 30 (2009), 860–874.
    • (2009) Immunity , vol.30 , pp. 860-874
    • Meng, G.1    Zhang, F.2    Fuss, I.3    Kitani, A.4    Strober, W.5
  • 37
    • 84927126118 scopus 로고    scopus 로고
    • An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
    • 37 Canna, S.W., de Jesus, A.A., Gouni, S., Brooks, S.R., Marrero, B., Liu, Y., et al. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat Genet 46 (2014), 1140–1146.
    • (2014) Nat Genet , vol.46 , pp. 1140-1146
    • Canna, S.W.1    de Jesus, A.A.2    Gouni, S.3    Brooks, S.R.4    Marrero, B.5    Liu, Y.6
  • 39
    • 84911922142 scopus 로고    scopus 로고
    • An inherited mutation in NLRC4 causes autoinflammation in human and mice
    • 39 Kitamura, A., Sasaki, Y., Abe, T., Kano, H., Yasutomo, K., An inherited mutation in NLRC4 causes autoinflammation in human and mice. J Exp Med 211 (2014), 2385–2396.
    • (2014) J Exp Med , vol.211 , pp. 2385-2396
    • Kitamura, A.1    Sasaki, Y.2    Abe, T.3    Kano, H.4    Yasutomo, K.5
  • 40
    • 84940453310 scopus 로고    scopus 로고
    • Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
    • 40 Kim, M.L., Chae, J.J., Park, Y.H., De Nardo, D., Stirzaker, R.A., Ko, H.J., et al. Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β. J Exp Med 212 (2015), 927–938.
    • (2015) J Exp Med , vol.212 , pp. 927-938
    • Kim, M.L.1    Chae, J.J.2    Park, Y.H.3    De Nardo, D.4    Stirzaker, R.A.5    Ko, H.J.6
  • 41
    • 78650006414 scopus 로고    scopus 로고
    • Clinical, molecular, and genetic characteristics of PAPA syndrome: a review
    • 41 Smith, E.J., Allantaz, F., Bennett, L., Zhang, D., Gao, X., Wood, G., et al. Clinical, molecular, and genetic characteristics of PAPA syndrome: a review. Curr Genomics 11 (2010), 519–527.
    • (2010) Curr Genomics , vol.11 , pp. 519-527
    • Smith, E.J.1    Allantaz, F.2    Bennett, L.3    Zhang, D.4    Gao, X.5    Wood, G.6
  • 42
    • 84857458569 scopus 로고    scopus 로고
    • Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH)—a new autoinflammatory syndrome distinct from PAPA syndrome
    • 42 Braun-Falco, M., Kovnerystyy, O., Lohse, P., Ruzicka, T., Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH)—a new autoinflammatory syndrome distinct from PAPA syndrome. J Am Acad Dermatol 66 (2012), 409–415.
    • (2012) J Am Acad Dermatol , vol.66 , pp. 409-415
    • Braun-Falco, M.1    Kovnerystyy, O.2    Lohse, P.3    Ruzicka, T.4
  • 43
    • 85028275682 scopus 로고    scopus 로고
    • Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases
    • 43 Holzinger, D., Fassl, S.K., de Jager, W., Lohse, P., Rohrig, U.F., Gattorno, M., et al. Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. J Allergy Clin Immunol 136 (2015), 1337–1345.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 1337-1345
    • Holzinger, D.1    Fassl, S.K.2    de Jager, W.3    Lohse, P.4    Rohrig, U.F.5    Gattorno, M.6
  • 44
    • 35348934890 scopus 로고    scopus 로고
    • Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants
    • 44 Yu, J.W., Fernandes-Alnemri, T., Datta, P., Wu, J., Juliana, C., Solorzano, L., et al. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell 28 (2007), 214–227.
    • (2007) Mol Cell , vol.28 , pp. 214-227
    • Yu, J.W.1    Fernandes-Alnemri, T.2    Datta, P.3    Wu, J.4    Juliana, C.5    Solorzano, L.6
  • 45
    • 79952184583 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
    • 45 Bulua, A.C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K.Y., et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 208 (2011), 519–533.
    • (2011) J Exp Med , vol.208 , pp. 519-533
    • Bulua, A.C.1    Simon, A.2    Maddipati, R.3    Pelletier, M.4    Park, H.5    Kim, K.Y.6
  • 46
    • 77953089570 scopus 로고    scopus 로고
    • Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome
    • 46 Simon, A., Park, H., Maddipati, R., Lobito, A.A., Bulua, A.C., Jackson, A.J., et al. Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Proc Natl Acad Sci U S A 107 (2010), 9801–9806.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9801-9806
    • Simon, A.1    Park, H.2    Maddipati, R.3    Lobito, A.A.4    Bulua, A.C.5    Jackson, A.J.6
  • 47
    • 84907487955 scopus 로고    scopus 로고
    • Unprenylated RhoA contributes to IL-1β hypersecretion in mevalonate kinase deficiency model through stimulation of Rac1 activity
    • 47 van der Burgh, R., Pervolaraki, K., Turkenburg, M., Waterham, H.R., Frenkel, J., Boes, M., Unprenylated RhoA contributes to IL-1β hypersecretion in mevalonate kinase deficiency model through stimulation of Rac1 activity. J Biol Chem 289 (2014), 27757–27765.
    • (2014) J Biol Chem , vol.289 , pp. 27757-27765
    • van der Burgh, R.1    Pervolaraki, K.2    Turkenburg, M.3    Waterham, H.R.4    Frenkel, J.5    Boes, M.6
  • 48
    • 84899144232 scopus 로고    scopus 로고
    • Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds
    • 48 Tricarico, P.M., Kleiner, G., Valencic, E., Campisciano, G., Girardelli, M., Crovella, S., et al. Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. Int J Mol Sci 15 (2014), 6843–6856.
    • (2014) Int J Mol Sci , vol.15 , pp. 6843-6856
    • Tricarico, P.M.1    Kleiner, G.2    Valencic, E.3    Campisciano, G.4    Girardelli, M.5    Crovella, S.6
  • 50
    • 84863232739 scopus 로고    scopus 로고
    • Mutations in proteasome subunit beta type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity
    • 50 Liu, Y., Ramot, Y., Torrelo, A., Paller, A.S., Si, N., Babay, S., et al. Mutations in proteasome subunit beta type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity. Arthritis Rheum 64 (2012), 895–907.
    • (2012) Arthritis Rheum , vol.64 , pp. 895-907
    • Liu, Y.1    Ramot, Y.2    Torrelo, A.3    Paller, A.S.4    Si, N.5    Babay, S.6
  • 52
    • 84949599562 scopus 로고    scopus 로고
    • Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
    • 52 Zhou, Q., Wang, H., Schwartz, D.M., Stoffels, M., Park, Y.H., Zhang, Y., et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet 48 (2016), 67–73.
    • (2016) Nat Genet , vol.48 , pp. 67-73
    • Zhou, Q.1    Wang, H.2    Schwartz, D.M.3    Stoffels, M.4    Park, Y.H.5    Zhang, Y.6
  • 53
    • 84927779736 scopus 로고    scopus 로고
    • NLRP3 at the interface of metabolism and inflammation
    • 53 Haneklaus, M., O'Neill, L.A., NLRP3 at the interface of metabolism and inflammation. Immunol Rev 265 (2015), 53–62.
    • (2015) Immunol Rev , vol.265 , pp. 53-62
    • Haneklaus, M.1    O'Neill, L.A.2
  • 55
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • 55 Martinon, F., Petrilli, V., Mayor, A., Tardivel, A., Tschopp, J., Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (2006), 237–241.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 57
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • 57 Duewell, P., Kono, H., Rayner, K.J., Sirois, C.M., Vladimer, G., Bauernfeind, F.G., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464 (2010), 1357–1361.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1    Kono, H.2    Rayner, K.J.3    Sirois, C.M.4    Vladimer, G.5    Bauernfeind, F.G.6
  • 58
    • 47849085872 scopus 로고    scopus 로고
    • The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
    • 58 Halle, A., Hornung, V., Petzold, G.C., Stewart, C.R., Monks, B.G., Reinheckel, T., et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9 (2008), 857–865.
    • (2008) Nat Immunol , vol.9 , pp. 857-865
    • Halle, A.1    Hornung, V.2    Petzold, G.C.3    Stewart, C.R.4    Monks, B.G.5    Reinheckel, T.6
  • 59
    • 77956958947 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    • 59 Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol 11 (2010), 897–904.
    • (2010) Nat Immunol , vol.11 , pp. 897-904
    • Masters, S.L.1    Dunne, A.2    Subramanian, S.L.3    Hull, R.L.4    Tannahill, G.M.5    Sharp, F.A.6
  • 60
    • 0016251282 scopus 로고
    • Colchicine therapy for familial mediterranean fever. A double-blind trial
    • 60 Dinarello, C.A., Wolff, S.M., Goldfinger, S.E., Dale, D.C., Alling, D.W., Colchicine therapy for familial mediterranean fever. A double-blind trial. N Engl J Med 291 (1974), 934–937.
    • (1974) N Engl J Med , vol.291 , pp. 934-937
    • Dinarello, C.A.1    Wolff, S.M.2    Goldfinger, S.E.3    Dale, D.C.4    Alling, D.W.5
  • 61
    • 0015519154 scopus 로고
    • Colchicine for familial Mediterranean fever
    • 61 Goldfinger, S.E., Colchicine for familial Mediterranean fever. N Engl J Med, 287, 1972, 1302.
    • (1972) N Engl J Med , vol.287 , pp. 1302
    • Goldfinger, S.E.1
  • 62
    • 84955730816 scopus 로고    scopus 로고
    • Colchicine—update on mechanisms of action and therapeutic uses
    • 62 Leung, Y.Y., Yao Hui, L.L., Kraus, V.B., Colchicine—update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum 45 (2015), 341–350.
    • (2015) Semin Arthritis Rheum , vol.45 , pp. 341-350
    • Leung, Y.Y.1    Yao Hui, L.L.2    Kraus, V.B.3
  • 63
    • 0037295409 scopus 로고    scopus 로고
    • Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein, and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in tumour necrosis factor receptor associated periodic syndrome (TRAPS): clinical and laboratory findings in a series of seven patients
    • 63 Drewe, E., McDermott, E.M., Powell, P.T., Isaacs, J.D., Powell, R.J., Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein, and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in tumour necrosis factor receptor associated periodic syndrome (TRAPS): clinical and laboratory findings in a series of seven patients. Rheumatology (Oxford) 42 (2003), 235–239.
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 235-239
    • Drewe, E.1    McDermott, E.M.2    Powell, P.T.3    Isaacs, J.D.4    Powell, R.J.5
  • 64
    • 0034921664 scopus 로고    scopus 로고
    • Treatment of TRAPS with etanercept: use in pediatrics
    • 64 Nigrovic, P.A., Sundel, R.P., Treatment of TRAPS with etanercept: use in pediatrics. Clin Exp Rheumatol 19 (2001), 484–485.
    • (2001) Clin Exp Rheumatol , vol.19 , pp. 484-485
    • Nigrovic, P.A.1    Sundel, R.P.2
  • 65
    • 0037792866 scopus 로고    scopus 로고
    • Interleukin-1-receptor antagonist in the Muckle-Wells syndrome
    • 65 Hawkins, P.N., Lachmann, H.J., McDermott, M.F., Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med 348 (2003), 2583–2584.
    • (2003) N Engl J Med , vol.348 , pp. 2583-2584
    • Hawkins, P.N.1    Lachmann, H.J.2    McDermott, M.F.3
  • 66
    • 8444225132 scopus 로고    scopus 로고
    • Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
    • 66 Hoffman, H.M., Rosengren, S., Boyle, D.L., Cho, J.Y., Nayar, J., Mueller, J.L., et al. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 364 (2004), 1779–1785.
    • (2004) Lancet , vol.364 , pp. 1779-1785
    • Hoffman, H.M.1    Rosengren, S.2    Boyle, D.L.3    Cho, J.Y.4    Nayar, J.5    Mueller, J.L.6
  • 67
    • 33845686908 scopus 로고    scopus 로고
    • Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations
    • 67 Leslie, K.S., Lachmann, H.J., Bruning, E., McGrath, J.A., Bybee, A., Gallimore, J.R., et al. Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations. Arch Dermatol 142 (2006), 1591–1597.
    • (2006) Arch Dermatol , vol.142 , pp. 1591-1597
    • Leslie, K.S.1    Lachmann, H.J.2    Bruning, E.3    McGrath, J.A.4    Bybee, A.5    Gallimore, J.R.6
  • 68
    • 40549122679 scopus 로고    scopus 로고
    • Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up
    • 68 Ross, J.B., Finlayson, L.A., Klotz, P.J., Langley, R.G., Gaudet, R., Thompson, K., et al. Use of anakinra (Kineret) in the treatment of familial cold autoinflammatory syndrome with a 16-month follow-up. J Cutan Med Surg 12 (2008), 8–16.
    • (2008) J Cutan Med Surg , vol.12 , pp. 8-16
    • Ross, J.B.1    Finlayson, L.A.2    Klotz, P.J.3    Langley, R.G.4    Gaudet, R.5    Thompson, K.6
  • 69
    • 84863228835 scopus 로고    scopus 로고
    • Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes
    • 69 Sibley, C.H., Plass, N., Snow, J., Wiggs, E.A., Brewer, C.C., King, K.A., et al. Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease treated with anakinra: a cohort study to determine three- and five-year outcomes. Arthritis Rheum 64 (2012), 2375–2386.
    • (2012) Arthritis Rheum , vol.64 , pp. 2375-2386
    • Sibley, C.H.1    Plass, N.2    Snow, J.3    Wiggs, E.A.4    Brewer, C.C.5    King, K.A.6
  • 71
    • 33845807104 scopus 로고    scopus 로고
    • Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis
    • 71 Cailliez, M., Garaix, F., Rousset-Rouviere, C., Bruno, D., Kone-Paut, I., Sarles, J., et al. Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis. J Inherit Metab Dis, 29, 2006, 763.
    • (2006) J Inherit Metab Dis , vol.29 , pp. 763
    • Cailliez, M.1    Garaix, F.2    Rousset-Rouviere, C.3    Bruno, D.4    Kone-Paut, I.5    Sarles, J.6
  • 72
    • 84941994738 scopus 로고    scopus 로고
    • Treatment of colchicine-resistant Familial Mediterranean fever in children and adolescents
    • 72 Eroglu, F.K., Besbas, N., Topaloglu, R., Ozen, S., Treatment of colchicine-resistant Familial Mediterranean fever in children and adolescents. Rheumatol Int 35 (2015), 1733–1737.
    • (2015) Rheumatol Int , vol.35 , pp. 1733-1737
    • Eroglu, F.K.1    Besbas, N.2    Topaloglu, R.3    Ozen, S.4
  • 73
    • 84983108468 scopus 로고    scopus 로고
    • On-demand treatment with anakinra: a treatment option for selected TRAPS patients
    • 73 Grimwood, C., Despert, V., Jeru, I., Hentgen, V., On-demand treatment with anakinra: a treatment option for selected TRAPS patients. Rheumatology (Oxford) 54 (2015), 1749–1751.
    • (2015) Rheumatology (Oxford) , vol.54 , pp. 1749-1751
    • Grimwood, C.1    Despert, V.2    Jeru, I.3    Hentgen, V.4
  • 74
    • 71149101614 scopus 로고    scopus 로고
    • Therapy of autoinflammatory syndromes
    • 74 Hoffman, H.M., Therapy of autoinflammatory syndromes. J Allergy Clin Immunol 124 (2009), 1129–1140.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 1129-1140
    • Hoffman, H.M.1
  • 75
    • 49449094179 scopus 로고    scopus 로고
    • Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies
    • 75 Hoffman, H.M., Throne, M.L., Amar, N.J., Sebai, M., Kivitz, A.J., Kavanaugh, A., et al. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum 58 (2008), 2443–2452.
    • (2008) Arthritis Rheum , vol.58 , pp. 2443-2452
    • Hoffman, H.M.1    Throne, M.L.2    Amar, N.J.3    Sebai, M.4    Kivitz, A.J.5    Kavanaugh, A.6
  • 76
    • 84868313379 scopus 로고    scopus 로고
    • Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial
    • 76 Hashkes, P.J., Spalding, S.J., Giannini, E.H., Huang, B., Johnson, A., Park, G., et al. Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial. Ann Intern Med 157 (2012), 533–541.
    • (2012) Ann Intern Med , vol.157 , pp. 533-541
    • Hashkes, P.J.1    Spalding, S.J.2    Giannini, E.H.3    Huang, B.4    Johnson, A.5    Park, G.6
  • 77
    • 84942107560 scopus 로고    scopus 로고
    • A 24-month open-label study of canakinumab in neonatal-onset multisystem inflammatory disease
    • 77 Sibley, C.H., Chioato, A., Felix, S., Colin, L., Chakraborty, A., Plass, N., et al. A 24-month open-label study of canakinumab in neonatal-onset multisystem inflammatory disease. Ann Rheum Dis 74 (2015), 1714–1719.
    • (2015) Ann Rheum Dis , vol.74 , pp. 1714-1719
    • Sibley, C.H.1    Chioato, A.2    Felix, S.3    Colin, L.4    Chakraborty, A.5    Plass, N.6
  • 78
    • 84941261493 scopus 로고    scopus 로고
    • Treatment of adult hyper-IgD syndrome with canakinumab
    • 78 Curtis, C.D., Fox, C.C., Treatment of adult hyper-IgD syndrome with canakinumab. J Allergy Clin Immunol Pract 3 (2015), 817–818.
    • (2015) J Allergy Clin Immunol Pract , vol.3 , pp. 817-818
    • Curtis, C.D.1    Fox, C.C.2
  • 79
    • 84945472265 scopus 로고    scopus 로고
    • Canakinumab efficacy and long-term tocilizumab administration in tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
    • 79 La Torre, F., Muratore, M., Vitale, A., Moramarco, F., Quarta, L., Cantarini, L., Canakinumab efficacy and long-term tocilizumab administration in tumor necrosis factor receptor-associated periodic syndrome (TRAPS). Rheumatol Int 35 (2015), 1943–1947.
    • (2015) Rheumatol Int , vol.35 , pp. 1943-1947
    • La Torre, F.1    Muratore, M.2    Vitale, A.3    Moramarco, F.4    Quarta, L.5    Cantarini, L.6
  • 80
    • 84880787644 scopus 로고    scopus 로고
    • Inhibition of HSP90 molecular chaperones: moving into the clinic
    • 80 Garcia-Carbonero, R., Carnero, A., Paz-Ares, L., Inhibition of HSP90 molecular chaperones: moving into the clinic. Lancet Oncol 14 (2013), e358–e369.
    • (2013) Lancet Oncol , vol.14 , pp. e358-e369
    • Garcia-Carbonero, R.1    Carnero, A.2    Paz-Ares, L.3
  • 81
    • 68949092245 scopus 로고    scopus 로고
    • Fungal zymosan and mannan activate the cryopyrin inflammasome
    • 81 Lamkanfi, M., Malireddi, R.K., Kanneganti, T.D., Fungal zymosan and mannan activate the cryopyrin inflammasome. J Biol Chem 284 (2009), 20574–20581.
    • (2009) J Biol Chem , vol.284 , pp. 20574-20581
    • Lamkanfi, M.1    Malireddi, R.K.2    Kanneganti, T.D.3
  • 82
    • 84937702457 scopus 로고    scopus 로고
    • Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and nonischemic injury in the mouse
    • 82 Marchetti, C., Toldo, S., Chojnacki, J., Mezzaroma, E., Liu, K., Salloum, F.N., et al. Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and nonischemic injury in the mouse. J Cardiovasc Pharmacol 66 (2015), 1–8.
    • (2015) J Cardiovasc Pharmacol , vol.66 , pp. 1-8
    • Marchetti, C.1    Toldo, S.2    Chojnacki, J.3    Mezzaroma, E.4    Liu, K.5    Salloum, F.N.6
  • 83
    • 84924415042 scopus 로고    scopus 로고
    • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
    • 83 Coll, R.C., Robertson, A.A., Chae, J.J., Higgins, S.C., Munoz-Planillo, R., Inserra, M.C., et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 21 (2015), 248–255.
    • (2015) Nat Med , vol.21 , pp. 248-255
    • Coll, R.C.1    Robertson, A.A.2    Chae, J.J.3    Higgins, S.C.4    Munoz-Planillo, R.5    Inserra, M.C.6
  • 84
    • 84924356420 scopus 로고    scopus 로고
    • The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
    • 84 Youm, Y.H., Nguyen, K.Y., Grant, R.W., Goldberg, E.L., Bodogai, M., Kim, D., et al. The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med 21 (2015), 263–269.
    • (2015) Nat Med , vol.21 , pp. 263-269
    • Youm, Y.H.1    Nguyen, K.Y.2    Grant, R.W.3    Goldberg, E.L.4    Bodogai, M.5    Kim, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.