Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells

European Journal of Immunology

Volumn 46, Issue 11, 2016, Pages 2574-2586

  Lachmandas, Ekta ^a   Beigier Bompadre, Macarena ^b   Cheng, Shih Chin ^a   Kumar, Vinod ^c   van Laarhoven, Arjan ^a   Wang, Xinhui ^a,d   Ammerdorffer, Anne ^a   Boutens, Lily ^a   de Jong, Dirk ^a   Kanneganti, Thirumala Devi ^e   Gresnigt, Mark S ^a   Ottenhoff, Tom H M ^f   Joosten, Leo A B ^a   Stienstra, Rinke ^a   Wijmenga, Cisca ^c   Kaufmann, Stefan H E ^b   van Crevel, Reinout ^a   Netea, Mihai G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d QINGHAI NORMAL UNIVERSITY   (China)

^e ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^f LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Glycolysis; Immunometabolism; mTOR; Mycobacterium tuberculosis; TLR2

Indexed keywords

ASCORBIC ACID; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD3 ANTIGEN; DEOXYGLUCOSE; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEXOKINASE; HEXOKINASE 3; INSULIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 6; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 3; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 5; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTOME; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WORTMANNIN; AKT1 PROTEIN, HUMAN; AKT1 PROTEIN, MOUSE; ANTIINFECTIVE AGENT; GLUCOSE; MTOR PROTEIN, HUMAN; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TLR2 PROTEIN, HUMAN; TLR2 PROTEIN, MOUSE;

ACIDIFICATION; AEROBIC GLYCOLYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD3+ T LYMPHOCYTE; CELL ACTIVATION; CELL ISOLATION; CELL METABOLISM; CELL STIMULATION; CITRIC ACID CYCLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; EX VIVO STUDY; FEMALE; GLUCOSE INTAKE; GLUCOSE METABOLISM; GLYCOLYSIS; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LACTATE BLOOD LEVEL; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TUBERCULOSIS; UPREGULATION; ANIMAL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; OXIDATIVE PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; GENE EXPRESSION PROFILING; GLUCOSE; GLYCOLYSIS; HOST-PATHOGEN INTERACTIONS; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MYCOBACTERIUM TUBERCULOSIS; OXIDATIVE PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; TOLL-LIKE RECEPTOR 2; TOR SERINE-THREONINE KINASES; TUBERCULOSIS;

EID: 84990181732     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201546259     Document Type: Article

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