Toll-Like Receptor 2-Deficient Mice Succumb to Mycobacterium tuberculosis Infection

American Journal of Pathology

Volumn 164, Issue 1, 2004, Pages 49-57

  Drennan, Michael B ^a,d   Nicolle, Delphine ^b   Quesniaux, Valerie J F ^b   Jacobs, Muazzam ^a   Allie, Nasiema ^a   Mpagi, Joseph ^a   Frémond, Cécile ^b   Wagner, Hermann ^c   Kirschning, Carsten ^c   Ryffel, Bernhard ^b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b CNRS   (France)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; CELL SURFACE RECEPTOR; CYTOKINE; MEMBRANE PROTEIN; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL CELL WALL; CONTROLLED STUDY; DISEASE ASSOCIATION; GRANULOMA; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; MACROPHAGE ACTIVATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE; TUBERCULOSIS; ANIMAL; CD4+ T LYMPHOCYTE; GENETICS; IMMUNOLOGY; LUNG; LYMPHOCYTE ACTIVATION; MICROBIOLOGY; PATHOLOGY; PERITONEUM MACROPHAGE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; LUNG; LYMPHOCYTE ACTIVATION; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MYCOBACTERIUM TUBERCULOSIS; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS; TUBERCULOSIS;

EID: 1542574298     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63095-7     Document Type: Article

References (46)

1. Flynn JL, Chan J: Immunology of tuberculosis. Annu Rev Immunol 2001, 19:93-129
2. Luster AD: The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 2002, 14:129-135
3. Takeda K, Kaisho T, Akira S: Toll-like receptors. Annu Rev Immunol 2003, 21:335-376
4. Underhill DM, Ozinsky A, Smith KD, Aderem A: Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci USA 1999, 96:14459-14463
5. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S: Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999, 11:443-451
6. Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 1999, 285: 732-736
7. Jones BW, Means TK, Heldwein KA, Keen MA, Hill PJ, Belisle JT, Fenton MJ: Different Toll-like receptor agonists induce distinct macrophage responses. J Leukoc Biol 2001, 69:1036-1044
8. Means TK, Wang S, Lien E, Yoshimura A, Golenbock DT, Fenton MJ: Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 1999, 163:3920-3927
9. Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ, Bloom BR, Modlin RL: Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001, 291:1544-1547
10. Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL: Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol 2000, 165:3804-3810
11. Hertz CJ, Kiertscher SM, Godowski PJ, Bouis DA, Norgard MV, Roth MD, Modlin RL: Microbial lipopeptides stimulate dendritic cell maturation via toll-like receptor 2. J Immunol 2001, 166:2444-2450
12. Noss EH, Pai RK, Sellati TJ, Radolf JD, Belisle J, Golenbock DT, Boom WH, Harding CV: Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis. J Immunol 2001, 167:910-918
13. Abel B, Thieblemont N, Quesniaux VJ, Brown N, Mpagi J, Miyake K, Bihl F, Ryffel B: Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 2002, 169:3155-3162
14. Reiling N, Holscher C, Fehrenbach A, Kroger S, Kirschning CJ, Goyert S, Ehlers S: Cutting edge: toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 2002, 169:3480-3484
15. Michelsen KS, Aicher A, Mohaupt M, Hartung T, Dimmeler S, Kirschning CJ, Schumann RR: The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2. J Biol Chem 2001, 276:25680-25686
16. Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old LJ: Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 1997, 94:8093-8098
17. Jacobs M, Marino MW, Brown N, Abel B, Bekker LG, Quesniaux VJ, Fick L, Ryffel B: Correction of defective host response to Mycobacterium bovis BCG infection in TNF-deficient mice by bone marrow transplantation. Lab Invest 2000, 80:901-914
18. Garcia I, Guler R, Vesin D, Olleros ML, Vassalli P, Chvatchko Y, Jacobs M, Ryffel B: Lethal Mycobacterium bovis Bacillus Calmette Guerin infection in nitric oxide synthase 2-deficient mice: cell-mediated immunity requires nitric oxide synthase 2. Lab Invest 2000, 80:1385-1397
19. Sallusto F, Lanzavecchia A: Mobilizing dendritic cells for tolerance, priming and chronic inflammation. J Exp Med 1999, 189:611-614
20. Holscher C, Kohler G, Muller U, Mossmann H, Schaub GA, Brombacher F: Defective nitric-oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in γ-interferon receptor or inducible nitric-oxide synthase. Infect Immun 1998, 66:1208-1215
21. Kirman J, McCoy K, Hook S, Prout M, Delahunt B, Orme I, Frank A, Le Gros G: CTLA-4 blockade enhances the immune response induced by mycobacterial infection but does not lead to increased protection. Infect Immun 1999, 67:3786-3792
22. Sousa CR, Hieny S, Scharton-Kersten T, Jankovic D, Charest H, Germain RN, Sher A: In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med 1997, 186:1819-1829
23. Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreiber R, Mak TW, Bloom BR: Tumor necrosis factor-α is required in the protective immune response against M. tuberculosis in mice. Immunity 1995, 2:561-572
24. Liu YJ: Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 2001, 106:259-262
25. Stenger S, Modlin RL: Control of Mycobacterium tuberculosis through mammalian Toll-like receptors. Curr Opin Immunol 2002, 14:452-457
26. Means TK, Jones BW, Schromm AB, Shurtleff BA, Smith JA, Keane J, Golenbock DT, Vogel SN, Fenton MJ: Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses. J Immunol 2001, 166:4074-4082
27. Kamath AB, Alt J, Debbabi H, Behar SM: Toll-like receptor 4-defective C3H/HeJ mice are not more susceptible than other C3H substrains to infection with Mycobacterium tuberculosis. Infect Immun 2003, 71: 4112-4118
28. Bulut Y, Faure E, Thomas L, Equils O, Arditi M: Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol 2001, 167:987-994
29. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S: Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002, 169: 10-14
30. Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM: Cutting edge: immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol 2002, 168:1533-1537
31. Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K: Plasmodium berghei infection in mice induces liver injury by an IL-12-and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol 2001, 167:5928-5934
32. Takeuchi O, Hoshino K, Akira S: Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol 2000, 165:5392-5396
33. Wooten RM, Ma Y, Yoder RA, Brown JP, Weis JH, Zachary JF, Kirschning CJ, Weis JJ: Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdoderi. J Immunol 2002, 168:348-355
34. Wolfs TG, Buurman WA, van Schadewijk A, de Vries B, Daemen MA, Hiemstra PS, van 't Veer C: In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J Immunol 2002, 168:1286-1293
35. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R: Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001, 2:947-950
36. Flesch IE, Hess JH, Oswald IP, Kaufmann SH: Growth inhibition of Mycobacterium bovis by IFN-gamma stimulated macrophages: regulation by endogenous tumor necrosis factor-alpha and by IL-10. Int Immunol 1994, 6:693-700
37. Flesch IE, Kaufmann SH: Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4, and tumor necrosis factor. Infect Immun 1990, 58:2675-2677
38. Chan J, Xing Y, Magliozzo RS, Bloom BR: Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J Exp Med 1992, 175:1111-1122
39. Roach DR, Bean AG, Demangel C, France MP, Briscoe H, Britton WJ: TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J Immunol 2002, 168:4620-4627
40. Jacobs M, Brown N, Allie N, Ryffel B: Fatal Mycobacterium bovis BCG infection in TNF-LT-alpha-deficient mice. Clin Immunol 2000, 94:192-199
41. Bean AG, Roach DR, Briscoe H, France MP, Korner H, Sedgwick JD, Britton WJ: Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin. J Immunol 1999, 162:3504-3511
42. Moreira AL, Tsenova-Berkova L, Wang J, Laochumroonvorapong P, Freeman S, Freedman VH, Kaplan G: Effect of cytokine modulation by thalidomide on the granulomatous response in murine tuberculosis. Tuber Lung Dis 1997, 78:47-55
43. Rook GAW, Taverne J, Leveton C, Steele J: The role of gamma-interferon, vitamin D3 metabolites and tumour necrosis factor in the pathogenesis of tuberculosis. Immunology 1987, 62:229-234
44. Moreira AL, Tsenova L, Aman MH, Bekker LG, Freeman S, Mangaliso B, Schroder U, Jagirdar J, Rom WN, Tovey MG, Freedman VH, Kaplan G: Mycobacterial antigens exacerbate disease manifestations in Mycobacterium tuberculosis-infected mice. Infect Immun 2002, 70:2100-2107
45. Engele M, Stossel E, Castiglione K, Schwerdtner N, Wagner M, Bolcskei P, Rollinghoff M, Stenger S: Induction of TNF in human alveolar macrophages as a potential evasion mechanism of virulent Mycobacterium tuberculosis. J Immunol 2002, 168:1328-1337
46. + T cells and could be an efficient vaccine target. J Immunol 2003, 171:32-36