Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages

BMC Biochemistry

Volumn 15, Issue 1, 2014, Pages

  Zullo, Alfred J ^a,b   Jurcic Smith, Kristen L ^a   Lee, Sunhee ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Autophagy; Bacille Calmette Gu rin (BCG); Inhibitors; M. tuberculosis; mTOR; Mycobacteria

Indexed keywords

AUTOPHAGY PROTEIN 5; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; TORIN 1; TORIN 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERIAL VIABILITY; BACTERICIDAL ACTIVITY; COLONY FORMING UNIT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM EXPOSURE; MACROPHAGE; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; SHORT COURSE THERAPY;

CORYNEBACTERINEAE; MAMMALIA; MURINAE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; AUTOPHAGY; CELL LINE; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; MYCOBACTERIUM SMEGMATIS; NAPHTHYRIDINES; PROTEIN KINASE INHIBITORS; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84896697458     PISSN: None     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/1471-2091-15-4     Document Type: Article

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