EHHM, a novel phenolic natural product from Livistona chinensis, induces autophagy-related apoptosis in hepatocellular carcinoma cells

Oncology Letters

Volumn 12, Issue 5, 2016, Pages 3739-3748

  Cheng, Xinsheng ^a,b   Zhong, Feng ^a   He, Kun ^a   Sun, Shibo ^a   Chen, Hongbo ^c   Zhou, Jie ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b The 6th Affiliated Hospital of Shenzhen University Health Science Center   (China)

^c TSINGHUA UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; EHHM; Hepatocellular carcinoma

Indexed keywords

LIVISTONA CHINENSIS EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROLIFERATION ASSAY; CELL VIABILITY ASSAY; COLONY FORMATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; LIVER CELL CARCINOMA; MICROSCOPY; MORPHOLOGY; MORTALITY; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; TUMOR XENOGRAFT; WESTERN BLOTTING;

EID: 84990046257     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2016.5178     Document Type: Article

References (55)

1. Chen JG and Zhang SW: Liver cancer epidemic in China: Past, present and future. Semin Cancer Biol 21: 59-69, 2011.
2. Bei CH, Bai H, Yu HP, Yang Y, Liang QQ, Deng YY, Tan SK and Qiu XQ: Combined effects of six cytokine gene polymorphisms and SNP-SNP interactions on hepatocellular carcinoma risk in southern guangxi, china. Asian Pac J Cancer Prev 15: 6961-6967, 2014.
3. Liu HZ, Peng J, Peng CY, Yan M and Zheng F: Glutathione S-transferase M1 null genotype and hepatocellular carcinoma susceptibility in china and india: Evidence from an updated meta-analysis. Asian Pac J Cancer Prev 15: 4851-4856, 2014.
4. Fattovich G, Stroffolini T, Zagni I and Donato F: Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology 127 (5 Suppl 1): S35-S50, 2004.
5. Bruix J and Sherman M; American Association for the Study of Liver Diseases: Management of hepatocellular carcinoma: An update. Hepatology 53: 1020-1022, 2011.
6. Lin GN, Jiang XM, Peng JW, Xiao JJ, Liu DY and Xia ZJ: Prognostic significance of the peripheral blood absolute monocyte count in patients with locally advanced or metastatic hepatocellular carcinoma receiving systemic chemotherapy. Asian Pac J Cancer Prev 15: 6387-6390, 2014.
7. Cheung S and Tai J: In vitro studies of the dry fruit of Chinese fan palm Livistona chinensis. Oncol Rep 14: 1331-1336, 2005.
8. Kaur G and Singh RP: Antibacterial and membrane damaging activity of livistona chinensis fruit extract. Food Chem Toxicol 46: 2429-2434, 2008.
9. Zeng X, Wang Y, Qiu Q, Jiang C, Jing Y, Qiu G and He X: Bioactive phenolics from the fruits of Livistona chinensis. Fitoterapia 83: 104-109, 2012.
10. Singh R and Kaur G: Hemolytic activity of aqueous extract of Livistona chinensis fruits. Food Chem Toxicol 46: 553-556, 2008.
11. Zhang YX, Abliz G, Ye WJ, Mutalipu Z, Li XW, Wang HQ, Buranjiang G and Upur H: Mechanisms of hela cell apoptosis induced by abnormal Savda Munziq total phenolics combined with chemotherapeutic agents. Asian Pac J Cancer Prev 15: 743-747, 2014.
12. Xu H, Tian YN, Dun BY, Liu HT, Dong GK, Wang JH, Lu SS, Chen B and She JX: A novel monoclonal antibody induces cancer cell apoptosis and enhances the activity of chemotherapeutic drugs. Asian Pac J Cancer Prev 15: 4423-4428, 2014.
13. Wang CD, Yuan CF, Bu YQ, Wu XM, Wan JY, Zhang L, Hu N, Liu XJ, Zu Y, Liu GL and Song FZ: Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev 15: 769-773, 2014.
14. Wang YX, Cai H, Jiang G, Zhou TB and Wu H: Silibinin inhibits proliferation, induces apoptosis and causes cell cycle arrest in human gastric cancer MGC803 cells via STAT3 pathway inhibition. Asian Pac J Cancer Prev 15: 6791-6798, 2014.
15. Lowe SW and Lin AW: Apoptosis in cancer. Carcinogenesis 21: 485-95, 2000.
16. Chen H, Zeng X, Gao C, Ming P, Zhang J, Guo C, Zhou L, Lu Y, Wang L, Huang L, et al: A new arylbenzofuran derivative functions as an anti-tumour agent by inducing DNA damage and inhibiting PARP activity. Sci Rep 5: 10893, 2015.
17. Hsin IL, Ou CC, Wu TC, Jan MS, Wu MF, Chiu LY, Lue KH and Ko JL: GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells. Autophagy 7: 873-882, 2011.
18. Sun J, Zhang C, Bao YL, Wu Y, Chen ZL, Yu CL, Huang YX, Sun Y, Zheng LH, Wang X and Li YX: Parthenolide-induced apoptosis, autophagy and suppression of proliferation in HepG2 cells. Asian Pac J Cancer Prev 15: 4897-4902, 2014.
19. Luo GX, Cai J, Lin JZ, Luo WS, Luo HS, Jiang YY and Zhang Y: Autophagy inhibition promotes gambogic acid-induced suppression of growth and apoptosis in glioblastoma cells. Asian Pac J Cancer Prev 13: 6211-6216, 2012.
20. Mathew R, Karantza-Wadsworth V and White E: Role of autophagy in cancer. Nat Rev Cancer 7: 961-967, 2007.
21. Schweichel JU and Merker HJ: The morphology of various types of cell death in prenatal tissues. Teratology 7: 253-266, 1973.
22. Levine B and Klionsky DJ: Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477, 2004.
23. Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y and Kondo S: Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 11: 448-457, 2004.
24. Cui Q, Tashiro S, Onodera S, Minami M and Ikejima T: Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull 30: 859-864, 2007.
25. Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Bianchi K, Fehrenbacher N, Elling F, Rizzuto R, et al: Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell 25: 193-205, 2007.
26. Lee JY, Lee YM, Chang GC, Yu SL, Hsieh WY, Chen JJ, Chen HW and Yang PC: Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: The versatile adjuvant for gefitinib therapy. PLos One 6: e23756, 2011.
27. Fang HT, Zhang B, Pan XF, Gao L, Zhen T, Zhao HX, Ma L, Xie J, Liu Z, Yu XJ, et al: Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated. Proc Natl Acad Sci USA 109: 2521-2526, 2012.
28. Lennartsson J, Ma H, Wardega P, Pelka K, Engström U, Hellberg C and Heldin CH: The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar and tumor growth in vivo. J Biol Chem 288: 15736-15744, 2013.
29. Zhao YH, Wang T, Yu GF, Zhuang DM, Zhang Z, Zhang HX, Zhao DP and Yu AL: Anti-proliferation effects of interferon-gamma on gastric cancer cells. Asian Pac J Cancer Prev 14: 5513-5518, 2013.
30. Yao G, Yang L, Hu Y, Liang J, Liang J and Hou Y: Nonylphenol-induced thymocyte apoptosis involved caspase-3 activation and mitochondrial depolarization. Mol Immunol 43: 915-926, 2006.
31. Yang L, Zhou X, Yang J, Yin X, Han L and Zhao D: Aspirin inhibits cytotoxicity of prion peptide PrP106-126 to neuronal cells associated with microglia activation in vitro. J Neuroimmunol 199: 10-17, 2008.
32. Zhang G, Gurtu V, Kain SR and Yan G: Early detection of apoptosis using a fluorescent conjugate of annexin V. Biotechniques 23: 525-531, 1997.
33. Wei H, Li Z, Hu S, Chen X and Cong X: Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. J Cell Biochem 111: 967-978, 2010.
34. Walsh DM, Tseng BP, Rydel RE, Podlisny MB and Selkoe DJ: The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry 39: 10831-10839, 2000.
35. Liu Y, Cao W, Zhang B, Liu YQ, Wang ZY, Wu YP, Yu XJ, Zhang XD, Ming PH, Zhou GB and Huang L: The natural compound magnolol inhibits invasion and exhibits potential in human breast cancer therapy. Sci Rep 3: 3098, 2013.
36. Fernandes-Alnemri T, Litwack G and Alnemri ES: CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269: 30761-30764, 1994.
37. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43, 1995.
38. Mizushima N and Komatsu M: Autophagy: Renovation of cells and tissues. Cell 147: 728-741, 2011.
39. He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, et al: Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem 278: 29278-29287, 2003.
40. Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y and Yoshimori T: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 117: 2805-2812, 2004.
41. Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N and Yue Z: Distinct regulation of autophagic activity by Atg14L and rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 11: 468-476, 2009.
42. Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, et al: Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 280: 20722-20729, 2005.
43. Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Sato S, Ishikawa K, et al: Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 7: 176-187, 2011.
44. White E: Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 12: 401-410, 2012.
45. Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P and Shen HM: Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285: 10850-10861, 2010.
46. Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R and Tashiro Y: Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct Funct 23: 33-42, 1998.
47. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
48. Pourhoseingholi MA, Fazeli Z, Zali MR and Alavian SM: Burden of hepatocellular carcinoma in Iran; Bayesian projection and trend analysis. Asian Pac J Cancer Prev 11: 859-862, 2010.
49. Norsa’adah B and Nurhazalini-Zayani CG: Epidemiology and survival of hepatocellular carcinoma in north-east Peninsular Malaysia. Asian Pac J Cancer Prev 14: 6955-6959, 2013.
50. Arzumanyan A, Reis Hm and Feitelson MA: Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer 13: 123-135, 2013.
51. Kondo Y, Kanzawa T, Sawaya R and Kondo S: The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 726-734, 2005.
52. Apel A, Herr I, Schwarz H, Rodemann HP and Mayer A: Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 68: 1485-1494, 2008.
53. Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D and Yahalom J: A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61: 439-444, 2001.
54. Kanzawa T, Kondo Y, Ito H, Kondo S and Germano I: Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 63: 2103-2108, 2003.
55. Boya P, González-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D, Souquere S, Yoshimori T, et al: Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 25: 1025-1040, 2005.