Aspirin inhibits cytotoxicity of prion peptide PrP106-126 to neuronal cells associated with microglia activation in vitro

Journal of Neuroimmunology

Volumn 199, Issue 1-2, 2008, Pages 10-17

  Yang, Lifeng ^a   Zhou, Xiangmei ^a   Yang, Jianmin ^a   Yin, Xiaomin ^a   Han, Lifang ^a   Zhao, Deming ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Aspirin; Cytokines; Microglia; Neuron; NF B; PrP106 126

Indexed keywords

ACETYLSALICYLIC ACID; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PRION PROTEIN; PRION PROTEIN[106-126]; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; MICROGLIA; MOUSE; NERVE CELL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; CELLS, CULTURED; HUMANS; INTERLEUKIN-1BETA; MICE; MICROGLIA; NEURONS; NF-KAPPA B; PEPTIDE FRAGMENTS; PRIONS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 47549115787     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2008.04.028     Document Type: Article

References (36)

1. Ashikawa K., Majumdar S., Banerjee S., Bharti A.C., Shishodia S., and Aggarwal B.B. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J. Immunol. 169 (2002) 6490-6497
2. Baeuerle P.A., and Henkel T. Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12 (1994) 141-179
3. Baker C.A., and Manuelidis L. Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 675-679
4. Bales K.R., Du Y., Dodel R.C., Yan G.M., Hamilton-Byrd E., and Paul S.M. The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation. Brain Res. Mol. Brain Res. 57 (1998) 63-72
5. Bonifati D.M., and Kishore U. Role of complement in neurodegeneration and neuroinflammation. Mol. Immunol. 44 (2007) 999-1010
6. Brown D.R., Schmidt B., and Kretzschmar H.A. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 380 (1996) 345-347
7. Ciesielski-Treska J., Grant N.J., Ulrich G., Corrotte M., Bailly Y., Haeberle A.M., Chasserot-Golaz S., and Bader M.F. Fibrillar prion peptide (106-126) and scrapie prion protein hamper phagocytosis in microglia. Glia 46 (2004) 101-115
8. Dash P.K., and Moore A.N. Enhanced processing of APP induced by IL-1 beta can be reduced by indomethacin and nordihydroguaiaretic acid. Biochem. Biophys. Res. Commun. 208 (1995) 542-548
9. Dheen S.T., Kaur C., and Ling E.A. Microglial activation and its implications in the brain diseases. Curr. Med. Chem. 14 (2007) 1189-1197
10. Fabrizi C., Silei V., Menegazzi M., Salmona M., Bugiani O., Tagliavini F., Suzuki H., and Lauro G.M. The stimulation of inducible nitric-oxide synthase by the prion protein fragment 106-126 in human microglia is tumor necrosis factor-alpha-dependent and involves p38 mitogen-activated protein kinase. J. Biol. Chem. 276 (2001) 25692-25696
11. Forloni G., Angeretti N., Chiesa R., Monzani E., Salmona M., Bugiani O., and Tagliavini F. Neurotoxicity of a prion protein fragment. Nature 362 (1993) 543-546
12. Garcao P., Oliveira C.R., and Agostinho P. Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration. J. Neurosci. Res. 84 (2006) 182-193
13. Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16 (1998) 225-260
14. Ghoshal A., Das S., Ghosh S., Mishra M.K., Sharma V., Koli P., Sen E., and Basu A. Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 55 (2007) 483-496
15. Giese A., Brown D.R., Groschup M.H., Feldmann C., Haist I., and Kretzschmar H.A. Role of microglia in neuronal cell death in prion disease. Brain Pathol. 8 (1998) 449-457
16. Grilli M., Pizzi M., Memo M., and Spano P. Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274 (1996) 1383-1385
17. Higuchi Y., Otsu K., Nishida K., Hirotani S., Nakayama H., Yamaguchi O., Matsumura Y., Ueno H., Tada M., and Hori M. Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy. J. Mol. Cell. Cardiol. 34 (2002) 233-240
18. Iacobelli M., Rohwer F., Shanahan P., Quiroz J.A., and McGuire K.L. IL-2-mediated cell cycle progression and inhibition of apoptosis does not require NF-kappa B or activating protein-1 activation in primary human T cells. J. Immunol. 162 (1999) 3308-3315
19. Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 18 (2000) 621-663
20. Kim J.I., Ju W.K., Choi J.H., Choi E., Carp R.I., Wisniewski H.M., and Kim Y.S. Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice. Brain Res. Mol. Brain Res. 73 (1999) 17-27
21. Konturek P.C., Bazela K., Kukharskyy V., Bauer M., Hahn E.G., and Schuppan D. Helicobacter pylori upregulates prion protein expression in gastric mucosa: a possible link to prion disease. World J. Gastroenterol. 11 (2005) 7651-7656
22. Liu B., and Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304 (2003) 1-7
23. Marella M., and Chabry J. Neurons and astrocytes respond to prion infection by inducing microglia recruitment. J. Neurosci. 24 (2004) 620-627
24. Muhleisen H., Gehrmann J., and Meyermann R. Reactive microglia in Creutzfeldt-Jakob disease. Neuropathol. Appl. Neurobiol. 21 (1995) 505-517
25. Peyrin J.M., Lasmezas C.I., Haik S., Tagliavini F., Salmona M., Williams A., Richie D., Deslys J.P., and Dormont D. Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines. Neuroreport 10 (1999) 723-729
26. Prusiner S.B. Prions. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13363-13383
27. Rao P., Hsu K.C., and Chao M.V. Upregulation of NF-kappa B-dependent gene expression mediated by the p75 tumor necrosis factor receptor. J. Interferon Cytokine Res. 15 (1995) 171-177
28. Safar J., Roller P.P., Gajdusek D.C., and Gibbs Jr. C.J. Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein. J. Biol. Chem. 268 (1993) 20276-20284
29. Schmedtje Jr. J.F., Ji Y.S., Liu W.L., DuBois R.N., and Runge M.S. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 272 (1997) 601-608
30. Shepard L.W., Yang M., Xie P., Browning D.D., Voyno-Yasenetskaya T., Kozasa T., and Ye R.D. Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA. J. Biol. Chem. 276 (2001) 45979-45987
31. Streit W.J. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40 (2002) 133-139
32. Uryu M., Karino A., Kamihara Y., and Horiuchi M. Characterization of prion susceptibility in Neuro2a mouse neuroblastoma cell subclones. Microbiol. Immunol. 51 (2007) 661-669
33. van Loo G., De Lorenzi R., Schmidt H., Huth M., Mildner A., Schmidt-Supprian M., Lassmann H., Prinz M.R., and Pasparakis M. Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat. Immunol. 7 (2006) 954-961
34. Veerhuis R., Boshuizen R.S., and Familian A. Amyloid associated proteins in Alzheimer's and prion disease. Curr. Drug Targets, CNS Neurol. Disord. 4 (2005) 235-248
35. Yao J., Keri J.E., Taffs R.E., and Colton C.A. Characterization of interleukin-1 production by microglia in culture. Brain. Res. 591 (1992) 88-93
36. Yin M.J., Yamamoto Y., and Gaynor R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396 (1998) 77-80