메뉴 건너뛰기




Volumn 241, Issue , 2016, Pages 174-185

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

Author keywords

Exosomes; Extracellular vesicles; Microvesicles; Therapeutic delivery

Indexed keywords

CONTROLLED DRUG DELIVERY;

EID: 84989172766     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.09.016     Document Type: Review
Times cited : (145)

References (141)
  • 1
    • 39649120532 scopus 로고    scopus 로고
    • A review of stimuli-responsive nanocarriers for drug and gene delivery
    • [1] Ganta, S., Devalapally, H., Shahiwala, A., Amiji, M., A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Control. Release 126:3 (2008), 187–204, 10.1016/j.jconrel.2007.12.017.
    • (2008) J. Control. Release , vol.126 , Issue.3 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amiji, M.4
  • 2
    • 68949208465 scopus 로고    scopus 로고
    • Nanocarriers' entry into the cell: relevance to drug delivery
    • [2] Hillaireau, H., Couvreur, P., Nanocarriers' entry into the cell: relevance to drug delivery. Cell. Mol. Life Sci. 66:17 (2009), 2873–2896, 10.1007/s00018-009-0053-z.
    • (2009) Cell. Mol. Life Sci. , vol.66 , Issue.17 , pp. 2873-2896
    • Hillaireau, H.1    Couvreur, P.2
  • 3
    • 84864324577 scopus 로고    scopus 로고
    • A review of nanocarriers for the delivery of small interfering RNA
    • [3] Kesharwani, P., Gajbhiye, V., Jain, N.K., A review of nanocarriers for the delivery of small interfering RNA. Biomaterials 33:29 (2012), 7138–7150, 10.1016/j.biomaterials.2012.06.068.
    • (2012) Biomaterials , vol.33 , Issue.29 , pp. 7138-7150
    • Kesharwani, P.1    Gajbhiye, V.2    Jain, N.K.3
  • 4
    • 77955175216 scopus 로고    scopus 로고
    • Strategies in the design of nanoparticles for therapeutic applications
    • [4] Petros, R.A., JM, D.S., Strategies in the design of nanoparticles for therapeutic applications. Nat. Rev. Drug Discov. 9:8 (2010), 615–627, 10.1038/nrd2591.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.8 , pp. 615-627
    • Petros, R.A.1    JM, D.S.2
  • 5
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: entering the mainstream
    • [5] Allen, T.M., Cullis, P.R., Drug delivery systems: entering the mainstream. Science 303:5665 (2004), 1818–1822, 10.1126/science.1095833.
    • (2004) Science , vol.303 , Issue.5665 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 6
    • 0347365764 scopus 로고    scopus 로고
    • An overview of current delivery systems in cancer gene therapy
    • [6] El-Aneed, A., An overview of current delivery systems in cancer gene therapy. J. Control. Release 94:1 (2004), 1–14, 10.1016/j.jconrel.2003.09.013.
    • (2004) J. Control. Release , vol.94 , Issue.1 , pp. 1-14
    • El-Aneed, A.1
  • 7
    • 84862704697 scopus 로고    scopus 로고
    • Virus-mediated gene delivery for human gene therapy
    • [7] Giacca, M., Zacchigna, S., Virus-mediated gene delivery for human gene therapy. J. Control. Release 161:2 (2012), 377–388, 10.1016/j.jconrel.2012.04.008.
    • (2012) J. Control. Release , vol.161 , Issue.2 , pp. 377-388
    • Giacca, M.1    Zacchigna, S.2
  • 8
    • 0035965501 scopus 로고    scopus 로고
    • Gene delivery with synthetic (nonviral) carriers
    • [8] Brown, M.D., Schätzlein, A.G., Uchegbu, I.F., Gene delivery with synthetic (nonviral) carriers. Int. J. Pharm. 229:1–2 (2001), 1–21, 10.1016/S0378-5173(01)00861-4.
    • (2001) Int. J. Pharm. , vol.229 , Issue.1-2 , pp. 1-21
    • Brown, M.D.1    Schätzlein, A.G.2    Uchegbu, I.F.3
  • 9
    • 84905903250 scopus 로고    scopus 로고
    • ScienceDirect bioactive nanocarbon assemblies: nanoarchitectonics and applications
    • [9] Nakanishi, W., Minami, K., Kumar, L., Ji, Q., Hill, J.P., Ariga, K., ScienceDirect bioactive nanocarbon assemblies: nanoarchitectonics and applications. Nano Today 9:3 (2014), 378–394, 10.1016/j.nantod.2014.05.002.
    • (2014) Nano Today , vol.9 , Issue.3 , pp. 378-394
    • Nakanishi, W.1    Minami, K.2    Kumar, L.3    Ji, Q.4    Hill, J.P.5    Ariga, K.6
  • 10
    • 84924559595 scopus 로고    scopus 로고
    • Current advances in lanthanide ion (Ln3 +)-based upconversion nanomaterials for drug delivery
    • [10] Yang, D., Ma, P., Hou, Z., Cheng, Z., Li, C., Lin, J., Current advances in lanthanide ion (Ln3 +)-based upconversion nanomaterials for drug delivery. Royal Society of Chemistry, 2015, 10.1039/C4CS00155A.
    • (2015) Royal Society of Chemistry
    • Yang, D.1    Ma, P.2    Hou, Z.3    Cheng, Z.4    Li, C.5    Lin, J.6
  • 11
    • 84908149812 scopus 로고    scopus 로고
    • Bioinspired nanoarchitectonics as emerging drug delivery systems
    • [11] Ariga, K., Kawakami, K., Ebara, M., Kotsuchibashi, Y., Ji, Q., Hill, J.P., Bioinspired nanoarchitectonics as emerging drug delivery systems. New J. Chem. 38:11 (2014), 5149–5163, 10.1039/C4NJ00864B.
    • (2014) New J. Chem. , vol.38 , Issue.11 , pp. 5149-5163
    • Ariga, K.1    Kawakami, K.2    Ebara, M.3    Kotsuchibashi, Y.4    Ji, Q.5    Hill, J.P.6
  • 12
    • 84971655160 scopus 로고    scopus 로고
    • Application of liposomes in medicine and drug delivery
    • [12] Daraee, H., Etemadi, A., Kouhi, M., et al. Application of liposomes in medicine and drug delivery. Artif Cells, Nanomedicine, Biotechnol. 44:1 (2016), 381–391, 10.3109/21691401.2014.953633.
    • (2016) Artif Cells, Nanomedicine, Biotechnol. , vol.44 , Issue.1 , pp. 381-391
    • Daraee, H.1    Etemadi, A.2    Kouhi, M.3
  • 13
    • 84961223487 scopus 로고
    • Rational design of liposomal drug delivery systems, a review: combined experimental and computational studies of lipidmembranes, liposomes and their PEGylation
    • [13] Bunker, A., Magarkar, A., Viitala, T., Rational design of liposomal drug delivery systems, a review: combined experimental and computational studies of lipidmembranes, liposomes and their PEGylation. Biochim. Biophys. Acta 2016 (1858), 2334–2352, 10.1016/j.bbamem.2016.02.025.
    • (1858) Biochim. Biophys. Acta , vol.2016 , pp. 2334-2352
    • Bunker, A.1    Magarkar, A.2    Viitala, T.3
  • 14
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • [14] Thomas, C.E., Ehrhardt, A., Kay, M.A., Progress and problems with the use of viral vectors for gene therapy. Nat. Rev. Genet. 4:5 (2003), 346–358, 10.1038/nrg1066.
    • (2003) Nat. Rev. Genet. , vol.4 , Issue.5 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 15
    • 33746438424 scopus 로고    scopus 로고
    • Toxicity of cationic lipids and cationic polymers in gene delivery
    • [15] Lv, H., Zhang, S., Wang, B., Cui, S., Yan, J., Toxicity of cationic lipids and cationic polymers in gene delivery. J. Control. Release 114:1 (2006), 100–109, 10.1016/j.jconrel.2006.04.014.
    • (2006) J. Control. Release , vol.114 , Issue.1 , pp. 100-109
    • Lv, H.1    Zhang, S.2    Wang, B.3    Cui, S.4    Yan, J.5
  • 16
    • 84960201366 scopus 로고    scopus 로고
    • PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
    • [16] Suk, J.S., Xu, Q., Kim, N., Hanes, J., Ensign, L.M., PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv. Drug Deliv. Rev. 99 (2016), 28–51, 10.1016/j.addr.2015.09.012.
    • (2016) Adv. Drug Deliv. Rev. , vol.99 , pp. 28-51
    • Suk, J.S.1    Xu, Q.2    Kim, N.3    Hanes, J.4    Ensign, L.M.5
  • 17
    • 84887501695 scopus 로고    scopus 로고
    • Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials
    • [17] Silva, A.K.A., Di Corato, R., Pellegrino, T., et al. Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials. Nanoscale 5:23 (2013), 11374–11384, 10.1039/c3nr01541f.
    • (2013) Nanoscale , vol.5 , Issue.23 , pp. 11374-11384
    • Silva, A.K.A.1    Di Corato, R.2    Pellegrino, T.3
  • 19
    • 84955203483 scopus 로고    scopus 로고
    • A novel platform for cancer therapy using extracellular vesicles
    • [19] Tominaga, N., Yoshioka, Y., Ochiya, T., A novel platform for cancer therapy using extracellular vesicles. Adv. Drug Deliv. Rev. 95 (2015), 50–55, 10.1016/j.addr.2015.10.002.
    • (2015) Adv. Drug Deliv. Rev. , vol.95 , pp. 50-55
    • Tominaga, N.1    Yoshioka, Y.2    Ochiya, T.3
  • 20
    • 84957603483 scopus 로고    scopus 로고
    • Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles
    • [20] Zhang, B., Wee, R., Yeo, Y., Tan, K.H., SK, L., Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles. 2016, 10.3390/ijms17020174.
    • (2016)
    • Zhang, B.1    Wee, R.2    Yeo, Y.3    Tan, K.H.4    SK, L.5
  • 21
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: composition, biogenesis and function
    • [21] Théry, C., Zitvogel, L., Amigorena, S., Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2:8 (2002), 569–579, 10.1038/nri855.
    • (2002) Nat. Rev. Immunol. , vol.2 , Issue.8 , pp. 569-579
    • Théry, C.1    Zitvogel, L.2    Amigorena, S.3
  • 22
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • [22] Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J.J., Lötvall, J.O., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9:6 (2007), 654–659, 10.1038/ncb1596.
    • (2007) Nat. Cell Biol. , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 23
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • [23] Tian, Y., Li, S., Song, J., et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 35:7 (2014), 2383–2390, 10.1016/j.biomaterials.2013.11.083.
    • (2014) Biomaterials , vol.35 , Issue.7 , pp. 2383-2390
    • Tian, Y.1    Li, S.2    Song, J.3
  • 24
    • 84922732779 scopus 로고    scopus 로고
    • Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine
    • [24] Lamichhane, T.N., Sokic, S., Schardt, J.S., Raiker, R.S., Lin, J.W., Jay, S.M., Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Eng Part B Rev. 21:1 (2015), 45–54, 10.1089/ten.teb.2014.0300.
    • (2015) Tissue Eng Part B Rev. , vol.21 , Issue.1 , pp. 45-54
    • Lamichhane, T.N.1    Sokic, S.2    Schardt, J.S.3    Raiker, R.S.4    Lin, J.W.5    Jay, S.M.6
  • 25
    • 84938094261 scopus 로고    scopus 로고
    • Cell or cell membrane-based drug delivery systems
    • [25] Tan, S., Wu, T., Zhang, D., Zhang, Z., Cell or cell membrane-based drug delivery systems. Theranostics. 5:8 (2015), 863–881, 10.7150/thno.11852.
    • (2015) Theranostics. , vol.5 , Issue.8 , pp. 863-881
    • Tan, S.1    Wu, T.2    Zhang, D.3    Zhang, Z.4
  • 26
    • 84861079568 scopus 로고    scopus 로고
    • Elucidating membrane structure and protein behavior using giant plasma membrane vesicles
    • [26] Sezgin, E., Kaiser, H.-J., Baumgart, T., Schwille, P., Simons, K., Levental, I., Elucidating membrane structure and protein behavior using giant plasma membrane vesicles. Nat. Protoc. 7:6 (2012), 1042–1051, 10.1038/nprot.2012.059.
    • (2012) Nat. Protoc. , vol.7 , Issue.6 , pp. 1042-1051
    • Sezgin, E.1    Kaiser, H.-J.2    Baumgart, T.3    Schwille, P.4    Simons, K.5    Levental, I.6
  • 27
    • 85027949556 scopus 로고    scopus 로고
    • Determination of the lowest concentrations of aldehyde fixatives for completely fixing various cellular structures by real-time imaging and quantification
    • [27] Zeng, F., Yang, W., Huang, J., Chen, Y., Chen, Y., Determination of the lowest concentrations of aldehyde fixatives for completely fixing various cellular structures by real-time imaging and quantification. Histochem. Cell Biol. 139:5 (2013), 735–749, 10.1007/s00418-012-1058-5.
    • (2013) Histochem. Cell Biol. , vol.139 , Issue.5 , pp. 735-749
    • Zeng, F.1    Yang, W.2    Huang, J.3    Chen, Y.4    Chen, Y.5
  • 28
    • 77956264919 scopus 로고    scopus 로고
    • A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    • [28] Sun, D., Zhuang, X., Xiang, X., et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol. Ther. 18:9 (2010), 1606–1614, 10.1038/mt.2010.105.
    • (2010) Mol. Ther. , vol.18 , Issue.9 , pp. 1606-1614
    • Sun, D.1    Zhuang, X.2    Xiang, X.3
  • 29
    • 84907228576 scopus 로고    scopus 로고
    • Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery
    • [29] Pascucci, L., Coccè, V., Bonomi, A., et al. Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery. J. Control. Release 192 (2014), 262–270, 10.1016/j.jconrel.2014.07.042.
    • (2014) J. Control. Release , vol.192 , pp. 262-270
    • Pascucci, L.1    Coccè, V.2    Bonomi, A.3
  • 30
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • [30] Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., Wood, M.J.A., Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29:4 (2011), 341–345, 10.1038/nbt.1807.
    • (2011) Nat. Biotechnol. , vol.29 , Issue.4 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.A.6
  • 31
    • 84878665716 scopus 로고    scopus 로고
    • The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
    • [31] Katsuda, T., Kosaka, N., Takeshita, F., Ochiya, T., The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics 13:10–11 (2013), 1637–1653, 10.1002/pmic.201200373.
    • (2013) Proteomics , vol.13 , Issue.10-11 , pp. 1637-1653
    • Katsuda, T.1    Kosaka, N.2    Takeshita, F.3    Ochiya, T.4
  • 32
    • 84938619192 scopus 로고    scopus 로고
    • Extracellular vesicles: commercial potential as byproducts of cell manufacturing for research and therapeutic use
    • [32] Smith, J.A., Ng, K.S., Mead, B.E., et al. Extracellular vesicles: commercial potential as byproducts of cell manufacturing for research and therapeutic use. Bioprocess Int. 13:4 (2015), 1–13.
    • (2015) Bioprocess Int. , vol.13 , Issue.4 , pp. 1-13
    • Smith, J.A.1    Ng, K.S.2    Mead, B.E.3
  • 33
    • 84937630931 scopus 로고    scopus 로고
    • Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges
    • [33] Fuhrmann, G., Herrmann, I.K., Stevens, M.M., Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges. Nano Today 10:3 (2015), 397–409, 10.1016/j.nantod.2015.04.004.
    • (2015) Nano Today , vol.10 , Issue.3 , pp. 397-409
    • Fuhrmann, G.1    Herrmann, I.K.2    Stevens, M.M.3
  • 34
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • [34] Vlassov, A.V., Magdaleno, S., Setterquist, R., Conrad, R., Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta, Gen. Subj. 1820:7 (2012), 940–948, 10.1016/j.bbagen.2012.03.017.
    • (2012) Biochim. Biophys. Acta, Gen. Subj. , vol.1820 , Issue.7 , pp. 940-948
    • Vlassov, A.V.1    Magdaleno, S.2    Setterquist, R.3    Conrad, R.4
  • 36
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: biology and emerging therapeutic opportunities
    • [36] EL Andaloussi, S., Mäger, I., Breakefield, X.O., Wood, M.J.A., Extracellular vesicles: biology and emerging therapeutic opportunities. Nat. Rev. Drug Discov. 12:5 (2013), 347–357, 10.1038/nrd3978.
    • (2013) Nat. Rev. Drug Discov. , vol.12 , Issue.5 , pp. 347-357
    • EL Andaloussi, S.1    Mäger, I.2    Breakefield, X.O.3    Wood, M.J.A.4
  • 37
    • 84862686204 scopus 로고    scopus 로고
    • Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery
    • [37] van Dommelen, S.M., Vader, P., Lakhal, S., et al. Microvesicles and exosomes: opportunities for cell-derived membrane vesicles in drug delivery. J. Control. Release 161:2 (2012), 635–644, 10.1016/j.jconrel.2011.11.021.
    • (2012) J. Control. Release , vol.161 , Issue.2 , pp. 635-644
    • van Dommelen, S.M.1    Vader, P.2    Lakhal, S.3
  • 38
  • 39
    • 79960944057 scopus 로고    scopus 로고
    • Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
    • [39] György, B., Szabó, T.G., Pásztói, M., et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 68:16 (2011), 2667–2688, 10.1007/s00018-011-0689-3.
    • (2011) Cell. Mol. Life Sci. , vol.68 , Issue.16 , pp. 2667-2688
    • György, B.1    Szabó, T.G.2    Pásztói, M.3
  • 40
    • 84858011488 scopus 로고    scopus 로고
    • Extracellular microvesicles: the need for internationally recognised nomenclature and stringent purification criteria
    • [40] J. Simpson, R., S., M., Extracellular microvesicles: the need for internationally recognised nomenclature and stringent purification criteria. J. Proteomics Bioinform., 5(2), 2012, 10000, 10.4172/jpb.10000e10.
    • (2012) J. Proteomics Bioinform. , vol.5 , Issue.2 , pp. 10000
    • J. Simpson, R.1
  • 41
    • 3142630225 scopus 로고    scopus 로고
    • Exosomes: endosomal-derived vesicles shipping extracellular messages
    • [41] Février, B., Raposo, G., Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16:4 (2004), 415–421, 10.1016/j.ceb.2004.06.003.
    • (2004) Curr. Opin. Cell Biol. , vol.16 , Issue.4 , pp. 415-421
    • Février, B.1    Raposo, G.2
  • 42
    • 33746886963 scopus 로고    scopus 로고
    • Systemic induction of the angiogenesis switch by the tetraspanin D6/CO-029
    • [42] Gesierich, S., Berezovskiy, I., Ryschich, E., Zo, M., Systemic induction of the angiogenesis switch by the tetraspanin D6/CO-029. Cancer Res. 66:14 (2006), 7083–7095, 10.1158/0008-5472.CAN-06-0391.
    • (2006) Cancer Res. , vol.66 , Issue.14 , pp. 7083-7095
    • Gesierich, S.1    Berezovskiy, I.2    Ryschich, E.3    Zo, M.4
  • 43
    • 0242525146 scopus 로고    scopus 로고
    • Exosomes bearing HLA-G are released by melanoma cells
    • [43] Riteau, B., Faure, F., Menier, C., et al. Exosomes bearing HLA-G are released by melanoma cells. Hum. Immunol. 64:11 (2003), 1064–1072, 10.1016/j.humimm.2003.08.344.
    • (2003) Hum. Immunol. , vol.64 , Issue.11 , pp. 1064-1072
    • Riteau, B.1    Faure, F.2    Menier, C.3
  • 44
    • 0034686667 scopus 로고    scopus 로고
    • Enrichment and localization of ganglioside G(D3) and caveolin-1 in shed tumor cell membrane vesicles
    • [44] Dolo, V., Li, R., Dillinger, M., et al. Enrichment and localization of ganglioside G(D3) and caveolin-1 in shed tumor cell membrane vesicles. Biochim. Biophys. Acta 1486:2–3 (2000), 265–274 http://www.ncbi.nlm.nih.gov/pubmed/10903477.
    • (2000) Biochim. Biophys. Acta , vol.1486 , Issue.2-3 , pp. 265-274
    • Dolo, V.1    Li, R.2    Dillinger, M.3
  • 45
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • [45] Akers, J.C., Gonda, D., Kim, R., Carter, B.S., Chen, C.C., Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J. Neuro-Oncol. 113:1 (2013), 1–11, 10.1007/s11060-013-1084-8.
    • (2013) J. Neuro-Oncol. , vol.113 , Issue.1 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3    Carter, B.S.4    Chen, C.C.5
  • 46
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • e11469
    • [46] Szajnik, M., Czystowska, M., Szczepanski, M.J., Mandapathil, M., Whiteside, T.L., Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One, 5(7), 2010, e11469, 10.1371/journal.pone.0011469.
    • (2010) PLoS One , vol.5 , Issue.7
    • Szajnik, M.1    Czystowska, M.2    Szczepanski, M.J.3    Mandapathil, M.4    Whiteside, T.L.5
  • 47
    • 20844458756 scopus 로고    scopus 로고
    • Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis
    • [47] Kim, S.H., Lechman, E.R., Bianco, N., et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J. Immunol. 174:10 (2005), 6440–6448, 10.4049/jimmunol.174.10.6440.
    • (2005) J. Immunol. , vol.174 , Issue.10 , pp. 6440-6448
    • Kim, S.H.1    Lechman, E.R.2    Bianco, N.3
  • 48
    • 79955571241 scopus 로고    scopus 로고
    • Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury
    • [48] Gatti, S., Bruno, S., Deregibus, M.C., et al. Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol. Dial. Transplant. 26:5 (2011), 1474–1483, 10.1093/ndt/gfr015.
    • (2011) Nephrol. Dial. Transplant. , vol.26 , Issue.5 , pp. 1474-1483
    • Gatti, S.1    Bruno, S.2    Deregibus, M.C.3
  • 49
    • 84864530691 scopus 로고    scopus 로고
    • Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells
    • [49] Cantaluppi, V., Gatti, S., Medica, D., et al. Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells. Kidney Int. 82:4 (2012), 412–427, 10.1038/ki.2012.105.
    • (2012) Kidney Int. , vol.82 , Issue.4 , pp. 412-427
    • Cantaluppi, V.1    Gatti, S.2    Medica, D.3
  • 50
    • 84862620981 scopus 로고    scopus 로고
    • Activated T cell exosomes promote tumor invasion via Fas signaling pathway
    • [50] Cai, Z., Yang, F., Yu, L., et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J. Immunol. 188:12 (2012), 5954–5961, 10.4049/jimmunol.1103466.
    • (2012) J. Immunol. , vol.188 , Issue.12 , pp. 5954-5961
    • Cai, Z.1    Yang, F.2    Yu, L.3
  • 51
    • 84858185865 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury
    • e33115
    • [51] Bruno, S., Grange, C., Collino, F., et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One, 7(3), 2012, e33115, 10.1371/journal.pone.0033115.
    • (2012) PLoS One , vol.7 , Issue.3
    • Bruno, S.1    Grange, C.2    Collino, F.3
  • 52
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    • [52] Ratajczak, J., Miekus, K., Kucia, M., et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20:5 (2006), 847–856, 10.1038/sj.leu.2404132.
    • (2006) Leukemia , vol.20 , Issue.5 , pp. 847-856
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3
  • 53
    • 79957538441 scopus 로고    scopus 로고
    • Exosome/microvesicle-mediated epigenetic reprogramming of cells
    • [53] Camussi, G., Deregibus, M., Bruno, S., Grange, C., Fonsato, V., Exosome/microvesicle-mediated epigenetic reprogramming of cells. Am. J. Cancer Res. 1:1 (2011), 98–110.
    • (2011) Am. J. Cancer Res. , vol.1 , Issue.1 , pp. 98-110
    • Camussi, G.1    Deregibus, M.2    Bruno, S.3    Grange, C.4    Fonsato, V.5
  • 54
    • 84866941540 scopus 로고    scopus 로고
    • Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes
    • [54] Wahlgren, J., Karlson, T.D.L., Brisslert, M., et al. Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes. Nucleic Acids Res., 40(17), 2012, e130, 10.1093/nar/gks463.
    • (2012) Nucleic Acids Res. , vol.40 , Issue.17 , pp. e130
    • Wahlgren, J.1    Karlson, T.D.L.2    Brisslert, M.3
  • 55
    • 33645315758 scopus 로고    scopus 로고
    • Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes
    • [55] Baj-Krzyworzeka, M., Szatanek, R., Weglarczyk, K., et al. Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes. Cancer Immunol. Immunother. 55:7 (2006), 808–818, 10.1007/s00262-005-0075-9.
    • (2006) Cancer Immunol. Immunother. , vol.55 , Issue.7 , pp. 808-818
    • Baj-Krzyworzeka, M.1    Szatanek, R.2    Weglarczyk, K.3
  • 56
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • [56] Liu, C., Yu, S., Zinn, K., et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J. Immunol. 176:3 (2006), 1375–1385, 10.4049/jimmunol.176.3.1375.
    • (2006) J. Immunol. , vol.176 , Issue.3 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn, K.3
  • 57
    • 84989183620 scopus 로고    scopus 로고
    • Immunological Tolerance: Methods and Protocols
    • Humana Press Inc. Totowa, NJ
    • [57] Fairchild, P.J., Immunological Tolerance: Methods and Protocols. 2007, Humana Press Inc., Totowa, NJ.
    • (2007)
    • Fairchild, P.J.1
  • 58
    • 79952159254 scopus 로고    scopus 로고
    • Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
    • e16899
    • [58] Hedlund, M., Nagaeva, O., Kargl, D., Baranov, V., Mincheva-Nilsson, L., Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells. PLoS One, 6(2), 2011, e16899, 10.1371/journal.pone.0016899.
    • (2011) PLoS One , vol.6 , Issue.2
    • Hedlund, M.1    Nagaeva, O.2    Kargl, D.3    Baranov, V.4    Mincheva-Nilsson, L.5
  • 59
    • 0037443410 scopus 로고    scopus 로고
    • Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo 1
    • [59] Skokos, D., Botros, H.G., Demeure, C., et al. Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo 1. J. Immunol. 170 (2003), 3037–3045, 10.4049/jimmunol.170.6.3037.
    • (2003) J. Immunol. , vol.170 , pp. 3037-3045
    • Skokos, D.1    Botros, H.G.2    Demeure, C.3
  • 60
    • 42749085108 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • [60] Théry, C., Clayton, A., Amigorena, S., Raposo, G., Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Current Protocols in Cell Biology, 2006, 3.22.1–3.22.29.
    • (2006) Current Protocols in Cell Biology , pp. 3.22.1-3.22.29
    • Théry, C.1    Clayton, A.2    Amigorena, S.3    Raposo, G.4
  • 61
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
    • [61] Witwer, K.W., Buza, E.I., Bernis, L.T., et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J. Extracell Vesicles. 2:20360 (2013), 1–25.
    • (2013) J. Extracell Vesicles. , vol.2 , Issue.20360 , pp. 1-25
    • Witwer, K.W.1    Buza, E.I.2    Bernis, L.T.3
  • 62
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    • [62] Tauro, B.J., Greening, D.W., Mathias, R.A., et al. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods 56 (2012), 293–304, 10.1016/j.ymeth.2012.01.002.
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1    Greening, D.W.2    Mathias, R.A.3
  • 63
    • 84888103828 scopus 로고    scopus 로고
    • Current methods for the isolation of extracellular vesicles
    • [63] Momen-heravi, F., Balaj, L., Alian, S., et al. Current methods for the isolation of extracellular vesicles. Biol. Chem. 394:10 (2013), 1253–1262, 10.1515/hsz-2013-0141.
    • (2013) Biol. Chem. , vol.394 , Issue.10 , pp. 1253-1262
    • Momen-heravi, F.1    Balaj, L.2    Alian, S.3
  • 64
    • 0037114287 scopus 로고    scopus 로고
    • Production and characterization of clinical grade exosomes derived from dendritic cells
    • [64] Lamparski, H.G., Metha-damani, A., Yao, J., et al. Production and characterization of clinical grade exosomes derived from dendritic cells. J. Imm. 270 (2002), 211–226.
    • (2002) J. Imm. , vol.270 , pp. 211-226
    • Lamparski, H.G.1    Metha-damani, A.2    Yao, J.3
  • 65
    • 85008708017 scopus 로고    scopus 로고
    • Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation
    • [65] Bobri, A., Colombo, M., Krumeich, S., Raposo, G., Thery, C., Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation., 1(18397), 2012, 1–11.
    • (2012) , vol.1 , Issue.18397 , pp. 1-11
    • Bobri, A.1    Colombo, M.2    Krumeich, S.3    Raposo, G.4    Thery, C.5
  • 66
    • 84867575631 scopus 로고    scopus 로고
    • Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers
    • [66] Alvarez, M.L., Khosroheidari, M., Ravi, R.K., Distefano, J.K., Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers. Kidney Int. 82 (2012), 1024–1032, 10.1038/ki.2012.256.
    • (2012) Kidney Int. , vol.82 , pp. 1024-1032
    • Alvarez, M.L.1    Khosroheidari, M.2    Ravi, R.K.3    Distefano, J.K.4
  • 67
    • 84923068135 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation and density gradient separation methods for isolating Tca8113 human tongue cancer cell line-derived exosomes
    • [67] Zhang, Z., Wang, C., Li, T., Zhe, L., Li, L., Comparison of ultracentrifugation and density gradient separation methods for isolating Tca8113 human tongue cancer cell line-derived exosomes. Oncol. Lett. 8 (2014), 1701–1706, 10.3892/ol.2014.2373.
    • (2014) Oncol. Lett. , vol.8 , pp. 1701-1706
    • Zhang, Z.1    Wang, C.2    Li, T.3    Zhe, L.4    Li, L.5
  • 69
    • 84899810743 scopus 로고    scopus 로고
    • Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes
    • [69] Kanwar, S.S., Dunlay, C.J., Simeone, D.M., Nagrath, S., Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes. Lab Chip 14 (2014), 1891–1900, 10.1039/c4lc00136b.
    • (2014) Lab Chip , vol.14 , pp. 1891-1900
    • Kanwar, S.S.1    Dunlay, C.J.2    Simeone, D.M.3    Nagrath, S.4
  • 70
    • 0013495952 scopus 로고    scopus 로고
    • Proteomic and biochemical analyses of human B cell-derived exosomes
    • [70] Wubbolts, R., Leckie, R.S., Veenhuizen, P.T.M., et al. Proteomic and biochemical analyses of human B cell-derived exosomes. J. Biol. Chem. 278:13 (2003), 10963–10972, 10.1074/jbc.M207550200.
    • (2003) J. Biol. Chem. , vol.278 , Issue.13 , pp. 10963-10972
    • Wubbolts, R.1    Leckie, R.S.2    Veenhuizen, P.T.M.3
  • 71
    • 0035166047 scopus 로고    scopus 로고
    • Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry
    • [71] Clayton, A., Court, J., Navabi, H., et al. Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry. J. Immunol. Methods 247 (2001), 163–174.
    • (2001) J. Immunol. Methods , vol.247 , pp. 163-174
    • Clayton, A.1    Court, J.2    Navabi, H.3
  • 72
    • 75749091133 scopus 로고    scopus 로고
    • Microfluidic isolation and transcriptome analysis of serum microvesicles
    • [72] Chen, C., Skog, J., Hsu, C.-H., et al. Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab Chip 10:4 (2010), 505–511, 10.1039/b916199f.
    • (2010) Lab Chip , vol.10 , Issue.4 , pp. 505-511
    • Chen, C.1    Skog, J.2    Hsu, C.-H.3
  • 73
    • 84906700936 scopus 로고    scopus 로고
    • Lab on a chip integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology
    • [73] He, M., Crow, J., Roth, M., Godwin, A.K., Lab on a chip integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab Chip 14 (2014), 3773–3780, 10.1039/C4LC00662C.
    • (2014) Lab Chip , vol.14 , pp. 3773-3780
    • He, M.1    Crow, J.2    Roth, M.3    Godwin, A.K.4
  • 74
    • 84870918654 scopus 로고    scopus 로고
    • Lab on a chip microfluidic filtration system to isolate extracellular vesicles from blood
    • [74] Davies, R.T., Kim, J., Jang, C., Choi, E., Gho, S., Park, J., Lab on a chip microfluidic filtration system to isolate extracellular vesicles from blood. Lab Chip 12 (2012), 5202–5210, 10.1039/c2lc41006k.
    • (2012) Lab Chip , vol.12 , pp. 5202-5210
    • Davies, R.T.1    Kim, J.2    Jang, C.3    Choi, E.4    Gho, S.5    Park, J.6
  • 75
    • 33748152342 scopus 로고    scopus 로고
    • Electrical forces for microscale cell manipulation
    • [75] Voldman, J., Electrical forces for microscale cell manipulation. Annu. Rev. Biomed. Eng. 8 (2006), 425–454, 10.1146/annurev.bioeng.8.061505.095739.
    • (2006) Annu. Rev. Biomed. Eng. , vol.8 , pp. 425-454
    • Voldman, J.1
  • 76
    • 84879926621 scopus 로고    scopus 로고
    • Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles
    • [76] Liu, Z.W., Wu, H., Fine, D., et al. Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. Lab Chip 13 (2013), 2879–2882, 10.1039/c3lc41343h.
    • (2013) Lab Chip , vol.13 , pp. 2879-2882
    • Liu, Z.W.1    Wu, H.2    Fine, D.3
  • 77
    • 84925655299 scopus 로고    scopus 로고
    • Acoustic purification of extracellular microvesicles
    • [77] Lee, K., Shao, H., Weissleder, R., Lee, H., Acoustic purification of extracellular microvesicles. ACS Nano 9:3 (2015), 2321–2327.
    • (2015) ACS Nano , vol.9 , Issue.3 , pp. 2321-2327
    • Lee, K.1    Shao, H.2    Weissleder, R.3    Lee, H.4
  • 78
    • 84863622552 scopus 로고    scopus 로고
    • Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages
    • [78] Kadiu, I., Narayanasamy, P., Dash, P.K., Zhang, W., Gendelman, H.E., Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J. Immunol. 189 (2016), 744–754, 10.4049/jimmunol.1102244.
    • (2016) J. Immunol. , vol.189 , pp. 744-754
    • Kadiu, I.1    Narayanasamy, P.2    Dash, P.K.3    Zhang, W.4    Gendelman, H.E.5
  • 79
    • 84943329505 scopus 로고    scopus 로고
    • Characterization of RNA from exosomes and other extracellular vesicles isolated by a novel spin column-based method
    • [79] Enderle, D., Spiel, A., Coticchia, C.M., et al. Characterization of RNA from exosomes and other extracellular vesicles isolated by a novel spin column-based method. PLoS One, 2015, 1–19, 10.1371/journal.pone.0136133.
    • (2015) PLoS One , pp. 1-19
    • Enderle, D.1    Spiel, A.2    Coticchia, C.M.3
  • 81
    • 84899624274 scopus 로고    scopus 로고
    • Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes
    • [81] Kastelowitz, N., Yin, H., Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes. Chembiochem 15 (2014), 923–928, 10.1002/cbic.201400043.
    • (2014) Chembiochem , vol.15 , pp. 923-928
    • Kastelowitz, N.1    Yin, H.2
  • 82
    • 84860252219 scopus 로고    scopus 로고
    • Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells
    • [82] Soo, C.Y., Song, Y., EC, C., AC, R., Gunn-, F., SJ, P., Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells. Immunology 136 (2012), 192–197, 10.1111/j.1365-2567.2012.03569.x.
    • (2012) Immunology , vol.136 , pp. 192-197
    • Soo, C.Y.1    Song, Y.2    EC, C.3    AC, R.4    Gunn-, F.5    SJ, P.6
  • 83
    • 80055118968 scopus 로고    scopus 로고
    • Sizing and phenotyping of cellular vesicles using nanoparticle tracking analysis
    • [83] Dragovic, R.A., Gardiner, C., Brooks, A.S., et al. Sizing and phenotyping of cellular vesicles using nanoparticle tracking analysis. Nanomedicine Nanotechnology, Biol. Med. 7:6 (2011), 780–788, 10.1016/j.nano.2011.04.003.
    • (2011) Nanomedicine Nanotechnology, Biol. Med. , vol.7 , Issue.6 , pp. 780-788
    • Dragovic, R.A.1    Gardiner, C.2    Brooks, A.S.3
  • 84
    • 84858702151 scopus 로고    scopus 로고
    • High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles — brief report
    • [84] Robert, S., Lacroix, R., Poncelet, P., et al. High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles — brief report. Arterioscler. Thromb. Vasc. Biol. 32 (2012), 1054–1058, 10.1161/ATVBAHA.111.244616.
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 1054-1058
    • Robert, S.1    Lacroix, R.2    Poncelet, P.3
  • 85
    • 78650007538 scopus 로고    scopus 로고
    • Optical and non-optical methods for detection and characterization of microparticles and exosomes
    • [85] van der Pol, E., Hoekstra, A.G., Sturk, A., Otto, C., van Leeuwen, T.G., Nieuwland, R., Optical and non-optical methods for detection and characterization of microparticles and exosomes. J. Thromb. Haemost. 8 (2010), 2596–2607, 10.1111/j.1538-7836.2010.04074.x.
    • (2010) J. Thromb. Haemost. , vol.8 , pp. 2596-2607
    • van der Pol, E.1    Hoekstra, A.G.2    Sturk, A.3    Otto, C.4    van Leeuwen, T.G.5    Nieuwland, R.6
  • 86
    • 84902788743 scopus 로고    scopus 로고
    • Determination of exosome concentration in solution using surface plasmon resonance spectroscopy
    • [86] Rupert, L.M., La, C., Eldh, M., et al. Determination of exosome concentration in solution using surface plasmon resonance spectroscopy. Anal. Chem. 86 (2014), 5929–5936.
    • (2014) Anal. Chem. , vol.86 , pp. 5929-5936
    • Rupert, L.M.1    La, C.2    Eldh, M.3
  • 87
    • 84900307606 scopus 로고    scopus 로고
    • Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
    • [87] Im, H., Shao, H., Park, Y.I.I., et al. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat. Biotechnol. 32:5 (2014), 490–495, 10.1038/nbt.2886.
    • (2014) Nat. Biotechnol. , vol.32 , Issue.5 , pp. 490-495
    • Im, H.1    Shao, H.2    Park, Y.I.I.3
  • 88
    • 80052035289 scopus 로고    scopus 로고
    • Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice
    • [88] Turiák, L., Misják, P., Szabó, T.G., et al. Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice. J. Proteome 74:10 (2011), 2025–2033, 10.1016/j.jprot.2011.05.023.
    • (2011) J. Proteome , vol.74 , Issue.10 , pp. 2025-2033
    • Turiák, L.1    Misják, P.2    Szabó, T.G.3
  • 89
    • 61349173156 scopus 로고    scopus 로고
    • Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes
    • [89] Conde-vancells, J., Rodriguez-suarez, E., Embade, N., et al. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J. Proteome 7 (2008), 5157–5166.
    • (2008) J. Proteome , vol.7 , pp. 5157-5166
    • Conde-vancells, J.1    Rodriguez-suarez, E.2    Embade, N.3
  • 90
    • 84878125516 scopus 로고
    • Molecular lipidomics of exosomes released by PC-3 prostate cancer cells
    • [90] Llorente, A., Skotland, T., Sylvänne, T., et al. Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim. Biophys. Acta 2013 (1831), 1302–1309, 10.1016/j.bbalip.2013.04.011.
    • (1831) Biochim. Biophys. Acta , vol.2013 , pp. 1302-1309
    • Llorente, A.1    Skotland, T.2    Sylvänne, T.3
  • 91
    • 84962733931 scopus 로고    scopus 로고
    • Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake
    • [91] Abels, E.R., Breakefield, X.O., Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake. Cell. Mol. Neurobiol. 36:3 (2016), 301–312, 10.1007/s10571-016-0366-z.
    • (2016) Cell. Mol. Neurobiol. , vol.36 , Issue.3 , pp. 301-312
    • Abels, E.R.1    Breakefield, X.O.2
  • 92
    • 84938826085 scopus 로고    scopus 로고
    • Extracellular vesicles: composition, biological relevance, and methods of study
    • [92] Zaborowski, M.P., Balaj, L., Breakefield, X.O., Lai, C.P., Extracellular vesicles: composition, biological relevance, and methods of study. Bioscience 65:8 (2015), 783–797, 10.1093/biosci/biv084.
    • (2015) Bioscience , vol.65 , Issue.8 , pp. 783-797
    • Zaborowski, M.P.1    Balaj, L.2    Breakefield, X.O.3    Lai, C.P.4
  • 93
    • 85001085848 scopus 로고    scopus 로고
    • Methods for the physical characterization and quantification of extracellular vesicles in biological samples
    • In Press
    • [93] Rupert, D.L.M., Claudio, V., Lässer, C., Bally, M., Methods for the physical characterization and quantification of extracellular vesicles in biological samples. Biochim. Biophys. Acta, 2016, 10.1016/j.bbagen.2016.07.028 In Press.
    • (2016) Biochim. Biophys. Acta
    • Rupert, D.L.M.1    Claudio, V.2    Lässer, C.3    Bally, M.4
  • 94
    • 84867118648 scopus 로고    scopus 로고
    • Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy
    • [94] Lee, Y., El Andaloussi, S., Wood, M.J.A., Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy. Hum. Mol. Genet. 21:R1 (2012), R125–R134, 10.1093/hmg/dds317.
    • (2012) Hum. Mol. Genet. , vol.21 , Issue.R1 , pp. R125-R134
    • Lee, Y.1    El Andaloussi, S.2    Wood, M.J.A.3
  • 95
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers
    • Nat. Cell Biol.;10(12):
    • [95] Skog J, Wurdinger T, Rijn S Van, et al. Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers. Nat. Cell Biol. 2008;10(12):1470–1476. doi: http://dx.doi.org/10.1038/ncb1800.Glioblastoma.
    • (2008) , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van, R.S.3
  • 97
    • 0032525252 scopus 로고    scopus 로고
    • Biologically active Fas antigen and its cognate ligand are expressed on plasma membrane-derived extracellular vesicles
    • [97] Albanese, J., Meterissian, S., Kontogiannea, M., et al. Biologically active Fas antigen and its cognate ligand are expressed on plasma membrane-derived extracellular vesicles. Blood 91:10 (1998), 3862–3874 http://www.ncbi.nlm.nih.gov/pubmed/9573024.
    • (1998) Blood , vol.91 , Issue.10 , pp. 3862-3874
    • Albanese, J.1    Meterissian, S.2    Kontogiannea, M.3
  • 98
    • 38749126175 scopus 로고    scopus 로고
    • Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens
    • [98] Obregon, C., Rothen-Rutishauser, B., Gitahi, S.K., Gehr, P., Nicod, L.P., Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens. Am. J. Pathol. 169:6 (2006), 2127–2136, 10.2353/ajpath.2006.060453.
    • (2006) Am. J. Pathol. , vol.169 , Issue.6 , pp. 2127-2136
    • Obregon, C.1    Rothen-Rutishauser, B.2    Gitahi, S.K.3    Gehr, P.4    Nicod, L.P.5
  • 99
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • [99] Théry, C., Ostrowski, M., Segura, E., Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9:8 (2009), 581–593, 10.1038/nri2567.
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.8 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 100
    • 85027933779 scopus 로고    scopus 로고
    • Exosomes: immune properties and potential clinical implementations
    • [100] Chaput, N., Théry, C., Exosomes: immune properties and potential clinical implementations. Semin. Immunopathol. 33:5 (2011), 419–440, 10.1007/s00281-010-0233-9.
    • (2011) Semin. Immunopathol. , vol.33 , Issue.5 , pp. 419-440
    • Chaput, N.1    Théry, C.2
  • 101
    • 0037490207 scopus 로고    scopus 로고
    • Exosome release is regulated by a calcium-dependent mechanism in K562 cells
    • [101] Savina, A., Furlan, M., Vidal, M., Colombo, M.I., Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J. Biol. Chem. 278:22 (2003), 20083–20090, 10.1074/jbc.M301642200.
    • (2003) J. Biol. Chem. , vol.278 , Issue.22 , pp. 20083-20090
    • Savina, A.1    Furlan, M.2    Vidal, M.3    Colombo, M.I.4
  • 102
    • 27744571140 scopus 로고    scopus 로고
    • Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases
    • [102] Distler, J.H.W., Pisetsky, D.S., Huber, L.C., Kalden, J.R., Gay, S., Distler, O., Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases. Arthritis Rheum. 52:11 (2005), 3337–3348, 10.1002/art.21350.
    • (2005) Arthritis Rheum. , vol.52 , Issue.11 , pp. 3337-3348
    • Distler, J.H.W.1    Pisetsky, D.S.2    Huber, L.C.3    Kalden, J.R.4    Gay, S.5    Distler, O.6
  • 103
    • 33645357271 scopus 로고    scopus 로고
    • Exosomes are released by cultured cortical neurones
    • [103] Fauré, J., Lachenal, G., Court, M., et al. Exosomes are released by cultured cortical neurones. Mol. Cell. Neurosci. 31:4 (2006), 642–648, 10.1016/j.mcn.2005.12.003.
    • (2006) Mol. Cell. Neurosci. , vol.31 , Issue.4 , pp. 642-648
    • Fauré, J.1    Lachenal, G.2    Court, M.3
  • 104
    • 38449095118 scopus 로고    scopus 로고
    • Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: trophic support for axons?
    • [104] Krämer-Albers, E.-M., Bretz, N., Tenzer, S., et al. Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: trophic support for axons?. Proteomics Clin. Appl. 1:11 (2007), 1446–1461, 10.1002/prca.200700522.
    • (2007) Proteomics Clin. Appl. , vol.1 , Issue.11 , pp. 1446-1461
    • Krämer-Albers, E.-M.1    Bretz, N.2    Tenzer, S.3
  • 105
    • 0029996607 scopus 로고    scopus 로고
    • Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury
    • [105] Miyoshi, H., Umeshita, K., Sakon, M., et al. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Gastroenterology 110:6 (1996), 1897–1904, 10.1053/gast.1996.v110.pm8964416.
    • (1996) Gastroenterology , vol.110 , Issue.6 , pp. 1897-1904
    • Miyoshi, H.1    Umeshita, K.2    Sakon, M.3
  • 106
    • 84866502787 scopus 로고    scopus 로고
    • Hypoxic enhancement of exosome release by breast cancer cells
    • [106] King, H.W., Michael, M.Z., Gleadle, J.M., Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer, 12(1), 2012, 421, 10.1186/1471-2407-12-421.
    • (2012) BMC Cancer , vol.12 , Issue.1 , pp. 421
    • King, H.W.1    Michael, M.Z.2    Gleadle, J.M.3
  • 107
    • 68549128599 scopus 로고    scopus 로고
    • Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors
    • [107] Wysoczynski, M., Ratajczak, M.Z., Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors. Int. J. Cancer 125:7 (2009), 1595–1603, 10.1002/ijc.24479.
    • (2009) Int. J. Cancer , vol.125 , Issue.7 , pp. 1595-1603
    • Wysoczynski, M.1    Ratajczak, M.Z.2
  • 108
    • 71749102668 scopus 로고    scopus 로고
    • Microenvironmental pH is a key factor for exosome traffic in tumor cells
    • [108] Parolini, I., Federici, C., Raggi, C., et al. Microenvironmental pH is a key factor for exosome traffic in tumor cells. J. Biol. Chem. 284:49 (2009), 34211–34222, 10.1074/jbc.M109.041152.
    • (2009) J. Biol. Chem. , vol.284 , Issue.49 , pp. 34211-34222
    • Parolini, I.1    Federici, C.2    Raggi, C.3
  • 109
    • 85013156831 scopus 로고    scopus 로고
    • Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
    • [109] de Jong, O.G., Verhaar, M.C., Chen, Y., et al. Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. J. Extracell Vesicles. 1 (2012), 1–12, 10.3402/jev.v1i0.18396.
    • (2012) J. Extracell Vesicles. , vol.1 , pp. 1-12
    • de Jong, O.G.1    Verhaar, M.C.2    Chen, Y.3
  • 110
    • 0018331202 scopus 로고
    • Plasma membrane vesiculation in 3T3 and SV3T3 cells. I. Morphological and biochemical characterization
    • [110] Scott, R.E., Perkins, R.G., Zschunke, M.A., BJ, H., PB, M., Plasma membrane vesiculation in 3T3 and SV3T3 cells. I. Morphological and biochemical characterization. J. Cell Sci. 35 (1979), 229–243.
    • (1979) J. Cell Sci. , vol.35 , pp. 229-243
    • Scott, R.E.1    Perkins, R.G.2    Zschunke, M.A.3    BJ, H.4    PB, M.5
  • 111
    • 0017139396 scopus 로고
    • Plasma membrane vesiculation: a new technique for isolation of plasma membranes
    • [111] Scott, R.E., Plasma membrane vesiculation: a new technique for isolation of plasma membranes. Science 194:4266 (1976), 743–745, 10.1126/science.982044.
    • (1976) Science , vol.194 , Issue.4266 , pp. 743-745
    • Scott, R.E.1
  • 112
    • 0035893961 scopus 로고    scopus 로고
    • The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself
    • [112] Dalle-Donne, I., Rossi, R., Milzani, A., Di Simplicio, P., Colombo, R., The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself. Free Radic. Biol. Med. 31:12 (2001), 1624–1632.
    • (2001) Free Radic. Biol. Med. , vol.31 , Issue.12 , pp. 1624-1632
    • Dalle-Donne, I.1    Rossi, R.2    Milzani, A.3    Di Simplicio, P.4    Colombo, R.5
  • 113
    • 33750701767 scopus 로고    scopus 로고
    • Reassembly of contractile actin cortex in cell blebs
    • [113] Charras, G.T., Hu, C.-K., Coughlin, M., Mitchison, T.J., Reassembly of contractile actin cortex in cell blebs. J. Cell Biol. 175:3 (2006), 477–490, 10.1083/jcb.200602085.
    • (2006) J. Cell Biol. , vol.175 , Issue.3 , pp. 477-490
    • Charras, G.T.1    Hu, C.-K.2    Coughlin, M.3    Mitchison, T.J.4
  • 114
    • 3943052117 scopus 로고    scopus 로고
    • Crawling toward a unified model of cell motility: spatial and temporal regulation of actin dynamics
    • [114] Rafelski, S.M., Theriot, J.A., Crawling toward a unified model of cell motility: spatial and temporal regulation of actin dynamics. Annu. Rev. Biochem. 73:1 (2004), 209–239, 10.1146/annurev.biochem.73.011303.073844.
    • (2004) Annu. Rev. Biochem. , vol.73 , Issue.1 , pp. 209-239
    • Rafelski, S.M.1    Theriot, J.A.2
  • 115
    • 0033564620 scopus 로고    scopus 로고
    • Regulation of plasma membrane blebbing by the cytoskeleton
    • 10.1002/(SICI)1097-4644(19990615)73:4 < 488::AID-JCB7 > 3.0.CO;2-P
    • [115] Hagmann, J., Burger, M.M., Dagan, D., Regulation of plasma membrane blebbing by the cytoskeleton. J. Cell. Biochem. 73:4 (1999), 488–499 10.1002/(SICI)1097-4644(19990615)73:4 < 488::AID-JCB7 > 3.0.CO;2-P.
    • (1999) J. Cell. Biochem. , vol.73 , Issue.4 , pp. 488-499
    • Hagmann, J.1    Burger, M.M.2    Dagan, D.3
  • 116
    • 77952920881 scopus 로고    scopus 로고
    • Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
    • [116] Kosaka, N., Iguchi, H., Yoshioka, Y., et al. Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells. 285 (23), 2010, 17442–17452, 10.1074/jbc.M110.107821.
    • (2010) , vol.285 , Issue.23 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3
  • 117
    • 79551625424 scopus 로고    scopus 로고
    • Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages
    • [117] Akao, Y., Iio, A., Itoh, T., et al. Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. Mol. Ther. 19:2 (2011), 395–399, 10.1038/mt.2010.254.
    • (2011) Mol. Ther. , vol.19 , Issue.2 , pp. 395-399
    • Akao, Y.1    Iio, A.2    Itoh, T.3
  • 118
    • 84949564767 scopus 로고    scopus 로고
    • Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of paclitaxel in autologous prostate cancer cells
    • [118] Saari, H., Lázaro-ibáñez, E., Viitala, T., Vuorimaa-laukkanen, E., Siljander, P., Yliperttula, M., Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of paclitaxel in autologous prostate cancer cells. J. Control. Release 220 (2015), 727–737, 10.1016/j.jconrel.2015.09.031.
    • (2015) J. Control. Release , vol.220 , pp. 727-737
    • Saari, H.1    Lázaro-ibáñez, E.2    Viitala, T.3    Vuorimaa-laukkanen, E.4    Siljander, P.5    Yliperttula, M.6
  • 119
    • 84891542333 scopus 로고    scopus 로고
    • Maximizing exosome colloidal stability following electroporation
    • [119] Hood, J.L., Scott, M.J., Wickline, S.A., Maximizing exosome colloidal stability following electroporation. Anal. Biochem. 448 (2014), 41–49, 10.1016/j.ab.2013.12.001.
    • (2014) Anal. Biochem. , vol.448 , pp. 41-49
    • Hood, J.L.1    Scott, M.J.2    Wickline, S.A.3
  • 120
    • 84926451271 scopus 로고    scopus 로고
    • Exosomes as drug delivery vehicles for Parkinson's disease therapy
    • [120] Haney, M.J., Klyachko, N.L., Zhao, Y., et al. Exosomes as drug delivery vehicles for Parkinson's disease therapy. J. Control. Release 207 (2015), 18–30, 10.1016/j.jconrel.2015.03.033.
    • (2015) J. Control. Release , vol.207 , pp. 18-30
    • Haney, M.J.1    Klyachko, N.L.2    Zhao, Y.3
  • 121
    • 84886625070 scopus 로고    scopus 로고
    • Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity
    • April
    • [121] Munoz, J.L., Bliss, S.A., SJ, G., SH, R., KL, L., P., R., Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity. Mol. Ther. Nucleic Acids, 2, 2013, e126, 10.1038/mtna.2013.60 April.
    • (2013) Mol. Ther. Nucleic Acids , vol.2 , pp. e126
    • Munoz, J.L.1    Bliss, S.A.2    SJ, G.3    SH, R.4    KL, L.5
  • 122
    • 84871923602 scopus 로고    scopus 로고
    • Systemically injected exosomes targeted to EGFR deliver antitumor MicroRNA to breast cancer cells
    • [122] Ohno, S., Takanashi, M., Sudo, K., et al. Systemically injected exosomes targeted to EGFR deliver antitumor MicroRNA to breast cancer cells. Mol. Ther. 21:1 (2012), 185–191, 10.1038/mt.2012.180.
    • (2012) Mol. Ther. , vol.21 , Issue.1 , pp. 185-191
    • Ohno, S.1    Takanashi, M.2    Sudo, K.3
  • 123
    • 84891858192 scopus 로고    scopus 로고
    • Exosome encased spherical nucleic acid gold nanoparticle conjugates as potent microRNA regulation agents
    • [123] Alhasan, A.H., Patel, P.C., Choi, C.H.J., Mirkin, C.A., Exosome encased spherical nucleic acid gold nanoparticle conjugates as potent microRNA regulation agents. Small 10:1 (2014), 186–192, 10.1002/smll.201302143.
    • (2014) Small , vol.10 , Issue.1 , pp. 186-192
    • Alhasan, A.H.1    Patel, P.C.2    Choi, C.H.J.3    Mirkin, C.A.4
  • 124
    • 84936886409 scopus 로고    scopus 로고
    • Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins
    • [124] Fuhrmann, G., Serio, A., Mazo, M., Nair, R., Stevens, M.M., Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. J. Control. Release 205 (2014), 35–44, 10.1016/j.jconrel.2014.11.029.
    • (2014) J. Control. Release , vol.205 , pp. 35-44
    • Fuhrmann, G.1    Serio, A.2    Mazo, M.3    Nair, R.4    Stevens, M.M.5
  • 125
    • 84925728665 scopus 로고    scopus 로고
    • Stabilization of exosome targeting peptides via engineered glycosylation
    • [125] Hung, M.E., Leonard, J.N., Stabilization of exosome targeting peptides via engineered glycosylation. J. Biol. Chem. 290 (2015), 8166–8172, 10.1074/jbc.M114.621383.
    • (2015) J. Biol. Chem. , vol.290 , pp. 8166-8172
    • Hung, M.E.1    Leonard, J.N.2
  • 126
    • 84989155654 scopus 로고    scopus 로고
    • Developments in T Cell Based Cancer Immunotherapies
    • [126] Wang, E., Ascierto, P.A., Stroncek, D.F., Developments in T Cell Based Cancer Immunotherapies. 2015.
    • (2015)
    • Wang, E.1    Ascierto, P.A.2    Stroncek, D.F.3
  • 129
    • 84949310102 scopus 로고    scopus 로고
    • Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
    • [129] Liu, Y., Li, D., Liu, Z., et al. Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse. Sci. Rep., 5(November), 2015, 17543, 10.1038/srep17543.
    • (2015) Sci. Rep. , vol.5 , pp. 17543
    • Liu, Y.1    Li, D.2    Liu, Z.3
  • 130
    • 84912151115 scopus 로고    scopus 로고
    • Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages
    • [130] Momen-Heravi, F., Bala, S., Bukong, T., Szabo, G., Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages. Nanomedicine Nanotechnology, Biol. Med. 10:7 (2014), 1517–1527, 10.1016/j.nano.2014.03.014.
    • (2014) Nanomedicine Nanotechnology, Biol. Med. , vol.10 , Issue.7 , pp. 1517-1527
    • Momen-Heravi, F.1    Bala, S.2    Bukong, T.3    Szabo, G.4
  • 131
    • 85005990374 scopus 로고    scopus 로고
    • A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery
    • [131] Hung, M.E., Leonard, J.N., A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery. J. Extracell Vesicles. 5:31027 (2016), 1–13, 10.3402/jev.v5.31027.
    • (2016) J. Extracell Vesicles. , vol.5 , Issue.31027 , pp. 1-13
    • Hung, M.E.1    Leonard, J.N.2
  • 132
    • 84954517903 scopus 로고    scopus 로고
    • Exosomes as nanocarriers for systemic delivery of the helicobacter pylori virulence factor CagA
    • [132] Shimoda, A., Ueda, K., Nishiumi, S., et al. Exosomes as nanocarriers for systemic delivery of the helicobacter pylori virulence factor CagA. Sci. Rep., 6, 2016, 18346, 10.1038/srep18346.
    • (2016) Sci. Rep. , vol.6 , pp. 18346
    • Shimoda, A.1    Ueda, K.2    Nishiumi, S.3
  • 133
    • 85014653850 scopus 로고    scopus 로고
    • Enhancement of Gemcitabine Sensitivity in Pancreatic Adenocarcinoma by Novel Exosome-Mediated Delivery of the Survivin-T34 A Mutant
    • [133] Aspe, J.R., Osterman, C.J.D., Jutzy, J.M.S., Deshields, S., Whang, S., Wall, N.R., Enhancement of Gemcitabine Sensitivity in Pancreatic Adenocarcinoma by Novel Exosome-Mediated Delivery of the Survivin-T34 A Mutant. 1, 2014, 1–9.
    • (2014) , vol.1 , pp. 1-9
    • Aspe, J.R.1    Osterman, C.J.D.2    Jutzy, J.M.S.3    Deshields, S.4    Whang, S.5    Wall, N.R.6
  • 134
    • 84884935709 scopus 로고    scopus 로고
    • Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors
    • [134] Jang, S.C., Kim, O.Y., CM, Y., et al. Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors. 9, 2013, 7698–7710.
    • (2013) , vol.9 , pp. 7698-7710
    • Jang, S.C.1    Kim, O.Y.2    CM, Y.3
  • 135
    • 84951831545 scopus 로고    scopus 로고
    • Bovine milk-derived exosomes for drug delivery
    • [135] Munagala, R., Aqil, F., Jeyabalan, J., Gupta, R.C., Bovine milk-derived exosomes for drug delivery. Cancer Lett. 371:1 (2016), 48–61, 10.1016/j.canlet.2015.10.020.
    • (2016) Cancer Lett. , vol.371 , Issue.1 , pp. 48-61
    • Munagala, R.1    Aqil, F.2    Jeyabalan, J.3    Gupta, R.C.4
  • 136
    • 84896450227 scopus 로고    scopus 로고
    • Recombinant outer membrane vesicles carrying Chlamydia muridarum HtrA induce antibodies that neutralize chlamydial infection in vitro
    • [136] Bartolini, E., Ianni, E., Frigimelica, E., et al. Recombinant outer membrane vesicles carrying Chlamydia muridarum HtrA induce antibodies that neutralize chlamydial infection in vitro. J. Extracell Vesicles. 2:20181 (2013), 1–14.
    • (2013) J. Extracell Vesicles. , vol.2 , Issue.20181 , pp. 1-14
    • Bartolini, E.1    Ianni, E.2    Frigimelica, E.3
  • 137
    • 84892960788 scopus 로고    scopus 로고
    • Exosomes carrying mycobacterial antigens can protect mice against an M. tuberculosis infection
    • [137] Cheng, Y., Schorey, J.S., Exosomes carrying mycobacterial antigens can protect mice against an M. tuberculosis infection. Eur. J. Immunol. 43:12 (2013), 3279–3290, 10.1097/MPG.0b013e3181a15ae8.Screening.
    • (2013) Eur. J. Immunol. , vol.43 , Issue.12 , pp. 3279-3290
    • Cheng, Y.1    Schorey, J.S.2
  • 138
    • 84905052545 scopus 로고    scopus 로고
    • Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma
    • [138] Mahaweni, N.M., Kaijen-Lambers, M.E.H., Dekkers, J., Aerts, J.G.J.V., Hegmans, J.P.J.J., Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma. J. Extracell vesicles. 2 (2013), 1–6, 10.3402/jev.v2i0.22492.
    • (2013) J. Extracell vesicles. , vol.2 , pp. 1-6
    • Mahaweni, N.M.1    Kaijen-Lambers, M.E.H.2    Dekkers, J.3    Aerts, J.G.J.V.4    Hegmans, J.P.J.J.5
  • 139
    • 76749139918 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes for cancer immunotherapy: what's next?
    • [139] Viaud, S., Thery, C., Ploix, S., et al. Dendritic cell-derived exosomes for cancer immunotherapy: what's next?. Cancer Res. 70:4 (2010), 1281–1285, 10.1158/0008-5472.CAN-09-3276.
    • (2010) Cancer Res. , vol.70 , Issue.4 , pp. 1281-1285
    • Viaud, S.1    Thery, C.2    Ploix, S.3
  • 140
    • 33748480677 scopus 로고    scopus 로고
    • Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen
    • [140] Colino, J., Snapper, C.M., Exosomes from bone marrow dendritic cells pulsed with diphtheria toxoid preferentially induce type 1 antigen-specific IgG responses in naive recipients in the absence of free antigen. J. Immunol. 177:6 (2006), 3757–3762, 10.4049/jimmunol.177.6.3757.
    • (2006) J. Immunol. , vol.177 , Issue.6 , pp. 3757-3762
    • Colino, J.1    Snapper, C.M.2
  • 141
    • 79955085152 scopus 로고    scopus 로고
    • Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes
    • [141] del Cacho, E., Gallego, M., Lee, S.H., et al. Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes. Vaccine 29:21 (2011), 3818–3825, 10.1016/j.vaccine.2011.03.022.
    • (2011) Vaccine , vol.29 , Issue.21 , pp. 3818-3825
    • del Cacho, E.1    Gallego, M.2    Lee, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.