Garcinol and its role in chronic diseases

Advances in Experimental Medicine and Biology

Volumn 928, Issue , 2016, Pages 435-452

  Behera, Amit K ^a   Swamy, Mahadeva M ^a   Natesh, Nagashayana ^b   Kundu, Tapas K ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

^b Central Government Health Scheme Dispensary No 3   (India)

Author keywords

Epigenetic enzymes; Inflammation; STAT3; Tumorigenesis

Indexed keywords

7 EPICLUSIANONE; ALPHA MANGOSTIN; ANACARDIC ACID; CAMBOGIN; CHALCONE DERIVATIVE; GAMBOGIC ACID; GARCIM 1; GARCIM 2; GARCIMULTIFLORONE D; GARCINIA CAMBOGIA EXTRACT; GARCINOL; GARCINOL 13 O METHYL ETHER; GUTTIFERONE A; ISOGARCINOL; KOLAVIRON; NATURAL PRODUCT; NUJIANGEXANTHONE A; OBLONGIFOLIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; XANTHOCHYMOL; TERPENE;

ALLERGY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BREAST CANCER; CANCER INHIBITION; CARDIOVASCULAR DISEASE; COLON CANCER; DEGENERATIVE DISEASE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TARGETING; GARCINIA; GARCINIA INDICA; HEAD AND NECK CANCER; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HEART VENTRICLE HYPERTROPHY; HUMAN; LIVER CELL CARCINOMA; MOUTH CANCER; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROSTATE CANCER; SIGNAL TRANSDUCTION; ANIMAL; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; DRUG EFFECTS; NEOPLASMS;

ANIMALS; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; DIABETES MELLITUS; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION; TERPENES;

EID: 84988981210     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-41334-1_18     Document Type: Chapter

References (62)

1. Baliga MS, Bhat HP, Pai RJ et al (2011) The chemistry and medicinal uses of the underutilized Indian fruit tree Garcinia indica Choisy (kokum): a review. Food Res Intern 44(7):1790–1799
2. Charaka samhita text, suthrasthaana, chapter 4th and 27th, Bhava prakasha text
3. Han CM, Zhou XY, Cao J et al (2015) 13, 14-Dihydroxy groups are critical for the anti-cancer effects of garcinol. Bioorg Chem 60:123–129
4. Mantelingu K, Reddy BA, Swaminathan V et al Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol 14(6):645–57
5. Hong J, Kwon SJ, Sang S et al (2007) Effects of garcinol and its derivatives on intestinal cell growth: inhibitory effects and autoxidation-dependent growth-stimulatory effects. Free Radic Biol Med 42(8):1211–1221
6. Balasubramanyam K, Altaf M, Varier RA et al (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem 279(32):33716–33726
7. Huang CC, Lin CM, Huang YJ et al (2015) Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. Biotechnol Appl Biochem. doi:10.1002/bab.1446
8. Tsai ML, Chiou YS, Chiou LY et al (2014) Garcinol suppresses inflammation-associated colon carcinogenesis in mice. Mol Nutr Food Res 58(9):1820–1829
9. Yoshida K, Tanaka T, Hirose Y et al (2005) Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tonguecarcinogenesis in rats. Cancer Lett 221(1):29–39
10. Ahmad A, Sarkar SH, Aboukameel A et al (2012) Anti-cancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling. Carcinogenesis 33 (12):2450–2456
11. Sethi G, Chatterjee S, Rajendran P et al (2014) Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo. Mol Cancer 13:66
12. Ahmad A, Sarkar SH, Bitar B et al (2012) Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol Cancer Ther 11(10):2193–2201
13. Ahmad A, Wang Z, Wojewoda C et al (2011) Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF-kappaB signaling. Front Biosci (Elite Ed) 3:1483–1492
14. Ahmad A, Wang Z, Ali R et al (2010) Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. J Cell Biochem 109(6):1134–1141
15. Pan MH, Chang WL, Lin-Shiau SY et al (2001) Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J Agric Food Chem 49(3):1464–1474
16. Prasad S, Ravindran J, Sung B et al (2010) Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins. Mol Cancer Ther 9(4):856–868
17. Oike T, Ogiwara H, Torikai K et al (2012) Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining. Int J Radiat Oncol Biol Phys 84(3):815–821
18. Chen X, Zhang X, Lu Y et al (2012) Chemoprevention of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol. Nutr Cancer 64(8):1211–1218
19. Li F, Shanmugam MK, Chen L (2013) Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila) 6(8):843–54
20. Parasramka MA, Gupta SV (2012) Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells. J Oncol 2012:709739
21. Cheng AC, Tsai ML, Liu CM et al (2010) Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food Funct 1(3):301–307
22. Liao CH, Sang S, Ho CT et al (2005) Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. Cell Biochem 96(1):155–169
23. Kadiyala CS, Zheng L, Du Y et al (2012) Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC). J Biol Chem 287(31):25869–25880
24. Wang Y, Wang Y, Luo M et al (2015) Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation. Biochim Biophys Acta 1852(1):34–46
25. Yun JM, Jialal I, Devaraj S (2011) Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. J Nutr Biochem 22(5):450–458
26. Pham TX, Lee J (2012) Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases. Nutrients 4(12):1868–1886
27. Hsu CL, Lin YJ, Ho CT et al (2012) Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food Funct 3(1):49–57
28. Chan EC, Dusting GJ, Guo N et al (2010) Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation. J Mol Cell Cardiol 49(2):176–185
29. Balasubramanyam K, Swaminathan V, Ranganathan A et al (2003) Small molecule modulators of histone acetyltransferase p300. J Biol Chem 278(21):19134–19140
30. Peng C, Zhang W, Zhao W, Zhu J, Huang X, Tian J (2015) Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts. Biochimie 113:1–9
31. Davidson SM, Townsend PA, Carroll C et al (2005) The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. ChemBioChem 6(1):162–170
32. Weng MS, Liao CH, Yu SY et al (2011) Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. J Agric Food Chem 59(3):1031–1040
33. Liao CH, Ho CT, Lin JK (2005) Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes. Biochem Biophys Res Commun 329(4):1306–1314
34. Cui ZL, Gu W, Ding T et al (2013) Histone modifications of Notch1 promoter affect lung CD4+ T cell differentiation in asthmatic rats. Int J Immunopathol Pharmacol 26(2):371–381
35. Tanaka T, Kohno H, Shimada R et al (2000) Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats. Carcinogenesis 21(6):1183–1189
36. Wang Y, Tsai ML, Chiou LY et al (2015) Antitumor activity of garcinol in human prostate cancer cells and xenograft mice. J Agric Food Chem 63(41):9047–9052
37. Heymsfield SB, Allison DB, Vasselli JR et al (1998) Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 280(18):1596–1600
38. Padhye S, Ahmad A, Oswal N et al (2009) Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs. J Hematol Oncol 2:38
39. Li F, Shanmugam MK, Siveen KS et al (2015) Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers. Oncotarget 6(7):5147–5163
40. Pieme CA, Ambassa P, Yankep E et al (2015) Epigarcinol and isogarcinol isolated from the root of Garcinia ovalifolia induce apoptosis of human promyelocytic leukemia (HL-60 cells). BMC Res Notes 8(1):700
41. Fu Y, Zhou H, Wang M et al (2014) Immune regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana L. against collagen-induced arthritis. J Agric Food Chem 62(18):4127–4134
42. Ito C, Itoigawa M, Miyamoto Y et al (2003) Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities. J Nat Prod 66(2):206–209
43. Nuñez-Figueredo Y, García-Pupo L, Ramírez-Sánchez J et al (2012) Neuroprotective action and free radical scavenging activity of guttiferone-A, a naturally occurring prenylatedbenzophenone. Arzneimittelforschung 62(12):583–589
44. Pardo-Andreu GL, Nuñez-Figueredo Y, Tudella VG et al (2011) The anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: ensuing energetic and oxidative stress implications. Toxicol Appl Pharmacol 253(3):282–289
45. Niero R, Dal Molin MM, Silva S et al (2012) Gastroprotective effects of extracts and guttiferone A isolated from Garcinia achachairu Rusby (Clusiaceae) against experimentally induced gastric lesions in mice. Naunyn Schmiedebergs Arch Pharmacol 385(11):1103–1109
46. Feng C, Zhou LY, Yu T et al (2012) A new anticancer compound, oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. Int J Cancer 131(6):1445–1454
47. Wang X, Lao Y, Xu N et al (2015) Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins. Sci Rep 5:10293
48. Lu Y, Cai S, Tan H et al (2015) Inhibitory effect of oblongifolin C on allergic inflammation through the suppression of mast cell activation. Mol Cell Biochem 406(1–2):263–271
49. Matsumoto K, Akao Y, Kobayashi E et al (2003) Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Biol Pharm Bull 26(4):569–571
50. Einbond LS, Mighty J, Kashiwazaki R et al (2013) Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med Chem 13(10):1540–1550
51. Sales L, Pezuk JA, Borges KS et al (2015) Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma. BMC Complement Altern Med 15(1):393
52. Liu X, Yu T, Gao XM et al (2010) Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of Garcinia multiflora. J Nat Prod 73(8):1355–1359
53. Wang LH, Yang JY, Yang SN et al (2014) Suppression of NF-jB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin-induced apoptosis in lung cancer. Curr Cancer Drug Targets 14(1):91–103
54. Shi X, Chen X, Li X et al (2014) Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. Clin Cancer Res 20(1):151–163
55. Wen C, Huang L, Chen J et al (2015) Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells. Int J Oncol 47(5):1663–1671
56. Iwu MM, Igboko OA, Okunji CO et al (1990) Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola. J Pharm Pharmacol 42(4):290–292
57. Oyenihi OR, Brooks NL, Oguntibeju OO (2015) Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes. BMC Complement Altern Med 15:236
58. Janhom P, Dharmasaroja P (2015) Neuroprotective effects of Alpha-Mangostin on MPP(+)-induced apoptotic cell death in neuroblastoma SH-SY5Y cells. J Toxicol 2015:919058
59. Hafeez BB, Mustafa A, Fischer JW et al (2014) a-Mangostin: a dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model. Antioxid Redox Signal 21(5):682–699
60. Wang JJ, Sanderson BJ, Zhang W (2012) Significant anti-invasive activities of a-mangostin from the mangosteen pericarp on two human skin cancer cell lines. Anticancer Res 32(9):3805–3816
61. Lu Y, Cai S, Nie J et al (2015) The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma. Biochem Pharmacol 100:61–72
62. Chi Y, Zhan XK, Yu H et al (2013) An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors. Chin Med J (Engl) 126(9):1642–1646