Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling

Carcinogenesis

Volumn 33, Issue 12, 2012, Pages 2450-2456

  Ahmad, Aamir ^a   Sarkar, Sanila H ^a   Aboukameel, Amro ^a   Ali, Shadan ^a   Biersack, Bernhard ^b   Seibt, Sebastian ^b   Li, Yiwei ^a   Bao, Bin ^a   Kong, Dejuan ^a   Banerjee, Sanjeev ^a   Schobert, Rainer ^b   Padhye, Subhash B ^c   Sarkar, Fazlul H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BAYREUTH   (Germany)

^c ISTRA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GARCINOL; GELATINASE B; INTERLEUKIN 6; PLASMINOGEN ACTIVATOR; STAT3 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG TARGETING; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHLORINE COMPOUNDS; FEMALE; HUMANS; INTERLEUKIN-6; MICE; MICE, INBRED ICR; NEOPLASM INVASIVENESS; NF-KAPPA B; PLATINUM COMPOUNDS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TERPENES;

EID: 84870377710     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs290     Document Type: Article

References (44)

1. Lee, K.W. et al. (2011) Molecular targets of phytochemicals for cancer prevention. Nat. Rev. Cancer, 11, 211-218.
2. Padhye, S. et al. (2009) Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs. J. Hematol. Oncol., 2, 38.
3. Ahmad, A. et al. (2012) Role of novel nutraceuticals garcinol, plumbagin and mangiferin in the prevention and therapy of human malignancies: mechanisms of anticancer activity. In Sarkar, F.H. (ed.) Nutraceuticals and Cancer. Springer, New York, pp. 179-199.
4. Ahmad, A. et al. (2010) Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. J. Cell. Biochem., 109, 1134-1141.
5. Ahmad, A. et al. (2011) Garcinol-induced apoptosis in prostate and pancreatic cancer cells is mediated by NF- kappaB signaling. Front. Biosci. (Elite Ed)., 3, 1483-1492.
6. Grivennikov, S.I. et al. (2010) Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev., 21, 11-19.
7. Bollrath, J. et al. (2009) IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep., 10, 1314-1319.
8. Bromberg, J.F. et al. (1999) Stat3 as an oncogene. Cell, 98, 295-303.
9. Devarajan, E. et al. (2009) STAT3 as a central regulator of tumor metastases. Curr. Mol. Med., 9, 626-633.
10. Sahu, R.P. et al. (2009) The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J. Natl. Cancer Inst., 101, 176-193.
11. Mantelingu, K. et al. (2007) Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem. Biol., 14, 645-657.
12. Ahmad, A. et al. (2011) Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells. Cancer Res., 71, 3400-3409.
13. Ji, X. et al. (2011) Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. J. Cell. Biochem., 112, 2773-2783.
14. Ahmad, A. et al. (2012) Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo leading to anticancer activity against breast cancer cells. Mol. Cancer Ther. (In Press) DOI:10.1158/1535-7163.MCT-12-0232-T, PMID: 22821148
15. Ahmad, A. et al. (2011) 3, 3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1. Int. J. Cancer, 129, 1781-1791.
16. Zhang, X. et al. (2012) Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc. Natl. Acad. Sci. U.S.A, 109, 9623-9628.
17. Sakaguchi, M. et al. (2012) Role and Regulation of STAT3 Phosphorylation at Ser727 in Melanocytes and Melanoma Cells. J. Invest. Dermatol., 132, 1877-1885.
18. Kujawski, M. et al. (2008) Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J. Clin. Invest., 118, 3367-3377.
19. Kwon, G.T. et al. (2012) Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling. J. Nutr. Biochem., 23, 228-238.
20. Siegel, R. et al. (2012) Cancer statistics, 2012. CA. Cancer J. Clin., 62, 10-29.
21. Simard, E.P. et al. (2012) Cancers with increasing incidence trends in the United States: 1999 through 2008. CA. Cancer J. Clin., (In Press) DOI:10.3322/caac.20141, PMID:22281605.
22. Yamaguchi, F. et al. (2000) Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind. J. Agric. Food Chem., 48, 2320-2325.
23. Pan, M.H. et al. (2001) Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J. Agric. Food Chem., 49, 1464-1474.
24. Hong, J. et al. (2007) Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects. Free Radic. Biol. Med., 42, 1211-1221.
25. Tanaka, T. et al. (2000) Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats. Carcinogenesis, 21, 1183-1189.
26. Liao, C.H. et al. (2005) Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. J. Cell. Biochem., 96, 155-169.
27. Koeberle, A. et al. (2009) Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the antiinflammatory and anti-carcinogenic garcinol. Biochem. Pharmacol., 77, 1513-1521.
28. Matsumoto, K. et al. (2003) Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Biol. Pharm. Bull., 26, 569-571.
29. Yoshida, K. et al. (2005) Dietary garcinol inhibits 4-nitroquinoline 1-oxideinduced tongue carcinogenesis in rats. Cancer Lett., 221, 29-39.
30. Hong, J. et al. (2006) Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives. Carcinogenesis, 27, 278-286.
31. Prasad, S. et al. (2010) Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins. Mol. Cancer Ther., 9, 856-868.
32. Chen, C.S. et al. (2011) Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast Cancer Res. Treat., 125, 73-87.
33. Cheng, A.C. et al. (2010) Garcinol inhibits cell growth in hepatocellular carcinoma Hep3B cells through induction of ROS-dependent apoptosis. Food Funct., 1, 301-307.
34. Balasubramanyam, K. et al. (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J. Biol. Chem., 279, 33716-33726.
35. Karin, M. (2006) Nuclear factor-kappaB in cancer development and progression. Nature, 441, 431-436.
36. Cheng, F. et al. (2012) STAT3 Inhibition augments the immunogenicity of B-cell lymphoma cells leading to effective antitumor immunity. Cancer Res., 72, 4440-4448.
37. Wang, M. et al. (2007) Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways. Blood, 109, 5455-5462.
38. Liao, C.H. et al. (2004) Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol. Mol. Carcinog., 41, 140-149.
39. Parasramka, M.A. et al. (2011) Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells. Nutr. Cancer, 63, 456-465.
40. Sen, N. et al. (2012) Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis. Proc. Natl. Acad. Sci. U.S.A., 109, 600-605.
41. Dave, B. et al. (2012) Selective small molecule stat3 inhibitor reduces breast cancer tumor-initiating cells and improves recurrence free survival in a human-xenograft model. PLoS ONE, 7, e30207.
42. Scuto, A. et al. (2011) STAT3 inhibition is a therapeutic strategy for ABClike diffuse large B-cell lymphoma. Cancer Res., 71, 3182-3188.
43. Behera, R. et al. (2010) Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells. Carcinogenesis, 31, 192-200.
44. Boreddy, S.R. et al. (2011) Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3. PLoS ONE, 6, e25799.