Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 1, 2015, Pages 34-46

  Wang, Yangwei ^a,b   Wang, Yonggang ^b,c   Luo, Manyu ^a,b   Wu, Hao ^a,b   Kong, Lili ^a,b   Xin, Ying ^b,d   Cui, Wenpeng ^a,b   Zhao, Yunjie ^e   Wang, Jingying ^e   Liang, Guang ^e   Miao, Lining ^a   Cai, Lu ^b  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b University of Louisville School of Medicine   (United States)

^c THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^d JILIN UNIVERSITY   (China)

^e WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Curcumin; Diabetic nephropathy; Fibrosis; Histone acetylation; JNK; P300 CBP

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CONNECTIVE TISSUE GROWTH FACTOR; CURCUMIN; CURCUMIN DERIVATIVE C66; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; HISTONE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE; HISTONE ACETYLATION; MALE; MOUSE; NONHUMAN; ACETYLATION; ANIMAL; C57BL MOUSE; CHEMISTRY; DIABETIC NEPHROPATHIES; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

ACETYLATION; ANIMALS; CHROMATIN IMMUNOPRECIPITATION; CURCUMIN; DIABETIC NEPHROPATHIES; HISTONES; MAP KINASE KINASE 4; MICE; MICE, INBRED C57BL; P300-CBP TRANSCRIPTION FACTORS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84911892273     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.11.006     Document Type: Article

References (50)

1. Kanwar Y.S., Sun L., Xie P., Liu F.Y., Chen S. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu. Rev. Pathol. 2011, 6:395-423.
2. Wolf G. New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology. Eur. J. Clin. Invest. 2004, 34:785-796.
3. Schena F.P., Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J. Am. Soc. Nephrol. 2005, 16(Suppl. 1):S30-S33.
4. Qian Y., Feldman E., Pennathur S., Kretzler M., Brosius F.C. From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes 2008, 57:1439-1445.
5. Hishikawa K., Oemar B.S., Nakaki T. Static pressure regulates connective tissue growth factor expression in human mesangial cells. J. Biol. Chem. 2001, 276:16797-16803.
6. Malgorzewicz S., Skrzypczak-Jankun E., Jankun J. Plasminogen activator inhibitor-1 in kidney pathology (Review). Int. J. Mol. Med. 2013, 31:503-510.
7. Li Y., Chen Q., Liu F.Y., Peng Y.M., Wang S., Li J., Li J., Duan S.B., Sun L., Ling G.H., Luo J.H. Norcantharidin inhibits the expression of extracellular matrix and TGF-beta1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway. Lab. Invest. 2011, 91:1706-1716.
8. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912.
9. Czaja M.J. JNK regulation of hepatic manifestations of the metabolic syndrome. Trends Endocrinol. Metab. 2010, 21:707-713.
10. Hirosumi J., Tuncman G., Chang L., Gorgun C.Z., Uysal K.T., Maeda K., Karin M., Hotamisligil G.S. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
11. Zhou L., Xue H., Wang Z., Ni J., Yao T., Huang Y., Yu C., Lu L. Angiotensin-(1-7) attenuates high glucose-induced proximal tubular epithelial-to-mesenchymal transition via inhibiting ERK1/2 and p38 phosphorylation. Life Sci. 2012, 90:454-462.
12. Waeber G., Delplanque J., Bonny C., Mooser V., Steinmann M., Widmann C., Maillard A., Miklossy J., Dina C., Hani E.H., Vionnet N., Nicod P., Boutin P., Froguel P. The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat. Genet. 2000, 24:291-295.
13. Watanabe N., Shikata K., Shikata Y., Sarai K., Omori K., Kodera R., Sato C., Wada J., Makino H. Involvement of MAPKs in ICAM-1 expression in glomerular endothelial cells in diabetic nephropathy. Acta Med. Okayama 2011, 65:247-257.
14. Suzuki H., Uchida K., Nitta K., Nihei H. Role of mitogen-activated protein kinase in the regulation of transforming growth factor-beta-induced fibronectin accumulation in cultured renal interstitial fibroblasts. Clin. Exp. Nephrol. 2004, 8:188-195.
15. Huang A., Yang Y.M., Yan C., Kaley G., Hintze T.H., Sun D. Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice. Diabetes 2012, 61:3181-3188.
16. Jayaraman S. Epigenetics of autoimmune diabetes. Epigenomics 2011, 3:639-648.
17. Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
18. Kaur H., Chen S., Xin X., Chiu J., Khan Z.A., Chakrabarti S. Diabetes-induced extracellular matrix protein expression is mediated by transcription coactivator p300. Diabetes 2006, 55:3104-3111.
19. Chen S., Feng B., George B., Chakrabarti R., Chen M., Chakrabarti S. Transcriptional coactivator p300 regulates glucose-induced gene expression in endothelial cells. Am. J. Physiol. Endocrinol. Metab. 2010, 298:E127-E137.
20. Luo S.F., Lin C.C., Chen H.C., Lin W.N., Lee I.T., Lee C.W., Hsiao L.D., Yang C.M. Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells. Toxicol. Appl. Pharmacol. 2008, 232:396-407.
21. Babu P.S., Srinivasan K. Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol. Cell. Biochem. 1997, 166:169-175.
22. Hanai H., Sugimoto K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr. Pharm. Des. 2009, 15:2087-2094.
23. Hasan S.T., Zingg J.M., Kwan P., Noble T., Smith D., Meydani M. Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. Atherosclerosis 2014, 232:40-51.
24. Gupta S.C., Patchva S., Aggarwal B.B. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013, 15:195-218.
25. Farhangkhoee H., Khan Z.A., Chen S., Chakrabarti S. Differential effects of curcumin on vasoactive factors in the diabetic rat heart. Nutr. Metab. (Lond.) 2006, 3:27.
26. Chuengsamarn S., Rattanamongkolgul S., Luechapudiporn R., Phisalaphong C., Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care 2012, 35:2121-2127.
27. Pan Y., Zhu G., Wang Y., Cai L., Cai Y., Hu J., Li Y., Yan Y., Wang Z., Li X., Wei T., Liang G. Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart. J. Nutr. Biochem. 2013, 24:146-155.
28. Yun J.M., Jialal I., Devaraj S. Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. J. Nutr. Biochem. 2011, 22:450-458.
29. Dhillon N., Aggarwal B.B., Newman R.A., Wolff R.A., Kunnumakkara A.B., Abbruzzese J.L., Ng C.S., Badmaev V., Kurzrock R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin. Cancer Res. 2008, 14:4491-4499.
30. Pan Y., Wang Y., Cai L., Cai Y., Hu J., Yu C., Li J., Feng Z., Yang S., Li X., Liang G. Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats. Br. J. Pharmacol. 2012, 166:1169-1182.
31. Pan Y., Zhang X., Wang Y., Cai L., Ren L., Tang L., Wang J., Zhao Y., Wang Y., Liu Q., Li X., Liang G. Targeting JNK by a new curcumin analog to inhibit NF-kB-mediated expression of cell adhesion molecules attenuates renal macrophage infiltration and injury in diabetic mice. PLoS One 2013, 8:e79084.
32. Pan Y., Wang Y., Zhao Y., Peng K., Li W., Wang Y., Zhang J., Zhou S., Liu Q., Li X., Cai L., Liang G. Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy. Diabetes 2014, 63:3497-3511.
33. Ramirez-Alcantara V., LoGuidice A., Boelsterli U.A. Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G990-G998.
34. Miao X., Bai Y., Sun W., Cui W., Xin Y., Wang Y., Tan Y., Miao L., Fu Y., Su G., Cai L. Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants. Nutr. Metab. (Lond.) 2012, 9:84.
35. White N.H., Sun W., Cleary P.A., Danis R.P., Davis M.D., Hainsworth D.P., Hubbard L.D., Lachin J.M., Nathan D.M. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10years after the Diabetes Control and Complications Trial. Arch. Ophthalmol. 2008, 126:1707-1715.
36. Villeneuve L.M., Reddy M.A., Lanting L.L., Wang M., Meng L., Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:9047-9052.
37. Zhong Q., Kowluru R.A. Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J. Cell. Biochem. 2010, 110:1306-1313.
38. Miao F., Chen Z., Genuth S., Paterson A., Zhang L., Wu X., Li S., Cleary P., Riggs A., Harlan D., Lorenzi G., Kolterman O., Sun W., Lachin J., Natarajan R. Evaluating the Role of Epigenetic histone modifications in the Metabolic Memory of Type 1 Diabetes. Diabetes 2014, 63:1748-1762.
39. Roth S.Y., Denu J.M., Allis C.D. Histone acetyltransferases. Annu. Rev. Biochem. 2001, 70:81-120.
40. Miao F., Gonzalo I.G., Lanting L., Natarajan R. In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. J. Biol. Chem. 2004, 279:18091-18097.
41. Chen S.S., Jenkins A.J., Majewski H. Elevated plasma prostaglandins and acetylated histone in monocytes in Type 1 diabetes patients. Diabet. Med. 2009, 26:182-186.
42. Sun H., Yang X., Zhu J., Lv T., Chen Y., Chen G., Zhong L., Li Y., Huang X., Huang G., Tian J. Inhibition of p300-HAT results in a reduced histone acetylation and down-regulation of gene expression in cardiac myocytes. Life Sci. 2010, 87:707-714.
43. Tsai S.Y., Huang Y.L., Yang W.H., Tang C.H. Hepatocyte growth factor-induced BMP-2 expression is mediated by c-Met receptor, FAK, JNK, Runx2, and p300 pathways in human osteoblasts. Int. Immunopharmacol. 2012, 13:156-162.
44. Karukurichi K.R., Wang L., Uzasci L., Manlandro C.M., Wang Q., Cole P.A. Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis. J. Am. Chem. Soc. 2010, 132:1222-1223.
45. Villeneuve L.M., Reddy M.A., Natarajan R. Epigenetics: deciphering its role in diabetes and its chronic complications. Clin. Exp. Pharmacol. Physiol. 2011, 38:451-459.
46. Brouwers B., Pruniau V.P., Cauwelier E.J., Schuit F., Lerut E., Ectors N., Declercq J., Creemers J.W. Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy. J. Biol. Chem. 2013, 288:27200-27207.
47. Jin X., Zeng L., He S., Chen Y., Tian B., Mai G., Yang G., Wei L., Zhang Y., Li H., Wang L., Qiao C., Cheng J., Lu Y. Comparison of single high-dose streptozotocin with partial pancreatectomy combined with low-dose streptozotocin for diabetes induction in rhesus monkeys. Exp. Biol. Med. (Maywood) 2010, 235:877-885.
48. Loeffler I., Liebisch M., Wolf G. Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy. Am. J. Physiol. Renal. Physiol. 2012, 303:F733-F745.
49. Noonan W.T., Banks R.O. Renal function and glucose transport in male and female mice with diet-induced type II diabetes mellitus. Proc. Soc. Exp. Biol. Med. 2000, 225:221-230.
50. Hartner A., Cordasic N., Klanke B., Veelken R., Hilgers K.F. Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice. Nephrol. Dial. Transplant. 2003, 18:1999-2004.