Garcinol suppresses inflammation-associated colon carcinogenesis in mice

Molecular Nutrition and Food Research

Volumn 58, Issue 9, 2014, Pages 1820-1829

  Tsai, Mei Ling ^a   Chiou, Yi Shiou ^b   Chiou, Li Yu ^b   Ho, Chi Tang ^c   Pan, Min Hsiung ^b,d  

^a NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c RUTGERS UNIVERSITY   (United States)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Azoxymethane Dextran sulfate sodium; Chemopreventive; Colon carcinogenesis; Garcinol; Inflammation

Indexed keywords

MUS;

ANTINEOPLASTIC AGENT; AUTACOID; AZOXYMETHANE; BETA CATENIN; DEXTRAN SULFATE; GARCINOL; TERPENE;

ANIMAL; CHEMICALLY INDUCED; COLITIS; COLONIC NEOPLASMS; COMPLICATION; DRUG EFFECTS; HEPATITIS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID METABOLISM; MALE; METABOLISM; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTICARCINOGENIC AGENTS; AZOXYMETHANE; BETA CATENIN; COLITIS; COLONIC NEOPLASMS; DEXTRAN SULFATE; HEPATITIS; INFLAMMATION MEDIATORS; LIPID METABOLISM; MALE; MICE, INBRED ICR; NEOPLASMS, EXPERIMENTAL; SIGNAL TRANSDUCTION; TERPENES;

EID: 84907680204     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400149     Document Type: Article

References (43)

1. Jemal, A., Siegel, R., Ward, E., Hao, Y. et al., Cancer statistics, 2009. CA Cancer J. Clin. 2009, 59, 225-249.
2. Davis, C. D., Hord, N. G., Nutritional "omics" technologies for elucidating the role(s) of bioactive food components in colon cancer prevention. J. Nutr. 2005, 135, 2694-2697.
3. Wogan, G. N., Hecht, S. S., Felton, J. S., Conney, A. H. et al., Environmental and chemical carcinogenesis. Semin. Cancer Biol. 2004, 14, 473-486.
4. Steed, H., Walsh, S., Reynolds, N., A brief report of the epidemiology of obesity in the inflammatory bowel disease population of Tayside, Scotland. Obes. Facts. 2009, 2, 370-372.
5. Park, S. Y., Kim, J. S., Seo, Y. R., Sung, M. K., Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice. Int. J. Obes. (Lond) 2012, 36, 273-280.
6. Yasui, Y., Suzuki, R., Miyamoto, S., Tsukamoto, T. et al., A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis. Int. J. Cancer 2007, 121, 2331-2339.
7. Giovannucci, E., Michaud, D., The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 2007, 132, 2208-2225.
8. Yamada, K., Araki, S., Tamura, M., Sakai, I. et al., Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ. Int. J. Epidemiol. 1998, 27, 794-798.
9. Chiou, Y. S., Ma, N. J., Sang, S., Ho, C. T. et al., Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J. Agric. Food Chem. 2012, 60, 3441-3451.
10. Teixeira, L. G., Leonel, A. J., Aguilar, E. C., Batista, N. V. et al., The combination of high-fat diet-induced obesity and chronic ulcerative colitis reciprocally exacerbates adipose tissue and colon inflammation. Lipids Health Dis. 2011, 10, 1-15.
11. Shao, J., Evers, B. M., Sheng, H., Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells. Cancer Res. 2004, 64, 229-235.
12. MacDonald, B. T., Tamai, K., He, X., Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 2009, 17, 9-26.
13. Tanti, J. F., Ceppo, F., Jager, J., Berthou, F., Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front. Endocrinol. (Lausanne) 2012, 3, 1-15.
14. Ding, Q., Xia, W., Liu, J. C., Yang, J. Y. et al., Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol. Cell 2005, 19, 159-170.
15. Miyamoto, S., Tanaka, T., Murakami, A., Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice. Chem. Biol. Interact. 2010, 183, 271-275.
16. Pan, M. H., Lai, C. S., Wu, J. C., Ho, C. T., Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds. Mol. Nutr. Food Res. 2011, 55, 32-45.
17. Ramamoorthi, G., Sivalingam, N., Molecular mechanism of TGF-beta signaling pathway in colon carcinogenesis and status of curcumin as chemopreventive strategy. Tumour Biol. 2014. doi: 10.1007/s13277-014-1840-1.
18. Lai, C. S., Wu, J. C., Yu, S. F., Badmaev, V. et al., Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis. Mol. Nutr. Food Res. 2011, 55, 1819-1828.
19. Saadat, N., Gupta, S. V., Potential role of garcinol as an anticancer agent. J. Oncol. 2012, 2012, 647206, 1-8.
20. Kolodziejczyk, J., Masullo, M., Olas, B., Piacente, S. et al., Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma. Platelets 2009, 20, 487-492.
21. Hsu, C. L., Lin, Y. J., Ho, C. T., Yen, G. C., Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food Funct. 2012, 3, 49-57.
22. Hsu, C. L., Lin, Y. J., Ho, C. T., Yen, G. C., The inhibitory effect of pterostilbene on inflammatory responses during the interaction of 3T3-L1 adipocytes and RAW 264.7 macrophages. J. Agric. Food Chem. 2013, 61, 602-610.
23. Hong, J., Kwon, S. J., Sang, S., Ju, J. et al., Effects of garcinol and its derivatives on intestinal cell growth: inhibitory effects and autoxidation-dependent growth-stimulatory effects. Free Radic. Biol. Med. 2007, 42, 1211-1221.
24. Liao, C. H., Sang, S., Ho, C. T., Lin, J. K., Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. J. Cell. Biochem. 2005, 96, 155-169.
25. Tanaka, T., Kohno, H., Shimada, R., Kagami, S. et al., Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats. Carcinogenesis 2000, 21, 1183-1189.
26. Shirakami, Y., Shimizu, M., Tsurumi, H., Hara, Y. et al., EGCG and Polyphenon E attenuate inflammation-related mouse colon carcinogenesis induced by AOM plus DDS. Mol. Med. Report 2008, 1, 355-361.
27. Nowak, J., Weylandt, K. H., Habbel, P., Wang, J. et al., Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis 2007, 28, 1991-1995.
28. Bird, R. P., Good, C. K., The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol. Lett. 2000, 112-113, 395-402.
29. Miyoshi, N., Nagasawa, T., Mabuchi, R., Yasui, Y. et al., Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin. Cancer Prev. Res. (Phila) 2011, 4, 924-934.
30. Rubin, D. C., Shaker, A., Levin, M. S., Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front. Immunol. 2012, 3, 1-10.
31. Collins, P. D., Strategies for detecting colon cancer and dysplasia in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 2013, 19, 860-863.
32. Jawad, N., Direkze, N., Leedham, S. J., Inflammatory bowel disease and colon cancer. Recent Results Cancer Res. 2011, 185, 99-115.
33. Kim, I. W., Myung, S. J., Do, M. Y., Ryu, Y. M. et al., Western-style diets induce macrophage infiltration and contribute to colitis-associated carcinogenesis. J. Gastroenterol. Hepatol. 2010, 25, 1785-1794.
34. Zhao, W., Song, L., Hongzhu, D., Amelioration of dextran sulfate sodium-induced chronic colitis by sulfasalazine salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters. Yakugaku Zasshi 2010, 130, 1239-1249.
35. Karlsson, A., Jagervall, A., Pettersson, M., Andersson, A. K. et al., Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters. Int. Immunopharmacol. 2008, 8, 20-27.
36. Chiou, Y. S., Tsai, M. L., Wang, Y. J., Cheng, A. C. et al., Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice. J. Agric. Food Chem. 2010, 58, 8833-8841.
37. Saud, S. M., Young, M. R., Jones-Hall, Y. L., Ileva, L. et al., Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and beta-catenin. Cancer Res. 2013, 73, 5473-5484.
38. Li, H., Wu, W. K., Li, Z. J., Chan, K. M. et al., 2, 3', 4, 4', 5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice. Br. J. Pharmacol. 2010, 160, 1352-1361.
39. Saxena, A., Chumanevich, A., Fletcher, E., Larsen, B. et al., Adiponectin deficiency: role in chronic inflammation induced colon cancer. Biochim. Biophys. Acta 2012, 1822, 527-536.
40. Cho, H. J., Park, J., Lee, H. W., Lee, Y. S. et al., Regulation of adipocyte differentiation and insulin action with rapamycin. Biochem. Biophys. Res. Commun. 2004, 321, 942-948.
41. de, L. C., Olefsky, J. M., Inflammation and insulin resistance. FEBS Lett. 2008, 582, 97-105.
42. Vigneron, F., Dos, S. P., Lemoine, S., Bonnet, M. et al., GSK-3beta at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways. Cardiovasc. Res. 2011, 90, 49-56.
43. Ahmad, A., Sarkar, S. H., Bitar, B., Ali, S. et al., Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol. Cancer Ther. 2012, 11, 2193-2201.