A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation

International Journal of Cancer

Volumn 131, Issue 6, 2012, Pages 1445-1454

  Feng, Chao ^a   Zhou, Li Ying ^a   Yu, Ting ^b   Xu, Gang ^c   Tian, Hong Lei ^a   Xu, Jin Jie ^a   Xu, Hong Xi ^d   Luo, Kathy Qian ^b  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b Nanyang Technological University   (Singapore)

^c KUNMING INSTITUTE OF BOTANY   (China)

^d SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

anticancer drug discovery; apoptosis; Bax; herbal medicine; oblongifolin C

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ETOPOSIDE; GLYCOPROTEIN P; OBLONGIFOLIN C; PACLITAXEL; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BID; UNCLASSIFIED DRUG; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL STRAIN MCF 7; CHROMOSOMAL PARAMETERS; CHROMOSOME FRAGMENTATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ENZYME ACTIVATION; ENZYME RELEASE; GARCINIA; GARCINIA YUNNANENSIS; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; FEMALE; GARCINIA; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MITOCHONDRIA; P-GLYCOPROTEIN; RECEPTOR, ERBB-2; TERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864117228     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27365     Document Type: Article

References (38)

1. Aggarwal BB, Ichikawa H, Garodia P, Weerasinghe P, Sethi G, Bhatt ID, Pandey MK, Shishodia S, Nair MG,. From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer. Exp Opin Ther Targets 2006; 10: 87-118.
2. Newman DJ, Cragg GM, Snader KM,. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 2003; 66: 1022-37.
3. Cragg GM, Newman DJ,. Plants as a source of anti-cancer agents. J Ethnopharmacol 2005; 100: 72-9.
4. Bhalla K, Ibrado AM, Tourkina E, Tang C, Mahoney ME, Huang Y,. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia 1993; 7: 563-8.
5. Takano Y, Okudaira M, Harmon BV,. Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol Res Pract 1993; 189: 197-203.
6. Hertzberg RP, Caranfa MJ, Hecht SM,. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex. Biochemistry 1989; 28: 4629-38.
7. Fearnhead HO, Chwalinski M, Snowden RT, Ormerod MG, Cohen GM,. Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle. Biochem Pharmacol 1994; 48: 1073-9.
8. Desagher S, Martinou JC,. Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000; 10: 369-77.
9. Du C, Fang M, Li Y, Li L, Wang X,. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000; 102: 33-42.
10. Wang JY, Ki SW,. Choosing between growth arrest and apoptosis through the retinoblastoma tumour suppressor protein, Abl and p73. Biochem Soc Trans 2001; 29: 666-73.
11. Cohen GM,. Caspases: the executioners of apoptosis. Biochem J 1997; 326: 1-16.
12. Cryns V, Yuan J,. Proteases to die for. Genes Dev 1998; 12: 1551-70.
13. Thornberry NA, Lazebnik Y,. Caspases: enemies within. Science 1998; 281: 1312-6.
14. Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH,. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 2000; 7: 1166-73.
15. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ,. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292: 727-30.
16. Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD,. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol cell 2005; 17: 525-35.
17. Adams JM, Cory S,. The Bcl-2 protein family: arbiters of cell survival. Science 1998; 281: 1322-6.
18. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X,. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-89.
19. Gottesman MM,. Mechanisms of cancer drug resistance. Ann Rev Med 2002; 53: 615-27.
20. Hall MD, Handley MD, Gottesman MM,. Is resistance useless? Multidrug resistance and collateral sensitivity. Trends Pharmacol Sci 2009; 30: 546-56.
21. Yu D, Liu B, Tan M, Li J, Wang SS, Hung MC,. Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms. Oncogene 1996; 13: 1359-65.
22. Luo KQ, Yu VC, Pu Y, Chang DC,. Application of the fluorescence resonance energy transfer method for studying the dynamics of caspase-3 activation during UV-induced apoptosis in living HeLa cells. Biochem Biophys Res Commun 2001; 283: 1054-60.
23. Tian H, Ip L, Luo H, Chang DC, Luo KQ,. A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine. Br J Pharmacol 2007; 150: 321-34.
24. Tian H-L, Yu T, Xu N-N, Feng C, Zhou L-Y, Luo H-W, Chang DC, Le X-F, Luo KQ,. A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. Cancer Lett 2010; 297: 18-30.
25. Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE,. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 1997; 277: 373-6.
26. Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, Vaigro-Wolff A, Gray-Goodrich M, Campbell H, et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 1991; 83: 757-66.
27. Xu G, Feng C, Zhou Y, Han Q-B, Qiao C-F, Huang S-X, Chang DC, Zhao Q-S, Luo KQ, Xu H-X,. Bioassay and ultraperformance liquid chromatography/mass spectrometry guided isolation of apoptosis-inducing benzophenones and xanthone from the pericarp of Garcinia yunnanensis Hu. J Agric Food Chem 2008; 56: 11144-50.
28. Kuete V, Komguem J, Beng VP, Meli AL, Tangmouo JG, Etoa FX, Lontsi D,. Antimicrobial components of the methanolic extract from the stem bark of Garcinia smeathmannii Oliver (Clusiaceae). South African J Bot 2007; 73: 347-54.
29. Lannang AM, Komguem J, Ngninzeko FN, Tangmouo JG, Lontsi D, Ajaz A, Choudhary MI, Sondengam BL, Atta Ur R,. Antioxidant benzophenones and xanthones from the root bark of Garcinia smeathmannii. Bull Chem Soc Ethiopia 2006; 20: 247-52.
30. Herath K, Jayasuriya H, Ondeyka JG, Guan Z, Borris RP, Stijfhoorn E, Stevenson D, Wang J, Sharma N, MacNaul K, Menke JG, Ali A, et al. Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. J Nat Prod 2005; 68: 617-19.
31. Hamed W, Brajeul S, Mahuteau-Betzer F, Thoison O, Mons S, Delpech B, Hung NV, Sevenet T, Marazano C,. Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia. J Nat Prod 2006; 69: 774-77.
32. Gu Q, Wang JD, Xia HHX, Lin MCM, He H, Zou B, Tu SP, Yang Y, Liu XG, Lam SK, Wong WM, Chan AOO, et al. Activation of the caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis 2005; 26: 541-46.
33. Vu CCQ, Bortner CD, Cidlowski JA,. Differential involvement of initiator caspases in apoptotic volume decrease and potassium efflux during Fas- and UV-induced cell death. J Biol Chem 2001; 276: 37602-11.
34. Wen XF, Yang G, Mao W, Thornton A, Liu J, Bast Jr RC, Le XF,. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: Implications for HER2-targeted antibody therapy. Oncogene 2006; 25: 6986-96.
35. Alvarez M, Paull K, Monks A, Hose C, Lee JS, Weinstein J, Grever M, Bates S, Fojo T,. Generation of a drug resistance profile by quantitation of mdr-1/P- glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen. J Clin Invest 1995; 95: 2205-14.
36. Bliss CI,. The method of probits. Science 1934; 79: 38-39.
37. Finney DJ,. Probit analysis, 3rd edn. New York: Cambridge University Press, 1977.
38. Xu G, Kan WLT, Zhou Y, Song JZ, Han QB, Qiao CF, Cho CH, Rudd JA, Lin G, Xu HX,. Cytotoxic acylphloroglucinol derivatives from the twigs of Garcinia cowa. J Nat Prod 2010; 73: 104-08.