Inhibitory effect of oblongifolin C on allergic inflammation through the suppression of mast cell activation

Molecular and Cellular Biochemistry

Volumn 406, Issue 1-2, 2015, Pages 263-271

  Lu, Yue ^a,b   Cai, Shuangfan ^a,b   Tan, Hongsheng ^a,b   Fu, Wenwei ^a,b   Zhang, Hong ^a,b   Xu, Hongxi ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery   (China)

Author keywords

Mouse bone marrow derived mast cells; Nuclear factor B; Oblongifolin C; Passive systemic anaphylaxis; Tyrosine kinase activity

Indexed keywords

CALCIUM ION; CYCLOOXYGENASE 2; FEXOFENADINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOTRIENE C4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OBLONGIFOLIN C; PHOSPHOLIPASE C GAMMA1; PROSTAGLANDIN D2; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN KINASE SYK; STRESS ACTIVATED PROTEIN KINASE; ANTIINFLAMMATORY AGENT; CALCIUM; TERPENE;

ALLERGIC INFLAMMATION; ALLERGIC REACTION; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIALLERGIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW DERIVED MAST CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GARCINIA; GARCINIA YUNNANENSIS; IN VITRO STUDY; INFLAMMATION; MALE; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PERICARP; PROSTAGLANDIN RELEASE; SIGNAL TRANSDUCTION; SOLVENT EXTRACTION; SYSTEMIC ANAPHYLAXIS; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; DEGRANULATION; DRUG EFFECTS; HYPERSENSITIVITY; INSTITUTE FOR CANCER RESEARCH MOUSE; MAST CELL; METABOLISM; PHOSPHORYLATION; PRECLINICAL STUDY; PROTEIN PROCESSING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CALCIUM; CELL DEGRANULATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HYPERSENSITIVITY; LEUKOTRIENE C4; MALE; MAP KINASE SIGNALING SYSTEM; MAST CELLS; MICE, INBRED BALB C; MICE, INBRED ICR; NF-KAPPA B; PHOSPHORYLATION; PROSTAGLANDIN D2; PROTEIN PROCESSING, POST-TRANSLATIONAL; TERPENES;

EID: 84945972009     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-015-2444-9     Document Type: Article

References (37)

1. Metz M, Maurer M (2007) Mast cells–key effector cells in immune responses. Trends Immunol 28:234–241. doi:10.1016/j.it.2007.03.003
2. Gregory GD, Brown MA (2006) Mast cells in allergy and autoimmunity: implications for adaptive immunity. Methods Mol Biol 315:35–50
3. Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ (2006) Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 442:997–1002. doi:10.1038/nature05010
4. Galli SJ, Nakae S, Tsai M (2005) Mast cells in the development of adaptive immune responses. Nat Immunol 6:135–142
5. Marshall JS (2004) Mast-cell responses to pathogens. Nat Rev Immunol 4:787–799. doi:10.1038/nri1460
6. Marone G, Triggiani M, de Paulis A (2005) Mast cells and basophils: friends as well as foes in bronchial asthma? Trends Immunol 26:25–31. doi:10.1016/j.it.2004.10.010
7. Galli SJ, Grimbaldeston M, Tsai M (2008) Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 8:478–486
8. Heavey DJ, Ernst PB, Stevens RL, Befus AD, Bienenstock J, Austen KF (1988) Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. J Immunol 140:1953–1957
9. Roth K, Chen WM, Lin TJ (2008) Positive and negative regulatory mechanisms in high-affinity IgE receptor-mediated mast cell activation. Arch Immunol Ther Exp (Warsz) 56:385–399
10. Gilfillan AM, Tkaczyk C (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 6:218–230
11. Feng C, Zhou LY, Yu T, Xu G, Tian HL, Xu JJ, Xu HX, Luo KQ (2012) A new anticancer compound, oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. Int J Cancer 131:1445–1454. doi:10.1002/ijc.27365
12. Lao Y, Wan G, Liu Z, Wang X, Ruan P, Xu W, Xu D, Xie W, Zhang Y, Xu H, Xu N (2014) The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation. Autophagy 10:736–749. doi:10.4161/auto.28034
13. Xu G, Feng C, Zhou Y, Han QB, Qiao CF, Huang SX, Chang DC, Zhao QS, Luo KQ, Xu HX (2008) Bioassay and ultraperformance liquid chromatography/mass spectrometry guided isolation of apoptosis-inducing benzophenones and xanthone from the pericarp of Garcinia yunnanensis Hu. J Agric Food Chem 56:11144–11150. doi:10.1021/jf802690g
14. Murakami M, Austen KF, Bingham CO 3rd, Friend DS, Penrose JF, Arm JP (1995) Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. J Biol Chem 270:22653–22656
15. Lu Y, Yang JH, Li X, Hwangbo K, Hwang SL, Taketomi Y, Murakami M, Chang YC, Kim CH, Son JK, Chang HW (2011) Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Biochem Pharmacol 82:1700–1708
16. Abell K, Watson CJ (2005) The Jak/Stat pathway: a novel way to regulate PI3K activity. Cell Cycle 4:897–900
17. Hart PH (2001) Regulation of the inflammatory response in asthma by mast cell products. Immunol Cell Biol 79:149–153. doi:10.1046/j.1440-1711.2001.00983.x
18. Shen W, Li Y, Tang Y, Cummins J, Huard J (2005) NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. Am J Pathol 167:1105–1117. doi:10.1016/s0002-9440(10)61199-6
19. Soberman RJ, Christmas P (2003) The organization and consequences of eicosanoid signaling. J Clin Invest 111:1107–1113
20. Sanderson MP, Wex E, Kono T, Uto K and Schnapp A Syk and Lyn mediate distinct Syk phosphorylation events in FcvarepsilonRI-signal transduction: Implications for regulation of IgE-mediated degranulation. Mol Immunol
21. Kawakami T, Galli SJ (2002) Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2:773–786
22. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 271:695–701
23. Hitomi K, Tahara-Hanaoka S, Someya S, Fujiki A, Tada H, Sugiyama T, Shibayama S, Shibuya K, Shibuya A (2010) An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Nat Immunol 11:601–607. doi:10.1038/ni.1886
24. Ciprandi G, Tosca MA, Cosentino C, Riccio AM, Passalacqua G, Canonica GW (2003) Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules. J Allergy Clin Immunol 112:S78–S82
25. Rivera J (2002) Molecular adapters in Fc(epsilon)RI signaling and the allergic response. Curr Opin Immunol 14:688–693
26. Nadler MJ, Matthews SA, Turner H, Kinet JP (2000) Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function. Adv Immunol 76:325–355
27. Lee JH, Kim JW, Ko NY, Mun SH, Her E, Kim BK, Han JW, Lee HY, Beaven MA, Kim YM, Choi WS (2008) Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol 121:1225–1231
28. Hwang SL, Li X, Lu Y, Jin Y, Jeong YT, Kim YD, Lee IK, Taketomi Y, Sato H, Cho YS, Murakami M, Chang HW (2013) AMP-activated protein kinase negatively regulates FcepsilonRI-mediated mast cell signaling and anaphylaxis in mice. J Allergy Clin Immunol 132(729–736):e12. doi:10.1016/j.jaci.2013.02.018
29. Barbu EA, Zhang J, Siraganian RP (2010) The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells. J Biol Chem 285:15761–15768
30. Kalesnikoff J, Galli SJ (2008) New developments in mast cell biology. Nat Immunol 9:1215–1223
31. Parravicini V, Gadina M, Kovarova M, Odom S, Gonzalez-Espinosa C, Furumoto Y, Saitoh S, Samelson LE, O’Shea JJ, Rivera J (2002) Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 3:741–748
32. Gomez G, Gonzalez-Espinosa C, Odom S, Baez G, Cid ME, Ryan JJ, Rivera J (2005) Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J Immunol 175:7602–7610
33. Tshori S, Razin E (2010) Editorial: mast cell degranulation and calcium entry–the Fyn-calcium store connection. J Leukoc Biol 88:837–838. doi:10.1189/jlb.0610365
34. Gijon MA, Spencer DM, Kaiser AL, Leslie CC (1999) Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2. J Cell Biol 145:1219–1232
35. Evans JH, Spencer DM, Zweifach A, Leslie CC (2001) Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes. J Biol Chem 276:30150–30160
36. Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18:621–663
37. Peng Y, Power MR, Li B, Lin TJ (2005) Inhibition of IKK down-regulates antigen + IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation. J Leukoc Biol 77:975–983. doi:10.1189/jlb.0204115