메뉴 건너뛰기




Volumn 46, Issue 9, 2016, Pages 785-833

A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study

Author keywords

Endocrine Disruptor Screening Program; ExpoCast; high throughput screening; myclobutanil; propiconazole; Tox21; ToxCast; triadimefon

Indexed keywords

ANDROGEN; ENDOCRINE DISRUPTOR; ESTROGEN; FUNGICIDE; MYCLOBUTANIL; PROPICONAZOLE; THYROID HORMONE; TRIADIMEFON; TRIAZOLE DERIVATIVE; NITRILE; SYSTHANE;

EID: 84988908518     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408444.2016.1193722     Document Type: Review
Times cited : (31)

References (131)
  • 1
    • 84988810120 scopus 로고
    • D.M.Andersen, G.P.O’Hara, W.R.Brown 1993. RH-3866:dietary oncogenicity study in female mice. final report:Report No. 89R-261. Unpublished study prepared by Rohm and Haas Co. MRID 42809102.
    • (1993)
    • Andersen, D.M.1    O’Hara, G.P.2    Brown, W.R.3
  • 2
    • 0026554628 scopus 로고
    • UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism
    • R.A.Barter, C.D.Klaassen 1992. UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol Appl Pharmacol. 113:36–42.
    • (1992) Toxicol Appl Pharmacol , vol.113 , pp. 36-42
    • Barter, R.A.1    Klaassen, C.D.2
  • 3
    • 0036173230 scopus 로고    scopus 로고
    • Development of an immuno-immobilized androgen receptor assay (IRA) and its application for the characterization of the receptor binding affinity of different pesticides
    • E.R.Bauer, N.Bitsch, H.Brunn, H.Sauerwein, H.H.Meyer 2002. Development of an immuno-immobilized androgen receptor assay (IRA) and its application for the characterization of the receptor binding affinity of different pesticides. Chemosphere. 46:1107–1115.
    • (2002) Chemosphere , vol.46 , pp. 1107-1115
    • Bauer, E.R.1    Bitsch, N.2    Brunn, H.3    Sauerwein, H.4    Meyer, H.H.5
  • 4
    • 0035721572 scopus 로고    scopus 로고
    • Dopamine as a prolactin (PRL) inhibitor
    • N.Ben-Jonathan, R.Hnasko 2001. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev. 22:724–763.
    • (2001) Endocr Rev , vol.22 , pp. 724-763
    • Ben-Jonathan, N.1    Hnasko, R.2
  • 5
    • 84988852204 scopus 로고
    • E.Bomhard, B.Schilde 1991. MEB 6447:Chronic toxicity and cancerogenicity studies on Wistar rats with administration in diet over a period of 105 weeks:lab project number:20774:101922. Unpublished study prepared by Bayer AG, Dept of Toxicology. MRID 42153901:1029 p.
    • (1991)
    • Bomhard, E.1    Schilde, B.2
  • 6
    • 84988852197 scopus 로고
    • C.Borders, C.Salamon 1985. Two-generation reproduction study in albino rats with CGA-64250 technical. Unpublished study prepared by Toxigenics, Inc. MRID 00151514.
    • (1985)
    • Borders, C.1    Salamon, C.2
  • 9
    • 84888033883 scopus 로고    scopus 로고
    • Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics
    • C.M.Butt, H.M.Stapleton 2013. Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics. Chem Res Toxicol. 26:1692–1702.
    • (2013) Chem Res Toxicol , vol.26 , pp. 1692-1702
    • Butt, C.M.1    Stapleton, H.M.2
  • 10
    • 84988845886 scopus 로고    scopus 로고
    • P.Coder 2012. Propiconazole – uterotrophic assay in ovariectomized rats (OECD guideline 440; US EPA OPPTS 890.1600):Unpublished study prepared by WIL Research Laboratories, LLC, Ashland, OH USA. MRID 48619003.
    • (2012)
    • Coder, P.1
  • 11
    • 84988845871 scopus 로고
    • R.Costlow, W.Kane 1984a. Teratology study with RH-53,866 in rats:Final Report:Report No. 83R-024. Unpublished study prepared by Rohm and Haas Co. 123 p. MRID 00141672.
    • (1984)
    • Costlow, R.1    Kane, W.2
  • 12
    • 84988843088 scopus 로고
    • R.Costlow, W.Kane 1984b. Teratology study with RH-53, 866 in rabbits:Report No. 83R-217. Unpublished study prepared by Rohm and Haas Co. 139 p. MRID 00164971.
    • (1984)
    • Costlow, R.1    Kane, W.2
  • 13
    • 84988845881 scopus 로고
    • R.Costlow, J.Harris 1985. RH-53,866:two generation reproduction study in rats:Report No. 84R-117. Unpublished study prepared by Rohm and Haas Co. 225 p. MRID 00149581.
    • (1985)
    • Costlow, R.1    Harris, J.2
  • 14
    • 84988843103 scopus 로고    scopus 로고
    • K.K.Coady, L.K.Sosinski 2011. Myclobutanil:evaluation of myclobutanil in the human recombinant aromatase assay. Unpublished study prepared by Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, MI. Laboratory Project Study ID No.:111015, November 28, 2011. MRID 48618103.
    • (2011)
    • Coady, K.K.1    Sosinski, L.K.2
  • 15
    • 0029875537 scopus 로고    scopus 로고
    • A structure–activity relationship for the neurotoxicity of triazole fungicides
    • K.M.Crofton 1996. A structure–activity relationship for the neurotoxicity of triazole fungicides. Toxicol Lett. 84:155–159.
    • (1996) Toxicol Lett , vol.84 , pp. 155-159
    • Crofton, K.M.1
  • 16
    • 84988843100 scopus 로고
    • G.Clemens, V.Jasty, C.Troup, R.Hartnagel 1990. A toxicity study in the rabbit with MEB 6447 (Triadimefon):Report No. 100035. Upublished study prepared by Miles Laboratories, Inc. MRID 41616005:179 p.
    • (1990)
    • Clemens, G.1    Jasty, V.2    Troup, C.3    Hartnagel, R.4
  • 17
    • 84899822044 scopus 로고    scopus 로고
    • Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action
    • R.A.Currie, R.C.Peffer, A.K.Goetz, C.J.Omiecinski, J.I.Goodman 2014. Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action. Toxicology 321:80–88.
    • (2014) Toxicology , vol.321 , pp. 80-88
    • Currie, R.A.1    Peffer, R.C.2    Goetz, A.K.3    Omiecinski, C.J.4    Goodman, J.I.5
  • 18
    • 84988839601 scopus 로고    scopus 로고
    • J.Davis 2011. The Hershberger bioassay (OPPTS 890.1400); triadimefon. Unpublished study prepared by ILS, Integrated Laboratory Systems, Inc. MRID 48619604:107.
    • (2011)
    • Davis, J.1
  • 19
    • 33751298289 scopus 로고    scopus 로고
    • Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action
    • V.L.Dellarco, D.McGregor, S.C.Berry, S.M.Cohen, A.R.Boobis 2006. Thiazopyr and thyroid disruption:case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action. Crit Rev Toxicol. 36:793–801.
    • (2006) Crit Rev Toxicol , vol.36 , pp. 793-801
    • Dellarco, V.L.1    McGregor, D.2    Berry, S.C.3    Cohen, S.M.4    Boobis, A.R.5
  • 20
    • 84988809150 scopus 로고
    • R.Eiben 1984. MED 6447 (Triadimefon):Two-Generation Study with Rats:Supplementary Study:Report No. 12712. Unpublished study prepared by Bayer AG, Institute of Toxicology. MRID 155075:168p.
    • (1984)
    • Eiben, R.1
  • 21
    • 84988832337 scopus 로고
    • H.Fritz 1984a. Expanded report on CGA-64250 technical segment II teratology study in rats. Project No. 790011, 21 September 1984. Unpublished study prepared by Ciba-Geigy. Syngenta File No. CGA64250/2150. MRID 00058604.
    • (1984)
    • Fritz, H.1
  • 22
    • 84988845257 scopus 로고
    • H.Fritz 1984b. Expanded report on CGA64250 technical segment II reproductive study in rabbits. Project No. 790009. Unpublished study prepared by Ciba-Geigy. Syngenta File No. CGA64250/2151. MRID 00058605.
    • (1984)
    • Fritz, H.1
  • 23
    • 0033771336 scopus 로고    scopus 로고
    • Prolactin: structure, function, and regulation of secretion
    • M.E.Freeman, B.Kanyicska, A.Lerant, G.Nagy 2000. Prolactin:structure, function, and regulation of secretion. Physiol Rev. 80:1523–1631.
    • (2000) Physiol Rev , vol.80 , pp. 1523-1631
    • Freeman, M.E.1    Kanyicska, B.2    Lerant, A.3    Nagy, G.4
  • 24
    • 0037006012 scopus 로고    scopus 로고
    • Reproductive changes in male rats treated perinatally with an aromatase inhibitor
    • D.C.Gerardin, O.C.Pereira 2002. Reproductive changes in male rats treated perinatally with an aromatase inhibitor. Pharmacol Biochem Behav. 71:301–305.
    • (2002) Pharmacol Biochem Behav , vol.71 , pp. 301-305
    • Gerardin, D.C.1    Pereira, O.C.2
  • 25
    • 84988855379 scopus 로고
    • M.Giknis 1987. CGA 64250 technical:teratology (segment II) study in rats. Project No.86004. Syngenta File No. CGA64250/1586. Unpublished study prepared by Ciba-Geigy. MRID 40425001.
    • (1987)
    • Giknis, M.1
  • 27
    • 67650760524 scopus 로고    scopus 로고
    • Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals
    • A.K.Goetz, D.J.Dix 2009a. Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals. Toxicol Sci. 110:449–462.
    • (2009) Toxicol Sci , vol.110 , pp. 449-462
    • Goetz, A.K.1    Dix, D.J.2
  • 28
    • 66049136991 scopus 로고    scopus 로고
    • Toxicogenomic effects common to triazole antifungals and conserved between rats and humans
    • A.K.Goetz, D.J.Dix 2009b. Toxicogenomic effects common to triazole antifungals and conserved between rats and humans. Toxicol Appl Pharmacol. 238:80–89.
    • (2009) Toxicol Appl Pharmacol , vol.238 , pp. 80-89
    • Goetz, A.K.1    Dix, D.J.2
  • 31
    • 84988885272 scopus 로고
    • P.Goldman, J.Harris 1986. RH-3866:Dietary chronic and oncogenicity study in mice:Final Report:Report Number 84R-023. Unpublished study prepared by Rohm and Haas Co. 3326 p. MRID 00164990.
    • (1986)
    • Goldman, P.1    Harris, J.2
  • 32
    • 84988809168 scopus 로고
    • P.Goldman, J.Harris, K.Lampe 1986a. RH-3866:a three-month dietary toxicity study in mice:Report No. 83R-136. Unpublished study prepared by Rohm & Haas Co. 522 p. MRID 00165245.
    • (1986)
    • Goldman, P.1    Harris, J.2    Lampe, K.3
  • 33
    • 84988905511 scopus 로고
    • P.Goldman, J.Harris, J.Frantz 1986b. RH-3866:one year dietary study in Beagle dogs:Protocol No. 84P-203:Report No. 84R-078. Unpublished study prepared by Rohm & Haas Co. 775 p. MRID 00165248.
    • (1986)
    • Goldman, P.1    Harris, J.2    Frantz, J.3
  • 34
    • 33845808673 scopus 로고    scopus 로고
    • Transcriptional profiles in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil
    • S.D.Hester, D.C.Wolf, S.Nesnow, S.F.Thai 2006. Transcriptional profiles in liver from rats treated with tumorigenic and non-tumorigenic triazole conazole fungicides:propiconazole, triadimefon, and myclobutanil. Toxicol Pathol. 34:879–894.
    • (2006) Toxicol Pathol , vol.34 , pp. 879-894
    • Hester, S.D.1    Wolf, D.C.2    Nesnow, S.3    Thai, S.F.4
  • 35
    • 84988805030 scopus 로고
    • K.Hoffman, P.Groning 1978. Meb 6447 long-term toxicity study on dogs (two-year feeding study):Report No. 7882; Report No. 66656. Unpublished study received Apr 28, 1980 under 3125-318; prepared by Bayer, AG, submitted by Mobay Chemical Corp, Kansas City:Mo; CDL:099413-D. MRID 32539.
    • (1978)
    • Hoffman, K.1    Groning, P.2
  • 36
    • 84988885276 scopus 로고
    • B.Hunter, N.Slater, R.Heywood 1982a. CGA 64 250:potential tumorigenic and toxic effects in prolonged dietary administration to rats:CBG 193/8284 (Test No. 789023). Final rept. Unpublished study prepared by Huntingdon Research Centre, England. MRID 00129918.
    • (1982)
    • Hunter, B.1    Slater, N.2    Heywood, R.3
  • 37
    • 84988802625 scopus 로고
    • B.Hunter, D.Scholey, R.Haywood 1982b. CGA 64 250:long-term feeding study in mice. CBGI195/81827. Final Report. Unpublished study prepared by Huntingdon Research Centre, England. MRID 00129570.
    • (1982)
    • Hunter, B.1    Scholey, D.2    Haywood, R.3
  • 38
    • 0032755932 scopus 로고    scopus 로고
    • Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy
    • A.Hood, R.Hashmi, C.D.Klaassen 1999. Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. Toxicol Appl Pharmacol. 160:163–170.
    • (1999) Toxicol Appl Pharmacol , vol.160 , pp. 163-170
    • Hood, A.1    Hashmi, R.2    Klaassen, C.D.3
  • 39
    • 0037213832 scopus 로고    scopus 로고
    • The potential for oestrogenic effects of pesticides in headwater streams in the UK
    • M.R.Hurst, D.A.Sheehan 2003. The potential for oestrogenic effects of pesticides in headwater streams in the UK. Sci Total Environ 301:87–96.
    • (2003) Sci Total Environ , vol.301 , pp. 87-96
    • Hurst, M.R.1    Sheehan, D.A.2
  • 40
    • 84988855363 scopus 로고    scopus 로고
    • IARC. 1999. Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis, IARC Scientific Publication No. 147. International Agency for Research on Cancer, Lyon, France.
    • (1999)
  • 41
    • 84988905121 scopus 로고
    • W.Johnson, S.Thompson 1985. One-year subchronic oral toxicity study in Beagle dogs with CGA-64250 technical (Final Report). FDRL Study No. 7737. Unpublished study prepared by Research Laboratories, Inc. 570 p. Syngenta File No. CGA64250/1544. MRID 00151515.
    • (1985)
    • Johnson, W.1    Thompson, S.2
  • 42
    • 27744504199 scopus 로고    scopus 로고
    • Comparison of regulatory estimates of drinking water concentrations with monitoring data
    • R.L.Jones 2005. Comparison of regulatory estimates of drinking water concentrations with monitoring data. J Agric Food Chem. 53:8835–8839.
    • (2005) J Agric Food Chem , vol.53 , pp. 8835-8839
    • Jones, R.L.1
  • 46
    • 10044236969 scopus 로고    scopus 로고
    • Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells
    • H.Kojima, E.Katsura, S.Takeuchi, K.Niiyama, K.Kobayashi 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 112:524–531.
    • (2004) Environ Health Perspect , vol.112 , pp. 524-531
    • Kojima, H.1    Katsura, E.2    Takeuchi, S.3    Niiyama, K.4    Kobayashi, K.5
  • 47
    • 33750009766 scopus 로고    scopus 로고
    • Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line
    • N.P.Laville, F.Brion, N.Hinfray, C.Casellas, J.-M.Porcher, S.Ait-Aissa 2006. Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line. Toxicology. 228:98–108.
    • (2006) Toxicology , vol.228 , pp. 98-108
    • Laville, N.P.1    Brion, F.2    Hinfray, N.3    Casellas, C.4    Porcher, J.-M.5    Ait-Aissa, S.6
  • 48
    • 84988809156 scopus 로고    scopus 로고
    • M.J.LeBaron, M.R.Schisler, N.R.Visconti 2011a. Evaluation of myclobutanil in an in vitro estrogen receptor binding assay. Unpublished study prepared by Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, MI. Laboratory Study No.:111118, December 14, 2011. MRID 48618104.
    • (2011)
    • LeBaron, M.J.1    Schisler, M.R.2    Visconti, N.R.3
  • 49
    • 84988816020 scopus 로고    scopus 로고
    • M.J.LeBaron, M.R.Schisler, N.R.Visconti 2011b. Evaluation of myclobutanil in an in vitro androgen receptor binding assay. Unpublished study prepared by Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, MI. Laboratory Study No.:111113, December 5, 2011. MRID 48618102.
    • (2011)
    • LeBaron, M.J.1    Schisler, M.R.2    Visconti, N.R.3
  • 50
    • 84988873440 scopus 로고    scopus 로고
    • M.J.LeBaron, H.L.Kan 2011c. Evaluation of myclobutanil in an in vitro estrogen receptor transcriptional activation assay in human cell line hERα-HeLa-9903. Unpublished study prepared by Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, MI. Laboratory Report No.:101193, December 12, 2011. MRID 48618105.
    • (2011)
    • LeBaron, M.J.1    Kan, H.L.2
  • 51
    • 84988816093 scopus 로고    scopus 로고
    • M.J.LeBaron, H.L.Kan, A.W.Perala 2011d. Evaluation of myclobutanil in the in vitro steroidogenesis assay. Unpublished study prepared by Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, MI. Laboratory Study No.:101192, December 5, 2011. MRID 48618110.
    • (2011)
    • LeBaron, M.J.1    Kan, H.L.2    Perala, A.W.3
  • 52
    • 84988901944 scopus 로고
    • E.Loser, D.Lorke 1979. Meb 6447 Multigeneration Reproduction Study on Rats:Report No. 8297; Report No. 67752. Unpublished study received Apr 28, 1980 under 3125-318; prepared by Bayer, AG, submitted by Mobay Chemical Corp, Kansas City:Mo; CDL:099413-F. MRID 32541.
    • (1979)
    • Loser, E.1    Lorke, D.2
  • 53
    • 84988881863 scopus 로고
    • S.Mallow et al. 1987. CGA 64250:a modified teratology (segment II) study in albino rats. Project No.86189. Syngenta File No. CGA64250/1587. Unpublished study prepared by Ciba-Geigy. MRID 40425002.
    • (1987)
    • Mallow, S.1
  • 56
    • 0033377108 scopus 로고    scopus 로고
    • Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor
    • M.S.Marty, J.W.Crissman, E.W.Carney 1999. Evaluation of the EDSTAC female pubertal assay in CD rats using 17beta-estradiol, steroid biosynthesis inhibitors, and a thyroid inhibitor. Toxicol Sci. 52:269–277.
    • (1999) Toxicol Sci , vol.52 , pp. 269-277
    • Marty, M.S.1    Crissman, J.W.2    Carney, E.W.3
  • 59
    • 0029563556 scopus 로고
    • Mechanistic considerations for the relevance of animal data on thyroid neoplasia to human risk assessment
    • R.M.McClain 1995. Mechanistic considerations for the relevance of animal data on thyroid neoplasia to human risk assessment. Mutat Res. 333:131–142.
    • (1995) Mutat Res , vol.333 , pp. 131-142
    • McClain, R.M.1
  • 61
    • 84988832416 scopus 로고
    • J.E.McLaughlin, L.J.DiDonato 1984. RH-3866:a three month dietary study in dogs. Unpublished study report prepared by Rohm and Hass Company, a wholly-owned subsidiary of The Dow Chemical Company, Midland, Michigan.
    • (1984)
    • McLaughlin, J.E.1    DiDonato, L.J.2
  • 62
    • 84988855426 scopus 로고
    • U.Mohr 1976. Meb 6447:Subchronic Toxicity Study on Rats (Twelve-week Feeding Experiment):Report No. R 840a; Report No. 44300. Unpublished study received Aug 15, 1977 under 3125-318; prepared by Medizinische Hochschule Hannover, Abteilung fur Experimentalle Pathologie, West Germany, submitted by Mobay Chemical Corp, Kansas City, Mo; CDL:2311312-C.
    • (1976)
    • Mohr, U.1
  • 63
    • 0030346704 scopus 로고    scopus 로고
    • Use of a specific aromatase inhibitor for determining whether there is a role for oestrogen in follicle/oocyte maturation, ovulation and preimplantation embryo development
    • N.R.Moudgal, G.Shetty, N.Selvaraj, A.S.Bhatnagar 1996. Use of a specific aromatase inhibitor for determining whether there is a role for oestrogen in follicle/oocyte maturation, ovulation and preimplantation embryo development. J Reprod Fertil Suppl. 50:69–81.
    • (1996) J Reprod Fertil Suppl , vol.50 , pp. 69-81
    • Moudgal, N.R.1    Shetty, G.2    Selvaraj, N.3    Bhatnagar, A.S.4
  • 65
    • 84988827761 scopus 로고
    • K.Nagumo, Y.Teraki, T.Chiba 1981. Teratogenicity test of MEB 6447 in pregnant rats:submitter 80257. Unpublished study received Jan 5, 1982 under 1F2474; prepared by St Marianna Univ, First Dept of Anatomy, Laboratory of Embryology, submitted by Mobay Chemical Corp, Kansas City, Mo; CDL:070570-A. MRID 89023.
    • (1981)
    • Nagumo, K.1    Teraki, Y.2    Chiba, T.3
  • 67
    • 84988816092 scopus 로고    scopus 로고
    • OECD. 2012. Guidance Document on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption, Environment Directorate, Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology, 524.
    • (2012)
  • 68
    • 84988861195 scopus 로고
    • G.O’Hara, L.DiDonato 1984. RH-3866:three month dietary toxicity study in rats:Final Report:Report No. 83R-068. Unpublished study prepared by Rohm and Haas Co. 702 p. MRID 00145048.
    • (1984)
    • O’Hara, G.1    DiDonato, L.2
  • 69
    • 80053440198 scopus 로고    scopus 로고
    • Multi-species analyses of direct activators of the constitutive androstane receptor
    • C.J.Omiecinski, D.M.Coslo, T.Chen, E.M.Laurenzana, R.C.Peffer 2011. Multi-species analyses of direct activators of the constitutive androstane receptor. Toxicol Sci. 123:550–562.
    • (2011) Toxicol Sci , vol.123 , pp. 550-562
    • Omiecinski, C.J.1    Coslo, D.M.2    Chen, T.3    Laurenzana, E.M.4    Peffer, R.C.5
  • 70
    • 9944266190 scopus 로고    scopus 로고
    • A novel nonradioactive method for measuring aromatase activity using a human ovarian granulosa-like tumor cell line and an estrone ELISA
    • K.Ohno, N.Araki, T.Yanase, H.Nawata, M.Iida 2004. A novel nonradioactive method for measuring aromatase activity using a human ovarian granulosa-like tumor cell line and an estrone ELISA. Toxicological Sci. 82:443–450.
    • (2004) Toxicological Sci , vol.82 , pp. 443-450
    • Ohno, K.1    Araki, N.2    Yanase, T.3    Nawata, H.4    Iida, M.5
  • 71
    • 84978901238 scopus 로고    scopus 로고
    • Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast Phase I and II chemical libraries
    • K.Paul Friedman, E.D.Watt, M.W.Hornung, J.M.Hedge, R.S.Judson, K.M.Crofton, K.A.Houck, S.O.Simmons 2016. Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast Phase I and II chemical libraries. Toxicol Sci. 151:160–80.
    • (2016) Toxicol Sci , vol.151 , pp. 160-180
    • Paul Friedman, K.1    Watt, E.D.2    Hornung, M.W.3    Hedge, J.M.4    Judson, R.S.5    Crofton, K.M.6    Houck, K.A.7    Simmons, S.O.8
  • 75
    • 84905224441 scopus 로고    scopus 로고
    • The effects of bromocriptine treatment during early pregnancy on postpartum maternal behaviors in rats
    • A.K.Price, R.S.Bridges 2014. The effects of bromocriptine treatment during early pregnancy on postpartum maternal behaviors in rats. Dev Psychobiol. 56:1431–1437.
    • (2014) Dev Psychobiol , vol.56 , pp. 1431-1437
    • Price, A.K.1    Bridges, R.S.2
  • 76
    • 84988816113 scopus 로고
    • D.Raab, M.Youreneff, M.Giknis,. 1987. Propiconazole:a teratology study in New Zealand rabbits:final report amendment No. 1:Laboratory Project ID 86043. Unpublished study prepared by Ciba-Geigy. Syngenta File No. CGA64250/1589. MRID 40425004.
    • (1987)
    • Raab, D.1    Youreneff, M.2    Giknis, M.3
  • 77
    • 0002174470 scopus 로고
    • Bromocriptine
    • Laurence D.R., McLean A.E.M., Weatherall M., (eds), London, UK: Academic Press
    • B.P.Richardson, I.Turkalji, E.Fluckiger 1984. Bromocriptine. In:D.R.Laurence, A.E.M.McLean, M.Weatherall, editors. Safety testing of new drugs. London, UK:Academic Press. p. 19–63.
    • (1984) Safety testing of new drugs , pp. 19-63
    • Richardson, B.P.1    Turkalji, I.2    Fluckiger, E.3
  • 83
    • 84922476606 scopus 로고    scopus 로고
    • Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors
    • D.Rouquie, H.Tinwell, O.Blanck, F.Schorsch, D.Geter, S.Wason, R.Bars 2014. Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors. Regul Toxicol Pharmacol. 70:673–680.
    • (2014) . Regul Toxicol Pharmacol , vol.70 , pp. 673-680
    • Rouquie, D.1    Tinwell, H.2    Blanck, O.3    Schorsch, F.4    Geter, D.5    Wason, S.6    Bars, R.7
  • 84
    • 0036070511 scopus 로고    scopus 로고
    • Induction and Inhibition of aromatase (CYP 19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells
    • I.T.Sanderson, J.Boerma, G.W.A.Lansbergen, M.van den Berg 2002. Induction and Inhibition of aromatase (CYP 19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 182, 44–54.
    • (2002) Toxicol Appl Pharmacol , vol.182 , pp. 44-54
    • Sanderson, I.T.1    Boerma, J.2    Lansbergen, G.W.A.3    van den Berg, M.4
  • 85
    • 84988906191 scopus 로고
    • K.Sachsse, P.Suter, H.Luetkemeier 1979a. CGA-64250 Techn. Three months toxicity study on rats:Project No. 790014. Final rept. Unpublished study prepared by Ciba Geigy Ltd., Switzerland, Syngenta File No. 64250/1538. MRID 00058606.
    • (1979)
    • Sachsse, K.1    Suter, P.2    Luetkemeier, H.3
  • 86
    • 84988885315 scopus 로고
    • K.Sachsse, R.Bathe, H.Luetkemeier 1979b. CGA-64250 3-month toxicity study on dogs:Report No. 78/5751. CDL:244271-R. Final rept. Unpublished study prepared by Ciba Geigy Ltd., Switzerland. Syngenta File No. CGA64250/1539. MRID 00058607.
    • (1979)
    • Sachsse, K.1    Bathe, R.2    Luetkemeier, H.3
  • 87
    • 84920267321 scopus 로고    scopus 로고
    • Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital
    • A.Schraplau, B.Schewe, F.Neuschafer-Rube, S.Ringel, C.Neuber, B.Kleuser, G.P.Puschel 2015. Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital. Toxicology 328:21–28.
    • (2015) Toxicology , vol.328 , pp. 21-28
    • Schraplau, A.1    Schewe, B.2    Neuschafer-Rube, F.3    Ringel, S.4    Neuber, C.5    Kleuser, B.6    Puschel, G.P.7
  • 88
    • 84988873422 scopus 로고    scopus 로고
    • L.P.Sheets, R.Gilmore, H.Hoss 2008. A developmental neurotoxicity study with technical grade triadimefon in wistar rats. Project Number 07/D72/IL, 201766. Unpublished study prepared by Bayer CropScience. p. 1179.
    • (2008)
    • Sheets, L.P.1    Gilmore, R.2    Hoss, H.3
  • 89
    • 84988827734 scopus 로고
    • T.Shellenberger, L.Billups 1986. Chronic toxicity and oncogenicity study with RH 3866 in rats:final report:Project No. 8342. Unpublished study prepared by Rohm & Haas Co. Project No. 85RC-61 prepared by Tegeris Laboratories, Inc. 3536 p. MRID 00165247.
    • (1986)
    • Shellenberger, T.1    Billups, L.2
  • 90
    • 84988827733 scopus 로고
    • Y.Shimizu 1987. A thirteen week feeding subchronic study of RH-3866 in rats. Report No. NRILS 86-2024;R & H Report No 87RC-038. Unpublished study from NRI Life Science, Kanagawa, Japan and prepared by Rohm & Haas Co. 09 July 1987.
    • (1987)
    • Shimizu, Y.1
  • 91
    • 0034029020 scopus 로고    scopus 로고
    • Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations. Endocrine Disrupter Screening and Testing Advisory Committee
    • T.E.Stoker, L.G.Parks, L.E.Gray, R.L.Cooper 2000. Endocrine-disrupting chemicals:prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations. Endocrine Disrupter Screening and Testing Advisory Committee. Crit Rev Toxicol. 30:197–252.
    • (2000) Crit Rev Toxicol , vol.30 , pp. 197-252
    • Stoker, T.E.1    Parks, L.G.2    Gray, L.E.3    Cooper, R.L.4
  • 93
    • 1542271014 scopus 로고    scopus 로고
    • The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats
    • H.Tamada, Y.Shimizu, T.Inaba, N.Kawate, T.Sawada 2004. The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats. J Endocrinol. 180:337–345.
    • (2004) J Endocrinol , vol.180 , pp. 337-345
    • Tamada, H.1    Shimizu, Y.2    Inaba, T.3    Kawate, N.4    Sawada, T.5
  • 95
    • 70350499883 scopus 로고    scopus 로고
    • Impact of estrogen replacement on letrozole-induced embryopathic effects
    • G.M.Tiboni, F.Marotta, A.P.Castigliego, C.Rossi 2009. Impact of estrogen replacement on letrozole-induced embryopathic effects. Hum Reprod. 24:2688–2692.
    • (2009) . Hum Reprod , vol.24 , pp. 2688-2692
    • Tiboni, G.M.1    Marotta, F.2    Castigliego, A.P.3    Rossi, C.4
  • 96
    • 47649116188 scopus 로고    scopus 로고
    • Effects of the aromatase inhibitor letrozole on in utero development in rats
    • G.M.Tiboni, F.Marotta, C.Rossi, F.Giampietro 2008. Effects of the aromatase inhibitor letrozole on in utero development in rats. Hum Reprod. 23:1719–1723.
    • (2008) . Hum Reprod , vol.23 , pp. 1719-1723
    • Tiboni, G.M.1    Marotta, F.2    Rossi, C.3    Giampietro, F.4
  • 97
    • 84879599189 scopus 로고    scopus 로고
    • Improving the human hazard characterization of chemicals: a Tox21 update
    • R.R.Tice, C.P.Austin, R.J.Kavlock, J.R.Bucher 2013. Improving the human hazard characterization of chemicals:a Tox21 update. Environ Health Perspect. 121:756–765.
    • (2013) Environ Health Perspect , vol.121 , pp. 756-765
    • Tice, R.R.1    Austin, C.P.2    Kavlock, R.J.3    Bucher, J.R.4
  • 98
    • 36349019788 scopus 로고    scopus 로고
    • In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases
    • Z.Tong, H.Li, I.Goljer, O.McConnell, A.Chandrasekaran 2007. In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos:Biol Fate Chem. 35:2203–2210.
    • (2007) Drug Metab Dispos: Biol Fate Chem , vol.35 , pp. 2203-2210
    • Tong, Z.1    Li, H.2    Goljer, I.3    McConnell, O.4    Chandrasekaran, A.5
  • 99
    • 7544250772 scopus 로고    scopus 로고
    • Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans
    • E.R.Trosken, K.Scholz, R.W.Lutz, W.Volkel, J.A.Zarn, W.K.Lutz 2004. Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 30:387–394.
    • (2004) Endocr Res , vol.30 , pp. 387-394
    • Trosken, E.R.1    Scholz, K.2    Lutz, R.W.3    Volkel, W.4    Zarn, J.A.5    Lutz, W.K.6
  • 100
    • 33749667750 scopus 로고    scopus 로고
    • Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles
    • E.R.Trosken, M.Adamska, M.Arand, J.A.Zarn, C.Patten, W.Volkel, W.K.Lutz 2006a. Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. Toxicology 228:24–32.
    • (2006) Toxicology , vol.228 , pp. 24-32
    • Trosken, E.R.1    Adamska, M.2    Arand, M.3    Zarn, J.A.4    Patten, C.5    Volkel, W.6    Lutz, W.K.7
  • 101
    • 31044449968 scopus 로고    scopus 로고
    • Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation
    • E.R.Trosken, K.Fischer, W.Volkel, W.K.Lutz 2006b. Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of estradiol product formation. Toxicology 219:33–40.
    • (2006) Toxicology , vol.219 , pp. 33-40
    • Trosken, E.R.1    Fischer, K.2    Volkel, W.3    Lutz, W.K.4
  • 103
    • 84988823823 scopus 로고
    • T.Unger, D.Van Goethem, T.Shellenberger 1982. A teratological evaluation of bayleton in mated female rats:MRI Project No. 7272-B. Unpublished study prepared by Midwest Research Institute.MRID 149336:52 p.
    • (1982)
    • Unger, T.1    Van Goethem, D.2    Shellenberger, T.3
  • 104
    • 84988823824 scopus 로고    scopus 로고
    • USEPA. 2007a. Integrated Summary Report on Aromatase.
    • (2007)
  • 105
    • 84988833215 scopus 로고    scopus 로고
    • USEPA. 2007b. Myclobutanil:Acute and Chronic Food and Drinking Water Dietary Exposure and Risk Assessments for Section 3 Use on Snap Bean, Mint, Papaya, Gooseberry, Currant, Caneberry, Bell and Non-Bell Pepper, Head and Leaf Lettuce, and Artichoke PC Code 128857 DP 341690.
    • (2007)
  • 106
    • 84988799633 scopus 로고    scopus 로고
    • USEPA. 2008. Mycobutanil:Amended Human Health Risk Assessment for Proposed Use on Section 3 Requests for Use on Snap Bean, Mint, Papaya, Gooseberry, Currant, Caneberry, Bell and Non-Bell Pepper, Head and Leaf Lettuce, and Artichoke PC Code 128857 DP Barcode:341689.
    • (2008)
  • 107
    • 84988823386 scopus 로고    scopus 로고
    • USEPA. 2009. Triadimefon:Human Health Risk Assessment to Support Reinstatement of Use on Residential Turf Decision No. 391164.38.
    • (2009)
  • 108
    • 84988828442 scopus 로고    scopus 로고
    • USEPA. 2011. US EPA EDSP21 Work Plan. Available from:https://wwwepagov/endocrine-disruption/endocrine-disruptor-screening-program-21st-century-edsp21-workplan-summary.
    • (2011)
  • 109
    • 84988828441 scopus 로고    scopus 로고
    • USEPA. 2012. Prioritization of the Endocrine Disruptor Screening Program Universe of Chemicals for an Estrogen Receptor Adverse Outcome Pathway Using Computational Toxicology Tools. Available from:https://wwwregulationsgov/#!documentDetail;D=EPA-HQ-OPP-2012-0818-0017.
    • (2012)
  • 110
    • 84988833216 scopus 로고    scopus 로고
    • USEPA. 2013. Information Collection Request for the Endocrine Disruptor Screening Program, EPA ICR #2488.01, Attachment F:Calculations for Paperwork Burden and Costs for Data Generation Activities.
    • (2013)
  • 111
    • 84988833233 scopus 로고    scopus 로고
    • USEPA. 2014a. Endocrine Disruptor Screening Program Comprehensive Management Plan.
    • (2014)
  • 112
    • 84988842964 scopus 로고    scopus 로고
    • USEPA. 2014b. Integrated Bioactivity and Exposure Ranking:A Computational Approach for the Prioritization and Screening of Chemicals in the Endocrine Disruptor Screening Program. Available from:http://www.regulations.gov/#!documentDetail;D = EPA-HQ-OPP-2014-0614-0003.
    • (2014)
  • 113
    • 84988833244 scopus 로고    scopus 로고
    • USEPA. 2014c. New High-throughput Methods to Estimate Chemical Exposure.
    • (2014)
  • 114
    • 84988828459 scopus 로고    scopus 로고
    • USEPA. 2014d. Propiconazole Human Health Risk Assessment for the Section 3 Registration on Rapeseed Crop Subgroup 20A.
    • (2014)
  • 115
    • 84988828454 scopus 로고    scopus 로고
    • USEPA. 2014e. ToxCast Data Invitrodb_v1.
    • (2014)
  • 116
    • 84988828469 scopus 로고    scopus 로고
    • USEPA. 2015a. Endocrine Disruptor Screening Program Tier 1 Assessments. Available from:http://www2epagov/ingredients-used-pesticide-products/endocrine-disruptor-screening-program-tier-1-assessments.
    • (2015)
  • 117
    • 84988842968 scopus 로고    scopus 로고
    • USEPA. 2015b. Use of High-Throughput Assays and Computational Tools; Endocrine Disruptor Screening Program; Notice of Availability and Opportunity for Comment. Available from:http://federalregister.gov/a/2015-15182, Federal Register.
    • (2015)
  • 118
    • 0036176692 scopus 로고    scopus 로고
    • Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation
    • N.R.Vansell, C.D.Klaassen 2002. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Drug Metab Dispos:Biol Fate Chem. 30:240–246.
    • (2002) Drug Metab Dispos: Biol Fate Chem , vol.30 , pp. 240-246
    • Vansell, N.R.1    Klaassen, C.D.2
  • 119
    • 0034106868 scopus 로고    scopus 로고
    • Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro
    • A.M.Vinggaard, C.Hnida, V.Breinholt, J.C.Larsen 2000. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol in vitro. 14:227–234.
    • (2000) Toxicol in vitro , vol.14 , pp. 227-234
    • Vinggaard, A.M.1    Hnida, C.2    Breinholt, V.3    Larsen, J.C.4
  • 120
    • 0030220632 scopus 로고    scopus 로고
    • Triadimefon and triadimenol: effects on monoamine uptake and release
    • Q.D.Walker, R.B.Mailman 1996. Triadimefon and triadimenol:effects on monoamine uptake and release. Toxicol Appl Pharmacol. 139:227–233.
    • (1996) . Toxicol Appl Pharmacol , vol.139 , pp. 227-233
    • Walker, Q.D.1    Mailman, R.B.2
  • 123
    • 84930085761 scopus 로고    scopus 로고
    • Quantitative in vitro-to-in vivo extrapolation in a high-throughput environment
    • B.A.Wetmore 2014. Quantitative in vitro-to-in vivo extrapolation in a high-throughput environment. Toxicology. 332:94–101.
    • (2014) Toxicology , vol.332 , pp. 94-101
    • Wetmore, B.A.1
  • 125
    • 84988842897 scopus 로고
    • G.W.Wolfe 1993. RH-3866 technical:104-week dietary oncogenicity toxicity study in rats. Report No. 89RC-260Unpublished study prepared by Rohm & Haas Co. 522 p. MRID 42809101.
    • (1993)
    • Wolfe, G.W.1
  • 126
    • 80052429397 scopus 로고    scopus 로고
    • Application of an integrated testing strategy to the U.S. EPA endocrine disruptor screening program
    • C.E.Willett, P.L.Bishop, K.M.Sullivan 2011. Application of an integrated testing strategy to the U.S. EPA endocrine disruptor screening program. Toxicol Sci. 123:15–25.
    • (2011) Toxicol Sci , vol.123 , pp. 15-25
    • Willett, C.E.1    Bishop, P.L.2    Sullivan, K.M.3
  • 130
    • 84892712724 scopus 로고    scopus 로고
    • Comparison of simulated pesticide concentrations in surface drinking water with monitoring data: explanations for observed differences and proposals for a new regulatory modeling approach
    • M.F.Winchell, N.J.Snyder 2014. Comparison of simulated pesticide concentrations in surface drinking water with monitoring data:explanations for observed differences and proposals for a new regulatory modeling approach. J Agric Food Chem. 62:348–359.
    • (2014) . J Agric Food Chem , vol.62 , pp. 348-359
    • Winchell, M.F.1    Snyder, N.J.2
  • 131
    • 33845793865 scopus 로고    scopus 로고
    • Toxicity profiles in rats treated with tumorigenic and nontumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil
    • D.C.Wolf, J.W.Allen, M.H.George, S.D.Hester, G.Sun, T.Moore, S.F.Thai, D.Delker, E.Winkfield, S.Leavitt,. 2006. Toxicity profiles in rats treated with tumorigenic and nontumorigenic triazole conazole fungicides:propiconazole, triadimefon, and myclobutanil. Toxicol Pathol. 34:895–902.
    • (2006) Toxicol Pathol , vol.34 , pp. 895-902
    • Wolf, D.C.1    Allen, J.W.2    George, M.H.3    Hester, S.D.4    Sun, G.5    Moore, T.6    Thai, S.F.7    Delker, D.8    Winkfield, E.9    Leavitt, S.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.