Effects of the aromatase inhibitor letrozole on in utero development in rats

Human Reproduction

Volumn 23, Issue 8, 2008, Pages 1719-1723

  Tiboni, G M ^a   Marotta, F ^a   Rossi, C ^a   Giampietro, F ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Developmental toxicity; Letrozole; Rat

Indexed keywords

DRINKING WATER; LETROZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; FEMALE; FETUS GROWTH; INCIDENCE; NONHUMAN; ORGANOGENESIS; PREGNANCY OUTCOME; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; PRENATAL MORTALITY; RAT; VERTEBRA MALFORMATION;

RATTUS;

EID: 47649116188     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/den100     Document Type: Article

References (28)

1. Admirex® prescribing information. http://www.astrazeneca-us.com/pi/ arimidex.pdf
2. Albrecht ED, Aberdeen GW, Pepe GJ. The role of estrogen in the maintenance of primate pregnancy. Am J Obstet Gynecol 2000;182:432-438.
3. Bishai R, Arbour L, Lyons C, Koren G. Intrauterine exposure to clomiphene and neonatal persistent hyperplastic primary vitreous. Teratology 1999;60:143-145.
4. Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 4th edn. Baltimore, USA: William & Wilkins Press, 2002, 289-292, 192.
5. Carlier P, Choulika S, Efthymiou ML. Clomiphene-exposed pregnancies - analysis of 39 information request including 29 cases with known outcome. Therapie 1996;51:532-536.
6. Casper RF. Aromatase inhibitors in ovarian stimulation. J Steroid Biochem Mol Biol 2007;106:71-75.
7. Casper RF, Mitwally MF. Review: aromatase inhibitors for ovulation induction. J Clin Endocrinol Metab 2006;91:760-771.
8. Courtney KD, Valerio DA. Teratology in the Macaca mulatta. Teratology 1968;1:163-172.
9. de Ziegler D, Mattenberger C, Luyet C, Romoscanu I, Irion NF, Bianchi-Demicheli F. Clinical use of aromatase inhibitors (AI) in premenopausal women. J Steroid Biochem Mol Biol 2005;95:121-127.
10. Dziadek M. Preovulatory administration of clomiphene citrate to mice causes fetal growth retardation and neural tube defects (exencephaly) by an indirect maternal effect. Teratology 1993;46:263-273.
11. Eneroth G, Eneroth V, Forsberg U, Grant CA, Gustafsson JA. Clomiphene-induced hydramnios and fetal cataracts in rats inhibited by progesterone. Teratology 1971;7:487.
12. Femara® patient prescribing information. Available at: www.pharma.us.novartis.com/product/pi/pdf/Femara.pdf
13. Fisher CR, Graves KH, Parlow AF, Simpson ER. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 1998;9:6965-6970.
14. Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS. The pharmacology of letrozole. J Steroid Biochem Mol Biol 2003;87:35-45.
15. Holzer H, Casper R, Tulandi T. A new era in ovulation induction. Fertil Steril 2006;85:277-284.
16. Honda S, Harada N, Ito S, Takagi Y, Maeda S. Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the cyp19 gene. Biochem Biophys Res Commun 1998;18:445-449.
17. Inouye M. Differential staining of cartilage and bone in fetal mouse skeleton by Alcian blue and alizarin red S. Cong Anom 1976;16:171-173.
18. Kafali H, Iriadam M, Ozardali I, Demir N. Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease. Arch Med Res 2004;35:103-108.
19. Kimmel CA, Trammel C. A rapid procedure for routine staining of cartilage and bone in fetal and adult animals. Stain Technol 1981;56:271- 273.
20. Kuczuk MJ, Scott WJ. Potentiation of acetazolamide-induced ectrodactyly in SWV and C57/BL mice by cadmium sulphate. Teratology 1984;29:427-435.
21. McCormack S, Clark JH. Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers. Science 1979;204:629-631.
22. Messinis IE. Ovulation induction: a mini review. Hum Reprod 2005;20:2688-2697.
23. Motta CM, Hutchinson JSM. Effects of clomiphene citrate on early pregnancy in guinea-pigs. J Reprod Fert 1991;92:65-73.
24. Sipe CS, Davis WA, Maifeld M, Van Voorhis BJ. A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol using gonadotropins. Fertil Steril 2006;86:1676-1681.
25. Tulandi T, Martin J, Al-Fadhli R, Kabli N, Forman R, Hitkari J, Librach C, Greenblatt E, Casper RF. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil Steril 2006;85:1761-1765.
26. Webster WS, Freeman JA. Is this drug safe in pregnancy? Reprod Toxicol 2001;15:619-629.
27. Wilson JC. Methods for administering agents and detecting malformations in experimental animals. In: Wilson JG, Warkany J(eds). Teratology: Principles and Techniques. Chicago, USA: Press Syndicate of the University of Chicago, 1965,262-277.
28. Wise LD, Beck SL, Beltrame D, Beyer BK, Chahoud I, Clark RL, Clark R, Druga AM, Feuston MH, Guittin P et al. Terminology of developmental abnormalities in common laboratory mammals (version 1). Teratology 1997;55:249-292.