In vitro glucuronidation of thyroxine and triiodothyronine by liver microsomes and recombinant human UDP-glucuronosyltransferases

Drug Metabolism and Disposition

Volumn 35, Issue 12, 2007, Pages 2203-2210

  Tong, Zeen ^a   Li, Hongshan ^a   Goljer, Igor ^a   McConnell, Oliver ^a   Chandrasekaran, Appavu ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B17; GLUCURONOSYLTRANSFERASE 2B4; GLUCURONOSYLTRANSFERASE 2B7; LIOTHYRONINE; RECOMBINANT ENZYME; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG GLUCURONIDATION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MALE; MASS SPECTROMETRY; MONKEY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HAPLORHINI; HUMANS; HYDROGEN-ION CONCENTRATION; ISOENZYMES; MICE; MICROSOMES, LIVER; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RATS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THYROXINE; TRIIODOTHYRONINE;

MUS; RATTUS;

EID: 36349019788     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.016972     Document Type: Article

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