Toxicogenomic effects common to triazole antifungals and conserved between rats and humans

Toxicology and Applied Pharmacology

Volumn 238, Issue 1, 2009, Pages 80-89

  Goetz, Amber K ^a,b   Dix, David J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

CAR; Myclobutanil; Propiconazole; PXR; Toxicogenomics; Triadimefon

Indexed keywords

ANTIFUNGAL AGENT; CYTOCHROME P450 2B2; CYTOCHROME P450 2B6; CYTOCHROME P450 3A1; CYTOCHROME P450 3A4; CYTOCHROME P450 4A11; CYTOCHROME P450 A22; GLUCURONOSYLTRANSFERASE 1A1; MULTIDRUG RESISTANCE PROTEIN 1; MYCLOBUTANIL; PROPICONAZOLE; TRIADIMEFON; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANDROGEN METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; ESTROGEN METABOLISM; GENE EXPRESSION REGULATION; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIVER TOXICITY; MALE; NONHUMAN; RAT; STEROID METABOLISM; TOXICOGENETICS; XENOBIOTIC METABOLISM;

ANIMALS; ANTIFUNGAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; LIVER; MALE; NITRILES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPECIES SPECIFICITY; TIME FACTORS; TOXICOGENETICS; TRIAZOLES;

RATTUS; RODENTIA;

EID: 66049136991     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.04.016     Document Type: Article

References (24)

1. Allen J.W., Wolf D.C., George M.H., Hester S.D., Sun G., Thai S.-F., Delker D.A., Moore T., Jones C., Nelson G., Roop B.C., Leavitt S., Winkfield E., Ward W.O., and Nesnow S. Toxicity profiles in mice treated with hepatotumorigenic and non-hepatotumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Toxicol. Pathol. 34 (2006) 853-862
2. Ghannoum M.A., and Rice L.B. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin. Microbiol. Rev. 12 (1999) 501-517
3. Goetz A.K., Bao W., Ren H., Schmid J.E., Tully D.B., Wood C.R., Rockett J.C., Narotsky M.G., Sun G., Lambert G.R., Thai S.-F., Wolf D.C., Nesnow S., and Dix D.J. Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides. Toxicol. Sci. 215 (2006) 274-284
4. Goetz A.K., Ren H., Schmid J.E., Blystone C.R., Thillainadarajah I., Best D.S., Nichols H.P., Strader L.F., Wolf D.C., Narotsky M.G., Rockett J.C., and Dix D.J. Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat. Toxicol. Sci. 95 (2007) 227-239
5. Guo G.L., Staudinger J., Ogura K., and Klaassen C.D. Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16α-carbonitrile is via interaction with pregnane × receptor. Mol. Pharmacol. 61 (2002) 832-839
6. Hester S.D., Wolf D.C., Nesnow S., and Thai S.-F. Transcriptional profiles in liver from rats treated with tumorigenic and non-tumorigenic triazoles conazole fungicides: propiconazole, triadimefon, and myclobutanil. Toxicol. Pathol. 34 (2006) 879-894
7. Hester S.D., and Nesnow S. Transcriptional responses in thyroid tissues from rats treated with a tumorigenic and a non-tumorigenic triazole conazole fungicide. Toxicol. Appl. Pharmacol. 227 (2008) 357-369
8. Honkakoski P., and Negishi M. Review article: regulation of cytochrome P450 (CYP) genes by nuclear receptors. J. Biochem. 347 (2000) 321-337
9. Jigorel E., LeVee M., Boursier-Neyret C., Bertrand M., and Fardel O. Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes. Drug Metab. Dispos. 33 (2005) 1418-1422
10. Jigorel E., LeVee M., Boursier-Neyret C., Parmentier Y., and Fardel O. Differential regulation f sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab. Dispo. 34 (2006) 1756-1763
11. LeCluyse E.L., Bullock P.L., Parkinson A., and Hochman J.H. Cultured rat hepatocytes. Pharm. Biotechnol. 8 (1996) 121-159
12. LeCluyse E., Madan A., Hamilton G., Carroll K., Deán R., and Parkinson A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem. Mol. Toxicol. 14 (2000) 177-188
13. Martin M.T., Brennan R., Hu W., Ayanoglu E., Lau C., Ren H., Wood C.R., Corton J.C., Kavlock R.J., and Dix D.J. Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity. Toxicol. Sci. 97 (2007) 595-613
14. Meng L.J., Wang P., Wolkoff A.W., Kim R.B., Tirona R.G., Hofmann A.F., and Pang K.S. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by oatp1 and oatp2. Hepatology. 35 (2002) 1031-1040
15. Ortiz D.F., Moseley J., Calderon G., Swift A.L., Li S., and Arias I.M. Identification of HAX-1 as a protein that binds bile salt export protein and regulated its abundance in the apical membrane of Madin-Darby canine kidney cells. J. Biol. Chem. 279 (2004) 32761-32770
16. Staudinger J.L., Madan A., Carol K.M., and Parkinson A. Regulation of drug transporter gene expression by nuclear receptors. Drug Metab. Dispos. 31 (2003) 523-527
17. Tully D.B., Bao W., Goetz A.K., Blystone C.R., Ren H., Schmid J.E., Strader L.F., Wood C.R., Best D.S., Narotsky M.G., Wolf D.C., Rockett J.C., and Dix D.J. Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides. Toxicol. Appl. Pharmacol. 215 (2006) 260-273
18. U.S. Environmental Protection Agency. Myclobutanil; pesticide tolerances. Office of Prevention, Pesticides and Toxic Substances, Washington DC. Fed. Regist. 60 (1995) 40500-40503
19. U.S. Environmental Protection Agency. Myclobutanil; pesticide tolerances for emergency exemptions. Office of Prevention, Pesticides and Toxic Substances, Washington DC. Fed. Regist. 70 (2005) 49499-49507
20. U.S. Environmental Protection Agency. Propiconazole; pesticide tolerances for emergency exemptions. Office of Prevention, Pesticides, and Toxic Substances, Washington DC. Fed. Regist. 70 (2005) 43284-43292
21. U.S. Environmental Protection Agency. Triadimefon. Preliminary Human Health Risk Assessment Revised. Office of Prevention, Pesticides, and Toxic Substances (2006) Washington DC
22. Vanden Bossche H., Marichal P., Gorrens J., and Coene M.-C. Biochemical basis for the activity and selectivity of oral antifungal drugs. Br. J. Clin. Pract. Suppl. 71 (1990) 41-46
23. Ward W.O., Delker D.A., Hester S.D., Thai S.-F., Wolf D.C., Allen J.W., and Nesnow S. Transcriptional profiles in liver from mice treated with hepatotumorigenic and nonhepatotumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Toxicol. Pathol. 34 (2006) 863-878
24. Wolf D.C., Allen J.W., George M.H., Hester S.D., Sun G., Moore T., Thai S.-F., Delker D., Winkfield E., Leavitt S., Nelson G., Roop B.C., Jones C., Thibodeaux J., and Nesnow S. Toxicity profiles in rats treated with tumorigenic and nontumorigenic triazole conazole fungicides: propiconazole, triadimefon, and myclobutanil. Toxicol. Pathol. 34 (2006) 895-902