Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses

Environmental Science and Technology

Volumn 48, Issue 15, 2014, Pages 8706-8716

  Rotroff, Daniel M ^a,b,d   Martin, Matt T ^b   Dix, David J ^b   Filer, Dayne L ^b   Houck, Keith A ^b   Knudsen, Thomas B ^b   Sipes, Nisha S ^b   Reif, David M ^b   Xia, Menghang ^c   Huang, Ruili ^c   Judson, Richard S ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL ENGINEERING; ENVIRONMENTAL PROTECTION;

ENDOCRINE DISRUPTOR; ENVIRONMENTAL CHEMICALS; ESTROGEN RECEPTOR; GROWTH RESPONSE; HIGH-THROUGHPUT SCREENING; IN-VITRO ASSAYS; MULTIPLE ASSAYS; REGULATORY REVIEW;

CHEMICALS;

17ALPHA ESTRADIOL; 2 NAPHTHOL; 4 NONYLPHENOL; CAPTAFOL; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYLESTRADIOL; ETHYL PARABEN; FOOD ADDITIVE; INDUSTRIAL CHEMICAL; PESTICIDE; PHARMACEUTICAL VEHICLES AND ADDITIVES; PHTHALIC ACID; PHTHALIC ACID DIBUTYL ESTER; ANTIESTROGEN; ESTROGEN; ESTROGEN RECEPTOR ALPHA, HUMAN;

ARTICLE; CELL GROWTH; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DIMERIZATION; DRUG POTENCY; ENDOCRINE FUNCTION TEST; ESTROGEN ACTIVITY; ESTROGEN RECEPTOR INTERACTION SCORE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS FRAGMENTOGRAPHY; PREDICTIVE VALUE; RECEPTOR BINDING; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; TRANSACTIVATION; AGONISTS; ALGORITHM; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOASSAY; CHEMICAL MODEL; MCF 7 CELL LINE;

ALGORITHMS; ANIMALS; BIOLOGICAL ASSAY; ENDOCRINE DISRUPTORS; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MCF-7 CELLS; MODELS, CHEMICAL; PESTICIDES; SIGNAL TRANSDUCTION;

EID: 84905638971     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es502676e     Document Type: Article

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