Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the toxcast phase I and II chemical libraries

Toxicological Sciences

Volumn 151, Issue 1, 2016, Pages 160-180

  Friedman, Katie Paul ^a,b   Watt, Eric D ^a,c   Hornung, Michael W ^c   Hedge, Joan M ^b   Judson, Richard S ^c   Crofton, Kevin M ^c   Houck, Keith A ^c   Simmons, Steven O ^c  

^a OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

endocrine; Predictive toxicology < in vitro and altenatives; Thyroid < endocrine toxicology in vitro and altenatives

Indexed keywords

2 IMIDAZOLIDINETHIONE; 2 MERCAPTOBENZOTHIAZOLE; 2 NAPHTHYLAMINE; 3 METHYLANILINE; 4 CHLOROANILINE; 4 METHYLANILINE; CATECHOL; CHLORPYRIFOS; DAIDZEIN; DODECYL SULFATE SODIUM; GENISTEIN; GUAIACOL; KETOCONAZOLE; MERCURY CHLORIDE; METHYLTHIOURACIL; OXIDOREDUCTASE INHIBITOR; OXYTETRACYCLINE; PHTHALIC ACID DIBUTYL ESTER; PROPYLTHIOURACIL; QUERCETIN; RESORCINOL; SALICYLHYDROXAMIC ACID; SIMVASTATIN; SODIUM AZIDE; TANNIN; THYROID HORMONE; THYROID PEROXIDASE; THYROPEROXIDASE INHIBITOR; TIOGUANINE; TRICLOSAN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; IODIDE PEROXIDASE;

ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; FEMALE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MALE; MICROSOME; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; SCREENING; SOLUBILITY; THYROID HORMONE SYNTHESIS; ANIMAL; ANIMAL TESTING ALTERNATIVE; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; HEK293 CELL LINE; LONG EVANS RAT; METABOLISM; MOLECULAR LIBRARY; PIG; RISK ASSESSMENT; THYROID GLAND;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IODIDE PEROXIDASE; MALE; RATS, LONG-EVANS; RISK ASSESSMENT; SMALL MOLECULE LIBRARIES; SUS SCROFA; THYROID GLAND;

EID: 84978901238     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw034     Document Type: Article

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