Understanding the Differential Selectivity of Arrestins toward the Phosphorylation State of the Receptor

ACS Chemical Neuroscience

Volumn 7, Issue 9, 2016, Pages 1212-1224

  Sensoy, Ozge ^a,b   Moreira, Irina S ^c,d   Morra, Giulia ^b,e  

^a ISTANBUL MEDIPOL UNIVERSITY   (Turkey)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UTRECHT UNIVERSITY   (Netherlands)

^e CNR   (Italy)

Author keywords

arrestin preactivated state; Arrestin GPCR coupling; functional selectivity; molecular dynamics simulations

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PHOSPHATE; PHOSPHOPEPTIDE; RETINA S ANTIGEN; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MUTANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; STATIC ELECTRICITY; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; MUTATION; NONLINEAR SYSTEM; PHOSPHORYLATION; ROTATION;

AMINO ACID SUBSTITUTION; ANIMALS; ARRESTINS; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; NONLINEAR DYNAMICS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; ROTATION;

EID: 84988646853     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00073     Document Type: Article

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