Interfering with the chronic immune response rescues chronic degeneration after traumatic brain injury

Journal of Neuroscience

Volumn 36, Issue 38, 2016, Pages 9962-9975

  Ertürk, Ali ^a,b,c,d   Mentz, Susanne ^a   Stout, Erik E ^d   Hedehus, Maj ^d   Dominguez, Sara L ^d   Neumaier, Lisa ^a   Krammer, Franziska ^a   Llovera, Gemma ^a   Srinivasan, Karpagam ^d   Hansen, David V ^d   Liesz, Arthur ^a,b,c   Scearce Levie, Kimberly A ^d   Sheng, Morgan ^d  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Germany 3 Munich Cluster for Systems Neurology   (Germany)

^c Graduate School of Systemic Neurosciences   (Germany)

^d GENENTECH INC   (United States)

Author keywords

3D imaging; Axon; Degeneration; Inflammation; Spine; Trauma

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC SPINE; FEMALE; FLOW CYTOMETRY; GENE SILENCING; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPEN FIELD TEST; PRIORITY JOURNAL; ROTAROD TEST; SENSORIMOTOR FUNCTION; SOMATOSENSORY CORTEX; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN; C57BL MOUSE; CHRONIC DISEASE; COMPLICATION; CONVALESCENCE; DIAGNOSTIC IMAGING; DISEASE MODEL; EXPLORATORY BEHAVIOR; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOTOR ACTIVITY; NERVE CELL; PATHOLOGY; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; TIME FACTOR; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANIMALS; BRAIN; BRAIN INJURIES, TRAUMATIC; CALCIUM-BINDING PROTEINS; CHRONIC DISEASE; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FEMALE; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MOTOR ACTIVITY; NERVE DEGENERATION; NEURONS; PSYCHOMOTOR PERFORMANCE; RECEPTORS, CHEMOKINE; RECOVERY OF FUNCTION; TIME FACTORS;

EID: 84988514078     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1898-15.2016     Document Type: Article

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