Traumatic brain injury as a risk factor for Alzheimer's disease: A review

Neuropsychology Review

Volumn 10, Issue 2, 2000, Pages 115-129

  Lye, Tanya C ^a   Shores, E Arthur ^a  

^a MACQUARIE UNIVERSITY   (Australia)

Author keywords

Alzheimer's disease; Brain reserve capacity; Threshold; Traumatic brain injury

Indexed keywords

ALZHEIMER DISEASE; BRAIN INJURY; CHOLINERGIC SYSTEM; HUMAN; MODEL; NEUROPATHOLOGY; REVIEW; RISK FACTOR; THEORY;

AGE OF ONSET; ALZHEIMER DISEASE; BRAIN; BRAIN INJURIES; COHORT STUDIES; EUROPE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; META-ANALYSIS; MINNESOTA; MODELS, NEUROLOGICAL; ODDS RATIO; RISK FACTORS; TRAUMA SEVERITY INDICES; UNITED STATES;

EID: 0033913011     PISSN: 10407308     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009068804787     Document Type: Review

References (122)

1. Allsop, D., Haga, S., Bruton, C., Ishii, T., and Roberts, G. (1990). Neurofibrillary tangles in some cases of Dementia Pugilistica share antigens with amyloid β-protein of Alzheimer's disease. American Journal of Pathology 136: 255-260.
2. Amaducci, L. A., Fratiglioni, L., Rocca, W. A., Fieschi, C., Livrea, P., Pedone, D., Bracco, L., Lippi, A., Gandolfo, C., Bino, G., Prencipe, M., Bonatti, M. L., Girotti, F., Carella, F., Tavolato, B., Ferla, S., Lenzi, G. L., Carolei, A., Gambi, A., Grigoletto, F., and Schoenberg, B. S. (1986). Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of an Italian population. Neurology 36: 922-931.
3. Adreasen, N. C., Flaum, M., Swayze, V., O'Leary, D. S., Alliger, R., Cohen, G., Ehrhardt, J., and Yuh, W. T. C. (1993). Intelligence and brain structure in normal individuals. American Journal of Psychiatry 150: 130-134.
4. Badcock, K. M. (1987). The Head Injury Study at Flinders Medical Centre, Flinders Medical Centre, Adelaide.
5. Bell, D. S. (1992). Medicolegal Assessment of Head Injury, Charles C. Thomas, Springfield.
6. Blessed, G., Tomlinson, B. E., and Roth, M. (1968). The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry 114: 797-811.
7. Bonaiuto, S., Rocca, W. A., Lippi, A., Luciani, P., Turtu, F., Cavarzeran, F., and Amaducci, L. (1990). Impact of education and occupation on the prevalence of Alzheimer's disease and multi-infarct dementia in Appignano, Macerata Province, Italy. Neurology 40: S346.
8. Broe, G. A., Henderson, A. S., Creasey, H., McCusker, E., Korten, A. E., Jorm, A. F., Longley, W., and Anthony, J. C. (1990). A case-control study of Alzheimer's disease in Australia. Neurology 40: 1698-1707.
9. Calne, D. B., McGeer, E., Eisen, A., and Spencer, P. (1986). Alzheimer's disease, Parkinson's disease and motoneurone disease: Abiotrophic interaction between ageing and environment? The Lancet 2: 1067-1070.
10. Canadian Study of Health and Aging (CSHA) (1994). The Canadian Study of Health and Aging: Risk factors for Alzheimer's disease in Canada. Neurology 44: 2073-2080.
11. Chadwick, O., Rutter, M., Brown, G., Shaffer, D., and Traub, M. (1981). A prospective study of children with head injuries: II. Cognitive sequelae. Psychological Medicine 11: 49-61.
12. Chandra, V., Kokmen, E., Schoenberg, B. S., and Beard, C. M. (1989). Head trauma with loss of consciousness as a risk factor for Alzheimer's disease. Neurology 39: 1576-1578.
13. Chandra, V., Philipose, V., Bell, P. A., Lazaroff, A., and Schoenberg, B. S. (1987). Case-control study of late onset "probable Alzheimer's disease." Neurology 37: 1295-1300.
14. Clinton, J., Ambler, M. W., and Roberts, G. W. (1991). Post-traumatic Alzheimer's disease: Preponderance of a single plaque type. Neuropathology and Applied Neurobiology 17: 69-74.
15. Cooper, S.-A. (1997). High prevalence of dementia among people with learning disabilities not attributable to Down's syndrome. Psychological Medicine 27: 609-616.
16. Corsellis, J. A. N., Bruton, C. J., and Freeman-Browne, D. (1973). The aftermath of boxing. Psychological Medicine 3: 270-303.
17. Coyle, J. T., Price, D. L., and Delong, M. R. (1983). Alzheimer's disease: A disorder of cortical cholingeric innervation. Science 219: 1184-1189.
18. Cummings, J. L., Vinters, H. V., Cole, G. M., and Khachaturian, Z. S. (1998). Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 51: S2-S17.
19. Decker, M. W., and McGaugh, J. L. (1991). The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7: 151-168.
20. Dixon, C. E., Ma, X., and Marion, D. W. (1997). Reduced evoked release of acetylcholine in the rodent neocortex following traumatic brain injury. Brain Research 749: 127-130.
21. Dixon, C. E., Taft, W. C., and Hayes, R. L. (1993). Mechanisms of mild traumatic brain injury. Journal of Head Trauma Rehabilitation 8: 1-12.
22. Elwood, R. W. (1993). Clinical discriminations and neuropsychological tests: An appeal to Bayes' Theorem. The Clinical Neuropsychologist 7: 224-233.
23. Esiri, M. M. (1994). Dementia and normal aging: Neuropathology. In Huppert, F. A., Brayne, C., and O'Connor, D. W. (eds.), Dementia and Normal Aging, Cambridge University Press, Cambridge, pp. 385-432.
24. Fearnside, M. R., and Simpson, D. A. (1997). Epidemiology. In Reilly, P., and Bullock, R. (eds.), Head Injury: Pathophysiology and Management of Severe Closed Injury, Chapman Hall, London, pp. 3-23.
25. Francis, P. T., Palmer, A. M., Sims, N. R., Bowen, D. M., Davison, A. N., Esiri, M. M., Neary, D., Snowdon, J. S., and Wilcock, G. K. (1985). Neurochemical studies of early-onset Alzheimer's disease. The New England Journal of Medicine 313: 7-11.
26. Francis, P. T., Palmer, A. M., Snape, M., and Wilcock, G. K. (1999). The cholinergic hypothesis of Alzheimer's disease: A review of progress. Journal of Neurology, Neurosurgery and Psychiatry 66: 137-147.
27. French, L. R., Schuman, L. M., Mortimer, J. A., Hutton, J. T., Boatman, R. A., and Christians, B. (1985). A case-control study of dementia of the Alzheimer's type. American Journal of Epidemiology 121: 414-421.
28. Gedye, A., Beattie, B. L., Tuokko, H., Horton, A., and Korsarek, E. (1989). Severe head injury hastens age of onset of Alzheimer's disease. Journal of American Geriatric Society 37: 970-973.
29. Glassman, R. B. (1987). An hypothesis about redundancy and reliability in the brains of higher species: Analogies with genes, internal organs, and engineering systems. Neuroscience and Biobehavioural Reviews 11: 275-285.
30. Glassman, R. B., and Smith, A. (1988). Neural spare capacity and the concept of diaschisis. In Finger, S., LeVere, T. E., Almli, C. R., and Stein, D. G. (eds.), Brain Injury and Recovery: Theoretical and Controversial Issues, Plenum Press, New York, pp. 45-69.
31. Graves, A. B., White, E., Koepsell, T. D., Reifler, B. V., van Belle, G., Larson, E. B., and Raskind, M. (1990). The association between head trauma and Alzheimer's disease. American Journal of Epidemiology 131: 491-501.
32. Growdon, J. H. (1998). Apolipoprotein E and Alzheimer's disease. Archives of Neurology 55: 1053-1054.
33. Hardy, J. (1997). Amyloid, the presenilins and Alzheimer's disease. Trends in Neurosciences 20: 154-159.
34. Hayes, R. L., Jenkins, L. W., and Lyeth, B. G. (1992). Neurochemical aspects of head injury: Role of excitatory neurotransmission. Journal of Head Trauma Rehabilitation 7: 16-28.
35. Henderson, A. S. (1988). The risk factors for Alzheimer's disease: A review and a hypothesis. Acta Psychiatrica Scandinavica 78: 257-275.
36. Heyman, A., Wilkinson, W. E., Stafford, J. A., Helms, M. J., Sigmon, A. H., and Weinberg, T. (1984). Alzheimer's disease: A study of epidemiological aspects. Annals of Neurology 15: 335-341.
37. Hill, L. R., Klauber, M. R., Salmon, D. P., Yu, E. S. H., Liu, W. T., Zhang, M., and Katzman, R. (1993). Functional status, education, and the diagnosis of dementia in the Shanghai survey. Neurology 43: 138-145.
38. Jonker, C., Schmand, B., Lindeboom, J., Havekes, L. M., and Launer, L. J. (1998). Association between Apolipoprotein E ε4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia. Archives of Neurology 55: 1065-1069.
39. Jordan, B. D., Relkin, N. R., Ravdin, L. D., Jacobs, A. R., Bennett, A., and Gandy, S. (1997). Apolipoprotein E ε4 associated with chronic traumatic brain injury in boxing. Journal of American Medical Association 278: 136-140.
40. Jorm, A. F. (1990). The Epidemiology of Alzheimer's Disease and Related Disorders, Chapman and Hall, London.
41. Jorm, A. F., and Henderson, A. S. (1993). The Problem of Dementia in Australia, 3rd Ed., Australian Government Publishing Service, Canberra.
42. Jorm, A. F., Henderson, A. S., Scott, R., Christensen, H., Mackinnon, A. J., and Korten, A. E. (1994). Does education protect against cognitive impairment? A comparison of the elderly in two Australian cities. International Journal of Geriatric Psychiatry 9: 357-363.
43. Kanayama, G., Takeda, M., Niigawa, H., Ikura, Y., Tamii, H., Taniguchi, N., Kudo, T., Miyamae, Y., Morihara, T., and Nishimura, T. (1996). The effects of repetitive mild brain injury on cytoskeletal protein and behaviour. Methods and Findings in Experimental and Clinical Pharmacology 18: 105-115.
44. Katzman, R. (1993). Education and the prevalence of dementia and Alzheimer's disease. Neurology 43: 13-20.
45. Katzman, R., Aronson, M., Fuld, P., Kawas, C., Brown, T., Morgenstern, H., Frishman, W., Gidez, L., Eder, H., and Ooi, W. L. (1989). Development of dementing illnesses in an 80-year-old volunteer cohort. Annals of Neurology 25: 317-324.
46. Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., and Peck, A. (1988). Chemical, pathological and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Annals of Neurology 23: 138-144.
47. Klunk, W. E. (1998). Biological markers of Alzheimer's disease. Neurobiology of Aging 19: 145-147.
48. Kondo, K., Niino, M., and Shido, K. (1994). A case-control study of Alzheimer's disease in Japan - Significance of lifestyles. Dementia 5: 314-326.
49. Levin, H. S., and Goldstein, F. C. (1995). Closed head injury and Alzheimer's disease: Epidemiologic, neurobehavioural and neuropathologic links. Journal of the International Neuropsychological Society 1: 183.
50. Lewin, W., Marshall, T. F., and Roberts, A. H. (1979). Long-term outcome after severe head injury. British Medical Journal 2: 1533-1538.
51. Lilienfeld, A. M., and Lilienfeld, D. E. (1980). Foundations of Epidemiology, 2nd Ed., Oxford University Press, New York.
52. Lott, I. T. (1992). The neurology of Alzheimer disease in Down syndrome. In Nadel, L., and Epstein, C. J. (eds.), Down Syndrome and Alzheimer Disease, Wiley-Liss, New York, pp. 1-14.
53. Mayeux, R., Ottman, R., Maestre, G., Ngai, C., Tang, M.-X., Ginsberg, H., Chun, M., Tycko, B., and Shelanski, M. (1995). Synergistic effects of traumatic brain injury and apolipoprotein-ε4 in patients with Alzheimer's disease. Neurology 45: 555-557.
54. Mayeux, R., Ottman, R., Tang, M., Noboa-Bauza, L., Marder, K., Gurland, B., and Stern, Y. (1993). Genetic Susceptibility and head injury as risk factors for Alzheimers disease among community-dwelling elderly persons and their first degree relatives. Annals of Neurology 33: 494-501.
55. McConway, K. (1994). Investigating causes and evaluating treatments. In McConway, K. (ed.), Studying Health and Disease, Open University Press, United Kingdom, pp. 97-111.
56. Mendez, M. F., Underwood, K. L., Zander, B. A., Mastri, A. R., Sung, J. H., and Frey, W. H. (1992). Risk factors in Alzheimer's disease: A clinicopathologic study. Neurology 42: 770-775.
57. Mori, E., Hirono, N., Yamashita, H., Imamura, T., Ikejiri, Y., Ikeda, M., Kitagaki, H., Shimomura, T., and Yoneda, Y. (1997). Premorbid brain size as a determinant of reserve capacity against intellectual decline in Alzheimer's disease. American Journal of Psychiatry 154: 18-24.
58. Morris, J. C., Storandt, M., McKeel, D. W., Rubin, E. H., Price, J. L., Grant, E. A., and Berg, L. (1996). Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease. Neurology 46: 707-719.
59. Mortimer, J. A. (1988). Do psychosocial risk factors contribute to Alzheimer's disease? In Henderson, A. S., and Henderson, J. H. (eds.), Etiology of Dementia of Alzheimer's type, John Wiley, New York, pp. 39-52.
60. Mortimer, J. A. (1994). What are the risk factors for dementia? In Huppert, F. A., Brayne, C., and O'Connor, D. W. (eds.), Dementia and Normal Aging, Cambridge University Press, Cambridge, pp. 208-229.
61. Mortimer, J. A. (1995). The epidemiology of Alzheimer's disease: Beyond risk factors. In Iqbal, K., Mortimer, J. A., Winblad, B., and Wisniewski, H. M. (eds.), Research Advances in Alzheimer's Disease and Related Disorders, John Wiley and Sons, New York, pp. 3-13.
62. Mortimer, J. A. (1997). Brain reserve and the clinical expression of Alzheimer's disease. Geriatrics 52: S50-S53.
63. Mortimer, J. A., French, L. R., Mutton, J. T., and Schuman, L. M. (1985). Head injury as a risk factor for Alzheimer's disease. Neurology 35: 264-267.
64. Mortimer, J. A., and Graves, A. B. (1993). Education and other socioeconomic determinants of dementia and Alzheimer's disease. Neurology 43: S39-S44.
65. Mortimer, J. A., and Pirozzolo, F. J. (1985). Remote effects of head trauma. Developmental Neuropsychology 1: 215-229.
66. Mortimer, J. A., Van Duijn, C. M., Chandra, V., Fratiglioni, L., Graves, A. B., Heyman, A., Jorm, A. F., Kokmen, E., Kondo, K., Rocca, W. A., Shalat, S. L., Soininen, H., and Hofman, A. (1991). Head trauma as a risk factor for Alzheimer's disease: A collaborative re-analysis of case-control studies. International Journal of Epidemiology 20: S28-S35.
67. Murakami, N., Yamaki, T., Iwamoto, Y., Sakakibara, T., Kobori, N., Fushiki, S., and Ueda, S. (1998). Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus. Journal of Neurotrauma 15: 993-1003.
68. Murdoch, I., Perry, E. K., Court, J. A., Graham, D. J., and Dewar, D. (1998). Cortical cholinergic dysfunction after human head injury. Journal of Neurotrauma 15: 295-305.
69. Naugle, R. I. (1987). Catastrophic minor head trauma. Archives of Clinical Neuropsychology 2: 93-100.
70. Nemetz, P. N., Leibson, C., Naessens, J. M., Beard, M., Kokmen, E., Annegers, J. F., and Kurland, L. T. (1999). Traumatic brain injury and time to onset of Alzheimer's disease: A population-based study. American Journal of Epidemiology 149: 32-40.
71. Neve, R. L., and Robakis, N. K. (1998). Alzheimer's disease: A reexamination of the amyloid hypothesis. Trends in Neurosciences 21: 15-19.
72. Nicoll, J. A. R., Roberts, G. W., and Graham, D. I. (1995). Apolipoprotein E e4 allele is associated with deposition of amyloid β-protein following head injury. Nature Medicine 1: 135-148.
73. Nicoll, J. A. R., Roberts, G. W., and Graham, D. I. (1996). Amyloid β-protein, APOE genotype and head injury. Annals of the New York Academy of Sciences 777: 271-275.
74. Ott, A., Breteler, M. M. B., van Harskamp, F., Claus, J. J., van der Cammen, T. J. M., Grobbee, D. E., and Hofman, A. (1995). Prevalence of Alzheimer's disease and vascular dementia: Association with education. The Rotterdam Study. British Medical Journal 310: 970-973.
75. Palmer, A. M., and Gershon, S. (1990). Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? FASEB Journal 4: 2745-2752.
76. Perry, E. K., and Perry, R. H. (1988). Aging and dementia: Neurochemical and neuropathological comparisons. In Henderson, A. S., and Henderson, J. H. (eds.), Etiology of Dementia of the Alzheimer's Type, Wiley and Sons, New York, pp. 213-228.
77. Perry, E. K., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson., P. H., and Perry, R. H. (1978). Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. British Medical Journal 2: 1457-1459.
78. Poirier, J. (1996). Apolipoprotein E in the brain and its role in Alzheimer's disease. Journal of Psychiatry and Neuroscience 21: 128-134.
79. Poirier, J., Davignon, J., Bouthillier, D., Kogan, S., Bertrand, P., and Gauthier, S. (1993). Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342: 697-699.
80. Raby, C. A., Morganti-Kossmann, M. C., Kossmann, T., Stahel, P. F., Watson, M. D., Evans, L. M., Mehta, P. D., Spiegel, K., Kuo, Y., Roher, A. E., and Emmerling, M. R. (1998). Traumatic brain injury increases β-Amyloid peptide 1-42 in cerebrospinal fluid. Journal of Neurochemistry 71: 2505-2509.
81. Rasmusson, D. X., Brandt, J., Martin, D. B., and Folstein, M. F. (1995). Head injury as a risk factor in Alzheimer's disease. Brain Injury 9: 213-219.
82. Reyes-Ortiz, C. A. (1997). Delirium, dementia, and brain reserve. Journal of the American Geriatrics Society 45: 778-779.
83. Roberts, A. H. (1979). Severe Accidental Head Injury, Macmillan Press, London.
84. Roberts, G. W. (1988). Immunocytochemistry of neurofibrillary tangles in dementia pugilistica and Alzheimer's disease: Evidence for a common genesis. The Lancet ii: 1456-1458.
85. Roberts, G. W., Allsop, D., and Bruton, C. (1990). The occult aftermath of boxing. Journal of Neurology, Neurosurgery and Psychiatry 53: 373-378.
86. Roberts, G. W., Gentleman, S. M., Lynch, A., Murray, L., Landon, M., and Graham, D. I. (1994). β Amyloid protein deposition in the brain after severe closed head injury: Implications for the pathogenesis of Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry 57: 419-425.
87. Roth, M. (1986). The association of clinical and neurological findings bearing on the classification and aetiology of Alzheimer's disease. British Medical Bulletin 42: 42-50.
88. Rudelli, R., Strom, J. O., Welch, P. T., and Ambler, M. W. (1982). Post-traumatic premature Alzheimer's disease. Archives of Neurology 39: 570-575.
89. Salib, E., and Hillier, V. (1997). Head injury and the risk of Alzheimer's disease: A case-control study. International Journal of Geriatric Psychiatry 12: 363-368.
90. Sandercock, P. (1989). The odds ratio: A useful tool in neurosciences. Journal of Neurology, Neurosurgery and Psychiatry 52: 817-820.
91. Satz, P. (1993). Brain reserve capacity on symptom onset after brain injury: A formulation and review of evidence for threshold theory. Neuropsychology 7: 273-295.
92. Schlesselman, J. J. (1982). Case-Control Studies: Design, Conduct, Analysis, Oxford University Press, New York.
93. Schmand, B., Smit, J. H., Geerlings, M. I., and Lindeboom, J. (1997). The effects of intelligence and education on the development of dementia. A test of the brain reserve hypothesis. Psychological Medicine 27: 1337-1344.
94. Schmidt, R. H., and Grady, S. (1995). Loss of forebrain cholinergic neurons following fluid percussion injury: Implications for cognitive impairment in closed head injury. Journal of Neurosurgery 83: 496-502.
95. Schofield, P. W., Logroscino, G., Andrews, H. F., Albert, S., and Stern, Y. (1997a). An association between head circumference and Alzheimer's disease in a population-based study of aging and dementia. Neurology 49: 30-37.
96. Schofield, P. W., Mosesson, R. E., Stern, Y., and Mayeux, R. (1995). The age at onset of Alzheimer's disease and an intracranial area measurement. Archives of Neurology 52: 95-98.
97. Schofield, P. W., Tang, M., Marder, K., Bell, K., Dooneief, G., Chun, M., Sano, M., Stern, Y., and Mayeux, R. (1997b). Alzheimer's disease after remote head injury: An incidence study. Journal of Neurology, Neurosurgery and Psychiatry 62: 119-124.
98. Shuttleworth-Jordan, A. B. (1997). Age and education effects on brain-damaged subjects: "Negative" findings revisited. The Clinical Neuropsychologist 11: 205-209.
99. Slooter, A. J. C., Cruts, M., Kalmijn, S., Hofman, A., Breteler, M. M. B., Van Broeckhoven, C., and van Duijn, C. M. (1998). Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: The Rotterdam study. Archives of Neurology 55: 964-968.
100. Snowdon, D. A., Kemper, S. J., Mortimer, J. A., Greiner, L. H., Wekstein, D. R., and Markesbury, W. R. (1996). Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Journal of American Medical Association 275: 528-532.
101. Sorenson, S. R. and Kraus, J. F. (1991). Occurrence, severity and outcomes of brain injury. Journal of Head Trauma Rehabilitation 6: 1-10.
102. Sosin, D. M., Sniezek, J. E., and Waxweiler, R. J. (1995). Trends in death associated with traumatic brain injury, 1979 through 1992. Journal of the American Medical Association 273: 1778-1780.
103. Spear, J. (1995). Are professional footballers at risk of developing dementia? International Journal of Geriatric Psychiatry 10: 1011-1014.
104. Stern, Y., Alexander, G. E., Prohovnik, I., and Mayeux, R. (1992). Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Annals of Neurology 32: 371-375.
105. Stern, Y., Alexander, G. E., Prohovnik, I., Stricks, L., Link, B., Lennon, M. C., and Mayeux, R. (1995). Relationship between lifetime occupation and parietal flow: Implications for a reserve against Alzheimer's disease pathology. Neurology 45: 55-60.
106. Stern, Y., Gurland, B., Tatemichi, T. K., Tang, M. X., Wilder, D., and Mayeux, R. (1994). Influence of education and occupation on the incidence of Alzheimer's disease. Journal of American Medical Association 271: 1004-1010.
107. Storey, E., and Masters, C. L. (1995). Amyloid, aluminium and the aetiology of Alzheimer's disease. The Medical Journal of Australia 163: 256-259.
108. Sullivan, P., Petitti, D., and Barbaccia, J. (1987). Head trauma and age of onset of dementia of the Alzheimer's type. Journal of American Medical Association 257: 2289-2290.
109. Swaab, D. F. (1991). Brain aging and Alzheimer's disease, "Wear and Tear" versus "Use it or lose it." Neurobiology of Aging 12: 317-324.
110. Tang, M.-X., Maestre, G., Tsai, W.-Y., Liu, X.-H., Feng, L., Chung, W.-Y., Chun, M., Schofield, P., Stern, Y., Tycko, B., and Mayeux, R. (1996). Effect of age, ethnicity, and head injury on the association between APOE genotypes and Alzheimer's disease. Annals of the New York Academy of Sciences 802: 6-15.
111. Teasdale, G. M. (1995). Head Injury. Journal of Neurology, Neurosurgery, and Psychiatry 58: 526-539.
112. Teasdale, G. M., Nicoll, J. A. R., Murray, G., and Fiddes, M. (1997). Association of apolipoprotein E polymorphism with outcome after head injury. Lancet 350: 1069-1071.
113. Teuber, H. L. (1974). Recovery of function after lesions of the central nervous system: History and prospects. Neurosciences Research Program Bulletin 12: 197-211.
114. Tomlinson, B. E., Blessed, G., and Roth, M. (1970). Observations on the brains of demented old people. Journal of the Neurological Sciences 11: 205-242.
115. Uhl, G. R., McKinney, M., and Hedreen, J. (1982). Dementia Pugilistica: Loss of basal forebrain cholinergic neurons and cortical cholinergic markers. Annals of Neurology 12: 99.
116. Unverzagt, F. W., Hui, S. L., Farlow, M. R., Hall, K. S., and Hendrie, H. C. (1998). Cognitive decline and education in mild dementia. Neurology 50: 181-185.
117. Whitehouse, P., Kitt, C. A., Hedreen, J. C., Struble, R. G., and Price, D. L. (1985). Neuropathological findings in cholinergic systems in Alzheimer's disease. In Gottfries, C. G. (ed.), Normal Aging, Alzheimer's Disease and Senile Dementia, Universite de Bruxelles, Belgium, pp. 83-91.
118. Whitehouse, P. J., Lerner, A., and Hedera, P. (1993). Dementia. In Heilman, K. M., and Valenstein, E. (eds.), Clinical Neuropsychology, 3rd Ed., Oxford University Press, New York.
119. Willerman, L., Schultz, R., Rutledge, J. N., and Bigler, E. D. (1991). In vivo brain size and intelligence. Intelligence 15: 223-228.
120. Williams, D. B., Annegers, J. F., Kokmen, E., O'Brien, P. C., and Kurland, L. T. (1991). Brain injury and neurologic sequelae: A cohort study of dementia, parkinsonism, and amyotrophic lateral sclerosis. Neurology 41: 1554-1557.
121. Wisniewski, T., and Frangione, B. (1992). Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid. Neuroscience Letters 135: 235-238.
122. Yasuda, M., Mori, E., Kitagaki, H., Yamashita, H., Hirono, N., Shimada, K., Maeda, K., and Tanaka, C. (1998). Apolipoprotein E ε4 allele and whole brain atrophy in late-onset Alzheimer's disease. American Journal of Psychiatry 155: 779-784.