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Volumn 38, Issue 10, 2016, Pages 1016-1026

Anti-inflammatory effects of melatonin in multiple sclerosis

Author keywords

melatonin; MTNR1A; multiple sclerosis; ROR ; TH17 cells; Tr1 regulatory cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; LUZINDOLE; MELATONIN; MESALAZINE; NATALIZUMAB; TRANSCRIPTION FACTOR FOXP3; VITAMIN D;

EID: 84988354824     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201600018     Document Type: Article
Times cited : (44)

References (131)
  • 1
    • 0000883002 scopus 로고
    • Evidences associating pineal gland function with alterations in pigmentation
    • McCord CP, Allen FP. 1917. Evidences associating pineal gland function with alterations in pigmentation. J Exp Zool 23: 207–24.
    • (1917) J Exp Zool , vol.23 , pp. 207-224
    • McCord, C.P.1    Allen, F.P.2
  • 2
    • 33947460818 scopus 로고
    • Isolation of melatonin, the pineal gland factor that lightens melanocytes
    • Lerner AB, Case JD, Takahashi Y, Lee TH, et al. 1958. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc 80:2587.
    • (1958) J Am Chem Soc , vol.80 , pp. 2587
    • Lerner, A.B.1    Case, J.D.2    Takahashi, Y.3    Lee, T.H.4
  • 3
    • 0028843866 scopus 로고
    • High-affinity binding of melatonin by human circulating T lymphocytes (CD4+)
    • Gonzalez-Haba MG, Garcia-Mauriño S, Calvo JR, Goberna R, et al. 1995. High-affinity binding of melatonin by human circulating T lymphocytes (CD4+). FASEB J 9: 1331–5.
    • (1995) FASEB J , vol.9 , pp. 1331-1335
    • Gonzalez-Haba, M.G.1    Garcia-Mauriño, S.2    Calvo, J.R.3    Goberna, R.4
  • 4
    • 0036481625 scopus 로고    scopus 로고
    • Melatonin-immune system relationships
    • Guerrero JM, Reiter RJ. 2002. Melatonin-immune system relationships. Curr Top Med Chem 2: 167–79.
    • (2002) Curr Top Med Chem , vol.2 , pp. 167-179
    • Guerrero, J.M.1    Reiter, R.J.2
  • 5
    • 0031132118 scopus 로고    scopus 로고
    • Expression of the Mel1a-melatonin receptor mRNA in T and B subsets of lymphocytes from rat thymus and spleen
    • Pozo D, Delgado M, Fernandez-Santos JM, Calvo JR, et al. 1997. Expression of the Mel1a-melatonin receptor mRNA in T and B subsets of lymphocytes from rat thymus and spleen. FASEB J 11: 466–73.
    • (1997) FASEB J , vol.11 , pp. 466-473
    • Pozo, D.1    Delgado, M.2    Fernandez-Santos, J.M.3    Calvo, J.R.4
  • 6
    • 0031978840 scopus 로고    scopus 로고
    • Melatonin receptor genes
    • Kokkola T, Laitinen JT. 1998. Melatonin receptor genes. Ann Med 30: 88–94.
    • (1998) Ann Med , vol.30 , pp. 88-94
    • Kokkola, T.1    Laitinen, J.T.2
  • 7
    • 0031021914 scopus 로고    scopus 로고
    • Melatonin in humans
    • Brzezinski A. 1997. Melatonin in humans. N Engl J Med 336: 186–95.
    • (1997) N Engl J Med , vol.336 , pp. 186-195
    • Brzezinski, A.1
  • 8
    • 0036142587 scopus 로고    scopus 로고
    • Melatonin enters the cerebrospinal fluid through the pineal recess
    • Tricoire H, Locatelli A, Chemineau P, Malpaux B. 2002. Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology 143: 84–90.
    • (2002) Endocrinology , vol.143 , pp. 84-90
    • Tricoire, H.1    Locatelli, A.2    Chemineau, P.3    Malpaux, B.4
  • 10
    • 80054821679 scopus 로고    scopus 로고
    • Distribution, function and physiological role of melatonin in the lower gut
    • Chen C-Q. 2011. Distribution, function and physiological role of melatonin in the lower gut. World J Gastroenterol 17: 3888.
    • (2011) World J Gastroenterol , vol.17 , pp. 3888
    • Chen, C.-Q.1
  • 12
    • 10444245917 scopus 로고    scopus 로고
    • Human pineal physiology and functional significance of melatonin
    • Macchi MM, Bruce JN. 2004. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol 25: 177–95.
    • (2004) Front Neuroendocrinol , vol.25 , pp. 177-195
    • Macchi, M.M.1    Bruce, J.N.2
  • 13
    • 75149171319 scopus 로고    scopus 로고
    • Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations
    • Ji L-D, Xu J, Wu D-D, Xie S-D, et al. 2010. Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations. J Pineal Res 48: 133–41.
    • (2010) J Pineal Res , vol.48 , pp. 133-141
    • Ji, L.-D.1    Xu, J.2    Wu, D.-D.3    Xie, S.-D.4
  • 14
    • 48449103650 scopus 로고    scopus 로고
    • Immunomodulation by melatonin: its significance for seasonally occurring diseases
    • Srinivasan V, Spence WD, Trakt I, Pandi-Perumal SR, et al. 2008. Immunomodulation by melatonin: its significance for seasonally occurring diseases. Neuroimmunomodulation 15: 93–101.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 93-101
    • Srinivasan, V.1    Spence, W.D.2    Trakt, I.3    Pandi-Perumal, S.R.4
  • 15
    • 0029401790 scopus 로고
    • The influence of season, photoperiod, and pineal melatonin on immune function
    • Nelson RJ, Demas GE, Klein SL, Kriegsfeld LJ. 1995. The influence of season, photoperiod, and pineal melatonin on immune function. J Pineal Res 19: 149–65.
    • (1995) J Pineal Res , vol.19 , pp. 149-165
    • Nelson, R.J.1    Demas, G.E.2    Klein, S.L.3    Kriegsfeld, L.J.4
  • 16
    • 84941361355 scopus 로고    scopus 로고
    • Melatonin contributes to the seasonality of multiple sclerosis relapses
    • Farez MF, Mascanfroni ID, Mendez-Huergo SP, Yeste A, et al. 2015. Melatonin contributes to the seasonality of multiple sclerosis relapses. Cell 162: 1338–52.
    • (2015) Cell , vol.162 , pp. 1338-1352
    • Farez, M.F.1    Mascanfroni, I.D.2    Mendez-Huergo, S.P.3    Yeste, A.4
  • 18
    • 34548641697 scopus 로고    scopus 로고
    • Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin
    • Forrest CM, Mackay GM, Stoy N, Stone TW, et al. 2007. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br J Clin Pharmacol 64: 517–26.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 517-526
    • Forrest, C.M.1    Mackay, G.M.2    Stoy, N.3    Stone, T.W.4
  • 19
    • 42149096483 scopus 로고    scopus 로고
    • Melatonin treatment does not improve rheumatoid arthritis
    • Maestroni GJ, Otsa K, Cutolo M. 2008. Melatonin treatment does not improve rheumatoid arthritis. Br J Clin Pharmacol 65: 797–8.
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 797-798
    • Maestroni, G.J.1    Otsa, K.2    Cutolo, M.3
  • 20
    • 46749097473 scopus 로고    scopus 로고
    • Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
    • Pandi-Perumal SR, Trakht I, Srinivasan V, Spence DW, et al. 2008. Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways. Prog Neurobiol 85: 335–53.
    • (2008) Prog Neurobiol , vol.85 , pp. 335-353
    • Pandi-Perumal, S.R.1    Trakht, I.2    Srinivasan, V.3    Spence, D.W.4
  • 21
    • 0034613342 scopus 로고    scopus 로고
    • Identification of the melatonin-binding siteMT 3 as the quinone reductase 2
    • Nosjean O, Ferro M, Coge F, Beauverger P, et al. 2000. Identification of the melatonin-binding siteMT 3 as the quinone reductase 2. J Biol Chem 275: 31311–7.
    • (2000) J Biol Chem , vol.275 , pp. 31311-31317
    • Nosjean, O.1    Ferro, M.2    Coge, F.3    Beauverger, P.4
  • 22
    • 47249088189 scopus 로고    scopus 로고
    • Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new
    • Jockers R, Maurice P, Boutin JA, Delagrange P. 2008. Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new? Br J Pharmacol 154: 1182–95.
    • (2008) Br J Pharmacol , vol.154 , pp. 1182-1195
    • Jockers, R.1    Maurice, P.2    Boutin, J.A.3    Delagrange, P.4
  • 23
    • 0028920392 scopus 로고
    • Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand
    • Wiesenberg I, Missbach M, Kahlen JP, Schräder M, et al. 1995. Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res 23: 327–33.
    • (1995) Nucleic Acids Res , vol.23 , pp. 327-333
    • Wiesenberg, I.1    Missbach, M.2    Kahlen, J.P.3    Schräder, M.4
  • 24
    • 0035238364 scopus 로고    scopus 로고
    • The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes
    • Jetten AM, Kurebayashi S, Ueda E. 2001. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog Nucleic Acid Res Mol Biol 69: 205–47.
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.69 , pp. 205-247
    • Jetten, A.M.1    Kurebayashi, S.2    Ueda, E.3
  • 25
    • 84903696734 scopus 로고    scopus 로고
    • ROR and ROR are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D
    • Slominski AT, Kim TK, Takeda Y, Janjetovic Z, et al. 2014. ROR and ROR are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D. FASEB J 28: 2775–89.
    • (2014) FASEB J , vol.28 , pp. 2775-2789
    • Slominski, A.T.1    Kim, T.K.2    Takeda, Y.3    Janjetovic, Z.4
  • 26
    • 80054817139 scopus 로고    scopus 로고
    • Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor
    • Lardone PJ, Guerrero JM, Fernández-Santos JM, Rubio A, et al. 2011. Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor. J Pineal Res 51: 454–62.
    • (2011) J Pineal Res , vol.51 , pp. 454-462
    • Lardone, P.J.1    Guerrero, J.M.2    Fernández-Santos, J.M.3    Rubio, A.4
  • 27
    • 53449084976 scopus 로고    scopus 로고
    • Transcriptional activation of HIF-1 by ROR and its role in hypoxia signaling
    • Kim EJ, Yoo YG, Yang WK, Lim YS, et al. 2008. Transcriptional activation of HIF-1 by ROR and its role in hypoxia signaling. Arterioscler Thromb Vasc Biol 28: 1796–802.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1796-1802
    • Kim, E.J.1    Yoo, Y.G.2    Yang, W.K.3    Lim, Y.S.4
  • 28
    • 59349102293 scopus 로고    scopus 로고
    • A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production
    • Lardone PJ, Carrillo-Vico A, Molinero P, Rubio A, et al. 2008. A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production. Cell Mol Life Sci 66: 516–25.
    • (2008) Cell Mol Life Sci , vol.66 , pp. 516-525
    • Lardone, P.J.1    Carrillo-Vico, A.2    Molinero, P.3    Rubio, A.4
  • 29
    • 0033676245 scopus 로고    scopus 로고
    • Melatonin and its relation to the immune system and inflammation
    • Reiter RJ, Calvo JR, Karbownik M, Qi W, et al. 2000. Melatonin and its relation to the immune system and inflammation. Ann N Y Acad Sci 917: 376–86.
    • (2000) Ann N Y Acad Sci , vol.917 , pp. 376-386
    • Reiter, R.J.1    Calvo, J.R.2    Karbownik, M.3    Qi, W.4
  • 30
    • 0028618440 scopus 로고
    • Melatonin–a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro
    • Poeggeler B, Saarela S, Reiter RJ, Tan DX, et al. 1994. Melatonin–a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro. Ann N Y Acad Sci 738: 419–20.
    • (1994) Ann N Y Acad Sci , vol.738 , pp. 419-420
    • Poeggeler, B.1    Saarela, S.2    Reiter, R.J.3    Tan, D.X.4
  • 31
    • 38349125335 scopus 로고    scopus 로고
    • Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis
    • Gray E, Thomas TL, Betmouni S, Scolding N, et al. 2008. Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathol 18: 86–95.
    • (2008) Brain Pathol , vol.18 , pp. 86-95
    • Gray, E.1    Thomas, T.L.2    Betmouni, S.3    Scolding, N.4
  • 32
    • 77949420644 scopus 로고    scopus 로고
    • The “hygiene hypothesis” for autoimmune and allergic diseases: an update
    • Okada H, Kuhn C, Feillet H, Bach J-F. 2010. The “hygiene hypothesis” for autoimmune and allergic diseases: an update. Clin Exp Immunol 160: 1–9.
    • (2010) Clin Exp Immunol , vol.160 , pp. 1-9
    • Okada, H.1    Kuhn, C.2    Feillet, H.3    Bach, J.-F.4
  • 33
    • 0035796677 scopus 로고    scopus 로고
    • Melatonin modulation of lymphocyte proliferation and Th1/Th2 cytokine expression
    • Kühlwein E, Irwin M. 2001. Melatonin modulation of lymphocyte proliferation and Th1/Th2 cytokine expression. J Neuroimmunol 117: 51–7.
    • (2001) J Neuroimmunol , vol.117 , pp. 51-57
    • Kühlwein, E.1    Irwin, M.2
  • 34
    • 0031087697 scopus 로고    scopus 로고
    • Effect of melatonin and corticosteroid on in vitro cellular immune function in humans
    • Rogers N, van den Heuvel C, Dawson D. 1997. Effect of melatonin and corticosteroid on in vitro cellular immune function in humans. J Pineal Res 22: 75–80.
    • (1997) J Pineal Res , vol.22 , pp. 75-80
    • Rogers, N.1    van den Heuvel, C.2    Dawson, D.3
  • 35
    • 0029565036 scopus 로고
    • Selective effect of methoxyindoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells
    • Konakchieva R, Kyurkchiev S, Kehayov I, Taushanova P, et al. 1995. Selective effect of methoxyindoles on the lymphocyte proliferation and melatonin binding to activated human lymphoid cells. J Neuroimmunol 63: 125–32.
    • (1995) J Neuroimmunol , vol.63 , pp. 125-132
    • Konakchieva, R.1    Kyurkchiev, S.2    Kehayov, I.3    Taushanova, P.4
  • 36
    • 0031930503 scopus 로고    scopus 로고
    • Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells
    • Shaji AV, Kulkarni SK, Agrewala JN. 1998. Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells. Clin Exp Immunol 111: 181–5.
    • (1998) Clin Exp Immunol , vol.111 , pp. 181-185
    • Shaji, A.V.1    Kulkarni, S.K.2    Agrewala, J.N.3
  • 37
    • 0031573072 scopus 로고    scopus 로고
    • IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
    • Cameron MJ, Arreaza GA, Zucker P, Chensue SW, et al. 1997. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J Immunol 159: 4686–92.
    • (1997) J Immunol , vol.159 , pp. 4686-4692
    • Cameron, M.J.1    Arreaza, G.A.2    Zucker, P.3    Chensue, S.W.4
  • 38
    • 0028222756 scopus 로고
    • Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse
    • Pennline KJ, Roque-Gaffney E, Monahan M. 1994. Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 71: 169–75.
    • (1994) Clin Immunol Immunopathol , vol.71 , pp. 169-175
    • Pennline, K.J.1    Roque-Gaffney, E.2    Monahan, M.3
  • 40
    • 0030116344 scopus 로고    scopus 로고
    • Role of the pineal gland and melatonin in the development of autoimmune diabetes in non-obese diabetic mice
    • Conti A, Maestroni GJ. 1996. Role of the pineal gland and melatonin in the development of autoimmune diabetes in non-obese diabetic mice. J Pineal Res 20: 164–72.
    • (1996) J Pineal Res , vol.20 , pp. 164-172
    • Conti, A.1    Maestroni, G.J.2
  • 41
    • 70949107842 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Abraham C, Cho JH. 2009. Inflammatory bowel disease. N Engl J Med 361: 2066–78.
    • (2009) N Engl J Med , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.H.2
  • 42
    • 0029349171 scopus 로고
    • Melatonin reduces the severity of dextran-induced colitis in mice
    • Pentney PT, Bubenik GA. 1995. Melatonin reduces the severity of dextran-induced colitis in mice. J Pineal Res 19: 31–9.
    • (1995) J Pineal Res , vol.19 , pp. 31-39
    • Pentney, P.T.1    Bubenik, G.A.2
  • 43
    • 34147219227 scopus 로고    scopus 로고
    • Protective effect of melatonin in acetic acid induced colitis in rats
    • Nosál'ová V, Zeman M, Cerná S, Navarová J, et al. 2007. Protective effect of melatonin in acetic acid induced colitis in rats. J Pineal Res 42: 364–70.
    • (2007) J Pineal Res , vol.42 , pp. 364-370
    • Nosál'ová, V.1    Zeman, M.2    Cerná, S.3    Navarová, J.4
  • 44
    • 0038389797 scopus 로고    scopus 로고
    • Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis
    • Dong W-G, Mei Q, Yu J-P, Xu J-M, et al. 2003. Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. World J Gastroenterol 9: 1307–11.
    • (2003) World J Gastroenterol , vol.9 , pp. 1307-1311
    • Dong, W.-G.1    Mei, Q.2    Yu, J.-P.3    Xu, J.-M.4
  • 45
    • 0035191499 scopus 로고    scopus 로고
    • Melatonin reduces dinitrobenzene sulfonic acid-induced colitis
    • Cuzzocrea S, Mazzon E, Serraino I, Lepore V, et al. 2001. Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. J Pineal Res 30: 1–12.
    • (2001) J Pineal Res , vol.30 , pp. 1-12
    • Cuzzocrea, S.1    Mazzon, E.2    Serraino, I.3    Lepore, V.4
  • 46
    • 51649109708 scopus 로고    scopus 로고
    • Melatonin usage in ulcerative colitis: a case report
    • Maldonado MD, Calvo JR. 2008. Melatonin usage in ulcerative colitis: a case report. J Pineal Res 45: 339–40.
    • (2008) J Pineal Res , vol.45 , pp. 339-340
    • Maldonado, M.D.1    Calvo, J.R.2
  • 48
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy EH, Panayi GS. 2001. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 344: 907–16.
    • (2001) N Engl J Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 49
    • 0025305046 scopus 로고
    • Constant darkness enhances autoimmunity to type II collagen and exaggerates development of collagen-induced arthritis in DBA/1 mice
    • Hansson I, Holmdahl R, Mattsson R. 1990. Constant darkness enhances autoimmunity to type II collagen and exaggerates development of collagen-induced arthritis in DBA/1 mice. J Neuroimmunol 27: 79–84.
    • (1990) J Neuroimmunol , vol.27 , pp. 79-84
    • Hansson, I.1    Holmdahl, R.2    Mattsson, R.3
  • 50
    • 0027151880 scopus 로고
    • Pinealectomy ameliorates collagen II-induced arthritis in mice
    • Hansson I, Holmdahl R, Mattsson R. 1993. Pinealectomy ameliorates collagen II-induced arthritis in mice. Clin Exp Immunol 92: 432–6.
    • (1993) Clin Exp Immunol , vol.92 , pp. 432-436
    • Hansson, I.1    Holmdahl, R.2    Mattsson, R.3
  • 51
    • 0026633931 scopus 로고
    • The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice
    • Hansson I, Holmdahl R, Mattsson R. 1992. The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice. J Neuroimmunol 39: 23–30.
    • (1992) J Neuroimmunol , vol.39 , pp. 23-30
    • Hansson, I.1    Holmdahl, R.2    Mattsson, R.3
  • 52
    • 0036710116 scopus 로고    scopus 로고
    • Effects and mechanisms of melatonin on inflammatory and immune responses of adjuvant arthritis rat
    • Chen Q, Wei W. 2002. Effects and mechanisms of melatonin on inflammatory and immune responses of adjuvant arthritis rat. Int Immunopharmacol 2: 1443–9.
    • (2002) Int Immunopharmacol , vol.2 , pp. 1443-1449
    • Chen, Q.1    Wei, W.2
  • 53
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos GC. 2011. Systemic lupus erythematosus. N Engl J Med 365: 2110–21.
    • (2011) N Engl J Med , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 54
    • 33645524914 scopus 로고    scopus 로고
    • Sex-dependent effect of melatonin on systemic erythematosus lupus developed in Mrl/Mpj-Faslpr mice: it ameliorates the disease course in females, whereas it exacerbates it in males
    • Jimenez-Caliani AJ, Jimenez-Jorge S, Molinero P, Fernández-Santos JM, et al. 2006. Sex-dependent effect of melatonin on systemic erythematosus lupus developed in Mrl/Mpj-Faslpr mice: it ameliorates the disease course in females, whereas it exacerbates it in males. Endocrinology 147: 1717–24.
    • (2006) Endocrinology , vol.147 , pp. 1717-1724
    • Jimenez-Caliani, A.J.1    Jimenez-Jorge, S.2    Molinero, P.3    Fernández-Santos, J.M.4
  • 55
    • 77956849536 scopus 로고    scopus 로고
    • Regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice
    • Zhou L-L., Wei W, Si J-F., Yuan D-P. 2010. Regulatory effect of melatonin on cytokine disturbances in the pristane-induced lupus mice. Mediators Inflamm 2010: pii: 951210.
    • (2010) Mediators Inflamm , vol.2010 , pp. 951210
    • Zhou, L.-L.1    Wei, W.2    Si, J.-F.3    Yuan, D.-P.4
  • 56
    • 84883486213 scopus 로고    scopus 로고
    • Decreased daily melatonin levels in women with systemic lupus erythematosus − a short report
    • Robeva R, Tanev D, Kirilov G, Stoycheva M, et al. 2013. Decreased daily melatonin levels in women with systemic lupus erythematosus − a short report. Balkan Med J 30: 273–6.
    • (2013) Balkan Med J , vol.30 , pp. 273-276
    • Robeva, R.1    Tanev, D.2    Kirilov, G.3    Stoycheva, M.4
  • 57
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. 2008. Multiple sclerosis. The Lancet 372: 1502–17.
    • (2008) The Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 58
    • 84878354392 scopus 로고    scopus 로고
    • The epidemiology of multiple sclerosis in Latin America and the Caribbean: a systematic review
    • Cristiano E, Rojas J, Romano M, Frider N, et al. 2012. The epidemiology of multiple sclerosis in Latin America and the Caribbean: a systematic review. Mult Scler 19: 844–54.
    • (2012) Mult Scler , vol.19 , pp. 844-854
    • Cristiano, E.1    Rojas, J.2    Romano, M.3    Frider, N.4
  • 60
    • 0035321573 scopus 로고    scopus 로고
    • The prevalence of multiple sclerosis in the world: an update
    • Rosati G. 2001. The prevalence of multiple sclerosis in the world: an update. Neurol Sci 22: 117–39.
    • (2001) Neurol Sci , vol.22 , pp. 117-139
    • Rosati, G.1
  • 62
    • 84896903104 scopus 로고    scopus 로고
    • Immunology of relapse and remission in multiple sclerosis
    • Steinman L. 2014. Immunology of relapse and remission in multiple sclerosis. Annu Rev Immunol 32: 257–81.
    • (2014) Annu Rev Immunol , vol.32 , pp. 257-281
    • Steinman, L.1
  • 63
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. 2005. Immunology of multiple sclerosis. Annu Rev Immunol 23: 683–747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 64
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P, Korn T, Kuchroo VK. 2009. Interleukin-17 and type 17 helper T cells. N Engl J Med 361: 888–98.
    • (2009) N Engl J Med , vol.361 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 65
    • 84880257603 scopus 로고    scopus 로고
    • Interleukin-17 and a tale of two autoimmune diseases
    • Dominique LPB, Kuchroo VK. 2013. Interleukin-17 and a tale of two autoimmune diseases. Nat Med 19: 824–5.
    • (2013) Nat Med , vol.19 , pp. 824-825
    • Dominique, L.P.B.1    Kuchroo, V.K.2
  • 66
    • 84945133122 scopus 로고    scopus 로고
    • Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque
    • Frischer JM, Weigand SD, Guo Y, Kale N, et al. 2015. Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque. Ann Neurol 78: 710–21.
    • (2015) Ann Neurol , vol.78 , pp. 710-721
    • Frischer, J.M.1    Weigand, S.D.2    Guo, Y.3    Kale, N.4
  • 67
    • 84876517388 scopus 로고    scopus 로고
    • Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: associations with disease course and progression
    • Lourenco P, Shirani A, Saeedi J, Oger J, et al. 2013. Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: associations with disease course and progression. Mult Scler 19: 577–84.
    • (2013) Mult Scler , vol.19 , pp. 577-584
    • Lourenco, P.1    Shirani, A.2    Saeedi, J.3    Oger, J.4
  • 68
    • 33845302957 scopus 로고    scopus 로고
    • Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
    • Astier AL, Meiffren G, Freeman S, Hafler DA. 2006. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest 116: 3252–7.
    • (2006) J Clin Invest , vol.116 , pp. 3252-3257
    • Astier, A.L.1    Meiffren, G.2    Freeman, S.3    Hafler, D.A.4
  • 69
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. 2004. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 199: 971–9.
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 71
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • Sawcer S, Hellenthal G, Pirinen M, Spencer CCA, et al. 2011. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476: 214–9.
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1    Hellenthal, G.2    Pirinen, M.3    Spencer, C.C.A.4
  • 72
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, et al. 2013. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 45: 1353–60.
    • (2013) Nat Genet , vol.45 , pp. 1353-1360
    • Beecham, A.H.1    Patsopoulos, N.A.2    Xifara, D.K.3    Davis, M.F.4
  • 74
    • 33847679709 scopus 로고    scopus 로고
    • Association between parasite infection and immune responses in multiple sclerosis
    • Correale J, Farez M. 2007. Association between parasite infection and immune responses in multiple sclerosis. Ann Neurol 61: 97–108.
    • (2007) Ann Neurol , vol.61 , pp. 97-108
    • Correale, J.1    Farez, M.2
  • 75
    • 33747705430 scopus 로고    scopus 로고
    • The risk of relapses in multiple sclerosis during systemic infections
    • Correale J, Fiol M, Gilmore W. 2006. The risk of relapses in multiple sclerosis during systemic infections. Neurology 67: 652–9.
    • (2006) Neurology , vol.67 , pp. 652-659
    • Correale, J.1    Fiol, M.2    Gilmore, W.3
  • 76
    • 0035956494 scopus 로고    scopus 로고
    • Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study
    • Ascherio A, Munger KL, Lennette ET, Spiegelman D, et al. 2001. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA 286: 3083–8.
    • (2001) JAMA , vol.286 , pp. 3083-3088
    • Ascherio, A.1    Munger, K.L.2    Lennette, E.T.3    Spiegelman, D.4
  • 77
    • 84919780325 scopus 로고    scopus 로고
    • Sodium intake is associated with increased disease activity in multiple sclerosis
    • Farez MF, Fiol MP, Gaitan MI, Quintana FJ, et al. 2014. Sodium intake is associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 86: 26–31.
    • (2014) J Neurol Neurosurg Psychiatry , vol.86 , pp. 26-31
    • Farez, M.F.1    Fiol, M.P.2    Gaitan, M.I.3    Quintana, F.J.4
  • 78
    • 20444495271 scopus 로고    scopus 로고
    • Cigarette smoking and the progression of multiple sclerosis
    • Hernan MA. 2005. Cigarette smoking and the progression of multiple sclerosis. Brain 128: 1461–5.
    • (2005) Brain , vol.128 , pp. 1461-1465
    • Hernan, M.A.1
  • 79
    • 84896765960 scopus 로고    scopus 로고
    • Vitamin D as an early predictor of multiple sclerosis activity and progression
    • Ascherio A, Munger KL, White R, Köchert K, et al. 2014. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol 71: 306.
    • (2014) JAMA Neurol , vol.71 , pp. 306
    • Ascherio, A.1    Munger, K.L.2    White, R.3    Köchert, K.4
  • 80
    • 0034541242 scopus 로고    scopus 로고
    • Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis
    • Jin Y, de Pedro-Cuesta J, Söderström M, Stawiarz L, et al. 2000. Seasonal patterns in optic neuritis and multiple sclerosis: a meta-analysis. J Neurol Sci 181: 56–64.
    • (2000) J Neurol Sci , vol.181 , pp. 56-64
    • Jin, Y.1    de Pedro-Cuesta, J.2    Söderström, M.3    Stawiarz, L.4
  • 81
    • 84913526146 scopus 로고    scopus 로고
    • Seasonal variation of relapse rate in multiple sclerosis is latitude dependent
    • Spelman T, Gray O, Trojano M, Petersen T, et al. 2014. Seasonal variation of relapse rate in multiple sclerosis is latitude dependent. Ann Neurol 76: 880–90.
    • (2014) Ann Neurol , vol.76 , pp. 880-890
    • Spelman, T.1    Gray, O.2    Trojano, M.3    Petersen, T.4
  • 83
    • 66549129834 scopus 로고    scopus 로고
    • Immunomodulatory effects of vitamin D in multiple sclerosis
    • Correale J, Ysrraelit MC, Gaitan MI. 2009. Immunomodulatory effects of vitamin D in multiple sclerosis. Brain 132: 1146–60.
    • (2009) Brain , vol.132 , pp. 1146-1160
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 84
    • 84866126261 scopus 로고    scopus 로고
    • Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis
    • Runia TF, Hop WCJ, de Rijke YB, Buljevac D, et al. 2012. Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology 79: 261–6.
    • (2012) Neurology , vol.79 , pp. 261-266
    • Runia, T.F.1    Hop, W.C.J.2    de Rijke, Y.B.3    Buljevac, D.4
  • 85
    • 77955291052 scopus 로고    scopus 로고
    • Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis
    • Simpson S, Taylor B, Blizzard L, Ponsonby A-L, et al. 2010. Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol 68: 193–203.
    • (2010) Ann Neurol , vol.68 , pp. 193-203
    • Simpson, S.1    Taylor, B.2    Blizzard, L.3    Ponsonby, A.-L.4
  • 86
    • 84866117980 scopus 로고    scopus 로고
    • Vitamin D and disease activity in multiple sclerosis before and during interferon-β treatment
    • Løken-Amsrud KI, Holmøy T, Bakke SJ, Beiske AG, et al. 2012. Vitamin D and disease activity in multiple sclerosis before and during interferon-β treatment. Neurology 79: 267–73.
    • (2012) Neurology , vol.79 , pp. 267-273
    • Løken-Amsrud, K.I.1    Holmøy, T.2    Bakke, S.J.3    Beiske, A.G.4
  • 87
    • 0030867140 scopus 로고    scopus 로고
    • Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis
    • Constantinescu CS, Hilliard B, Ventura E, Rostami A. 1997. Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology 65: 190–4.
    • (1997) Pathobiology , vol.65 , pp. 190-194
    • Constantinescu, C.S.1    Hilliard, B.2    Ventura, E.3    Rostami, A.4
  • 88
    • 1542653109 scopus 로고    scopus 로고
    • Melatonin ameliorates autoimmune encephalomyelitis through suppression of intercellular adhesion molecule-1
    • Kang JC, Ahn M, Kim YS, Moon C, et al. 2001. Melatonin ameliorates autoimmune encephalomyelitis through suppression of intercellular adhesion molecule-1. J Vet Sci 2: 85–9.
    • (2001) J Vet Sci , vol.2 , pp. 85-89
    • Kang, J.C.1    Ahn, M.2    Kim, Y.S.3    Moon, C.4
  • 89
    • 51649115364 scopus 로고    scopus 로고
    • Melatonin receptor antagonist luzindole is a powerful radical scavenger in vitro
    • Mathes AM, Wolf B, Rensing H. 2008. Melatonin receptor antagonist luzindole is a powerful radical scavenger in vitro. J Pineal Res 45: 337–8.
    • (2008) J Pineal Res , vol.45 , pp. 337-338
    • Mathes, A.M.1    Wolf, B.2    Rensing, H.3
  • 90
    • 84934299916 scopus 로고    scopus 로고
    • Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance
    • Álvarez-Sánchez N, Cruz-Chamorro I, López-González A, Utrilla JC, et al. 2015. Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance. Brain Behav Immun 50: 101–14.
    • (2015) Brain Behav Immun , vol.50 , pp. 101-114
    • Álvarez-Sánchez, N.1    Cruz-Chamorro, I.2    López-González, A.3    Utrilla, J.C.4
  • 91
    • 0032582677 scopus 로고    scopus 로고
    • Biological role of the CCAAT/enhancer-binding protein family of transcription factors
    • Lekstrom-Himes J, Xanthopoulos KG. 1998. Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem 273: 28545–8.
    • (1998) J Biol Chem , vol.273 , pp. 28545-28548
    • Lekstrom-Himes, J.1    Xanthopoulos, K.G.2
  • 92
    • 84887275003 scopus 로고    scopus 로고
    • TH17 cell differentiation is regulated by the circadian clock
    • Yu X, Rollins D, Ruhn KA, Stubblefield JJ, et al. 2013. TH17 cell differentiation is regulated by the circadian clock. Science 342: 727–30.
    • (2013) Science , vol.342 , pp. 727-730
    • Yu, X.1    Rollins, D.2    Ruhn, K.A.3    Stubblefield, J.J.4
  • 93
    • 81155160952 scopus 로고    scopus 로고
    • Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27
    • Pot C, Apetoh L, Kuchroo VK. 2011. Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27. Sem Immunol 23: 202–8.
    • (2011) Sem Immunol , vol.23 , pp. 202-208
    • Pot, C.1    Apetoh, L.2    Kuchroo, V.K.3
  • 94
    • 77955859470 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    • Gandhi R, Kumar D, Burns EJ, Nadeau M, et al. 2010. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol 11: 846–53.
    • (2010) Nat Immunol , vol.11 , pp. 846-853
    • Gandhi, R.1    Kumar, D.2    Burns, E.J.3    Nadeau, M.4
  • 95
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L, Quintana FJ, Pot C, Joller N, et al. 2010. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 11: 854–61.
    • (2010) Nat Immunol , vol.11 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3    Joller, N.4
  • 96
    • 84930576092 scopus 로고    scopus 로고
    • Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α
    • Mascanfroni ID, Takenaka MC, Yeste A, Patel B, et al. 2015. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Nat Med 21: 638–46.
    • (2015) Nat Med , vol.21 , pp. 638-646
    • Mascanfroni, I.D.1    Takenaka, M.C.2    Yeste, A.3    Patel, B.4
  • 97
    • 80051968211 scopus 로고    scopus 로고
    • In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling
    • Wu HY, Quintana FJ, da Cunha AP, Dake BT, et al. 2011. In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PLoS ONE 6: e23618.
    • (2011) PLoS ONE , vol.6
    • Wu, H.Y.1    Quintana, F.J.2    da Cunha, A.P.3    Dake, B.T.4
  • 98
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M, O'Garra A. 2010. The regulation of IL-10 production by immune cells. Nat Rev Immunol 10: 170–81.
    • (2010) Nat Rev Immunol , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 99
    • 84951782209 scopus 로고    scopus 로고
    • Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis
    • Chen S-J., Huang S-H., Chen J-W., Wang K-C., et al. 2016. Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis. Int Immunopharmacol 31: 169–77.
    • (2016) Int Immunopharmacol , vol.31 , pp. 169-177
    • Chen, S.-J.1    Huang, S.-H.2    Chen, J.-W.3    Wang, K.-C.4
  • 100
    • 84886728752 scopus 로고    scopus 로고
    • IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
    • Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, et al. 2013. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol 14: 1054–63.
    • (2013) Nat Immunol , vol.14 , pp. 1054-1063
    • Mascanfroni, I.D.1    Yeste, A.2    Vieira, S.M.3    Burns, E.J.4
  • 101
    • 0026951245 scopus 로고
    • Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis
    • Sandyk R, Awerbuch GI. 1992. Nocturnal plasma melatonin and alpha-melanocyte stimulating hormone levels during exacerbation of multiple sclerosis. Int J Neurosci 67: 173–86.
    • (1992) Int J Neurosci , vol.67 , pp. 173-186
    • Sandyk, R.1    Awerbuch, G.I.2
  • 102
    • 0028410563 scopus 로고
    • Relationship of nocturnal melatonin levels to duration and course of multiple sclerosis
    • Sandyk R, Awerbuch GI. 1994. Relationship of nocturnal melatonin levels to duration and course of multiple sclerosis. Int J Neurosci 75: 229–37.
    • (1994) Int J Neurosci , vol.75 , pp. 229-237
    • Sandyk, R.1    Awerbuch, G.I.2
  • 103
    • 0028426921 scopus 로고
    • The relationship of pineal calcification to cerebral atrophy on CT scan in multiple sclerosis
    • Sandyk R, Awerbuch GI. 1994. The relationship of pineal calcification to cerebral atrophy on CT scan in multiple sclerosis. Int J Neurosci 76: 71–9.
    • (1994) Int J Neurosci , vol.76 , pp. 71-79
    • Sandyk, R.1    Awerbuch, G.I.2
  • 104
    • 84959206259 scopus 로고    scopus 로고
    • Prevalence of comorbidities, overweight and obesity in an international sample of people with multiple sclerosis and associations with modifiable lifestyle factors
    • Marck CH, Neate SL, Taylor KL, Weiland TJ, et al. 2016. Prevalence of comorbidities, overweight and obesity in an international sample of people with multiple sclerosis and associations with modifiable lifestyle factors. PLoS ONE 11: e0148573.
    • (2016) PLoS ONE , vol.11
    • Marck, C.H.1    Neate, S.L.2    Taylor, K.L.3    Weiland, T.J.4
  • 105
    • 84857062468 scopus 로고    scopus 로고
    • Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis
    • Melamud L, Golan D, Luboshitzky R, Lavi I, et al. 2012. Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. J Neurol Sci 314: 37–40.
    • (2012) J Neurol Sci , vol.314 , pp. 37-40
    • Melamud, L.1    Golan, D.2    Luboshitzky, R.3    Lavi, I.4
  • 106
    • 54049091063 scopus 로고    scopus 로고
    • The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis
    • Akpınar Z, Tokgöz S, Gökbel H, Okudan N, et al. 2008. The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis. Psychiatry Res 161: 253–7.
    • (2008) Psychiatry Res , vol.161 , pp. 253-257
    • Akpınar, Z.1    Tokgöz, S.2    Gökbel, H.3    Okudan, N.4
  • 107
    • 84897574115 scopus 로고    scopus 로고
    • Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies
    • Wingerchuk DM, Carter JL. 2014. Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies. Mayo Clin Proc 89: 225–40.
    • (2014) Mayo Clin Proc , vol.89 , pp. 225-240
    • Wingerchuk, D.M.1    Carter, J.L.2
  • 108
    • 84895778126 scopus 로고    scopus 로고
    • Elevated melatonin levels in natalizumab-treated female patients with relapsing-remitting multiple sclerosis: Relationship to oxidative stress
    • Bahamonde C, Conde C, Aguera E, Lillo R, et al. 2014. Elevated melatonin levels in natalizumab-treated female patients with relapsing-remitting multiple sclerosis: Relationship to oxidative stress. Eur J Pharmacol 730: 26–30.
    • (2014) Eur J Pharmacol , vol.730 , pp. 26-30
    • Bahamonde, C.1    Conde, C.2    Aguera, E.3    Lillo, R.4
  • 109
    • 84864838067 scopus 로고    scopus 로고
    • Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients
    • Natarajan R, Einarsdottir E, Riutta A, Hagman S, et al. 2012. Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients. J Neuroimmunol 250: 106–10.
    • (2012) J Neuroimmunol , vol.250 , pp. 106-110
    • Natarajan, R.1    Einarsdottir, E.2    Riutta, A.3    Hagman, S.4
  • 111
    • 84896316429 scopus 로고    scopus 로고
    • The role of melatonin in the pathogenesis of multiple sclerosis: a case-control study
    • Ghorbani A, Salari M, Shaygannejad V, Norouzi R. 2013. The role of melatonin in the pathogenesis of multiple sclerosis: a case-control study. Int J Prev Med 4: S180–4.
    • (2013) Int J Prev Med , vol.4 , pp. S180-S184
    • Ghorbani, A.1    Salari, M.2    Shaygannejad, V.3    Norouzi, R.4
  • 112
    • 2942536034 scopus 로고    scopus 로고
    • Epidemiology of urinary melatonin in women and its relation to other hormones and night work
    • Schernhammer ES, Rosner B, Willett WC, Laden F, et al. 2004. Epidemiology of urinary melatonin in women and its relation to other hormones and night work. Cancer Epidemiol Biomarkers Prev 13: 936–43.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 936-943
    • Schernhammer, E.S.1    Rosner, B.2    Willett, W.C.3    Laden, F.4
  • 113
    • 83255185061 scopus 로고    scopus 로고
    • Shift work at young age is associated with increased risk for multiple sclerosis
    • Hedström AK, Åkerstedt T, Hillert J, Olsson T, et al. 2011. Shift work at young age is associated with increased risk for multiple sclerosis. Ann Neurol 70: 733–41.
    • (2011) Ann Neurol , vol.70 , pp. 733-741
    • Hedström, A.K.1    Åkerstedt, T.2    Hillert, J.3    Olsson, T.4
  • 115
    • 38949107656 scopus 로고    scopus 로고
    • Environmental factors and multiple sclerosis
    • Ebers GC. 2008. Environmental factors and multiple sclerosis. Lancet Neurol 7: 268–77.
    • (2008) Lancet Neurol , vol.7 , pp. 268-277
    • Ebers, G.C.1
  • 116
    • 69949125268 scopus 로고    scopus 로고
    • Melatonin prolongs islet graft survival in diabetic NOD mice
    • Lin G-J., Huang S-H., Chen Y-W., Hueng D-Y., et al. 2009. Melatonin prolongs islet graft survival in diabetic NOD mice. J Pineal Res 47: 284–92.
    • (2009) J Pineal Res , vol.47 , pp. 284-292
    • Lin, G.-J.1    Huang, S.-H.2    Chen, Y.-W.3    Hueng, D.-Y.4
  • 117
    • 14344264865 scopus 로고    scopus 로고
    • Dual effect of melatonin as proinflammatory and antioxidant in collagen-induced arthritis in rats
    • Jimenez-Caliani AJ, Jimenez-Jorge S, Molinero P, Guerrero JM, et al. 2005. Dual effect of melatonin as proinflammatory and antioxidant in collagen-induced arthritis in rats. J Pineal Res 38: 93–9.
    • (2005) J Pineal Res , vol.38 , pp. 93-99
    • Jimenez-Caliani, A.J.1    Jimenez-Jorge, S.2    Molinero, P.3    Guerrero, J.M.4
  • 118
    • 84857036017 scopus 로고    scopus 로고
    • Melatonin attenuates clock gene cryptochrome1, which may aggravate mouse anti-type II collagen antibody-induced arthritis
    • Bang J, Chang HW, Jung H-R, Cho C-H, et al. 2012. Melatonin attenuates clock gene cryptochrome1, which may aggravate mouse anti-type II collagen antibody-induced arthritis. Rheumatol Int 32: 379–85.
    • (2012) Rheumatol Int , vol.32 , pp. 379-385
    • Bang, J.1    Chang, H.W.2    Jung, H.-R.3    Cho, C.-H.4
  • 119
    • 84890130576 scopus 로고    scopus 로고
    • Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms
    • Trivedi PP, Jena GB. 2013. Melatonin reduces ulcerative colitis-associated local and systemic damage in mice: investigation on possible mechanisms. Dig Dis Sci 58: 3460–74.
    • (2013) Dig Dis Sci , vol.58 , pp. 3460-3474
    • Trivedi, P.P.1    Jena, G.B.2
  • 120
    • 84902288707 scopus 로고    scopus 로고
    • Melatonin attenuates dextran sodium sulfate induced colitis with sleep deprivation: possible mechanism by microarray analysis
    • Chung SH, Park YS, Kim OS, Kim JH, et al. 2014. Melatonin attenuates dextran sodium sulfate induced colitis with sleep deprivation: possible mechanism by microarray analysis. Dig Dis Sci 59: 1134–41.
    • (2014) Dig Dis Sci , vol.59 , pp. 1134-1141
    • Chung, S.H.1    Park, Y.S.2    Kim, O.S.3    Kim, J.H.4
  • 121
    • 33749365523 scopus 로고    scopus 로고
    • Melatonin modulates signal transduction pathways and apoptosis in experimental colitis
    • Mazzon E, Esposito E, Crisafulli C, Riccardi L, et al. 2006. Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. J Pineal Res 41: 363–73.
    • (2006) J Pineal Res , vol.41 , pp. 363-373
    • Mazzon, E.1    Esposito, E.2    Crisafulli, C.3    Riccardi, L.4
  • 122
    • 49549087478 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis
    • Esposito E, Mazzon E, Riccardi L, Caminiti R, et al. 2008. Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. J Pineal Res 45: 166–73.
    • (2008) J Pineal Res , vol.45 , pp. 166-173
    • Esposito, E.1    Mazzon, E.2    Riccardi, L.3    Caminiti, R.4
  • 123
    • 25644449484 scopus 로고    scopus 로고
    • Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis
    • Li J-H, Yu J-P, Yu H-G, Xu X-M, et al. 2005. Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis. Mediators Inflamm 2005: 185–93.
    • (2005) Mediators Inflamm , vol.2005 , pp. 185-193
    • Li, J.-H.1    Yu, J.-P.2    Yu, H.-G.3    Xu, X.-M.4
  • 124
    • 27144513254 scopus 로고    scopus 로고
    • Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro
    • Mei Q, Xu J-M, Xiang L, Hu Y-M, et al. 2005. Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro. Postgrad Med J 81: 667–72.
    • (2005) Postgrad Med J , vol.81 , pp. 667-672
    • Mei, Q.1    Xu, J.-M.2    Xiang, L.3    Hu, Y.-M.4
  • 125
  • 126
    • 56149118587 scopus 로고    scopus 로고
    • Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis
    • Li JH, Zhou W, Liu K, Li HX, et al. 2008. Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. Saudi Med J 29: 1088–94.
    • (2008) Saudi Med J , vol.29 , pp. 1088-1094
    • Li, J.H.1    Zhou, W.2    Liu, K.3    Li, H.X.4
  • 127
    • 33644890227 scopus 로고    scopus 로고
    • Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis
    • Marquez E, Sánchez-Fidalgo S, Calvo JR, la de Lastra CA, et al. 2006. Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis. J Pineal Res 40: 48–55.
    • (2006) J Pineal Res , vol.40 , pp. 48-55
    • Marquez, E.1    Sánchez-Fidalgo, S.2    Calvo, J.R.3    la de Lastra, C.A.4
  • 128
    • 85008943162 scopus 로고    scopus 로고
    • Investigation of the effect of intracolonic melatonin gel formulation on acetic acid-induced colitis
    • Esiringü F, Tuğcu-Demiröz F, Acartürk F, Coşkun Cevher Ş, et al. 2015. Investigation of the effect of intracolonic melatonin gel formulation on acetic acid-induced colitis. Drug Deliv 25: 1–9.
    • (2015) Drug Deliv , vol.25 , pp. 1-9
    • Esiringü, F.1    Tuğcu-Demiröz, F.2    Acartürk, F.3    Coşkun Cevher, Ş.4
  • 129
    • 79952446269 scopus 로고    scopus 로고
    • Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats
    • Tahan G, Gramignoli R, Marongiu F, Aktolga S, et al. 2011. Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. Dig Dis Sci 56: 715–20.
    • (2011) Dig Dis Sci , vol.56 , pp. 715-720
    • Tahan, G.1    Gramignoli, R.2    Marongiu, F.3    Aktolga, S.4
  • 130
    • 49549122616 scopus 로고    scopus 로고
    • Treatment with testosterone or estradiol in melatonin treated females and males MRL/MpJ-Faslpr mice induces negative effects in developing systemic lupus erythematosus
    • Jimenez-Caliani AJ, Jimenez-Jorge S, Molinero P, Rubio A, et al. 2008. Treatment with testosterone or estradiol in melatonin treated females and males MRL/MpJ-Faslpr mice induces negative effects in developing systemic lupus erythematosus. J Pineal Res 45: 204–11.
    • (2008) J Pineal Res , vol.45 , pp. 204-211
    • Jimenez-Caliani, A.J.1    Jimenez-Jorge, S.2    Molinero, P.3    Rubio, A.4
  • 131
    • 84862825938 scopus 로고    scopus 로고
    • Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy
    • Wu C-C, Lu K-C, Lin G-J, Hsieh H-Y, et al. 2012. Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy. J Pineal Res 52: 460–9.
    • (2012) J Pineal Res , vol.52 , pp. 460-469
    • Wu, C.-C.1    Lu, K.-C.2    Lin, G.-J.3    Hsieh, H.-Y.4


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