Effects and mechanisms of melatonin on inflammatory and immune responses of adjuvant arthritis rat

International Immunopharmacology

Volumn 2, Issue 10, 2002, Pages 1443-1449

  Chen, Qun ^a   Wei, Wei ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Adjuvant arthritis; Cyclic AMP; Enkephalin; Interleukin 2; Melatonin; Proliferation of lymphocyte

Indexed keywords

3 (4,5 2 DIMETHYLTHIAZOL 2 YL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BROMINE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CYCLIC AMP; FORSKOLIN; FREUND ADJUVANT; INTERLEUKIN 2; MELATONIN; METENKEPHALIN; NIFEDIPINE; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN BINDING; PROTEIN DETERMINATION; RADIOIMMUNOASSAY; RAT; SPLEEN CELL; THYMOCYTE; ANIMAL; ARTHRITIS; BIOSYNTHESIS; C57BL MOUSE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; SPRAGUE DAWLEY RAT;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CYCLIC AMP; ENKEPHALIN, METHIONINE; LYMPHOCYTE ACTIVATION; MELATONIN; MICE; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036710116     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(02)00088-7     Document Type: Article

References (18)

1. Xu S.Y., Shen Y.X., Xu D.J. Effects of total glucosides of paeony and moutan cortex on the functions of pineal gland in inflammatory-immune regulation in rats. Chin. J. Pharmacol. Toxicol. 8:1994;161-165.
2. Shen Y.X., Wei W., Xu S.Y. Effects of pinealictomy and melatonin on inflammation response. Chin. Pharmacol. Bull. 10:1994;123-124.
3. Wei W., Liang J.S., Chen X.G. Effects of melatonin on the functions of lymphocytes. Chin. Pharmacol. Bull. 8:1992;123-124.
4. Wei W., Liang J.S., Chen X.G. Effects of supernatants from cultured rat pineal gland on the function of lymphocytes. Chin. Pharmacol. Bull. 8:1992;125-127.
5. Wei W., Liang J.S., Chen X.G. Effects of melatonin and supernatants from cultured rat pineal gland on interleukin1. Chin. Pharmacol. Bull. 8:1992;66-68.
6. Shen Y.X., Wei W., Xu S.Y. Effects of pineal gland on immune cells in normal and adjuvant arthritis rats. Chin. Pharmacol. Bull. 11:1995;386-388.
7. Shen Y.X., Wei W., Xu S.Y. Effects of pinealictomy and melatonin on pituitary-adrenal axis. Chin. Pharmacol. Bull. 12:1996;62-65.
8. Xu S.Y., Wei W., Shen Y.X. Studies on the anti-inflammatory, immunoregulatory, and analgesic actions of melatonin. Drug Dev. Res. 39:1996;167-173.
9. Wei W., Shen Y.X., Ding C.H. Effects of melatonin on morphine-induced mice dependence and relation with enkephalin. Chin. Pharmacol. Bull. 14:1998;72-74.
10. Wei W., Chen M.Z., Xu S.Y. Pharmacological effects of isoxicam. Chin. Pharmacol. Bull. 2:1986;29-34.
11. 125I RIA Kit.
12. Lopez-Gonzalez M.A., Calvo J.R., Osuna C. Synergistic action of melatonin and vasoactive intestinal peptide in stimulating cyclic AMP production in human lymphocytes. J. Pineal Res. 12:1992;174-180.
13. Maestroni G.J.M. The immunoendocrine role of melatonin. J. Pineal Res. 14:1993;1-10.
14. Maestroni G.J.M., Conti A., Pierpaoli W. Role of the pineal gland in immunity: III. M antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology. 63:1988;465-469.
15. + cells to release opioid agonist(s) with immunoenhancing and antistress properties. J. Neuroimmunol. 28:1990;167-176.
16. Maestroni G.J.M., Hertens E., Galli P. New T-helper cell opioid cytokines as mediators of the immunological and hematopoietic action of melatonin. Proceedings of 2nd Locarno meeting on neuroendocrinoimmunity, Switzerland. 1996;21.
17. Maestroni G.J.M., Conti A. Anti-stress role of the melatonin-immuno-opioid network. Evidence for a physiological mechanism involving T cell-derived immunoreactive β-endorphin and met-enkephalin binding to thymic opioid receptors. Int. J. Neurosci. 61:1991;289-298.
18. Maestroni G.J.M., Conti A. Melatonin in relation to the immune system. Yu H.-S., Reiter R.J. Melatonin: biosynthesis, physiological effects and clinical applications. 1993;290-306 CRC Press, Boca Raton.