Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo

Inflammation Research

Volumn 62, Issue 6, 2013, Pages 599-607

  Cowden, Jeffery M ^a   Yu, Fuqu ^a   Challapalli, Mamatha ^a   Huang, Jing Feng ^b   Kim, Sunhwa ^a   Fung Leung, Wai Ping ^a   Ma, Jing Ying ^a   Riley, Jason P ^a   Zhang, Mai ^c   Dunford, Paul J ^a   Thurmond, Robin L ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b La Jolla BioConsulting   (United States)

^c Sialix Inc   (United States)

Author keywords

Histamine; Kupffer cells; Macrophages; Toll like receptors

Indexed keywords

1 (5 CHLORO 2 INDOLYLCARBONYL) 4 METHYLPIPERAZINE; ALANINE AMINOTRANSFERASE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; JNJ 28307474; MESSENGER RNA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; 1-((5-CHLORO-1H-INDOL-2-YL)CARBONYL)-4-METHYLPIPERAZINE; ALLERGEN; ANTIHISTAMINIC AGENT; G PROTEIN COUPLED RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, MOUSE; INDOLE DERIVATIVE; INTERLEUKIN 13; LIPOPOLYSACCHARIDE; OVALBUMIN; PIPERAZINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; KUPFFER CELL; LIVER DYSFUNCTION; MACROPHAGE; MOUSE; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BLOOD; CHEMICALLY INDUCED; DRUG-INDUCED LIVER INJURY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

ALLERGENS; ANIMALS; ASTHMA; DRUG-INDUCED LIVER INJURY; FEMALE; HISTAMINE ANTAGONISTS; HUMANS; INDOLES; INTERLEUKIN-13; KUPFFER CELLS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; PIPERAZINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878250205     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-013-0612-5     Document Type: Article

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