How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end

Arthritis and Rheumatism

Volumn 46, Issue 2, 2002, Pages 298-308

  Firestein, Gary S ^a   Zvaifler, Nathan J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; CELL ACTIVATION; CYTOKINE PRODUCTION; FIBROBLAST; HUMAN; IMMUNITY; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVITIS; T LYMPHOCYTE;

ARTHRITIS, RHEUMATOID; CHRONIC DISEASE; FIBROBLASTS; HUMANS; SYNOVITIS; T-LYMPHOCYTES;

EID: 0036169592     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.502     Document Type: Review

References (92)

1. How important are T cells in chronic rheumatoid synovitis?
2. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis
3. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor
4. Quantitative analysis of cytokine gene expression in rheumatoid arthritis
5. The role of T cells in the immunopathogenesis of rheumatoid arthritis: New perspectives
6. Low levels of interleukin-4 and high levels of transforming growth factor β in rheumatoid synovitis
7. Restricted cytokine expression in rheumatoid arthritis
8. The innate immune system in rheumatoid arthritis
9. Immunohistologic features in the synovium obtained from clinically uninvolved knee joints of patients with rheumatoid arthritis
10. Early synovitis: Synoviocytes and mononuclear cells
11. Asymptomatic synovitis precedes clinically manifest arthritis
12. Antifillagrin antibodies within a "normal" range predict rheumatoid arthritis in a linear fashion
13. When does rheumatoid arthritis begin and why do we need to know?
14. Presentation of self peptides by dendritic cells: Possible implications for the pathogenesis of rheumatoid arthritis
15. Collagen induced arthritis: An animal model of autoimmunity
16. Morphologic demonstration of two stages in the development of type II collagen-induced arthritis
17. Joint inflammation in experimental arthritis is preceded by tumor necrosis factor α-dependent infiltration of the synovium by mesenchymal cells
18. AP-1 and NF-KB regulation in rheumatoid arthritis and murine collagen induced arthritis
19. The effect of dexamethasone on the expression of activated NF-in adjuvant arthritis
20. Association of the course of collagen-induced arthritis with distinct patterns of cytokine and chemokine messenger RNA expression
21. Adjuvant-induced polyarthritis: Synovial cell activation prior to polyarthritis onset
22. Rheumatoid arthritis: A synovial disease?
23. Periarticular osteopenia in adjuvant induced arthritis: Role of interleukin-1 in decreased osteogenic and increased resorptive potential of bone marrow cells
24. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
25. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in TLR4 gene
26. Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infection
27. Collagen induced arthritis in C57BL/6 (H-2b) mice: New insights into an important disease model of rheumatoid arthritis
28. Immune interferon in the circulation of patients with autoimmune disease
29. The demonstration of an interleukin-2 like activity in the synovial fluids of rheumatoid arthritis patients
30. Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: A possible role in rheumatoid arthritis
31. Local production of tumor necrosis factor and IFN-in tuberculous pleuritis
32. Cytokines in symptomatic asthma airways
33. Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue
34. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
35. The expanding universe of T-cell subsets: Th1, Th2 and more
36. Divergent T-cell cytokine patterns in inflammatory arthritis
37. In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis
38. Th1/Th2 cytokine balance in arthritis
39. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis
40. Antagonistic and agonistic effects of transforming growth factor-β and IL-1 in rheumatoid synovium
41. Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis
42. Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis
43. Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy
44. The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis
45. Low-level production of interleukin-13 in synovial fluid and tissue from patients with arthritis
46. Interleukin-15 and its role in chronic inflammatory diseases
47. Interleukin 15: A proinflammatory role in rheumatoid arthritis synovitis
48. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
49. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis
50. Expression of interferon(IFN, IL-10, IL-12 and transforming growth factor-β (TGF-β) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA)
51. A proinflammatory role for IL-18 in rheumatoid arthritis
52. Cytokines and direct cell contact in synovitis: Relevance to therapeutic intervention
53. Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: Involvement of membrane-associated cytokines
54. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis
55. CXCR3 and CCR5 ligands in rheumatoid arthritis synovium
56. Predominance of mononuclear cells expressing the chemokine receptor CCR5 in synovial effusions of patients with different forms of arthritis
57. Chimeric anti-tumor necrosis factor-α monoclonal antibody treatment of patients with rheumatoid arthritis receiving methotrexate therapy
58. Collagen induced arthritis in CD4- or CD8-deficient mice
59. Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen
60. Transgenic mice expressing human tumor necrosis factor: A predictive genetic model of arthritis
61. Modulation of proinflammatory cytokine production in tumor necrosis factor α transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13
62. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implication for joint and gut associated immunopathologies
63. Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis
64. Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis
65. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal cartilage into SCID mice
66. Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene
67. Development of in vitro model systems for destructive joint diseases: Novel strategies for establishing inflammatory pannus
68. Invasive fibroblast-like synoviocytes in rheumatoid arthritis: Passive responders or transformed aggressors?
69. Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
70. Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases
71. Pannocytes: Distinctive cells found in rheumatoid arthritis articular cartilage erosions
72. Characterization of fibroblast like cells in pannus lesions of patients with rheumatoid arthritis sharing properties of fibroblasts and chondrocytes
73. Monoclonal expansion of synoviocytes in rheumatoid arthritis
74. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium
75. H-ras oncogene point mutations in arthritic synovium
76. Mesenchymal precursor cells in the circulation of normal individuals
77. Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint
78. Chondroprogenitor cells of synovial tissue
79. Multipotent mesenchymal stem cells from adult human synovial membrane
80. Expression and function of wingless and frizzled homologs in rheumatoid arthritis
81. Blockade of Wnt-5A/Frizzled 5 signaling inhibits rheumatoid synoviocyte activation
82. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor
83. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
84. Human mesenchymal stem cells promote human osteoclast differentiation from CD34+ bone marrow hematopoietic progenitors
85. Control of osteoclast differentiation
86. Bone resorption by tartrate resistant acid phosphatase-positive multinuclear cells isolated from rheumatoid synovium
87. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis
88. Involvement of the receptor activator of nuclear factor B ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
89. Clinical improvement and radiologic deterioration in rheumatoid arthritis: Evidence that the pathogenesis of synovial inflammation and articular erosion may differ
90. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement
91. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
92. Infliximab and methotrexate in the treatment of rheumatoid arthritis