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Volumn 5, Issue AUG, 2014, Pages

Gene expression profiling in mouse embryonic stem cells reveals glycogen synthase kinase-3-dependent targets of phosphatidylinositol 3-kinase and Wnt/β-catenin signaling pathways

Author keywords

Embryonic stem cells; Glycogen synthase kinase 3; Microarray; Phosphatidylinositol 3 kinase; Quantitative PCR; Signal transduction, gene expression; Wnt

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 84987825306     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00133     Document Type: Article
Times cited : (8)

References (63)
  • 1
    • 0019026208 scopus 로고
    • Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase
    • Embi N, Rylatt DB, Cohen P. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem (1980) 107:519-27. doi: 10.1111/j.1432-1033.1980.tb06059.x
    • (1980) Eur J Biochem , vol.107 , pp. 519-527
    • Embi, N.1    Rylatt, D.B.2    Cohen, P.3
  • 2
    • 0025286104 scopus 로고
    • Molecular cloning and expression of glycogen synthase kinase-3/factor A
    • Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J (1990) 9:2431-8.
    • (1990) EMBO J , vol.9 , pp. 2431-2438
    • Woodgett, J.R.1
  • 3
    • 77950894143 scopus 로고    scopus 로고
    • A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity
    • Buescher JL, Phiel CJ. A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity. J Biol Chem (2010) 285:7957-63. doi:10.1074/jbc.M109.091603
    • (2010) J Biol Chem , vol.285 , pp. 7957-7963
    • Buescher, J.L.1    Phiel, C.J.2
  • 4
    • 0034859101 scopus 로고    scopus 로고
    • The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
    • Grimes CA, Jope RS. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol (2001) 65:391-426. doi:10.1016/S0301-0082(01)00024-7
    • (2001) Prog Neurobiol , vol.65 , pp. 391-426
    • Grimes, C.A.1    Jope, R.S.2
  • 5
    • 0035477020 scopus 로고    scopus 로고
    • GSK3 takes centre stage more than 20 years after its discovery
    • Frame S, Cohen P. GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 359:1-16. doi:10.1042/0264-6021:3590001
    • (2001) Biochem J , vol.359 , pp. 1-16
    • Frame, S.1    Cohen, P.2
  • 6
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: tricks of the trade for a multi-tasking kinase
    • Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci (2003) 116:1175-86. doi:10.1242/jcs.00384
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 7
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross D, Alessi D, Cohen P, Andjelkovich M, Hemmings B. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1995) 378:785-9. doi:10.1038/378785a0
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.1    Alessi, D.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.5
  • 8
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA, Williams LT. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol (1996) 16: 4117-27.
    • (1996) Mol Cell Biol , vol.16 , pp. 4117-4127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.A.5    Williams, L.T.6
  • 9
    • 78650663065 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci
    • Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, et al. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem (2010) 285:41337-47. doi:10.1074/jbc.M110.170704
    • (2010) J Biol Chem , vol.285 , pp. 41337-41347
    • Popkie, A.P.1    Zeidner, L.C.2    Albrecht, A.M.3    D'Ippolito, A.4    Eckardt, S.5    Newsom, D.E.6
  • 10
    • 0038100185 scopus 로고    scopus 로고
    • Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
    • Takahashi K, Mitsui K, Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature (2003) 423:541-5. doi:10.1038/nature01646
    • (2003) Nature , vol.423 , pp. 541-545
    • Takahashi, K.1    Mitsui, K.2    Yamanaka, S.3
  • 11
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling and disease
    • Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell (2012) 149:1192-205. doi:10.1016/j.cell.2012.05.012
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 12
    • 0029664368 scopus 로고    scopus 로고
    • Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    • Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science (1996) 272:1023-6. doi:10.1126/science.272.5264.1023
    • (1996) Science , vol.272 , pp. 1023-1026
    • Rubinfeld, B.1    Albert, I.2    Porfiri, E.3    Fiol, C.4    Munemitsu, S.5    Polakis, P.6
  • 13
    • 0029683606 scopus 로고    scopus 로고
    • The axis-inducing activity, stability, and subcellular distribution of b-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    • Yost C, Torres M, Miller J, Huang E, Kimelman D, Moon R. The axis-inducing activity, stability, and subcellular distribution of b-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev (1996) 10:1443-54. doi:10.1101/gad.10.12.1443
    • (1996) Genes Dev , vol.10 , pp. 1443-1454
    • Yost, C.1    Torres, M.2    Miller, J.3    Huang, E.4    Kimelman, D.5    Moon, R.6
  • 14
    • 0030978351 scopus 로고    scopus 로고
    • beta-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J (1997) 16:3797-804. doi:10.1093/emboj/16.13.3797
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 15
    • 28644439005 scopus 로고    scopus 로고
    • mechanism for Wnt co-receptor phosphorylation and activation
    • Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, et al. mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 438:873-7. doi:10.1038/nature04185
    • (2005) Nature , vol.438 , pp. 873-877
    • Zeng, X.1    Tamai, K.2    Doble, B.3    Li, S.4    Huang, H.5    Habas, R.6
  • 16
    • 62849125293 scopus 로고    scopus 로고
    • Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6
    • Wu G, Huang H, Garcia Abreu J, He X. Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS One (2009) 4:e4926. doi:10.1371/journal.pone.0004926
    • (2009) PLoS One , vol.4
    • Wu, G.1    Huang, H.2    Garcia Abreu, J.3    He, X.4
  • 17
    • 78650484935 scopus 로고    scopus 로고
    • Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
    • Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, et al. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell (2010) 143:1136-48. doi:10.1016/j.cell.2010.11.034
    • (2010) Cell , vol.143 , pp. 1136-1148
    • Taelman, V.F.1    Dobrowolski, R.2    Plouhinec, J.L.3    Fuentealba, L.C.4    Vorwald, P.P.5    Gumper, I.6
  • 18
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma
    • Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science (1997) 275:1784-7. doi:10.1126/science.275.5307.1784
    • (1997) Science , vol.275 , pp. 1784-1787
    • Korinek, V.1    Barker, N.2    Morin, P.J.3    van Wichen, D.4    de Weger, R.5    Kinzler, K.W.6
  • 19
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 275:1787-90. doi:10.1126/science.275.5307.1787
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6
  • 20
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation [see comments]
    • Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation [see comments]. Nature (2000) 406:86-90. doi:10.1038/35017574
    • (2000) Nature , vol.406 , pp. 86-90
    • Hoeflich, K.P.1    Luo, J.2    Rubie, E.A.3    Tsao, M.S.4    Jin, O.5    Woodgett, J.R.6
  • 21
    • 33847405867 scopus 로고    scopus 로고
    • Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice
    • Liu KJ, Arron JR, Stankunas K, Crabtree GR, Longaker MT. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature (2007) 446:79-82. doi:10.1038/nature05557
    • (2007) Nature , vol.446 , pp. 79-82
    • Liu, K.J.1    Arron, J.R.2    Stankunas, K.3    Crabtree, G.R.4    Longaker, M.T.5
  • 22
    • 34548841091 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism
    • MacAulay K, Doble BW, Patel S, Hansotia T, Sinclair EM, Drucker DJ, et al. Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metab (2007) 6:329-37. doi:10.1016/j.cmet.2007.08.013
    • (2007) Cell Metab , vol.6 , pp. 329-337
    • MacAulay, K.1    Doble, B.W.2    Patel, S.3    Hansotia, T.4    Sinclair, E.M.5    Drucker, D.J.6
  • 23
    • 34249311572 scopus 로고    scopus 로고
    • Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
    • Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR. Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell (2007) 12:957-71. doi:10.1016/j.devcel.2007.04.001
    • (2007) Dev Cell , vol.12 , pp. 957-971
    • Doble, B.W.1    Patel, S.2    Wood, G.A.3    Kockeritz, L.K.4    Woodgett, J.R.5
  • 24
    • 78649708128 scopus 로고    scopus 로고
    • Gsk3beta is required in the epithelium for palatal elevation in mice
    • He F, Popkie AP, Xiong W, Li L, Wang Y, Phiel CJ, et al. Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn (2010) 239:3235-46. doi:10.1002/dvdy.22466
    • (2010) Dev Dyn , vol.239 , pp. 3235-3246
    • He, F.1    Popkie, A.P.2    Xiong, W.3    Li, L.4    Wang, Y.5    Phiel, C.J.6
  • 25
    • 84869854809 scopus 로고    scopus 로고
    • Novel reporter alleles of GSK-3alpha and GSK-3beta
    • Barrell WB, Szabo-Rogers HL, Liu KJ. Novel reporter alleles of GSK-3alpha and GSK-3beta. PLoS One (2012) 7:e50422. doi:10.1371/journal.pone.0050422
    • (2012) PLoS One , vol.7
    • Barrell, W.B.1    Szabo-Rogers, H.L.2    Liu, K.J.3
  • 26
    • 80051806451 scopus 로고    scopus 로고
    • GSK-3 is a master regulator of neural progenitor homeostasis
    • Kim WY, Wang X, Wu Y, Doble BW, Patel S, Woodgett JR, et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nat Neurosci (2009) 12:1390-97. doi:10.1038/nn.2408
    • (2009) Nat Neurosci , vol.12 , pp. 1390-1397
    • Kim, W.Y.1    Wang, X.2    Wu, Y.3    Doble, B.W.4    Patel, S.5    Woodgett, J.R.6
  • 27
    • 0034693230 scopus 로고    scopus 로고
    • Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling
    • Ding VW, Chen RH, McCormick F. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. J Biol Chem (2000) 275:32475-81. doi:10.1074/jbc.M005342200
    • (2000) J Biol Chem , vol.275 , pp. 32475-32481
    • Ding, V.W.1    Chen, R.H.2    McCormick, F.3
  • 28
    • 18444399216 scopus 로고    scopus 로고
    • Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    • McManus EJ, Sakamoto K, Armit LJ, Ronaldson L, Shpiro N, Marquez R, et al. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J (2005) 24:1571-83. doi:10.1038/sj.emboj.7600633
    • (2005) EMBO J , vol.24 , pp. 1571-1583
    • McManus, E.J.1    Sakamoto, K.2    Armit, L.J.3    Ronaldson, L.4    Shpiro, N.5    Marquez, R.6
  • 29
    • 72149109797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade
    • Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, Korswagen HC, et al. Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. J Biol Chem (2009) 284:35308-13. doi:10.1074/jbc.M109.078261
    • (2009) J Biol Chem , vol.284 , pp. 35308-35313
    • Ng, S.S.1    Mahmoudi, T.2    Danenberg, E.3    Bejaoui, I.4    de Lau, W.5    Korswagen, H.C.6
  • 30
    • 0029776032 scopus 로고    scopus 로고
    • A molecular mechanism for the effect of lithium on development
    • Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA (1996) 93:8455-9. doi:10.1073/pnas.93.16.8455
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8455-8459
    • Klein, P.S.1    Melton, D.A.2
  • 31
    • 0030449964 scopus 로고    scopus 로고
    • Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    • Stambolic V, Ruel L, Woodgett J. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol (1996) 6:1664-8. doi:10.1016/S0960-9822(02)70790-2
    • (1996) Curr Biol , vol.6 , pp. 1664-1668
    • Stambolic, V.1    Ruel, L.2    Woodgett, J.3
  • 32
    • 0035029426 scopus 로고    scopus 로고
    • Molecular Targets of Lithium Action
    • Phiel CJ, Klein PS. Molecular Targets of Lithium Action. Annu Rev Pharmacol Toxicol (2001) 41:789-813. doi:10.1146/annurev.pharmtox.41.1.789
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 789-813
    • Phiel, C.J.1    Klein, P.S.2
  • 34
    • 2642552331 scopus 로고    scopus 로고
    • Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    • Su Y, Ryder J, Li B, Wu X, Fox N, Solenberg P, et al. Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing. Biochemistry (2004) 43:6899-908. doi:10.1021/bi035627j
    • (2004) Biochemistry , vol.43 , pp. 6899-6908
    • Su, Y.1    Ryder, J.2    Li, B.3    Wu, X.4    Fox, N.5    Solenberg, P.6
  • 35
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3a regulates production of Alzheimer's disease amyloid-b peptides
    • Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3a regulates production of Alzheimer's disease amyloid-b peptides. Nature (2003) 423:435-9. doi:10.1038/nature01640
    • (2003) Nature , vol.423 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.3    Klein, P.S.4
  • 36
    • 21044449225 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
    • Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci USA (2005) 102:6990-5. doi:10.1073/pnas.0500466102
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6990-6995
    • Noble, W.1    Planel, E.2    Zehr, C.3    Olm, V.4    Meyerson, J.5    Suleman, F.6
  • 37
    • 68149150844 scopus 로고    scopus 로고
    • A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
    • Sereno L, Coma M, Rodriguez M, Sanchez-Ferrer P, Sanchez MB, Gich I, et al. A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. Neurobiol Dis (2009) 35:359-67. doi:10.1016/j.nbd.2009.05.025
    • (2009) Neurobiol Dis , vol.35 , pp. 359-367
    • Sereno, L.1    Coma, M.2    Rodriguez, M.3    Sanchez-Ferrer, P.4    Sanchez, M.B.5    Gich, I.6
  • 38
    • 84861325478 scopus 로고    scopus 로고
    • Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease
    • Hurtado DE, Molina-Porcel L, Carroll JC, Macdonald C, Aboagye AK, Trojanowski JQ, et al. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. J Neurosci (2012) 32:7392-402. doi:10.1523/JNEUROSCI.0889-12.2012
    • (2012) J Neurosci , vol.32 , pp. 7392-7402
    • Hurtado, D.E.1    Molina-Porcel, L.2    Carroll, J.C.3    Macdonald, C.4    Aboagye, A.K.5    Trojanowski, J.Q.6
  • 39
    • 79551594937 scopus 로고    scopus 로고
    • beta-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism
    • Kelly KF, Ng DY, Jayakumaran G, Wood GA, Koide H, Doble BW. beta-catenin enhances Oct-4 activity and reinforces pluripotency through a TCF-independent mechanism. Cell Stem Cell (2011) 8:214-27. doi:10.1016/j.stem.2010.12.010
    • (2011) Cell Stem Cell , vol.8 , pp. 214-227
    • Kelly, K.F.1    Ng, D.Y.2    Jayakumaran, G.3    Wood, G.A.4    Koide, H.5    Doble, B.W.6
  • 40
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 3:1101-8. doi:10.1038/nprot.2008.73
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 41
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: open software development for computational biology and bioinformatics
    • Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 5:R80. doi:10.1186/gb-2004-5-10-r80
    • (2004) Genome Biol , vol.5 , pp. R80
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3    Bolstad, B.4    Dettling, M.5    Dudoit, S.6
  • 42
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics (2003) 19:185-93. doi:10.1093/bioinformatics/19.2.185
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 43
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA (2001) 98:5116-21. doi:10.1073/pnas.091062498
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 44
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA (2003) 100:9440-5. doi:10.1073/pnas.1530509100
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 45
    • 84987794154 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B (1995) 57:289-300.
    • (1995) J R Stat Soc B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 46
    • 67849130563 scopus 로고    scopus 로고
    • ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
    • Chen J, Bardes EE, Aronow BJ, Jegga AG. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res (2009) 37:W305-11. doi:10.1093/nar/gkp427
    • (2009) Nucleic Acids Res , vol.37 , pp. W305-W311
    • Chen, J.1    Bardes, E.E.2    Aronow, B.J.3    Jegga, A.G.4
  • 47
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 17:9-26. doi:10.1016/j.devcel.2009.06.016
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 48
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    • Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol (2002) 22:1172-83. doi:10.1128/MCB.22.4.1172-1183.2002
    • (2002) Mol Cell Biol , vol.22 , pp. 1172-1183
    • Jho, E.H.1    Zhang, T.2    Domon, C.3    Joo, C.K.4    Freund, J.N.5    Costantini, F.6
  • 49
    • 84890492806 scopus 로고    scopus 로고
    • beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation
    • Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, et al. beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development (2014) 141:148-57. doi:10.1242/dev.101550
    • (2014) Development , vol.141 , pp. 148-157
    • Zhao, T.1    Gan, Q.2    Stokes, A.3    Lassiter, R.N.4    Wang, Y.5    Chan, J.6
  • 50
    • 80053193640 scopus 로고    scopus 로고
    • Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene
    • Soichot M, Hennart B, Al Saabi A, Leloire A, Froguel P, Levy-Marchal C, et al. Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene. PLoS One (2011) 6:e25470. doi:10.1371/journal.pone.0025470
    • (2011) PLoS One , vol.6
    • Soichot, M.1    Hennart, B.2    Al Saabi, A.3    Leloire, A.4    Froguel, P.5    Levy-Marchal, C.6
  • 51
    • 0036190875 scopus 로고    scopus 로고
    • PROMO: detection of known transcription regulatory elements using species-tailored searches
    • Messeguer X, Escudero R, Farre D, Nunez O, Martinez J, Alba MM. PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics (2002) 18:333-4. doi:10.1093/bioinformatics/18.2.333
    • (2002) Bioinformatics , vol.18 , pp. 333-334
    • Messeguer, X.1    Escudero, R.2    Farre, D.3    Nunez, O.4    Martinez, J.5    Alba, M.M.6
  • 52
    • 0042622245 scopus 로고    scopus 로고
    • Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
    • Farre D, Roset R, Huerta M, Adsuara JE, Rosello L, Alba MM, et al. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res (2003) 31:3651-3. doi:10.1093/nar/gkg605
    • (2003) Nucleic Acids Res , vol.31 , pp. 3651-3653
    • Farre, D.1    Roset, R.2    Huerta, M.3    Adsuara, J.E.4    Rosello, L.5    Alba, M.M.6
  • 53
    • 33845508214 scopus 로고    scopus 로고
    • Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
    • Pajares MA, Perez-Sala D. Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism? Cell Mol Life Sci (2006) 63:2792-803. doi:10.1007/s00018-006-6249-6
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2792-2803
    • Pajares, M.A.1    Perez-Sala, D.2
  • 54
    • 79955908085 scopus 로고    scopus 로고
    • BHMT gene polymorphisms as risk factors for cleft lip and cleft palate in a Chinese population
    • Hu Y, Chen E, Mu Y, Li J, Chen R. BHMT gene polymorphisms as risk factors for cleft lip and cleft palate in a Chinese population. Biomed Environ Sci (2011) 24:89-93. doi:10.3967/0895-3988.2011.02.001
    • (2011) Biomed Environ Sci , vol.24 , pp. 89-93
    • Hu, Y.1    Chen, E.2    Mu, Y.3    Li, J.4    Chen, R.5
  • 55
    • 79955956345 scopus 로고    scopus 로고
    • New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate
    • Martinelli M, Masiero E, Carinci F, Morselli PG, Pezzetti F, Scapoli L. New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate. Eur J Oral Sci (2011) 119:193-7. doi:10.1111/j.1600-0722.2011.00824.x
    • (2011) Eur J Oral Sci , vol.119 , pp. 193-197
    • Martinelli, M.1    Masiero, E.2    Carinci, F.3    Morselli, P.G.4    Pezzetti, F.5    Scapoli, L.6
  • 56
    • 77955170638 scopus 로고    scopus 로고
    • Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts
    • Mostowska A, Hozyasz KK, Biedziak B, Misiak J, Jagodzinski PP. Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts. Eur J Oral Sci (2010) 118:325-32. doi:10.1111/j.1600-0722.2010.00757.x
    • (2010) Eur J Oral Sci , vol.118 , pp. 325-332
    • Mostowska, A.1    Hozyasz, K.K.2    Biedziak, B.3    Misiak, J.4    Jagodzinski, P.P.5
  • 57
    • 34249026448 scopus 로고    scopus 로고
    • Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
    • Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, et al. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell (2007) 129:957-68. doi:10.1016/j.cell.2007.03.051
    • (2007) Cell , vol.129 , pp. 957-968
    • Gupta, S.1    Ramjaun, A.R.2    Haiko, P.3    Wang, Y.4    Warne, P.H.5    Nicke, B.6
  • 58
    • 48249099311 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer
    • Yang Y, Iwanaga K, Raso MG, Wislez M, Hanna AE, Wieder ED, et al. Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer. PLoS One (2008) 3:e2220. doi:10.1371/journal.pone.0002220
    • (2008) PLoS One , vol.3
    • Yang, Y.1    Iwanaga, K.2    Raso, M.G.3    Wislez, M.4    Hanna, A.E.5    Wieder, E.D.6
  • 59
    • 58549108859 scopus 로고    scopus 로고
    • The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations
    • Dubrovska A, Kim S, Salamone RJ, Walker JR, Maira SM, Garcia-Echeverria C, et al. The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci USA (2009) 106:268-73. doi:10.1073/pnas.0810956106
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 268-273
    • Dubrovska, A.1    Kim, S.2    Salamone, R.J.3    Walker, J.R.4    Maira, S.M.5    Garcia-Echeverria, C.6
  • 60
    • 84902152865 scopus 로고    scopus 로고
    • ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism
    • Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL, et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest (2014) 124:2696-708. doi:10.1172/JCI72171
    • (2014) J Clin Invest , vol.124 , pp. 2696-2708
    • Yang, Y.1    Ahn, Y.H.2    Chen, Y.3    Tan, X.4    Guo, L.5    Gibbons, D.L.6
  • 61
    • 14844313052 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane
    • Gradilone SA, Carreras FI, Lehmann GL, Marinelli RA. Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane. Biol Cell (2005) 97:831-6. doi:10.1042/BC20040115
    • (2005) Biol Cell , vol.97 , pp. 831-836
    • Gradilone, S.A.1    Carreras, F.I.2    Lehmann, G.L.3    Marinelli, R.A.4
  • 62
    • 69249129158 scopus 로고    scopus 로고
    • ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma
    • Lee MJ, Yu GR, Yoo HJ, Kim JH, Yoon BI, Choi YK, et al. ANXA8 down-regulation by EGF-FOXO4 signaling is involved in cell scattering and tumor metastasis of cholangiocarcinoma. Gastroenterology (2009) 137:1138-50. doi:10.1053/j.gastro.2009.04.015
    • (2009) Gastroenterology , vol.137 , pp. 1138-1150
    • Lee, M.J.1    Yu, G.R.2    Yoo, H.J.3    Kim, J.H.4    Yoon, B.I.5    Choi, Y.K.6
  • 63
    • 84875425493 scopus 로고    scopus 로고
    • FOXQ1, a novel target of the Wnt pathway and a new marker for activation of Wnt signaling in solid tumors
    • Christensen J, Bentz S, Sengstag T, Shastri VP, Anderle P. FOXQ1, a novel target of the Wnt pathway and a new marker for activation of Wnt signaling in solid tumors. PLoS One (2013) 8:e60051. doi:10.1371/journal.pone.0060051
    • (2013) PLoS One , vol.8
    • Christensen, J.1    Bentz, S.2    Sengstag, T.3    Shastri, V.P.4    Anderle, P.5


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