Gsk3β is required in the epithelium for palatal elevation in mice

Developmental Dynamics

Volumn 239, Issue 12, 2010, Pages 3235-3246

  He, Fenglei ^a,d   Popkie, Anthony P ^b   Xiong, Wei ^a   Li, Lu ^a   Wang, Ying ^a   Phiel, Christopher J ^b,c   Chen, Yiping ^a  

^a Tulane University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cleft palate; Gsk3 ; Palatal elevation; Palate development

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; MUTANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLEFT PALATE; CONTROLLED STUDY; EMBRYO; GENE ACTIVATION; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION; GENE INACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE SPECIFICITY;

ANIMALS; BETA CATENIN; CELL PROLIFERATION; CLEFT PALATE; EPITHELIUM; GLYCOGEN SYNTHASE KINASE 3; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MALE; MICE; MICE, KNOCKOUT; ORGAN CULTURE TECHNIQUES; PALATE; SIGNAL TRANSDUCTION; WNT PROTEINS;

MUS;

EID: 78649708128     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22466     Document Type: Article

References (52)

1. Alappat SR, Zhang Z, Suzuki K, Zhang X, Liu H, Jiang R, Yamada G, Chen Y. 2005. The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol 277: 102-113.
2. Barrow JR, Capecchi MR, Rossel M. 1999. Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants. Development 126: 5011-5026.
3. Blanton SH, Bertin T, Serna M, Stal S, Mulliken JB, Hecht JT. 2004. Association of chromosomal regions 3p21.2, 10p13, and 16p13.3 with nonsyndromic cleft lip and palate. Am J Med Genet 125A: 23-27.
4. Bulleit RF, Zimmerman EF. 1985. The influence of the epithelium on palate shelf reorientation. Development 88: 265-279.
5. Carroll TJ, Park J-S, Hayashi S, Majumdar A, McMahon AP. 2005. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 9: 283-292.
6. Casey LM, Lan Y, Cho ES, Maltby KM, Gridley T, Jiang R. 2006. Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn 235: 1830-1844.
7. Ciaraldi TP, Oh DK, Christiansen L, Nikoulina SE, Kong APS, Baxi S, Mudaliar S, Henry RR. 2006. Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab 291: E891-E898.
8. Dansky HM, Charlton SA, Sikes JL, Heath SC, Simantov R, Levin LF, Shu P, Moore KJ, Breslow JL, Smith JD. 1999. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19: 1960-1968.
9. DasGupta R, Fuchs E. 1999. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126: 4557-4568.
10. Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B, O'Rourke M, Koh GY, Soriano P, Betsholtz C. 2004. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet 36: 1111-1116.
11. Doble BW, Woodgett JR. 2003. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116: 1175-1186.
12. Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR. 2007. Functional redundancy of GSK-3alpha and GSK-3b in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell 12: 957-971.
13. Embi N, Rylatt DB, Cohen P. 1980. Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biol 107: 519-527.
14. Farley FW, Soriano P, Steffen LS, Dymecki SM. 2000. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28: 106-110.
15. Ferguson MWJ. 1988. Palate development. Development 103(suppl): 41-60.
16. Force T, Woodgett JR. 2008. Unique and overlapping functions of GSK-3 isoform in cell differentiation and proliferation and cardiovascular development. J Biol Chem 284: 9643-9647.
17. Frame S, Cohen P. 2001. GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359: 1-16.
18. Grigoryan T, Wend P, Klaus A, Birchmeier W. 2008. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev 22: 2308-2341.
19. Grimes CA, Jope RS. 2001. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 65: 391-426.
20. Gritli-Linde A. 2007. Molecular control of secondary palate development. Dev Biol 301: 309-326.
21. Hayashi S, Lewis P, Pevny L, McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119: S97-S101.
22. He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen YP. 2008. Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development 135: 3871-3879.
23. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. 2000. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappa B activation. Nature 406: 86-90.
24. Huang X, Goudy SL, Ketova T, Litingtung Y, Chiang C. 2008. Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn 237: 3079-3087.
25. Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F. 2002. Wnt/beta-Catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22: 1172-1183.
26. Kapoor M, Liu S, Shi-wen X, Huh K, McCann M, Denton CP, Woodgett JR, Abraham DJ, Leask A. 2008. GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest 118: 3279-3290.
27. Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. 2008. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest 118: 3609-3618.
28. Koillinen H, Lahermo P, Rautio J, Hukki J, Peyrard-Janvid M, Kere J. 2008. A genome-wide scan of non-syndromic cleft palate only (CPO) in Finnish multiplex families. J Med Genet 42: 177-184.
29. Lan Y, Jiang R. 2009. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136: 1387-1396.
30. Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R. 2004. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 131: 3207-3216.
31. Lan Y, Ryan RC, Zhang Z, Bullard SA, Bush JO, Maltby KM, Lidral AC, Jiang R. 2006. Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice. Dev Dyn 235: 1448-1454.
32. Lan Y, Wang Q, Ovitt CE, Jiang R. 2007. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis 45: 618-624.
33. Lazzaro C. 1940. Ccanismo di chiusura del palato secondario. Monit Zool Ital 51: 249-273.
34. Lee JM, Kim JY, Cho KW, Lee MJ, Cho SW, Kwak S, Cai J, Jung HS. 2008. Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development. Dev Biol 314: 341-350.
35. Liu KJ, Arron JR, Stankunas K, Crabtree GR, Longaker MT. 2007. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature 446: 79-82.
36. Liu P, Jenkins NA, Copeland NG. 2003. A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 13: 476-484.
37. Martinez-Alvarez C, Bonelli R, Tudela C, Gato A, Mena J, O'Kane S, Ferguson MW. 2000. Bulging medial edge epithelial cells and palatal fusion. Int J Dev Biol 44: 331-335.
38. Nawshad A, Hay ED. 2003. TGFβ3 signaling activates transcription of LEF1 gene to induce epithelial mesenchymal transformation during mouse palatal development. J Cell Biol 163: 1291-1301.
39. Niemann S, Zhao C, Pascu F, Stahl U, Aulepp U, Niswander L, Weber J, Muller U. 2004. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. Am J Hum Genet 74: 558-563.
40. Ontiveros CS, Salm SN, Wilson EL. 2008. Axin2 expression identifies progenitor cells in the murine prostate. Prostate 68: 1263-1272.
41. Rice R, Spencer-Dene B, Connor EC, Gritli-Linde A, McMahon AP, Dickson C, Thesleff I. Rice DPC. 2004. Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest 113: 1692-1700.
42. Song L, Li Y, Wang K, Wang YZ, Molotkov A, Gao L, Zhao T, Yamagami T, Wang Y, Gan Q, Pleasure DE, Zhou CJ. 2009. Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion. Development 136: 3161-3171.
43. Soriano P. 1997. The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 124: 2691-2700.
44. St. Amand TR, Zhang Y, Semina EV, Zhao X, Hu Y, Nguyen L, Murray JC, Chen YP. 2000. Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev Biol 217: 323-332.
45. Tallquist MD, Soriano P. 2003. Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development 130: 507-518.
46. Tudela C, Formoso MA, Martinez T, Perez R, Aparicio M, Maestro C, Del Rio A. Martinez E, Ferguson MW, Martinez-Alvarez C. 2002. TGF-beta3 is required for the adhesion and intercalation of medial epithelial cells during palatal fusion. Int J Dev Biol 46: 333-336.
47. van Amerongen R, Nusse R. 2009. Towards an integrated view of Wnt signaling in development. Development 136: 3205-3214.
48. Wang BE, Wang XD, Ernst JA, Polakis P, Gao WQ. 2008. Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling. PlosOne 3: e2186.
49. Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, Jiang R, Cserjesi P, Chen YP. 2009. Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol 330: 131-141.
50. Yang T, Huang YG, Ye W, Hansen P, Schnermann JB, Briggs JP. 2005. Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice. Am J Physiol Renal Physiol 288: F1125-F1132.
51. Yang Y, Topol L, Lee H, Wu J. 2003. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development 130: 1003-1015.
52. Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen YP. 2002. Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development 129: 4135-4146.